Loss of the mismatched human leukocyte antigen haplotype in two acute myelogenous leukemia relapses after haploidentical bone marrow transplantation with post-transplantation cyclophosphamide

Leukemia

Volumn 30, Issue 10, 2016, Pages 2102-2106

  McCurdy, S R ^a   Iglehart, B S ^b   Batista, D A ^b   Gocke, C D ^b   Ning, Y ^b   Knaus, H A ^a   Jackson, A M ^b   Leffell, M S ^b   Luznik, L ^a   Gojo, I ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; CYCLOPHOSPHAMIDE; FLUDARABINE; HLA ANTIGEN; MYCOPHENOLATE MOFETIL; TACROLIMUS; ALKYLATING AGENT;

ACUTE MYELOBLASTIC LEUKEMIA; BONE MARROW TRANSPLANTATION; CASE REPORT; DRUG SAFETY; GRAFT RECIPIENT; HAPLOTYPE; HETEROZYGOSITY LOSS; HIGH RISK PATIENT; HLA TYPING; HUMAN; KARYOTYPING; LETTER; LEUKEMIA RELAPSE; LEUKEMIA REMISSION; NONMYELOABLATIVE CONDITIONING; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT INDICATION; WHOLE BODY RADIATION; ACUTE MYELOID LEUKEMIA; GENETICS; IMMUNOLOGY;

ANTINEOPLASTIC AGENTS, ALKYLATING; BONE MARROW TRANSPLANTATION; CYCLOPHOSPHAMIDE; HAPLOTYPES; HLA ANTIGENS; HUMANS; KARYOTYPING; LEUKEMIA, MYELOID, ACUTE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84975165818     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2016.144     Document Type: Letter

References (13)

1. Kanakry CG, Fuchs EJ, Luznik L. Modern approaches to HLA-haploidentical blood or marrow transplantation. Nat Rev Clin Oncol 2015; 13: 132.
2. Ciurea SO, Zhang MJ, Bacigalupo AA, Bashey A, Appelbaum FR, Aljitawi OS et al. Haploidentical transplant with posttransplant cyclophosphamide vs matched unrelated donor transplant for acute myeloid leukemia. Blood 2015; 126: 1033-1040.
3. Luznik L, O'Donnell P, Symons H, Chen AR, Leffell MS, Zahurak M et al. HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide. Biol Blood Marrow Transplant 2008; 14: 9.
4. Hicklin DJ, Marincola FM, Ferrone S. HLA class I antigen downregulation in human cancers: T-cell immunotherapy revives an old story. Mol Med Today 1999; 5: 178-186.
5. Cabrera T, Maleno I, Lopez-Nevot M, Redondo M, Fernandez MA, Collado A et al. High frequency of HLA-B44 allelic losses in human solid tumors. Hum Immunol 2003; 64: 941-950.
6. Koopman LA, Corver WE, van der Slik AR, Giphart MJ, Fleuren GJ. Multiple genetic alterations cause frequent and heterogeneous human histocompatibility leukocyte antigen class i loss in cervical cancer. J Exp Med 2000; 191: 961-976.
7. Masuda K, Hiraki A, Fujii N, Watanabe T, Tanaka M, Matsue K et al. Loss or downregulation of HLA class I expression at the allelic level in freshly isolated leukemic blasts. Cancer Sci 2007; 98: 7.
8. Crucitti L, Crocchiolo R, Toffalori C, Mazzi B, Greco R, Signori A et al. Incidence, risk factors and clinical outcome of leukemia relapses with loss of the mismatched HLA after partially incompatible hematopoietic stem cell transplantation. Leukemia 2015; 29: 1143-1152.
9. Vago L, Toffalori C, Ciceri F, Fleischhauer K. Genomic loss of mismatched human leukocyte antigen and leukemia immune escape from haploidentical graft-versus-leukemia. Sem Oncol 2012; 39: 707-715.
10. Vago L, Perna SK, Zanussi M, Mazzi B, Barlassina C, Stanghellini MT et al. Loss of mismatched HLA in leukemia after stem-cell transplantation. N Engl J Med 2009; 361: 11.
11. McCurdy SR, Kanakry JA, Showel MM, Tsai HL, Bolaños-Meade J, Rosner GL et al. Risk-stratified outcomes of nonmyeloablative HLA-haploidentical BMT with high-dose posttransplantation cyclophosphamide. Blood 2015; 125: 3024-3031.
12. Tamaki H, Fujioka T, Ikegame K, Yoshihara S, Kaida K, Taniguchi K et al. Different mechanisms causing loss of mismatched human leukocyte antigens in relapsingt(6;11)(q27;q23) acute myeloid leukemia after haploidentical transplantation. Eur J Haematol 2012; 89: 497-500.
13. Zeidan AM, Forde PM, Symons H, Chen A, Smith BD, Pratz K et al. HLAhaploidentical donor lymphocyte infusions for patients with relapsed hematologic malignancies after related HLA-haploidentical bone marrow transplantation. Biol Blood Marrow Transplant 2014; 20: 314-318.