-
1
-
-
35148867907
-
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
-
Agger, K., Cloos, P.A., Christensen, J., et al. (2007). UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 449, 731-734.
-
(2007)
Nature
, vol.449
, pp. 731-734
-
-
Agger, K.1
Cloos, P.A.2
Christensen, J.3
-
2
-
-
34249026300
-
High-resolution profiling of histone methylations in the human genome
-
Barski, A., Cuddapah, S., Cui, K., et al. (2007). High-resolution profiling of histone methylations in the human genome. Cell 129, 823-837.
-
(2007)
Cell
, vol.129
, pp. 823-837
-
-
Barski, A.1
Cuddapah, S.2
Cui, K.3
-
3
-
-
34548128307
-
The development of inflammatory TH-17 cells requires interferon-regulatory factor 4
-
Brustle, A., Heink, S., Huber, M., et al. (2007). The development of inflammatory TH-17 cells requires interferon-regulatory factor 4. Nat. Immunol. 8, 958-966.
-
(2007)
Nat. Immunol.
, vol.8
, pp. 958-966
-
-
Brustle, A.1
Heink, S.2
Huber, M.3
-
4
-
-
84867581744
-
A validated regulatory network for Th17 cell specification
-
Ciofani, M., Madar, A., Galan, C., et al. (2012). A validated regulatory network for Th17 cell specification. Cell 151, 289-303.
-
(2012)
Cell
, vol.151
, pp. 289-303
-
-
Ciofani, M.1
Madar, A.2
Galan, C.3
-
5
-
-
80052277906
-
Control of TH17/Treg balance by hypoxia-inducible factor 1
-
Dang, E.V., Barbi, J., Yang, H.Y., et al. (2011). Control of TH17/Treg balance by hypoxia-inducible factor 1. Cell 146, 772-784.
-
(2011)
Cell
, vol.146
, pp. 772-784
-
-
Dang, E.V.1
Barbi, J.2
Yang, H.Y.3
-
6
-
-
77953293952
-
Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis
-
Durant, L., Watford, W.T., Ramos, H.L., et al. (2010). Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity 32, 605-615.
-
(2010)
Immunity
, vol.32
, pp. 605-615
-
-
Durant, L.1
Watford, W.T.2
Ramos, H.L.3
-
7
-
-
84902682101
-
MiR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression
-
Escobar, T.M., Kanellopoulou, C., Kugler, D.G., et al. (2014). miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression. Immunity 40, 865-879.
-
(2014)
Immunity
, vol.40
, pp. 865-879
-
-
Escobar, T.M.1
Kanellopoulou, C.2
Kugler, D.G.3
-
8
-
-
37749021324
-
Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity
-
Harris, T.J., Grosso, J.F., Yen, H.R., et al. (2007). Cutting edge: an in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. J. Immunol. 179, 4313-4317.
-
(2007)
J. Immunol.
, vol.179
, pp. 4313-4317
-
-
Harris, T.J.1
Grosso, J.F.2
Yen, H.R.3
-
9
-
-
84908029332
-
Inhibition of demethylases by GSK-J1/J4
-
Heinemann, B., Nielsen, J.M., Hudlebusch, H.R., et al. (2014). Inhibition of demethylases by GSK-J1/J4. Nature 514, E1-E2.
-
(2014)
Nature
, vol.514
, pp. E1-E2
-
-
Heinemann, B.1
Nielsen, J.M.2
Hudlebusch, H.R.3
-
10
-
-
36749082438
-
Identification of JmjC domaincontaining UTX and JMJD3 as histone H3 lysine 27 demethylases
-
Hong, S., Cho, Y.W., Yu, L.R., et al. (2007). Identification of JmjC domaincontaining UTX and JMJD3 as histone H3 lysine 27 demethylases. Proc. Natl Acad. Sci. USA 104, 18439-18444.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 18439-18444
-
-
Hong, S.1
Cho, Y.W.2
Yu, L.R.3
-
11
-
-
33748588423
-
The orphan nuclear receptor RORgt directs the differentiation program of proinflammatory IL-17+ T helper cells
-
Ivanov, I.I., McKenzie, B.S., Zhou, L., et al. (2006). The orphan nuclear receptor RORgt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126, 1121-1133.
-
(2006)
Cell
, vol.126
, pp. 1121-1133
-
-
Ivanov, I.I.1
McKenzie, B.S.2
Zhou, L.3
-
12
-
-
84859401055
-
Transcriptional and epigenetic control of T helper cell specification: Molecular mechanisms underlying commitment and plasticity
-
Kanno, Y., Vahedi, G., Hirahara, K., et al. (2012). Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity. Annu. Rev. Immunol. 30, 707-731.
-
(2012)
Annu. Rev. Immunol.
, vol.30
, pp. 707-731
-
-
Kanno, Y.1
Vahedi, G.2
Hirahara, K.3
-
13
-
-
34547232503
-
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
-
Korn, T., Bettelli, E., Gao, W., et al. (2007). IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells. Nature 448, 484-487.
-
(2007)
Nature
, vol.448
, pp. 484-487
-
-
Korn, T.1
Bettelli, E.2
Gao, W.3
-
14
-
-
61949463911
-
IL-17 and th17 cells
-
Korn, T., Bettelli, E., Oukka, M., et al. (2009). IL-17 and Th17 Cells. Ann. Rev. Immunol. 27, 485-517.
-
(2009)
Ann. Rev. Immunol.
, vol.27
, pp. 485-517
-
-
Korn, T.1
Bettelli, E.2
Oukka, M.3
-
15
-
-
84865120905
-
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
-
Kruidenier, L., Chung, C.W., Cheng, Z., et al. (2012). A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488, 404-408.
-
(2012)
Nature
, vol.488
, pp. 404-408
-
-
Kruidenier, L.1
Chung, C.W.2
Cheng, Z.3
-
16
-
-
78650306567
-
T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORgt
-
Lazarevic, V., Chen, X., Shim, J.H., et al. (2011). T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORgt. Nat. Immunol. 12, 96-104.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 96-104
-
-
Lazarevic, V.1
Chen, X.2
Shim, J.H.3
-
17
-
-
84923347358
-
Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation
-
Li, Q.,Zou, J., Wang,M., et al. (2014). Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation. Nat. Commun. 5, 5780.
-
(2014)
Nat. Commun.
, vol.5
, pp. 5780
-
-
Li, Q.1
Zou, J.2
Wang, M.3
-
18
-
-
84867421373
-
Shotgun and targeted proteomics reveal that pre-surgery serum levels of LRG1, SAA, and C4BP may refine prognosis of resected squamous cell lung cancer
-
Liu, Y.S., Luo, X.Y., Li, Q.R., et al. (2012). Shotgun and targeted proteomics reveal that pre-surgery serum levels of LRG1, SAA, and C4BP may refine prognosis of resected squamous cell lung cancer. J. Mol. Cell Biol. 4, 344-347.
-
(2012)
J. Mol. Cell Biol.
, vol.4
, pp. 344-347
-
-
Liu, Y.S.1
Luo, X.Y.2
Li, Q.R.3
-
19
-
-
44049104564
-
The differentiation of human TH-17 cells requires transforming growth factor-b and induction of the nuclear receptor RORgt
-
Manel, N., Unutmaz, D., and Littman, D.R. (2008). The differentiation of human TH-17 cells requires transforming growth factor-b and induction of the nuclear receptor RORgt. Nat. Immunol. 9, 641-649.
-
(2008)
Nat. Immunol.
, vol.9
, pp. 641-649
-
-
Manel, N.1
Unutmaz, D.2
Littman, D.R.3
-
20
-
-
60749107176
-
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo
-
McGeachy, M.J., Chen, Y., Tato, C.M., et al. (2009). The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat. Immunol. 10, 314-324.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 314-324
-
-
McGeachy, M.J.1
Chen, Y.2
Tato, C.M.3
-
21
-
-
78649263390
-
Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression
-
Miller, S.A., Mohn, S.E., and Weinmann, A.S. (2010). Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. Mol. Cell 40, 594-605.
-
(2010)
Mol. Cell
, vol.40
, pp. 594-605
-
-
Miller, S.A.1
Mohn, S.E.2
Weinmann, A.S.3
-
22
-
-
77951877914
-
IkBz regulates TH17 development by cooperating with ROR nuclear receptors
-
Okamoto, K., Iwai, Y., Oh-Hora, M., et al. (2010). IkBz regulates TH17 development by cooperating with ROR nuclear receptors. Nature 464, 1381-1385.
-
(2010)
Nature
, vol.464
, pp. 1381-1385
-
-
Okamoto, K.1
Iwai, Y.2
Oh-Hora, M.3
-
23
-
-
42649095378
-
Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor
-
Quintana, F.J., Basso, A.S., Iglesias, A.H., et al. (2008). Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor. Nature 453, 65-71.
-
(2008)
Nature
, vol.453
, pp. 65-71
-
-
Quintana, F.J.1
Basso, A.S.2
Iglesias, A.H.3
-
24
-
-
81255136238
-
Transcription factor c-Maf mediates the TGF-b-dependent suppression of IL-22 production in TH17 cells
-
Rutz, S., Noubade, R., Eidenschenk, C., et al. (2011). Transcription factor c-Maf mediates the TGF-b-dependent suppression of IL-22 production in TH17 cells. Nat. Immunol. 12, 1238-1245.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 1238-1245
-
-
Rutz, S.1
Noubade, R.2
Eidenschenk, C.3
-
25
-
-
77956954197
-
The Jmjd3-Irf4 axis regulatesM2 macrophage polarization and host responses against helminth infection
-
Satoh, T., Takeuchi, O., Vandenbon, A., et al. (2010). The Jmjd3-Irf4 axis regulatesM2 macrophage polarization and host responses against helminth infection. Nat. Immunol. 11, 936-944.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 936-944
-
-
Satoh, T.1
Takeuchi, O.2
Vandenbon, A.3
-
26
-
-
67651001561
-
The AP-1 transcription factor Batf controls TH17 differentiation
-
Schraml, B.U., Hildner, K., Ise,W., et al. (2009). The AP-1 transcription factor Batf controls TH17 differentiation. Nature 460, 405-409.
-
(2009)
Nature
, vol.460
, pp. 405-409
-
-
Schraml, B.U.1
Hildner, K.2
Ise, W.3
-
27
-
-
33847084602
-
Genome regulation by polycomb and trithorax proteins
-
Schuettengruber, B., Chourrout, D., Vervoort, M., et al. (2007). Genome regulation by polycomb and trithorax proteins. Cell 128, 735-745.
-
(2007)
Cell
, vol.128
, pp. 735-745
-
-
Schuettengruber, B.1
Chourrout, D.2
Vervoort, M.3
-
28
-
-
84887549060
-
The polycomb protein Ezh2 regulates differentiation and plasticity of CD4+ T helper type 1 and type 2 cells
-
Tumes, D.J., Onodera, A., Suzuki, A., et al. (2013). The polycomb protein Ezh2 regulates differentiation and plasticity of CD4+ T helper type 1 and type 2 cells. Immunity 39, 819-832.
-
(2013)
Immunity
, vol.39
, pp. 819-832
-
-
Tumes, D.J.1
Onodera, A.2
Suzuki, A.3
-
29
-
-
42649106556
-
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
-
Veldhoen, M., Hirota, K., Westendorf, A.M., et al. (2008). The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 453, 106-109.
-
(2008)
Nature
, vol.453
, pp. 106-109
-
-
Veldhoen, M.1
Hirota, K.2
Westendorf, A.M.3
-
30
-
-
84896402211
-
The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-gproducing T helper 17 cells
-
Wang, Y., Godec, J., Ben-Aissa, K., et al. (2014). The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-gproducing T helper 17 cells. Immunity 40, 355-366.
-
(2014)
Immunity
, vol.40
, pp. 355-366
-
-
Wang, Y.1
Godec, J.2
Ben-Aissa, K.3
-
31
-
-
58149214356
-
Global mapping ofH3K4me3 andH3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
-
Wei, G., Wei, L., Zhu, J., et al. (2009). Global mapping ofH3K4me3 andH3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity 30, 155-167.
-
(2009)
Immunity
, vol.30
, pp. 155-167
-
-
Wei, G.1
Wei, L.2
Zhu, J.3
-
32
-
-
35348826654
-
JMJD3 is a histone H3K27 demethylase
-
Xiang, Y., Zhu, Z., Han, G., et al. (2007). JMJD3 is a histone H3K27 demethylase. Cell Res. 17, 850-857.
-
(2007)
Cell Res.
, vol.17
, pp. 850-857
-
-
Xiang, Y.1
Zhu, Z.2
Han, G.3
-
33
-
-
34247593586
-
STAT3 regulates cytokine-mediated generation of inflammatory helper T cells
-
Yang, X.O., Panopoulos, A.D., Nurieva, R., et al. (2007). STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J. Biol. Chem. 282, 9358-9363.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 9358-9363
-
-
Yang, X.O.1
Panopoulos, A.D.2
Nurieva, R.3
-
34
-
-
37849048599
-
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR a and RORg
-
Yang, X.O., Pappu, B.P., Nurieva, R., et al. (2008). T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR a and RORg. Immunity 28, 29-39.
-
(2008)
Immunity
, vol.28
, pp. 29-39
-
-
Yang, X.O.1
Pappu, B.P.2
Nurieva, R.3
-
35
-
-
54549100120
-
Interactions amongthe transcription factors Runx1, RORgt and Foxp3 regulate the differentiation of interleukin 17-producing T cells
-
Zhang, F., Meng, G., and Strober,W. (2008). Interactions amongthe transcription factors Runx1, RORgt and Foxp3 regulate the differentiation of interleukin 17-producing T cells. Nat. Immunol. 9, 1297-1306.
-
(2008)
Nat. Immunol.
, vol.9
, pp. 1297-1306
-
-
Zhang, F.1
Meng, G.2
Strober, W.3
-
36
-
-
84940053663
-
JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice
-
Zhang, F., Xu, L., Xu, L., et al. (2015). JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice. J. Mol. Cell Biol. 7, 23-34.
-
(2015)
J. Mol. Cell Biol.
, vol.7
, pp. 23-34
-
-
Zhang, F.1
Xu, L.2
Xu, L.3
-
37
-
-
77952313777
-
Differentiation of effector CD4 T cell populations (∗)
-
Zhu, J., Yamane, H., and Paul, W.E. (2010). Differentiation of effector CD4 T cell populations (∗). Annu. Rev. Immunol. 28, 445-489.
-
(2010)
Annu. Rev. Immunol.
, vol.28
, pp. 445-489
-
-
Zhu, J.1
Yamane, H.2
Paul, W.E.3
|