메뉴 건너뛰기




Volumn 10, Issue , 2016, Pages 975-982

Mode of administration of dulaglutide: Implications for treatment adherence

Author keywords

Patient treatment satisfaction; Quality of life; Treatment satisfaction; Type 2 diabetes; Weekly GLP1

Indexed keywords

DULAGLUTIDE; EXENDIN 4; GLUCOSE; HEMOGLOBIN A1C; LIRAGLUTIDE; METFORMIN; PLACEBO;

EID: 84975263399     PISSN: None     EISSN: 1177889X     Source Type: Journal    
DOI: 10.2147/PPA.S82866     Document Type: Review
Times cited : (16)

References (40)
  • 1
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet. 2006;368:1696–1705.
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 2
    • 84944517749 scopus 로고    scopus 로고
    • Efficacy and safety of once-weekly glucagon-like peptide 1 receptor agonists for the management of type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials
    • Karagiannis T, Liakos A, Bekiari E, et al. Efficacy and safety of once-weekly glucagon-like peptide 1 receptor agonists for the management of type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Diabetes Obes Metab. 2015;17(11):1065–1074.
    • (2015) Diabetes Obes Metab , vol.17 , Issue.11 , pp. 1065-1074
    • Karagiannis, T.1    Liakos, A.2    Bekiari, E.3
  • 3
    • 84866268783 scopus 로고    scopus 로고
    • American Diabetes Association (ADA); European Association for the Study of Diabetes (EASD). Management of hyperglycemia in type 2 diabetes: A patient-centered approach: Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. American Diabetes Association (ADA); European Association for the Study of Diabetes (EASD). Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2012;35(6):1364–1379.
    • (2012) Diabetes Care , vol.35 , Issue.6 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 4
    • 84919999219 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes, 2015: A patient-centered approach: Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2015;38:140–149.
    • (2015) Diabetes Care , vol.38 , pp. 140-149
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 5
    • 84882276623 scopus 로고    scopus 로고
    • AACE comprehensive diabetes management algorithm 2013
    • Garber AJ, Abrahamson MJ, Barzilay JI, et al. AACE comprehensive diabetes management algorithm 2013. Endocr Pract. 2013;19:327–336.
    • (2013) Endocr Pract , vol.19 , pp. 327-336
    • Garber, A.J.1    Abrahamson, M.J.2    Barzilay, J.I.3
  • 6
    • 58149382533 scopus 로고    scopus 로고
    • Improving medication adherence in chronic cardiovascular disease
    • Albert NM. Improving medication adherence in chronic cardiovascular disease. Crit Care Nurse. 2008;28(5):54–64.
    • (2008) Crit Care Nurse , vol.28 , Issue.5 , pp. 54-64
    • Albert, N.M.1
  • 7
    • 20544460816 scopus 로고    scopus 로고
    • Impact of medication adherence on hospitalization risk and health care cost
    • Sokol MC, McGuigan KA, Verbrugge RR, Epstein RS. Impact of medication adherence on hospitalization risk and health care cost. Med Care. 2005;43(6):521–530.
    • (2005) Med Care , vol.43 , Issue.6 , pp. 521-530
    • Sokol, M.C.1    McGuigan, K.A.2    Verbrugge, R.R.3    Epstein, R.S.4
  • 8
    • 79952498421 scopus 로고    scopus 로고
    • A review of diabetes treatment adherence and the association with clinical and economic outcomes
    • Asche C, LaFleur J, Conner C. A review of diabetes treatment adherence and the association with clinical and economic outcomes. Clin Ther. 2011;33(1):74–109.
    • (2011) Clin Ther , vol.33 , Issue.1 , pp. 74-109
    • Asche, C.1    Lafleur, J.2    Conner, C.3
  • 9
    • 48249130928 scopus 로고    scopus 로고
    • Protein engineering strategies for sustained glucagon-like peptide-1 receptor-dependent control of glucose homeostasis
    • Picha KM, Cunningham MR, Drucker DJ, et al. Protein engineering strategies for sustained glucagon-like peptide-1 receptor-dependent control of glucose homeostasis. Diabetes. 2008;57(7):1926–1934.
    • (2008) Diabetes , vol.57 , Issue.7 , pp. 1926-1934
    • Picha, K.M.1    Cunningham, M.R.2    Drucker, D.J.3
  • 10
    • 77952756104 scopus 로고    scopus 로고
    • Engineering and characterization of the long-acting glucagon-like peptide-1 analogue LY2189265, an Fc fusion protein
    • Glaesner W, Vick AM, Millican R, et al. Engineering and characterization of the long-acting glucagon-like peptide-1 analogue LY2189265, an Fc fusion protein. Diabetes Metab Res Rev. 2010;26(4):287–296.
    • (2010) Diabetes Metab Res Rev , vol.26 , Issue.4 , pp. 287-296
    • Glaesner, W.1    Vick, A.M.2    Millican, R.3
  • 11
    • 79953032228 scopus 로고    scopus 로고
    • LY2189265, a long-acting glucagon-like peptide-1 analogue, showed a dose-dependent effect on insulin secretion in healthy subjects
    • Barrington P, Chien JY, Tibaldi F, Showalter HD, Schneck K, Ellis B. LY2189265, a long-acting glucagon-like peptide-1 analogue, showed a dose-dependent effect on insulin secretion in healthy subjects. Diabetes Obes Metab. 2011;13:434–438.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 434-438
    • Barrington, P.1    Chien, J.Y.2    Tibaldi, F.3    Showalter, H.D.4    Schneck, K.5    Ellis, B.6
  • 12
    • 84899717496 scopus 로고    scopus 로고
    • LY2189265, a long-acting glucagon-like peptide-1 analog does not affect gastric emptying of acetaminophen after multiple dosing in healthy subjects
    • Abs 600-P
    • Chien JY, Cui S, Chaudhary A, Loghin C. LY2189265, a long-acting glucagon-like peptide-1 analog does not affect gastric emptying of acetaminophen after multiple dosing in healthy subjects. Diabetes. 2010;59:Suppl 1:Abs 600-P.
    • (2010) Diabetes , vol.59
    • Chien, J.Y.1    Cui, S.2    Chaudhary, A.3    Loghin, C.4
  • 13
    • 79953065066 scopus 로고    scopus 로고
    • A 5-week study of the pharmacokinetics and pharmacodynamics of LY2189265, a novel, long-acting glucagon-like peptide-1 analogue, in patients with type 2 diabetes
    • Barrington P, Chien JY, Showalter HD, et al. A 5-week study of the pharmacokinetics and pharmacodynamics of LY2189265, a novel, long-acting glucagon-like peptide-1 analogue, in patients with type 2 diabetes. Diabetes Obes Metab. 2011;13(5):426–433.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.5 , pp. 426-433
    • Barrington, P.1    Chien, J.Y.2    Showalter, H.D.3
  • 14
    • 84866435806 scopus 로고    scopus 로고
    • Monotherapy with the once-weekly GLP-1 analogue dula for 12 weeks in patients with type 2 diabetes: Dose-dependent effects on glycemic control in a randomized, double-blind, placebo-controlled study
    • Grunberger G, Chang A, Garcia Soria G, Botros FT, Bsharat R, Milicevic Z. Monotherapy with the once-weekly GLP-1 analogue dula for 12 weeks in patients with type 2 diabetes: dose-dependent effects on glycemic control in a randomized, double-blind, placebo-controlled study. Diabet Med. 2012;29(10):1260–1267.
    • (2012) Diabet Med , vol.29 , Issue.10 , pp. 1260-1267
    • Grunberger, G.1    Chang, A.2    Garcia Soria, G.3    Botros, F.T.4    Bsharat, R.5    Milicevic, Z.6
  • 15
    • 79953035319 scopus 로고    scopus 로고
    • EGO Study Group. The effects of LY2189265, a long-acting glucagon-like peptide-1 analogue, in a randomized, placebo-controlled, double-blind study of overweight/obese patients with type 2 diabetes: The EGO study
    • Umpierrez GE, Blevins T, Rosenstock J, et al; EGO Study Group. The effects of LY2189265, a long-acting glucagon-like peptide-1 analogue, in a randomized, placebo-controlled, double-blind study of overweight/obese patients with type 2 diabetes: the EGO study. Diabetes Obes Metab. 2011;13(5):418–425.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.5 , pp. 418-425
    • Umpierrez, G.E.1    Blevins, T.2    Rosenstock, J.3
  • 16
    • 84904308261 scopus 로고    scopus 로고
    • Dose-finding results in an adaptive, seamless, randomized trial of once-weekly dulaglutide combined with metformin in type 2 diabetes patients (AWARD-5)
    • Skrivanek Z, Gaydos BL, Chien JY, et al. Dose-finding results in an adaptive, seamless, randomized trial of once-weekly dulaglutide combined with metformin in type 2 diabetes patients (AWARD-5). Diabetes Obes Metab. 2014;16(8):748–756.
    • (2014) Diabetes Obes Metab , vol.16 , Issue.8 , pp. 748-756
    • Skrivanek, Z.1    Gaydos, B.L.2    Chien, J.Y.3
  • 17
    • 84945317739 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of dulaglutide in patients with type 2 diabetes: Analyses of data from clinical trials
    • Geiser JS, Heathman MA, Cui X, et al. Clinical pharmacokinetics of dulaglutide in patients with type 2 diabetes: Analyses of data from clinical trials. Clin Pharmacokinet. 2016;55(5):625–634.
    • (2016) Clin Pharmacokinet , vol.55 , Issue.5 , pp. 625-634
    • Geiser, J.S.1    Heathman, M.A.2    Cui, X.3
  • 18
    • 84975308426 scopus 로고    scopus 로고
    • Accessed December 10, 2015
    • Trulicity (dulaglutide) product information. Available from: http://uspl.lilly.com/trulicity/trulicity.html#pi. Accessed December 10, 2015.
  • 19
    • 84975298479 scopus 로고    scopus 로고
    • Accessed December 10, 2015
    • Trulicity (dulaglutide) instructions for use. Available from: http://uspl.lilly.com/trulicity/trulicity.html#ug. Accessed December 10, 2015.
  • 20
    • 84908177336 scopus 로고    scopus 로고
    • Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): A randomised, open-label, phase 3, non-inferiority trial
    • Dungan KM, Povedano ST, Forst T, et al. Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial. Lancet. 2014;384(9951):1349–1357.
    • (2014) Lancet , vol.384 , Issue.9951 , pp. 1349-1357
    • Dungan, K.M.1    Povedano, S.T.2    Forst, T.3
  • 21
    • 84939565260 scopus 로고    scopus 로고
    • Safety and efficacy of once-weekly dulaglutide versus sitagliptin after 2 years in metformin-treated patients with type 2 diabetes (AWARD-5): A randomized, phase III study
    • Weinstock RS, Guerci B, Umpierrez G, Nauck MA, Skrivanek Z, Milicevic Z. Safety and efficacy of once-weekly dulaglutide versus sitagliptin after 2 years in metformin-treated patients with type 2 diabetes (AWARD-5): a randomized, phase III study. Diabetes Obes Metab. 2015;17(9):849–858.
    • (2015) Diabetes Obes Metab , vol.17 , Issue.9 , pp. 849-858
    • Weinstock, R.S.1    Guerci, B.2    Umpierrez, G.3    Nauck, M.A.4    Skrivanek, Z.5    Milicevic, Z.6
  • 22
    • 84962338740 scopus 로고    scopus 로고
    • Efficacy and safety of once-weekly dulaglutide versus insulin glargine in patients with type 2 diabetes on metformin and glimepiride (AWARD-2)
    • Giorgino F, Benroubi M, Sun JH, Zimmermann AG, Pechtner V. Efficacy and safety of once-weekly dulaglutide versus insulin glargine in patients with type 2 diabetes on metformin and glimepiride (AWARD-2). Diabetes Care. 2015;38(12):2241–2249.
    • (2015) Diabetes Care , vol.38 , Issue.12 , pp. 2241-2249
    • Giorgino, F.1    Benroubi, M.2    Sun, J.H.3    Zimmermann, A.G.4    Pechtner, V.5
  • 23
    • 84930074468 scopus 로고    scopus 로고
    • Once-weekly dulaglutide versus bedtime insulin glargine, both in combination with prandial insulin lispro, in patients with type 2 diabetes (AWARD-4): A randomised, open-label, phase 3, non-inferiority study
    • Blonde L, Jendle J, Gross J, et al. Once-weekly dulaglutide versus bedtime insulin glargine, both in combination with prandial insulin lispro, in patients with type 2 diabetes (AWARD-4): a randomised, open-label, phase 3, non-inferiority study. Lancet. 2015;385:2057–2066.
    • (2015) Lancet , vol.385 , pp. 2057-2066
    • Blonde, L.1    Jendle, J.2    Gross, J.3
  • 24
    • 84905012167 scopus 로고    scopus 로고
    • Efficacy and safety of dulaglutide added onto pioglitazone and metformin versus exenatide in type 2 diabetes in a randomized controlled trial (AWARD-1)
    • Wysham C, Blevins T, Arakaki R, et al. Efficacy and safety of dulaglutide added onto pioglitazone and metformin versus exenatide in type 2 diabetes in a randomized controlled trial (AWARD-1). Diabetes Care. 2014;37(8):2159–2167.
    • (2014) Diabetes Care , vol.37 , Issue.8 , pp. 2159-2167
    • Wysham, C.1    Blevins, T.2    Arakaki, R.3
  • 25
    • 84904360390 scopus 로고    scopus 로고
    • Efficacy and safety of dulaglutide monotherapy versus metformin in type 2 diabetes in a randomized controlled trial (AWARD-3)
    • Umpierrez G, Tofé Povedano S, Pérez Manghi F, Shurzinske L, Pechtner V. Efficacy and safety of dulaglutide monotherapy versus metformin in type 2 diabetes in a randomized controlled trial (AWARD-3). Diabetes Care. 2014;37(8):2168–2176.
    • (2014) Diabetes Care , vol.37 , Issue.8 , pp. 2168-2176
    • Umpierrez, G.1    Tofé Povedano, S.2    Pérez Manghi, F.3    Shurzinske, L.4    Pechtner, V.5
  • 26
    • 84952014744 scopus 로고    scopus 로고
    • A 1-year safety study of dulaglutide in Japanese patients with type 2 diabetes on a single oral hypoglycemic agent: An open-label, nonrandomized, phase 3 trial
    • Emoto M, Terauchi Y, Ozeki A, Oura T, Takeuchi M, Imaoka T. A 1-year safety study of dulaglutide in Japanese patients with type 2 diabetes on a single oral hypoglycemic agent: an open-label, nonrandomized, phase 3 trial. Endocr J. 2015;62(12):1101–1114.
    • (2015) Endocr J , vol.62 , Issue.12 , pp. 1101-1114
    • Emoto, M.1    Terauchi, Y.2    Ozeki, A.3    Oura, T.4    Takeuchi, M.5    Imaoka, T.6
  • 27
    • 84955172764 scopus 로고    scopus 로고
    • Achieving the composite endpoint of HbA1c<7.0%, no weight gain, and no hypoglycaemia in the once weekly dulaglutide AWARD program
    • Dungan KM, Raz I, Skrivanek Z, Sealls W, Fahrbach JL. Achieving the composite endpoint of HbA1c<7.0%, no weight gain, and no hypoglycaemia in the once weekly dulaglutide AWARD program. Diabetes Obes Metab. 2016;18(1):49–55.
    • (2016) Diabetes Obes Metab , vol.18 , Issue.1 , pp. 49-55
    • Dungan, K.M.1    Raz, I.2    Skrivanek, Z.3    Sealls, W.4    Fahrbach, J.L.5
  • 28
    • 84958767889 scopus 로고    scopus 로고
    • Early fasting glucose measurements can predict later glycemic response to once weekly dulaglutide
    • Grunberger G, Forst T, Fernández Landó L, et al. Early fasting glucose measurements can predict later glycemic response to once weekly dulaglutide. Diabet Med. 2016;33(3):391–394.
    • (2016) Diabet Med , vol.33 , Issue.3 , pp. 391-394
    • Grunberger, G.1    Forst, T.2    Fernández Landó, L.3
  • 30
    • 84914666192 scopus 로고    scopus 로고
    • Effects of the once-weekly glucagon-like peptide-1 receptor agonist dulaglutide on ambulatory blood pressure and heart rate in patients with type 2 diabetes mellitus
    • Ferdinand KC, White WB, Calhoun DA, et al. Effects of the once-weekly glucagon-like peptide-1 receptor agonist dulaglutide on ambulatory blood pressure and heart rate in patients with type 2 diabetes mellitus. Hypertension. 2014;64(4):731–737.
    • (2014) Hypertension , vol.64 , Issue.4 , pp. 731-737
    • Ferdinand, K.C.1    White, W.B.2    Calhoun, D.A.3
  • 31
    • 84959155948 scopus 로고    scopus 로고
    • Cardiovascular safety for once-weekly dulaglutide in type 2 diabetes: A pre-specified meta-analysis of prospectively adjudicated cardiovascular events
    • Ferdinand KC, Botros FT, Atisso CM, Sager PT. Cardiovascular safety for once-weekly dulaglutide in type 2 diabetes: a pre-specified meta-analysis of prospectively adjudicated cardiovascular events. Cardiovasc Diabetol. 2016;15:38.
    • (2016) Cardiovasc Diabetol , vol.15 , pp. 38
    • Ferdinand, K.C.1    Botros, F.T.2    Atisso, C.M.3    Sager, P.T.4
  • 32
    • 84975298465 scopus 로고    scopus 로고
    • Cost-effectiveness of dulaglutide 1.5 mg once weekly for the treatment of patients with type two diabetes mellitus in Sweden
    • Raibouaa A, Borgeke H, Alexiou D, Lowin J, Norrbacka K. Cost-effectiveness of dulaglutide 1.5 mg once weekly for the treatment of patients with type two diabetes mellitus in Sweden. Value Health. 2015;18(7):A607.
    • (2015) Value Health , vol.18 , Issue.7
    • Raibouaa, A.1    Borgeke, H.2    Alexiou, D.3    Lowin, J.4    Norrbacka, K.5
  • 33
    • 44449148293 scopus 로고    scopus 로고
    • The impact of medication regimen factors on adherence to chronic treatment: A review of literature
    • Ingersoll KS, Cohen J. The impact of medication regimen factors on adherence to chronic treatment: a review of literature. J Behav Med. 2008;31:213–224.
    • (2008) J Behav Med , vol.31 , pp. 213-224
    • Ingersoll, K.S.1    Cohen, J.2
  • 34
    • 84865984023 scopus 로고    scopus 로고
    • Patient-reported outcomes in trials of incretin-based therapies in patients with type 2 diabetes mellitus
    • Davies M, Speight J. Patient-reported outcomes in trials of incretin-based therapies in patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2012;14:882–892.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 882-892
    • Davies, M.1    Speight, J.2
  • 36
    • 84939478562 scopus 로고    scopus 로고
    • Treatment satisfaction in people with type 2 diabetes mellitus treated with once-weekly dulaglutide: Data from the AWARD-1 and AWARD-3 clinical trials
    • Reaney M, Yu M, Lakshmanan M, Pechtner V, van Brunt K. Treatment satisfaction in people with type 2 diabetes mellitus treated with once-weekly dulaglutide: data from the AWARD-1 and AWARD-3 clinical trials. Diabetes Obes Metab. 2015;17(9):896–903.
    • (2015) Diabetes Obes Metab , vol.17 , Issue.9 , pp. 896-903
    • Reaney, M.1    Yu, M.2    Lakshmanan, M.3    Pechtner, V.4    Van Brunt, K.5
  • 38
    • 84975306511 scopus 로고    scopus 로고
    • Open-label, parallel-arm, noninferiority comparison of the effects of two doses of LY2189265 and insulin glargine on glycemic control in patients with type 2 diabetes on stable doses of metformin and glimepiride (AWARD-2). Available from: ClinicalTrails.Gov. ClinicalTrials.Gov Identifier: NCT01075282
    • A Randomized, open-label, parallel-arm, noninferiority comparison of the effects of two doses of LY2189265 and insulin glargine on glycemic control in patients with type 2 diabetes on stable doses of metformin and glimepiride (AWARD-2). Available from: ClinicalTrails.gov. ClinicalTrials.gov Identifier: NCT01075282. Accessed November 20, 2015.
    • (2015) Accessed November , pp. 20
    • Randomized, A.1
  • 39
    • 84975308467 scopus 로고    scopus 로고
    • ClinicalTrails.gov. ClinicalTrials.gov Identifier: NCT01191268. Accessed November 20, 2015
    • The impact of LY2189265 versus insulin glargine in combination with insulin lispro for the treatment to target of type 2 diabetes mellitus (AWARD-4: Assessment of Weekly AdministRation of LY2189265 in Diabetes-4). Available from: ClinicalTrails.gov. ClinicalTrials.gov Identifier: NCT01191268. Accessed November 20, 2015.
  • 40
    • 85018214785 scopus 로고    scopus 로고
    • Safe and effective use of the once weekly dulaglutide single-dose pen in injection-naïve patients with type 2 diabetes
    • Matfin G, Van Brunt K, Zimmermann AG, Threlkeld R, Ignaut DA. Safe and effective use of the once weekly dulaglutide single-dose pen in injection-naïve patients with type 2 diabetes. J Diabetes Sci Technol. 2015;9(5):1071–1079.
    • (2015) J Diabetes Sci Technol , vol.9 , Issue.5 , pp. 1071-1079
    • Matfin, G.1    Van Brunt, K.2    Zimmermann, A.G.3    Threlkeld, R.4    Ignaut, D.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.