2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19

ACS Medicinal Chemistry Letters

Volumn 7, Issue 6, 2016, Pages 573-578

  Mallinger, Aurélie ^a   Schiemann, Kai ^b   Rink, Christian ^a   Sejberg, Jimmy ^a   Honey, Mark A ^a   Czodrowski, Paul ^b   Stubbs, Mark ^a   Poeschke, Oliver ^b   Busch, Michael ^b   Schneider, Richard ^b   Schwarz, Daniel ^b   Musil, Djordje ^b   Burke, Rosemary ^a   Urbahns, Klaus ^b   Workman, Paul ^a   Wienke, Dirk ^b   Clarke, Paul A ^a   Raynaud, Florence I ^a   Eccles, Suzanne A ^a   Esdar, Christina ^b   Rohdich, Felix ^b   Blagg, Julian ^a   more..

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b MERCK KGAA   (Germany)

Author keywords

aldehyde oxidase; CDK19; CDK8; kinase inhibitor; mediator complex

Indexed keywords

ALDEHYDE OXIDASE; ANTINEOPLASTIC AGENT; CYCLIN C; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 19; CYCLIN DEPENDENT KINASE 8; ISOQUINOLINE DERIVATIVE; NAPHTHYRIDINE DERIVATIVE; STAT1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLORECTAL CARCINOMA; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG PENETRATION; DRUG POTENCY; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; IN VIVO STUDY; METABOLIC STABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SUBSTITUTION REACTION; TUMOR XENOGRAFT;

EID: 84974633010     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.6b00022     Document Type: Article

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