Pathways to functional outcome in subjects with schizophrenia living in the community and their unaffected first-degree relatives

Schizophrenia Research

Volumn 175, Issue 1-3, 2016, Pages 154-160

  Galderisi, Silvana ^a   Rossi, Alessandro ^b   Rocca, Paola ^c   Bertolino, Alessandro ^d   Mucci, Armida ^a   Bucci, Paola ^a   Rucci, Paola ^e   Gibertoni, Dino ^e   Aguglia, Eugenio ^f   Amore, Mario ^g   Blasi, Giuseppe ^d   Comparelli, Anna ^h   Di Giannantonio, Massimo ⁱ   Goracci, Arianna ^j   Marchesi, Carlo ^k   Monteleone, Palmiero ^l   Montemagni, Cristiana ^c   Pinna, Federica ^m   Roncone, Rita ^b   Siracusano, Alberto ⁿ   Stratta, Paolo ^b   Torti, Maria Chiara ^o   Vita, Antonio ^p   Zeppegno, Patrizia ^q   Chieffi, Marcello ^a   Maj, Mario ^a   Piegari, Giuseppe ^a   Merlotti, Eleonora ^a   Rocco, Mariangela ^a   Campana, Teresa ^a   Plescia, Giuseppe ^a   Montefusco, Valentina ^a   Porcelli, Stefano ^r   Barlati, Stefano ^s   Carpiniello, Bernardo ^m   Signorelli, Maria Salvina ^f   Acciavatti, Tiziano ⁱ   Bellomo, Antonello ^t   Respino, Matteo ^g   Di Emidio, Gabriella ^b   Giusti, Laura ^b   Oldani, Lucio ^u   Tomasetti, Carmine ^v   Tenconi, Elena ^w   Ossola, Paolo ^k   Dell'Osso, Liliana ^x   Squarcione, Chiara ^y   Brugnoli, Roberto ^y   Niolu, Cinzia ⁿ   Bartoli, Luca ^z   Bolognesi, Simone ^j   Frieri, Tiziana ^c   more..

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF L'AQUILA   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

^d UNIVERSITY OF BARI   (Italy)

^e UNIVERSITY OF BOLOGNA   (Italy)

^f UNIVERSITY OF CATANIA   (Italy)

^g UNIVERSITY OF GENOA   (Italy)

^h SAPIENZA UNIVERSITY OF ROME   (Italy)

ⁱ UNIVERSITY OF CHIETI   (Italy)

^j UNIVERSITY OF SIENA   (Italy)

^k UNIVERSITY OF PARMA   (Italy)

^l UNIVERSITY OF SALERNO   (Italy)

^m UNIVERSITY OF CAGLIARI   (Italy)

ⁿ UNIVERSITY OF ROME TOR VERGATA   (Italy)

^o SAPIENZA UNIVERSITY OF ROME   (Italy)

^p UNIVERSITY OF BRESCIA   (Italy)

^q UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^r UNIVERSITY OF BOLOGNA   (Italy)

^s UNIVERSITY OF BRESCIA   (Italy)

^t UNIVERSITY OF FOGGIA   (Italy)

^u UNIVERSITY OF MILAN   (Italy)

^v UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^w UNIVERSITY OF PADOVA   (Italy)

^x UNIVERSITY OF PISA   (Italy)

^y SAPIENZA UNIVERSITY OF ROME   (Italy)

^z University of Milan ^*  (Italy)

more..

Author keywords

Avolition; Cognition; Interpersonal relationships; Schizophrenia first degree relatives; Structural equation model; Work skills

Indexed keywords

ADULT; AGE DISTRIBUTION; ARTICLE; ASSESSMENT OF HUMANS; AVOLITION; BEHAVIOR; BRIEF NEGATIVE SYMPTOM SCALE; COGNITION; COMPARATIVE STUDY; CONTROLLED STUDY; DISORIENTATION; EDUCATIONAL STATUS; FEMALE; FIRST-DEGREE RELATIVE; FUNCTIONAL OUTCOME; FUNCTIONAL STATUS; HUMAN; HUMAN RELATION; MAJOR CLINICAL STUDY; MALE; MENTAL PATIENT; NEUROCOGNITION; NONBIOLOGICAL MODEL; POSITIVE AND NEGATIVE SYNDROME SCALE; POST HOC ANALYSIS; PRIORITY JOURNAL; RESILIENCE; SCHIZOPHRENIA; SKILL; SOCIAL COGNITION; SOCIAL STIGMA; SPECIFIC LEVEL OF FUNCTIONING SCALE; STRUCTURAL EQUATION MODEL; UNAFFECTED FIRST DEGREE RELATIVE; VALIDATION PROCESS; WORK SKILL; CLINICAL TRIAL; EMPLOYMENT; FAMILY; GENETIC PREDISPOSITION; GENETICS; MULTICENTER STUDY; PSYCHOLOGICAL MODEL; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; STATISTICAL MODEL;

ADULT; COGNITION; EDUCATIONAL STATUS; EMPLOYMENT; FAMILY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERPERSONAL RELATIONS; MALE; MODELS, PSYCHOLOGICAL; MODELS, STATISTICAL; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SOCIAL STIGMA;

EID: 84975505510     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2016.04.043     Document Type: Article

References (42)

1. Awadalla, A.W., Ohaeri, J.U., Salih, A.A., Tawfiq, A.M., Subjective quality of life of family caregivers of community living Sudanese psychiatric patients. Soc. Psychiatry Psychiatr. Epidemiol. 40:9 (2005), 755–763.
2. Bora, E., Pantelis, C., Theory of mind impairments in first-episode psychosis, individuals at ultra-high risk for psychosis and in first-degree relatives of schizophrenia: systematic review and meta-analysis. Schizophr. Res. 144:1–3 (2013), 31–36.
3. Bowie, C.R., Reichenberg, A., Patterson, T.L., Heaton, R.K., Harvey, P.D., Determinants of real-world functional performance in schizophrenia subjects: correlations with cognition, functional capacity, and symptoms. Am. J. Psychiatry 163:3 (2006), 418–425.
4. Braff, D.L., Freedman, R., Schork, N.J., Gottesman, I.I., Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder. Schizophr. Bull. 33:1 (2007), 21–32.
5. Brohan, E., Elgie, R., Sartorius, N., Thornicroft, G., Self-stigma, empowerment and perceived discrimination among people with schizophrenia in 14 European countries: the GAMIAN-Europe study. Schizophr. Res. 122:1–3 (2010), 232–238.
6. Cornblatt, B.A., Keilp, J.G., Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophr. Bull. 20:1 (1994), 31–46.
7. de Achaval, D., Costanzo, E.Y., Villarreal, M., Jauregui, I.O., Chiodi, A., Castro, M.N., Fahrer, R.D., Leiguarda, R.C., Chu, E.M., Guinjoan, S.M., Emotion processing and theory of mind in schizophrenia patients and their unaffected first-degree relatives. Neuropsychologia 48:5 (2010), 1209–1215.
8. Delawalla, Z., Barch, D.M., Fisher Eastep, J.L., Thomason, E.S., Hanewinkel, M.J., Thompson, P.A., Csernansky, J.G., Factors mediating cognitive deficits and psychopathology among siblings of individuals with schizophrenia. Schizophr. Bull. 32:3 (2006), 525–537.
9. Eack, S.M., Mermon, D.E., Montrose, D.M., Miewald, J., Gur, R.E., Gur, R.C., Sweeney, J.A., Keshavan, M.S., Social cognition deficits among individuals at familial high risk for schizophrenia. Schizophr. Bull. 36:6 (2010), 1081–1088.
10. Fanous, A., Gardner, C., Walsh, D., Kendler, K.S., Relationship between positive and negative symptoms of schizophrenia and schizotypal symptoms in nonpsychotic relatives. Arch. Gen. Psychiatry 58:7 (2001), 669–673.
11. Foldemo, A., Gullberg, M., Ek, A.C., Bogren, L., Quality of life and burden in parents of outpatients with schizophrenia. Soc. Psychiatry Psychiatr. Epidemiol. 40:2 (2005), 133–138.
12. Galderisi, S., Bucci, P., Mucci, A., Kirkpatrick, B., Pini, S., Rossi, A., Vita, A., Maj, M., Categorical and dimensional approaches to negative symptoms of schizophrenia: focus on long-term stability and functional outcome. Schizophr. Res. 147:1 (2013), 157–162.
13. Galderisi, S., Rossi, A., Rocca, P., Bertolino, A., Mucci, A., Bucci, P., Rucci, P., Gibertoni, D., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Brugnoli, R., Dell'Osso, L., De Ronchi, D., Di Emidio, G., Di Giannantonio, M., Fagiolini, A., Marchesi, C., Monteleone, P., Oldani, L., Pinna, F., Roncone, R., Sacchetti, E., Santonastaso, P., Siracusano, A., Vita, A., Zeppegno, P., Maj, M., Italian Network For Research on Psychoses, The influence of illness-related variables, personal resources and context-related factors on real-life functioning of people with schizophrenia. World Psychiatry 13:3 (2014), 275–287.
14. Green, M.F., Leitman, D.I., Social cognition in schizophrenia. Schizophr. Bull. 34:4 (2008), 670–672.
15. Harvey, P.D., Strassnig, M., Predicting the severity of everyday functional disability in people with schizophrenia: cognitive deficits, functional capacity, symptoms, and health status. World Psychiatry 11:2 (2012), 73–79.
16. Irani, F., Platek, S.M., Panyavin, I.S., Calkins, M.E., Kohler, C., Siegel, S.J., Schachter, M., Gur, R.E., Gur, R.C., Self-face recognition and theory of mind in patients with schizophrenia and first-degree relatives. Schizophr. Res. 88:1–3 (2006), 151–160.
17. Jungbauer, J., Wittmund, B., Dietrich, S., Angermeyer, M.C., Subjective burden over 12 months in parents of patients with schizophrenia. Arch. Psychiatr. Nurs. 17:3 (2003), 126–134.
18. Kendler, K.S., McGuire, M., Gruenberg, A.M., Walsh, D., Schizotypal symptoms and signs in the Roscommon Family Study. Their factor structure and familial relationship with psychotic and affective disorders. Arch. Gen. Psychiatry 52:4 (1995), 296–303.
19. Kirkpatrick, B., Strauss, G.P., Nguyen, L., Fischer, B.A., Daniel, D.G., Cienfuegos, A., Marder, S.R., The brief negative symptom scale: psychometric properties. Schizophr. Bull. 37:2 (2011), 300–305.
20. Kurs, R., Farkas, H., Ritsner, M., Quality of life and temperament factors in schizophrenia: comparative study of patients, their siblings and controls. Qual. Life Res. 14:2 (2005), 433–440.
21. Lavoie, M.A., Plana, I., Jackson, P.L., Godmaire-Duhaime, F., Bedard Lacroix, J., Achim, A.M., Performance in multiple domains of social cognition in parents of patients with schizophrenia. Psychiatry Res. 220:1–2 (2014), 118–124.
22. Leifker, F.R., Bowie, C.R., Harvey, P.D., Determinants of everyday outcomes in schizophrenia: the influences of cognitive impairment, functional capacity, and symptoms. Schizophr. Res. 115:1 (2009), 82–87.
23. Margetic, B.A., Jakovljevic, M., Ivanec, D., Margetic, B., Temperament, character, and quality of life in patients with schizophrenia and their first-degree relatives. Compr. Psychiatry 52:4 (2011), 425–430.
24. Margetic, B.A., Jakovljevic, M., Furjan, Z., Margetic, B., Marsanic, V.B., Quality of life of key caregivers of schizophrenia patients and association with kinship. Cent. Eur. J. Public Health 21:4 (2013), 220–223.
25. Michie, P.T., Kent, A., Stienstra, R., Castine, R., Johnston, J., Dedman, K., Wichmann, H., Box, J., Rock, D., Rutherford, E., Jablensky, A., Phenotypic markers as risk factors in schizophrenia: neurocognitive functions. Aust. N. Z. J. Psychiatry 34 (2000), S74–S85 (suppl).
26. Montag, C., Neuhaus, K., Lehmann, A., Kruger, K., Dziobek, I., Heekeren, H.R., Heinz, A., Gallinat, J., Subtle deficits of cognitive theory of mind in unaffected first-degree relatives of schizophrenia patients. Eur. Arch. Psychiatry Clin. Neurosci. 262:3 (2012), 217–226.
27. Mucci, A., Galderisi, S., Merlotti, E., Rossi, A., Rocca, P., Bucci, P., Piegari, G., Chieffi, M., Vignapiano, A., Maj, M., Italian Network for Research on Psychoses, The brief negative symptom scale (BNSS): independent validation in a large sample of Italian patients with schizophrenia. Eur. Psychiatry 30:5 (2015), 641–647.
28. Park, S.G., Bennett, M.E., Couture, S.M., Blanchard, J.J., Internalized stigma in schizophrenia: relations with dysfunctional attitudes, symptoms, and quality of life. Psychiatry Res. 205:1–2 (2013), 43–47.
29. Remberk, B., Namyslowska, I., Rybakowski, F., Cognitive impairment and formal thought disorders in parents of early-onset schizophrenia patients. Neuropsychobiology 65:4 (2012), 206–215.
30. Sitskoorn, M.M., Aleman, A., Ebisch, S.J., Appels, M.C., Kahn, R.S., Cognitive deficits in relatives of patients with schizophrenia: a meta-analysis. Schizophr. Res. 71:2–3 (2004), 285–295.
31. Snitz, B.E., Macdonald, A.W. 3rd, Carter, C.S., Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes. Schizophr. Bull. 32:1 (2006), 179–194.
32. Sponheim, S.R., Steele, V.R., McGuire, K.A., Verbal memory processes in schizophrenia patients and biological relatives of schizophrenia patients: intact implicit memory, impaired explicit recollection. Schizophr. Res. 71:2–3 (2004), 339–348.
33. Staal, W.G., Hijman, R., Hulshoff Pol, H.E., Kahn, R.S., Neuropsychological dysfunctions in siblings discordant for schizophrenia. Psychiatry Res. 95:3 (2000), 227–235.
34. Strauss, G.P., Hong, L.E., Gold, J.M., Buchanan, R.W., McMahon, R.P., Keller, W.R., Fischer, B.A., Catalano, L.T., Culbreth, A.J., Carpenter, W.T., Kirkpatrick, B., Factor structure of the brief negative symptom scale. Schizophr. Res. 142:1–3 (2012), 96–98.
35. Toulopoulou, T., Rabe-Hesketh, S., King, H., Murray, R.M., Morris, R.G., Episodic memory in schizophrenic patients and their relatives. Schizophr. Res. 63:3 (2003), 261–271.
36. Tsuang, M.T., Genotypes, phenotypes, and the brain. A search for connections in schizophrenia. Br. J. Psychiatry 163:3 (1993), 299–307.
37. Tsuang, M.T., Stone, W.S., Seidman, L.J., Faraone, S.V., Zimmet, S., Wojcik, J., Kelleher, J.P., Green, A.I., Treatment of nonpsychotic relatives of patients with schizophrenia: four case studies. Biol. Psychiatry 45:11 (1999), 1412–1418.
38. Ventura, J., Hellemann, G.S., Thames, A.D., Koellner, V., Nuechterlein, K.H., Symptoms as mediators of the relationship between neurocognition and functional outcome in schizophrenia: a meta-analysis. Schizophr. Res. 113:2–3 (2009), 189–199.
39. Versmissen, D., Janssen, I., Myin-Germeys, I., Mengelers, R., Campo, J.A., van Os, J., Krabbendam, L., Evidence for a relationship between mentalising deficits and paranoia over the psychosis continuum. Schizophr. Res. 99:1–3 (2008), 103–110.
40. Vollema, M.G., Postma, B., Neurocognitive correlates of schizotypy in first degree relatives of schizophrenia patients. Schizophr. Bull. 28:3 (2002), 367–377.
41. Wallwork, R.S., Fortgang, R., Hashimoto, R., Weinberger, D.R., Dickinson, D., Searching for a consensus five-factor model of the Positive and Negative Syndrome Scale for schizophrenia. Schizophr. Res. 137:1–3 (2012), 246–250.
42. Webb, C., Pfeiffer, M., Mueser, K.T., Gladis, M., Mensch, E., DeGirolamo, J., Levinson, D.F., Burden and well-being of caregivers for the severely mentally ill: the role of coping style and social support. Schizophr. Res. 34:3 (1998), 169–180.