Reactivated CD4+Tm cells of T1D patients and siblings display an exaggerated effector phenotype with heightened sensitivity to activation-induced cell death

Diabetes

Volumn 64, Issue 6, 2015, Pages 2161-2171

  Bian, Michael Lei ^a   Haigh, Oscar ^b   Munster, David ^a   Harris, Mark ^c   Cotterill, Andrew ^c   Miles, John J ^b,d,e   Vuckovic, Slavica ^a,b,e  

^a Mater Research   (Australia)

^b QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^c MATER CHILDREN S HOSPITAL   (Australia)

^d CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^e UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; L SELECTIN; T LYMPHOCYTE RECEPTOR;

APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CELL DEATH; CHILD; CONTROLLED STUDY; DIABETIC PATIENT; EFFECTOR CELL; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; MEMORY CELL; MEMORY T LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; SCHOOL CHILD; SIBLING; T LYMPHOCYTE ACTIVATION; ADOLESCENT; CELL CULTURE; IMMUNOPHENOTYPING; METABOLISM; PHYSIOLOGY;

ADOLESCENT; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CHILD; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; IMMUNOPHENOTYPING; INTERFERON-GAMMA; INTERLEUKIN-10; MALE;

EID: 84974617885     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-1151     Document Type: Article

References (33)

1. Bluestone JA, Herold K, Eisenbarth G. Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature 2010;464:1293-1300.
2. Haskins K, Cooke A. CD4 T cells and their antigens in the pathogenesis of autoimmune diabetes. Curr Opin Immunol 2011;23:739-745.
3. Orban T, Bundy B, Becker DJ, et al.; Type 1 Diabetes TrialNet Abatacept Study Group. Co-stimulation modulation with abatacept in patients with recentonset type 1 diabetes: A randomised, double-blind, placebo-controlled trial. Lancet 2011;378:412-419.
4. Zhang J, Gao W, Yang X, et al. Tolerogenic vaccination reduced effector memory CD4 T cells and induced effector memory Treg cells for type I diabetes treatment. PLoS One 2013;8:e70056.
5. Sallusto F, Lenig D, Förster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999;401:708-712.
6. MacLeod MK, Kappler JW, Marrack P. Memory CD4 T cells: generation, reactivation and re- Assignment. Immunology 2010;130:10-15.
7. Danke NA, Yang J, Greenbaum C, Kwok WW. Comparative study of GAD65- specific CD4+ T cells in healthy and type 1 diabetic subjects. J Autoimmun 2005; 25:303-311.
8. Endl J, Rosinger S, Schwarz B, et al. Coexpression of CD25 and OX40 (CD134) receptors delineates autoreactive T-cells in type 1 diabetes. Diabetes 2006;55:50-60.
9. Viglietta V, Kent SC, Orban T, Hafler DA. GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes. J Clin Invest 2002;109:895-903.
10. Sewell AK. Why must T cells be cross-reactive? Nat Rev Immunol 2012;12: 669-677.
11. Wucherpfennig KW, Strominger JL. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 1995;80:695-705.
12. Honkanen J, Nieminen JK, Gao R, et al. IL-17 immunity in human type 1 diabetes. J Immunol 2010;185:1959-1967.
13. Ramaswamy M, Cruz AC, Cleland SY, et al. Specific elimination of effector memory CD4+ T cells due to enhanced Fas signaling complex formation and association with lipid raft microdomains. Cell Death Differ 2011;18: 712-720.
14. Kühtreiber WM, Hayashi T, Dale EA, Faustman DL. Central role of defective apoptosis in autoimmunity. J Mol Endocrinol 2003;31:373-399.
15. Li CR, Mueller EE, Bradley LM. Islet antigen-specific Th17 cells can induce TNF-α-dependent autoimmune diabetes. J Immunol 2014;192:1425-1432.
16. Watson ML, Rao JK, Gilkeson GS, et al. Genetic analysis of MRL-lpr mice: Relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. J Exp Med 1992;176:1645-1656.
17. Takahashi T, Tanaka M, Brannan CI, et al. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 1994;76: 969-976.
18. Hughes PD, Belz GT, Fortner KA, Budd RC, Strasser A, Bouillet P. Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity. Immunity 2008;28:197-205.
19. DeFranco S, Bonissoni S, Cerutti F, et al. Defective function of Fas in patients with type 1 diabetes associated with other autoimmune diseases. Diabetes 2001;50:483-488.
20. Vuckovic S, Withers G, Harris M, et al. Decreased blood dendritic cell counts in type 1 diabetic children. Clin Immunol 2007;123:281-288.
21. Bangs SC, Baban D, Cattan HJ, Li CK, McMichael AJ, Xu XN. Human CD4+ memory T cells are preferential targets for bystander activation and apoptosis. J Immunol 2009;182:1962-1971.
22. Polychronakos C, Li Q. Understanding type 1 diabetes through genetics: Advances and prospects. Nat Rev Genet 2011;12:781-792.
23. Huber A, Menconi F, Corathers S, Jacobson EM, Tomer Y. Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocr Rev 2008;29:697-725.
24. Saha B, Jyothi Prasanna S, Chandrasekar B, Nandi D. Gene modulation and immunoregulatory roles of interferon gamma. Cytokine 2010;50:1-14.
25. Dunn GP, Koebel CM, Schreiber RD. Interferons, immunity and cancer immunoediting. Nat Rev Immunol 2006;6:836-848.
26. Tseng CH. Thyroid cancer risk is not increased in diabetic patients. PLoS One 2012;7:e53096.
27. Gordon-Dseagu VL, Shelton N, Mindell JS. Epidemiological evidence of a relationship between type-1 diabetes mellitus and cancer: A review of the existing literature. Int J Cancer 2013;132:501-508.
28. Pakala SV, Kurrer MO, Katz JD. T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice. J Exp Med 1997;186:299-306.
29. Zhu J, Paul WE. CD4 T cells: fates, functions, and faults. Blood 2008;112: 1557-1569.
30. Muppidi JR, Siegel RM. Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death. Nat Immunol 2004;5:182- 189.
31. Matteucci E, Ghimenti M, Di Beo S, Giampietro O. Altered proportions of naïve, central memory and terminally differentiated central memory subsets among CD4+ and CD8 + T cells expressing CD26 in patients with type 1 diabetes. J Clin Immunol 2011;31:977-984.
32. Varela-Calvino R, Ellis R, Sgarbi G, Dayan CM, Peakman M. Characterization of the T-cell response to coxsackievirus B4: Evidence that effector memory cells predominate in patients with type 1 diabetes. Diabetes 2002;51: 1745-1753.
33. Wilkinson A, Bian L, Khalil D, et al. Type 1 diabetic children and siblings share a decrease in dendritic cell and monocyte numbers but are differentiated by expansion of CD4+T cells expressing IL-17. J Clin Cell Immunol 2011; (Suppl. 2):001.