Black ginseng extract exerts anti-hyperglycemic effect via modulation of glucose metabolism in liver and muscle

Journal of Ethnopharmacology

Volumn 190, Issue , 2016, Pages 231-240

  Seo, Yun Soo ^a   Shon, Mi Yae ^b   Kong, Ryong ^a   Kang, Ok Hwa ^a   Zhou, Tian ^a   Kim, Do Yeon ^b   Kwon, Dong Yeul ^a  

^a Wonkwang University   (South Korea)

^b International Ginseng Herb Research Institute   (South Korea)

Author keywords

Black ginseng; Diabetes mellitus; Glucose tolerance; Insulin signaling; Skeletal muscle

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ACYL COENZYME A OXIDASE; ANTIDIABETIC AGENT; BLACK GINSENG EXTRACT; CARNITINE PALMITOYLTRANSFERASE I; CARNITINE PALMITOYLTRANSFERASE IA; GINSENG EXTRACT; GINSENOSIDE RG 1; GLUCOSE 6 PHOSPHATASE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 4; GLYCOGEN PHOSPHORYLASE; GLYCOGEN SYNTHASE; GLYCOSYLATED HEMOGLOBIN; MEDIUM CHAIN ACYL COENZYME A DEHYDROGENASE; NICOTINAMIDE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); TRIACYLGLYCEROL; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; GLUCOSE BLOOD LEVEL; HBA(1C) PROTEIN, MOUSE; INSULIN; PLANT EXTRACT; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANTIDIABETIC ACTIVITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FREEZE DRYING; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; GLYCOGENOLYSIS; HYPERGLYCEMIA; LIVER METABOLISM; MOUSE; MUSCLE ATROPHY; MUSCLE METABOLISM; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; BLOOD; CELL LINE; CHEMICALLY INDUCED; CHEMISTRY; CLASSIFICATION; DIABETES MELLITUS, EXPERIMENTAL; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; INSTITUTE FOR CANCER RESEARCH MOUSE; ISOLATION AND PURIFICATION; LIVER; MALE; MEDICINAL PLANT; METABOLISM; PANAX; PHOSPHORYLATION; PHYTOTHERAPY; SIGNAL TRANSDUCTION; SKELETAL MUSCLE CELL; TIME FACTOR;

ANIMALS; BIOMARKERS; BLOOD GLUCOSE; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEMOGLOBIN A, GLYCOSYLATED; HYPOGLYCEMIC AGENTS; INSULIN; LIVER; MALE; MICE, INBRED ICR; MUSCLE FIBERS, SKELETAL; PANAX; PHOSPHORYLATION; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; SIGNAL TRANSDUCTION; STREPTOZOCIN; TIME FACTORS;

EID: 84975057000     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2016.05.060     Document Type: Article

References (31)

1. M. Abu-Farha, P. Cherian, I. Al-Khairi, A. Tiss, A. Khadir, S. Kavalakatt, S. Warsame, M. Dehbi, K. Behbehani, and J. Abubaker DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression Sci. Rep. 24 5 2015 14448 10.1038/srep14448
2. D.R. Alessi, M. Andjelkovic, B. Caudwell, P. Cron, N. Morrice, P. Cohen, and B.A. Hemmings Mechanism of activation of protein kinase B by insulin and IGF-1 EMBO J. 15 23 1996 6541 6551
3. J.G. Anderson, G. Ramadori, R.M. Ioris, M. Galiè, E.D. Berglund, K.C. Coate, T. Fujikawa, S. Pucciarelli, B. Moreschini, A. Amici, C. Andreani, and R. Coppari Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6 Mol. Metab. 4 11 2015 846 856
4. A.M. Andres, E.P. Ratliff, S. Sachithanantham, and S.T. Hui Diminished AMPK signaling response to fasting in thioredoxin-interacting protein knockout mice FEBS Lett. 585 8 2011 1223 1230
5. S.C. Bodine, T.N. Stitt, M. Gonzalez, W.O. Kline, G.L. Stover, R. Bauerlein, E. Zlotchenko, A. Scrimgeour, J.C. Lawrence, D.J. Glass, and G.D. Yancopoulos Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo Nat. Cell Biol. 3 11 2001 1014 1019
6. C. Chen, H. Zhang, S.L. Broitman, M. Reiche, I. Farrell, B.S. Cooperman, and Y.E. Goldman Dynamics of translation by single ribosomes through mRNA secondary structures Nat. Struct. Mol. Biol. 20 5 2013 582 588
7. T. Coll, E. Eyre, R. Rodríguez-Calvo, X. Palomer, R.M. Sánchez, M. Merlos, J.C. Laguna, and M. Vázquez-Carrera Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells J. Biol. Chem. 283 17 2008 11107 11116
8. R.J. DeBerardinis, J.J. Lum, G. Hatzivassiliou, and C.B. Thompson The biology of cancer: metabolic reprogramming fuels cell growth and proliferation Cell Metab. 7 1 2008 11 20
9. C.N. Gillis Panax ginseng pharmacology: a nitric oxide link? Biochem. Pharmacol. 54 1 1997 1 8
10. B.G. Ha, E.J. Shin, J.E. Park, and Y.H. Shon Anti-diabetic effect of balanced deep-sea water and its mode of action in high-fat diet induced diabetic mice Mar. Drugs 11 11 2013 4193 4212
11. C. Herder, S. Schneitler, W. Rathmann, B. Haastert, H. Schneitler, H. Winkler, R. Bredahl, E. Hahnloser, and S. Martin Low-grade inflammation, obesity, and insulin resistance in adolescents J. Clin. Endocrinol. Metab. 92 12 2007 4569 4574
12. D.W. Jung, H.H. Ha, X. Zheng, Y.T. Chang, and D.R. Williams Novel use of fluorescent glucose analogues to identify a new class of triazine-based insulin mimetics possessing useful secondary effects Mol. Biosyst. 7 2 2011 346 358
13. B.B. Kahn, T. Alquier, D. Carling, and D.G. Hardie AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism Cell Metab. 1 1 2005 15 25
14. K.S. Kang, H.Y. Kim, N. Yamabe, and T. Yokozawa Stereospecificity in hydroxyl radical scavenging activities of four ginsenosides produced by heat processing Bioorg. Med. Chem. Lett. 16 19 2006 5028 5031
15. P. Kapahi, D. Chen, A.N. Rogers, S.D. Katewa, P.W. Li, E.L. Thomas, and L. Kockel With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging Cell Metab. 11 6 2010 453 465
16. T. Karar, R.I. Alhammad, M.A. Fattah, A. Alanazi, and S. Qureshi Relation between glycosylated hemoglobin and lipid and thyroid hormone among patients with type 2 diabetes mellitus at King Abdulaziz Medical City, Riyadh J. Nat. Sci. Biol. Med 6 Suppl 1 2015 S75 S79
17. M.K. Kim, J.W. Lee, K.Y. Lee, and D.C. Yang Microbial conversion of major ginsenoside rb(1) to pharmaceutically active minor ginsenoside rd J. Microbiol. 43 5 2005 456 462
18. M. Laplante, and D.M. Sabatini mTOR signaling in growth control and disease Cell 149 2012 274 293
19. E. Latres, A.R. Amini, A.A. Amini, J. Griffiths, F.J. Martin, Y. Wei, H.C. Lin, G.D. Yancopoulos, and D.J. Glass Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway J. Biol. Chem. 280 4 2005 2737 2744
20. W.E. Mitch, and A.L. Goldberg Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway N. Engl. J. Med 335 25 1996 1897 1905
21. S.Y. Park, M.H. Kim, J.H. Ahn, S.J. Lee, J.H. Lee, W.S. Eum, S.Y. Choi, and H.Y. Kwon The stimulatory effect of essential fatty acids on glucose uptake involves both Akt and AMPK activation in C2C12 skeletal muscle cells Korean J. Physiol. Pharmacol. 18 3 2014 255 261
22. A.M. Quintela, R. Jiménez, L. Piqueras, M. Gómez-Guzmán, J. Haro, M.J. Zarzuelo, A. Cogolludo, M.J. Sanz, M. Toral, M. Romero, F. Pérez-Vizcaíno, and J. Duarte PPARβ activation restores the high glucose-induced impairment of insulin signalling in endothelial cells Br. J. Pharmacol. 171 12 2014 3089 3102
23. R. Rahimi, S. Nikfar, B. Larijani, and M. Abdollahi A review on the role of antioxidants in the management of diabetes and its complications Biomed. Pharmacother. 59 7 2005 365 373
24. M. Roden Muscle triglycerides and mitochondrial function: possible mechanisms for the development of type 2 diabetes Int. J. Obes. (Lond.) 29 Suppl 2 2005 S111 S115
25. L. Rossetti Glucose toxicity: the implications of hyperglycemia in the pathophysiology of diabetes mellitus Clin. Investig. Med. 18 4 1995 255 260
26. A.R. Saltiel, and C.R. Kahn Insulin signalling and the regulation of glucose and lipid metabolism Nature 414 6865 2001 799 806
27. Y. Shimoda, K. Matsuo, Y. Kitamura, K. Ono, T. Ueyama, S. Matoba, H. Yamada, T. Wu, J. Chen, N. Emoto, and K. Ikeda Diabetes-related Ankyrin repeat protein (DARP/Ankrd23) modifies glucose homeostasis by modulating AMPK activity in skeletal muscle PLoS One 10 9 2015 e0138624 10.1371/journal.pone.0138624 eCollection 2015
28. M. Stefanowicz, M. Straczkowski, and M. Karczewska-Kupczewska The role of SIRT1 in the pathogenesis of insulin resistance in skeletal muscle Postȩpy Hig. Med. Doświadczalnej 69 2015 63 68 10.5604/17322693.1136379 (Article in Polish)
29. B.S. Sun, L.J. Gu, Z.M. Fang, C.Y. Wang, Z. Wang, M.R. Lee, Z. Li, J.J. Li, and C.K. Sung Simultaneous quantification of 19 ginsenosides in black ginseng developed from Panax ginseng by HPLC-ELSD J. Pharm. Biomed. Anal. 50 1 2009 15 22
30. D.R. Whiting, L. Guariguata, C. Weil, and J. Shaw IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030 Diabetes Res. Clin. Pract. 94 3 2011 311 321
31. S. Wullschleger, R. Loewith, and M.N. Hall TOR signaling in growth and metabolism Cell 124 3 2006 471 484