Changes in cortical N-methyl-d-aspartate receptors and post-synaptic density protein 95 in schizophrenia, mood disorders and suicide

Australian and New Zealand Journal of Psychiatry

Volumn 50, Issue 3, 2016, Pages 275-283

  Dean, Brian ^a,b   Gibbons, Andrew S ^a,b   Boer, Simone ^a   Uezato, Akihito ^c   Meador Woodruff, James ^d   Scarr, Elizabeth ^a,b   McCullumsmith, Robert E ^e  

^a FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^e UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

bipolar disorders; cortex; major depressive disorders; NMDA; Schizophrenia

Indexed keywords

MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2C; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2D; POSTSYNAPTIC DENSITY PROTEIN 95; BIOLOGICAL MARKER; DLG4 PROTEIN, HUMAN; KETAMINE; MEMBRANE PROTEIN; SIGNAL PEPTIDE;

ADULT; ANTERIOR CINGULATE; ARTICLE; BIPOLAR DISORDER; BRAIN CORTEX; CONTROLLED STUDY; DORSOLATERAL PREFRONTAL CORTEX; FEMALE; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MIDDLE AGED; MOOD DISORDER; PARIETAL CORTEX; SCHIZOPHRENIA; SUICIDE; CINGULATE GYRUS; DEPRESSIVE DISORDER, MAJOR; GENETICS; METABOLISM; PREFRONTAL CORTEX;

ADULT; BIOMARKERS; BIPOLAR DISORDER; DEPRESSIVE DISORDER, MAJOR; FEMALE; GYRUS CINGULI; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KETAMINE; MALE; MEMBRANE PROTEINS; MIDDLE AGED; PREFRONTAL CORTEX; RECEPTORS, N-METHYL-D-ASPARTATE; SCHIZOPHRENIA; SUICIDE;

EID: 84975687637     PISSN: 00048674     EISSN: 14401614     Source Type: Journal    
DOI: 10.1177/0004867415586601     Document Type: Article

References (49)

1. Abdallah CG, Sanacora G, Duman RS, et al. (2015) Ketamine and rapidacting antidepressants: A window into a new neurobiology for mood disorder therapeutics. Annual Review of Medicine 66: 509-523.
2. Basham ME, Nordeen EJ and Nordeen KW (1996) Blockade of NMDA receptors in the anterior forebrain impairs sensory acquisition in the zebra finch (Poephila guttata). Neurobiology of Learning and Memory 66: 295-304.
3. Beneyto M and Meador-Woodruff JH (2008) Lamina-specific abnormalities of NMDA receptor-associated postsynaptic protein transcripts in the prefrontal cortex in schizophrenia and bipolar disorder. Neuropsychopharmacology 33: 2175-2186.
4. Beneyto M, Kristiansen LV, Oni-Orisan A, et al. (2007) Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders. Neuropsychopharmacology 32: 1888-1902.
5. Bitanihirwe BK, Lim MP and Woo TU (2010) N-methyl-d-aspartate receptor expression in parvalbumin-containing inhibitory neurons in the prefrontal cortex in bipolar disorder. Bipolar Disorder in Adults 12: 95-101.
6. Cook RD and Weisberg S (1999) Applied Regression Including Computing and Graphics. Hoboken, NJ: John Wiley.
7. D'Agostino RB, Belanger A and D'Agostino RB Jr (1990) A suggestion for using powerful and informative tests of normality. The American Statistician 44: 316-321.
8. Deakin JF, Slater P, Simpson MD, et al. (1989) Frontal cortical and left temporal glutamatergic dysfunction in schizophrenia. Journal of Neurochemistry 52: 1781-1786.
9. Dean B, Gray L and Scarr E (2006) Regionally specific changes in levels of cortical S100beta in bipolar 1 disorder but not schizophrenia. Australian and New Zealand Journal of Psychiatry 40: 217-224.
10. Dean B, Hussain T, Hayes W, et al. (1999a) Changes in serotonin2A and GABA(A) receptors in schizophrenia: Studies on the human dorsolateral prefrontal cortex. Journal of Neurochemistry 72: 1593-1599.
11. Dean B, Pavey G, Chai SY, et al. (1999b) The localisation and quantification of molecular changes in the human brain using in situ radioligand binding and autoradiography. In: Dean B, Kleinman JE and Hyde TM (eds) Using CNS Tissue in Psychiatric Research: A Practical Guide. Amsterdam: Harwood Academic Press, pp. 67-83.
12. Dean B, Tawadros N, Scarr E, et al. (2010) Regionally-specific changes in levels of tumour necrosis factor in the dorsolateral prefrontal cortex obtained postmortem from subjects with major depressive disorder. Journal of Affective Disorders 120: 245-248.
13. Dracheva S, Marras SA, Elhakem SL, et al. (2001) N-methyl-D-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia. The American Journal of Psychiatry 158: 1400-1410.
14. Eaton SL, Roche SL, Llavero HM, et al. (2013) Total protein analysis as a reliable loading control for quantitative fluorescent Western blotting. PLoS ONE 8: e72457.
15. Ferrer I, Santpere G, Arzberger T, et al. (2007) Brain protein preservation largely depends on the postmortem storage temperature: Implications for study of proteins in human neurologic diseases and management of brain banks: A BrainNet Europe Study. Journal of Neuropathology & Experimental Neurology 66: 35-46.
16. Foster P (1989) Neuroleptic equivalence. The Pharmaceutical Journal 243: 431-432.
17. Funk AJ, Rumbaugh G, Harotunian V, et al. (2009) Decreased expression of NMDA receptor-associated proteins in frontal cortex of elderly patients with schizophrenia. Neuroreport 20: 1019-1022.
18. Gladding CM and Raymond LA (2011) Mechanisms underlying NMDA receptor synaptic/extrasynaptic distribution and function. Molecular and Cellular Neurosciences 48: 308-320.
19. Grimwood S, Slater P, Deakin JF, et al. (1999) NR2B-containing NMDA receptors are up-regulated in temporal cortex in schizophrenia. Neuroreport 10: 461-465.
20. Hill C, Keks N, Roberts S, et al. (1996) Problem of diagnosis in postmortem brain studies of schizophrenia. The American Journal of Psychiatry 153: 533-537.
21. Holemans S, De PF, Horton RW, et al. (1993) NMDA glutamatergic receptors, labelled with [3H]MK-801, in brain samples from drug-free depressed suicides. Brain Research 616: 138-143.
22. Ishimaru M, Kurumaji A and Toru M (1994) Increases in strychnine-insensitive glycine binding sites in cerebral cortex of chronic schizophrenics: Evidence for glutamate hypothesis. Biological Psychiatry 35: 84-95.
23. Kingsbury AE, Foster OJ, Nisbet AP, et al. (1995) Tissue pH as an indicator of mRNA preservation in human post-mortem brain. Brain Research. Molecular Brain Research 28: 311-318.
24. Kornhuber J, Mack-Burkhardt F, Riederer P, et al. (1989) [3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients. Journal of Neural Transmission 77: 231-236.
25. Kristiansen LV, Patel SA, Haroutunian V, et al. (2010) Expression of the NR2B-NMDA receptor subunit and its Tbr-1/CINAP regulatory proteins in postmortem brain suggest altered receptor processing in schizophrenia. Synapse 64: 495-502.
26. McIlhinney RA, Philipps E, Le BB, et al. (2003) Assembly of N-methyl-D-aspartate (NMDA) receptors. Biochemical Society Transactions 31: 865-868.
27. McKillup S (2006) Statistics Explained: An Introductory Guide for Life Scientists. Cambridge: Cambridge University Press.
28. Malhotra AK, Pinals DA, Adler CM, et al. (1997) Ketamine-induced exacerbation of psychotic symptoms and cognitive impairment in neuroleptic-free schizophrenics. Neuropsychopharmacology 17: 141-150.
29. Miller GA and Chapman JP (2001) Misunderstanding analysis of covariance. Journal of Abnormal and Social Psychology 110: 40-48.
30. Newell KA, Zavitsanou K and Huang XF (2005) Ionotropic glutamate receptor binding in the posterior cingulate cortex in schizophrenia patients. Neuroreport 16: 1363-1367.
31. Nudmamud S and Reynolds GP (2001) Increased density of glutamate/Nmethyl-d-aspartate receptors in superior temporal cortex in schizophrenia. Neuroscience Letters 304: 9-12.
32. Nudmamud S, Reynolds LM and Reynolds GP (2003) N-acetylaspartate and N-Acetylaspartylglutamate deficits in superior temporal cortex in schizophrenia and bipolar disorder: A postmortem study. Biological Psychiatry 53: 1138-1141.
33. Nudmamud-Thanoi S and Reynolds GP (2004) The NR1 subunit of the glutamate/NMDA receptor in the superior temporal cortex in schizophrenia and affective disorders. Neuroscience Letters 372: 173-177.
34. Paoletti P and Neyton J (2007) NMDA receptor subunits: Function and pharmacology. Current Opinion in Pharmacology 7: 39-47.
35. Reynolds IJ (2001) [3H](+)MK801 radioligand binding assay at the N-methyl-d-aspartate receptor. Current Protocols in Pharmacology Chapter 1: Unit 1.20.
36. Roberts SB, Hill CA, Dean B, et al. (1998) Confirmation of the diagnosis of schizophrenia after death using DSM-IV: A Victorian experience. Australian and New Zealand Journal of Psychiatry 32: 73-76.
37. Ruffolo RR Jr (1982) Review important concepts of receptor theory. Journal of Autonomic Pharmacology 2: 277-295.
38. Scarr E, Beneyto M, Meador-Woodruff JH, et al. (2005) Cortical glutamatergic markers in schizophrenia. Neuropsychopharmacology 30: 1521-1531.
39. Scarr E, Gray L, Keriakous D, et al. (2006) Increased levels of SNAP-25 and synaptophysin in the dorsolateral prefrontal cortex in bipolar I disorder. Bipolar Disorders 8: 133-143.
40. Scarr E, Pavey G, Sundram S, et al. (2003) Decreased hippocampal NMDA, but not kainate or AMPA receptors in bipolar disorder. Bipolar Disorders 5: 257-264.
41. Scherzer CR, Landwehrmeyer GB, Kerner JA, et al. (1998) Expression of N-methyl-d-aspartate receptor subunit mRNAs in the human brain: Hippocampus and cortex. Journal of Comparative Neurology 390: 75-90.
42. Sowa-Kucma M, Szewczyk B, Sadlik K, et al. (2013) Zinc, magnesium and NMDA receptor alterations in the hippocampus of suicide victims. Journal of Affective Disorders 151: 924-931.
43. Stan AD, Ghose S, Gao XM, et al. (2006) Human postmortem tissue: What quality markers matter? Brain Research 1123: 1-11.
44. Stecher J, Muller WE and Hoyer S (1997) Learning abilities depend on NMDA-receptor density in hippocampus in adult rats. Journal of Neural Transmission 104: 281-289.
45. Sucher NJ, Awobuluyi M, Choi YB et al. (1996) NMDA receptors: from genes to channels. Trends in Pharmacological Sciences 17: 348-355.
46. Tucholski J, Simmons MS, Pinner AL, et al. (2013) N-linked glycosylation of cortical N-methyl-D-aspartate and kainate receptor subunits in schizophrenia. Neuroreport 24: 688-691.
47. Wong EH, Kemp JA, Priestley T, et al. (1986) The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proceedings of the National Academy of Sciences of the United States of America 83: 7104-7108.
48. Woo TU, Shrestha K, Lamb D, et al. (2008) N-methyl-d-aspartate receptor and calbindin-containing neurons in the anterior cingulate cortex in schizophrenia and bipolar disorder. Biological Psychiatry 64: 803-809.
49. Zavitsanou K, Ward PB and Huang XF (2002) Selective alterations in ionotropic glutamate receptors in the anterior cingulate cortex in schizophrenia. Neuropsychopharmacology 27: 826-833.