Body-mass index in 2.3 million adolescents and cardiovascular death in adulthood

New England Journal of Medicine

Volumn 374, Issue 25, 2016, Pages 2430-2440

  Twig, Gilad ^a,b,c   Yaniv, Gal ^a,b   Levine, Hagai ^d   Leiba, Adi ^a,b,c,f   Goldberger, Nehama ^e   Derazne, Estela ^b,c   Shor, Dana Ben Ami ^a,c   Tzur, Dorit ^b   Afek, Arnon ^c,e   Shamiss, Ari ^a,c   Haklai, Ziona ^e   Kark, Jeremy D ^d  

^a SHEBA MEDICAL CENTER   (Israel)

^b Defense Forces Medical Corps ^*  (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^e MINISTRY OF HEALTH   (Israel)

^f MOUNT AUBURN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADOLESCENT OBESITY; ADULT; ADULTHOOD; ARTICLE; BODY MASS; CARDIOVASCULAR MORTALITY; CAUSE OF DEATH; CEREBROVASCULAR ACCIDENT; DISEASE ASSOCIATION; FEMALE; HAZARD RATIO; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SUDDEN CARDIAC DEATH; CARDIOVASCULAR DISEASE; COMPLICATION; CORONARY ARTERY DISEASE; EPIDEMIOLOGY; FOLLOW UP; ISRAEL; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; OBESITY; PROPORTIONAL HAZARDS MODEL; SUDDEN DEATH; UNITED STATES; YOUNG ADULT;

ADOLESCENT; ADULT; BODY MASS INDEX; CARDIOVASCULAR DISEASES; CAUSE OF DEATH; CORONARY DISEASE; DEATH, SUDDEN; FEMALE; FOLLOW-UP STUDIES; HUMANS; ISRAEL; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; OBESITY; OVERWEIGHT; PROPORTIONAL HAZARDS MODELS; STROKE; UNITED STATES; YOUNG ADULT;

EID: 84975103763     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1503840     Document Type: Article

References (30)

1. Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA 2014;311:806-14.
2. Baker JL, Olsen LW, Sørensen TIA. Childhood body-mass index and the risk of coronary heart disease in adulthood. N Engl J Med 2007;357:2329-37.
3. Must A, Jacques PF, Dallal GE, Bajema CJ, Dietz WH. Long-term morbidity and mortality of overweight adolescents - a follow-up of the Harvard Growth Study of 1922 to 1935. N Engl J Med 1992;327:1350-5.
4. Franks PW, Hanson RL, Knowler WC, Sievers ML, Bennett PH, Looker HC. Childhood obesity, other cardiovascular risk factors, and premature death. N Engl J Med 2010;362:485-93.
5. Engeland A, Bjørge T, Søgaard AJ, Tverdal A. Body mass index in adolescence in relation to total mortality: 32-year follow-up of 227, 000 Norwegian boys and girls. Am J Epidemiol 2003;157:517-23.
6. Lawlor DA, Martin RM, Gunnell D, et al. Association of body mass index measured in childhood, adolescence, and young adulthood with risk of ischemic heart disease and stroke: findings from 3 historical cohort studies. Am J Clin Nutr 2006;83:767-73.
7. Olshansky SJ, Passaro DJ, Hershow RC, et al. A potential decline in life expectancy in the United States in the 21st century. N Engl J Med 2005;352:1138-45.
8. Fontaine KR, Redden DT, Wang C, Westfall AO, Allison DB. Years of life lost due to obesity. JAMA 2003;289:187-93.
9. O'Flaherty M, Allender S, Taylor R, Stevenson C, Peeters A, Capewell S. The decline in coronary heart disease mortality is slowing in young adults (Australia 1976-2006): a time trend analysis. Int J Cardiol 2012;158:193-8.
10. Ford ES, Capewell S. Coronary heart disease mortality among young adults in the U. S.from 1980 through 2002: concealed leveling of mortality rates. J Am Coll Cardiol 2007;50:2128-32.
11. Bjørge T, Engeland A, Tverdal A, Smith GD. Body mass index in adolescence in relation to cause-specific mortality: a follow-up of 230, 000 Norwegian adolescents. Am J Epidemiol 2008;168:30-7.
12. Van Dam RM, Willett WC, Manson JE, Hu FB. The relationship between overweight in adolescence and premature death in women. Ann Intern Med 2006;145:91-7.
13. Israel Central Bureau of Statistics. Characterization and classification of local authorities by the socio-economic level of the population. Jerusalem: Israel Central Bureau of Statistics, 2006.
14. Kuczmarski RJ, Ogden CL, Guo SS, et al. 2000 CDC growth charts for the United States: methods and development. Vital Health Stat 11 2002;2002(246):1-190.
15. Bibbins-Domingo K, Coxson P, Pletcher MJ, Lightwood J, Goldman L. Adolescent overweight and future adult coronary heart disease. N Engl J Med 2007;357:2371-9.
16. DiPietro L, Mossberg HO, Stunkard AJ. A 40-year history of overweight children in Stockholm: life-time overweight, morbidity, and mortality. Int J Obes Relat Metab Disord 1994;18:585-90.
17. Twig G, Afek A, Shamiss A, et al. Adolescence BMI and trends in adulthood mortality: a study of 2.16 million adolescents. J Clin Endocrinol Metab 2014;99:2095-103.
18. Shah RV, Murthy VL, Colangelo LA, et al. Association of fitness in young adulthood with survival and cardiovascular risk: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. JAMA Intern Med 2016;176:87-95.
19. Skinner AC, Perrin EM, Moss LA, Skelton JA. Cardiometabolic risks and severity of obesity in children and young adults. N Engl J Med 2015;373:1307-17.
20. Mangner N, Scheuermann K, Winzer E, et al. Childhood obesity: impact on cardiac geometry and function. JACC Cardiovasc Imaging 2014;7:1198-205.
21. Güven A, Özgen T, Güngör O, Aydýn M, Baysal K. Association between the corrected QT interval and carotid artery intimamedia thickness in obese children. J Clin Res Pediatr Endocrinol 2010;2:21-7.
22. McGill HC Jr, McMahan CA, Herderick EE, Malcom GT, Tracy RE, Strong JP. Origin of atherosclerosis in childhood and adolescence. Am J Clin Nutr 2000;72: Suppl: 1307S-1315S.
23. Würtz P, Wang Q, Kangas AJ, et al. Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change. PLoS Med 2014;11(12):e1001765.
24. Tirosh A, Shai I, Afek A, et al. Adolescent BMI trajectory and risk of diabetes versus coronary disease. N Engl J Med 2011;364:1315-25.
25. Jeffreys M, McCarron P, Gunnell D, McEwen J, Smith GD. Body mass index in early and mid-adulthood, and subsequent mortality: a historical cohort study. Int J Obes Relat Metab Disord 2003;27:1391-7.
26. Gray L, Lee IM, Sesso HD, Batty GD. Body weight in early and mid-adulthood in relation to subsequent coronary heart disease mortality: 80-year follow-up in the Harvard Alumni Study. Arch Intern Med 2011;171:1768-70.
27. Juonala M, Magnussen CG, Berenson GS, et al. Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med 2011;365:1876-85.
28. Kvaavik E, Tell GS, Klepp KI. Predictors and tracking of body mass index from adolescence into adulthood: follow-up of 18 to 20 years in the Oslo Youth Study. Arch Pediatr Adolesc Med 2003;157:1212-8.
29. Hägg S, Fall T, Ploner A, et al. Adiposity as a cause of cardiovascular disease: a Mendelian randomization study. Int J Epidemiol 2015;44:578-86.
30. Keith SW, Fontaine KR, Pajewski NM, Mehta T, Allison DB. Use of self-reported height and weight biases the body mass index-mortality association. Int J Obes (Lond) 2011;35:401-8.