Brain Mechanisms for Processing Affective (and Nonaffective) Touch Are Atypical in Autism

Cerebral Cortex

Volumn 26, Issue 6, 2016, Pages 2705-2714

  Kaiser, Martha D ^a   Yang, Daniel Y J ^a   Voos, Avery C ^a   Bennett, Randi H ^a   Gordon, Ilanit ^a   Pretzsch, Charlotte ^a   Beam, Danielle ^a   Keifer, Cara ^a   Eilbott, Jeffrey ^a   McGlone, Francis ^b   Pelphrey, Kevin A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

Author keywords

Affective touch; Autism spectrum disorder; Functional magnetic resonance imaging; Insula; Sensory hyper reactivity; Tactile perception

Indexed keywords

ADOLESCENT; AFFECTIVE TOUCH; ARTICLE; AUTISM; BRAIN ANALYSIS; BRAIN REGION; CHILD; CLINICAL ARTICLE; CLINICAL EVALUATION; CORRELATION ANALYSIS; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUNCTIONAL NEUROIMAGING; HUMAN; INFORMATION PROCESSING; LIKERT SCALE; MALE; PRIORITY JOURNAL; SCHOOL CHILD; SELF EVALUATION; TOUCH; AFFECT; ARM; BRAIN; BRAIN MAPPING; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; PRESCHOOL CHILD; PSYCHOLOGY; YOUNG ADULT;

ADOLESCENT; AFFECT; ARM; AUTISM SPECTRUM DISORDER; BRAIN; BRAIN MAPPING; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; TOUCH PERCEPTION; YOUNG ADULT;

EID: 84974588581     PISSN: 10473211     EISSN: 14602199     Source Type: Journal    
DOI: 10.1093/cercor/bhv125     Document Type: Article

References (40)

1. Abrams DA, Lynch CJ, Cheng CM, Phillips J, Supekar K, Ryali S, Uddin LQ, Menon V. 2013. Underconnectivity between voiceselective cortex and reward circuitry in children with autism. Proc Natl Acad Sci USA. 110:12061-12065.
2. American Psychiatric Association. 2013. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington (VA): American Psychiatric Publishing. American Academy of Pediatrics. 2012. Sensory integration therapies for children with developmental and behavioral disorders. Pediatrics. 129:1186-1189.
3. Baranek GT. 1999. Autism during infancy: A retrospective video analysis of sensory-motor and social behaviors at 9-12 months of age. J Autism Dev Disord. 29:213-224.
4. Barnett L. 2005. Keep in touch: the importance of touch in infant development. Infant Obs. 8:115-123.
5. Bennett RH, Bolling DZ, Anderson LC, Pelphrey KA, Kaiser MD. 2014. fNIRS detects temporal lobe response to affective touch. Soc Cogn Affect Neurosci. 9 (4):470-476.
6. Bradley MM, Lang PJ. 1994. Measuring emotion: the self-assessment manikin and the semantic differential. J Behav Ther Exp Psychiatry. 25:49-59.
7. Brothers L. 1990. The social brain: A project for integrating primate behavior and neurophysiology in a new domain. Concept Neurosci. 1:27-51.
8. Cascio C, McGlone F, Folger S, Tannan V, Baranek G, Pelphrey KA, Essick G. 2008. Tactile perception in adults with autism: A multidimensional psychophysical study. J Autism Dev Disord. 38:127-137.
9. Cascio CJ, Moana-Filho EJ, Guest S, Nebel MB, Weisner J, Baranek GT, Essick GK. 2012. Perceptual and neural response to affective tactile texture stimulation in adults with autism spectrum disorders. Autism Res. 5:231-244.
10. Cascio CJ, Lorenzi J, Baranek GT. 2013. Self-reported pleasantness ratings and examiner-coded defensiveness in response to touch in children with ASD: effects of stimulus material and bodily location. J Autism Dev Disord. 5:1-10.
11. Dapretto M, Davies MS, Pfeifer JH, Scott AA, Sigman M, Bookheimer SY, Iacoboni M. 2006. Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders. Nat Neurosci. 9:28-30.
12. Elliott CD. 1990. Differential ability scales. New York (NY): The Psychological Corporation
13. Essick G, James A, McGlone FP. 1999. Psychophysical assessment of the affective components of non-painful touch. Neuroreport. 10:2083-2087.
14. Fairhurst MT, Löken L, Grossmann T. 2014. Physiological and behavioral responses reveal 9-month-old infants' sensitivity to pleasant touch. Psychol Sci. 25:1124-1131.
15. Field T, Lasko D, Mundy P, Henteleff T, Kabat S, Talpins S, Dowling M. 1997. Brief report: Autistic children's attentiveness and responsivity improve after touch therapy. J Autism Dev Disord. 27:333-338.
16. Gordon I, Voos AC, Bennett RH, Bolling DZ, Pelphrey KA, Kaiser MD. 2013. Brain mechanisms for processing affective touch. Hum Brain Mapp. 34:914-922.
17. Grandin T. 1989. An autistic person's view of holding therapy. Communication (Published by National Autistic Society of England). 23:75-76.
18. JenkinsonM, Beckmann CF, Behrens TE, WoolrichMW, Smith SM. 2012. FSL. Neuroimage. 62:782-790.
19. Kaiser MD, Hudac CM, Shultz S, Lee S, Cheung C, Berken AM, Deen B, Pitskel NB, Sugrue DR, Voos AC, et al. 2010. Neural signatures of autism. Proc Natl Acad Sci USA. 107: 21223-21228.
20. Kern JK, Trivedi MH, Grannermann BD, Garver CR, Johnson DG, Andrews AA. 2007. Sensory correlations in autism. Autism. 11:123-134.
21. Kisilevsky BS, Fearon I, Muir DW. 1998. Fetuses differentiate vibracoustic stimuli. Infant Behav Dev. 21:25-46.
22. Kumazawa T, Perl ER. 1977. Primate cutaneous sensory units with unmyelinated C afferent fibers. J Neurophysiol. 40: 1325-1338.
23. Löken L, Wessberg J, Morrison I, McGlone F, Olausson H. 2009. Coding of pleasant touch by unmyelinated afferents in humans. Nat Neurosci. 12:547-548.
24. Lord C, Risi S, Lambrecht L, Cook EH, Leventhal BL, DiLavore PC, Pickles A, Rutter M. 2000. The Autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord. 30:205-223.
25. Lord C, Rutter M, Le Couteur A. 1994. Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord. 24:659-685.
26. Markram K, Markram H. 2010. The intense world theory: A unifying theory of the neurobiology of autism. FrontHumNeurosci. 4:224.
27. Mesulam MM, editor. 1985. Patterns in behavioral neuroanatomy: Association areas, the limbic system, and hemispheric specialization. Principles behavioral neurology. Philadelphia (PA): Springer. p. 1-58.
28. McGlone F, Vallbo AB, Olausson H, Löken L, Wessberg J. 2007. Discriminative touch and emotional touch. Can J Exp Psychol. 61:173-183.
29. McGlone F, Wessberg J, Olausson H. 2014. Discriminative and affective touch: sensing and feeling. Neuron. 82:737-755.
30. McLaren DG, Ries ML, Xu G, Johnson SC. 2012. A generalized form of context-dependent psychophysiological interactions (gPPI): A comparison to standard approaches. Neuroimage. 61:1277-1286.
31. Morrison I, Loken LS, Olausson H. 2010. The skin as a social organ. Exp Brain Res. 204:205-314.
32. Olausson H, Lamarre Y, Backlund H, Morin C, Wallin BG, Starck G, Ekholm S, Strigo I, Worsley K, Vallbo AB, et al. 2002. Unmyelinated tactile afferents signal touch and project to insular cortex. Nat Neurosci. 5:900-904.
33. Penfield W, Rasmussen T. 1950. The cerebral cortex of man: A clinical study of localization of function. New York: Macmillan.
34. Salimi-Khorshidi G, Douaud G, Beckmann CF, Glasser MF, Griffanti L, Smith SM. 2014. Automatic denoising of functional MRI data: combining independent component analysis and hierarchical fusion of classifiers. Neuroimage. 90:449-68.
35. Stack DM. 2001. The salience of touch and physical contact during infancy: unraveling some of the mysteries of the somesthetic sense. In: Bremner A, Fogel A, editors. Blackwell handbook of infant development. Oxford (UK): Blackwell Publishing Ltd. p. 351-378.
36. Thayer S. 1986. History and strategies of research on social touch. J Nonverbal Behav. 10:12-28.
37. Uddin LQ, Menon V. 2009. The anterior insula in autism: underconnected and under-examined. Neurosci Biobehav Rev. 33:1198-1203.
38. Vallbo A, Olausson H, Wessberg J, Norrsell U. 1993. A system of unmyelinated afferents for innocuous mechanoreception in the human skin. Brain Res. 628:301-304.
39. Voos A, Pelphrey KA, Kaiser MD. 2012. Autistic traits are associated with diminished neural response to affective touch. Soc Cogn Affect Neurosci. 8:378-386.
40. Yang DYJ, Rosenblau G, Keifer C, Pelphrey KA. 2015. An integrative neural model of social perception, action observation, and theory of mind. Neurosci Biobehav Rev. 51:263-275.