Patients with Cardiorenal Syndrome Revealed Increased Neurohormonal Activity, Tubular and Myocardial Damage Compared to Heart Failure Patients with Preserved Renal Function

CardioRenal Medicine

Volumn 4, Issue 4, 2014, Pages 257-268

  Palazzuoli, Alberto ^a   Ruocco, Gaetano ^a   Pellegrini, Marco ^b   Martini, Simona ^a   Castillo, Gabriele Del ^a   Beltrami, Matteo ^a   Franci, Beatrice ^a   Lucani, Barbara ^a   Nuti, Ranuccio ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY HOSPITAL OF SIENA   (Italy)

Author keywords

Biomarkers; Cardiorenal syndrome; Heart failure; Renal function

Indexed keywords

EID: 84974586990     PISSN: 16643828     EISSN: 16645502     Source Type: Journal    
DOI: 10.1159/000368375     Document Type: Article

References (40)

1. Smith GL, Lichtman JH, Bracken MB, Shlipak MG, Phillips CO, DiCapua P, Krumholz HM: Renal impairment and outcomes in heart failure: systematic review and meta-Analysis. J Am Coll Cardiol 2006; 47: 1987-1996.
2. Heywood JT, Fonarow GC, Costanzo MR, Mathur VS, Wigneswaran JR, Wynne J: High prevalence of renal dysfunction and its impact on outcome in 118,465 patients hospitalized with acute decompensated heart failure: A report from the ADHERE Database. J Card Fail 2007; 13: 422-430.
3. Klein L, Massie BM, Leimberger JD O Connor CM, Piña IL, Adams KF Jr, Califf RM, Gheorghiade M: Admission or changes in renal function during hospitalization for worsening heart failure predict post discharge survival. Cir Heart Fail 2008; 1: 25-33.
4. House AA, Anand I, Bellomo R, Cruz D, Bobek I, Anker SD, Aspromonte N, Bagshaw S, Berl T, Daliento L, Davenport A, Haapio M, Hillege H, McCullough P, Katz N, Maisel A, Mankad S, Zanco P, Mebazaa A, Palazzuoli A, Ronco F, Shaw A, Sheinfeld G, Soni S, Vescovo G, Zamperetti N, Ponikowski P, Ronco C; Acute Dialysis Quality Initiative Consensus Group: Definition and classification of Cardio-Renal Syndromes: workgroup statements from the 7th ADQI Consensus Conference. Nephrol Dial Transplant 2010; 25: 1416-1420.
5. Packer M: The neurohormonal hypothesis: A theory to explain heart disease progression in heart failure. J Am Coll Cardiol 1992; 20: 248-254.
6. Schrier RW: Role of diminished renal function in cardiovascular mortality: marker or pathogenetic factor? J Am Coll Cardiol 2006; 47: 1-8.
7. Vittorini S, Clerico A: Cardiovascular biomarkers: increasing impact of laboratory medicine in cardiology practice. Clin Chem Lab Med 2008; 46: 748-763.
8. Maisel AS, Katz N, Hillege HL, Shaw A, Zanco P, Bellomo R, Anand I, Anker SD, Aspromonte N, Bagshaw SM, Berl T, Bobek I, Cruz DN, Daliento L, Davenport A, Haapio M, House AA, Mankad S, McCullough P, Mebazaa A, Palazzuoli A, Ponikowski P, Ronco F, Sheinfeld G, Soni S, Vescovo G, Zamperetti N, Ronco C; Acute Dialysis Quality Initiative consensus group: biomarkers in kidney and heart disease. Nephrol Dial Transplant 2011; 26: 62-74.
9. McCullough PA, Bouchard J, Waikar SS, Siew ED, Endre ZH, Goldstein SL, Koyner JL, Macedo E, Doi K, Di Somma S, Lewington A, Thadhani R, Chakravarthi R, Ice C, Okusa MD, Duranteau J, Doran P, Yang L, Jaber BL, Meehan S, Kellum JA, Haase M, Murray PT, Cruz D, Maisel A, Bagshaw SM, Chawla LS, Mehta RL, Shaw AD, Ronco C: Implementation of novel biomarkers in the diagnosis, prognosis, and management of acute kidney injury: executive summary from the tenth consensus conference of the Acute Dialysis Quality Initiative (ADQI). Contrib Nephrol 2013; 182: 5-12.
10. National Kidney Foundation: K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 2002; 39:S1-S266.
11. Levey AS, Coresh J, Greene T, Stevens LA, Zhang YL, Hendriksen S, Kusek JW, Van Lente F; Chronic Kidney Disease Epidemiology Collaboration: Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med 2006; 145: 247-254.
12. Bagshaw SM, Cruz DN, Aspromonte N, Daliento L, Ronco F, Sheinfeld G, Anker SD Anand I, Bellomo R, Berl T, Bobek I, Davenport A, Haapio M, Hillege H, House A, Katz N, Maisel A, Mankad S, McCullough P, Mebazaa A, Palazzuoli A, Ponikowski P, Shaw A, Soni S, Vescovo G, Zamperetti N, Zanco P, Ronco C; for the Acute Dialysis Quality Initiative (ADQI) Consensus Group: Epidemiology of cardio-renal syndromes: workgroup statements from the 7th ADQI Consensus Conference. Nephrol Dial Transplant 2010; 25: 1406-1416.
13. Jessup M, Abraham WT, Casey DE, Feldman AM, Francis GS, Ganiats TG, Konstam MA, Mancini DM, Rahko PS, Silver MA, Stevenson LW, Yancy CW: 2009 Focused update. ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: A report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation 2009; 119: 1977-2016.
14. Metra M, Dei Cas L, Bristow MR: The pathophysiology of acute heart failure it is a lot about fluid accumulation. Am Heart J 2008; 155: 1-5.
15. Damman K, Navis G, Voors AA, Asselbergs FW, Smilde TD, Cleland JG, van Veldhuisen DJ, Hillege HL: Worsening renal function and prognosis in heart failure: systematic review and meta-Analysis. J Card Fail 2007; 13: 599-608.
16. Palazzuoli A, Masson S, Ronco C, Maisel A: Clinical relevance of biomarkers in heart failure and cardiorenal syndrome: The role of natriuretic peptides and troponin. Heart Fail Rev 2014; 19: 267-284.
17. Soni SS, Ronco C, Katz N, Cruz DN: Early diagnosis of acute kidney injury: The promise of novel biomarkers. Blood Purif 2009; 28: 165-174.
18. Cruz D, Goh CY, Palazzuoli A, Slavin L, Calabro A, Ronco C, Maisel A: Laboratory parameters of cardiac and kidney dysfunction in cardio-renal syndromes. Heart Fail Rev 2011; 16: 545-551.
19. Vesely DL: Natriuretic peptides and acute renal failure. Am J Physiol Renal Physiol 2003; 285:F167-F177.
20. Vesely DL: Discovery of new cardiovascular hormones for the treatment of congestive heart failure. Cardiovasc Hematol Disord Drug Targets 2007; 7: 47-62.
21. Kazory A: Emergence of blood urea nitrogen as a biomarker of neurohormonal activation in heart failure. Am J Cardiol 2010; 106: 694-700.
22. Brisco MA, Coca SG, Chen J, Owens AT, McCauley BD, Kimmel SE, Testani JM: Blood urea nitrogen/creatinine ratio identifies a high-risk but potentially reversible form of renal dysfunction in patients with decompensated heart failure. Circ Heart Fail 2013; 6: 233-239.
23. Lamb EJ, Kenny C, Abbas NA, John RI, Webb MC, Price CP, Vickery S: Cardiac troponin I concentration is commonly increased in nondialysis patients with CKD: experience with a sensitive assay. Am J Kidney Dis 2007; 49: 507-716.
24. Abbas NA, John RI, Webb MC, Kempson ME, Potter AN, Price CP, Vickery S, Lamb EJ: Cardiac troponins and renal function in nondialysis patients with chronic kidney disease. Clin Chem 2005; 51: 2059-2066.
25. Freda BJ, Tang WH, Van Lente F, Peacock WF, Francis GS: Cardiac troponins in renal insufficiency: review and clinical implications. J Am Coll Cardiol 2002; 40: 2065-2071.
26. Scheven L, de Jong PE, Hillege HL, Lambers Heerspink HJ, van Pelt LJ, Kootstra JE, Bakker SJ, Gansevoort RT; for the PREVEND study group: High-sensitive troponin T and N-Terminal pro-B type natriuretic peptide are associated with cardiovascular events despite the cross-sectional association with albuminuria and glomerular filtration rate. Eur Heart J 2012; 33: 2272-2281.
27. Ix JH, Katz R, Kestenbaum BR, de Boer IH, Chonchol M, Mukamal KJ, Rifkin D, Siscovick DS, Sarnak MJ, Shlipak MG: Fibroblast growth factor-23 and death, heart failure, and cardiovascular events in community-living individuals: CHS (Cardiovascular Health Study). J Am Coll Cardiol 2012; 60: 200-207.
28. Negishi K, Kobayashi M, Ochiai I, Yamazaki Y, Hasegawa H, Yamashita T, Shimizu T, Kasama S, Kurabayashi M: Association between fibroblast growth factor 23 and left ventricular hypertrophy in maintenance hemodialysis patients. Comparison with B-Type natriuretic peptide and cardiac troponin T. Circ J 2012; 74: 2734-2740.
29. Kociol RD, Pang PS, Gheorghiade M, Fonarow GC, O Connor CM, Felker GM: Troponin elevation in heart failure prevalence, mechanisms, and clinical implications. J Am Coll Cardiol 2010; 56: 1071-1078.
30. Agewall S, Giannitsis E, Jernberg T, Katus H: Troponin elevation in coronary vs non-coronary disease. Eur Heart J 2011; 32: 404-411.
31. Wagener G, Gubitosa G, Wang S, Borregaard N, Kim M, Lee HT: Urinary neutrophil gelatinase-Associated lipocalin and acute kidney injury after cardiac surgery. Am J Kidney Dis. 2008; 52: 425-433.
32. Yndestad A, Landro L, Ueland T, Dahl CP, Flo TH, Vinge LE, Espevik T, Froland SS, Husberg C, Christensen G, Dickstein K, Kjekshus J, Oie E, Gullestad L, Aukrust P: Increased systemic and myocardial expression of neutrophil gelatinase-Associated lipocalin in clinical and experimental heart failure. Eur Heart J 2009; 30: 1229-1236.
33. Damman K, Masson S, Hillege HL, Maggioni AP, Voor AA, Opasich C, van Veldhuisen DJ, Montagna L, Cosmi F, Tognoni G, Tavazzi L, Latini R: Clinical outcome of renal tubular damage in chronic heart failure. Eur Heart J 2011; 32: 2705-2712.
34. Aghel A, Shrestha K, Mullens W, Borowski A, Tang WH: Serum neutrophil gelatinase-Associated lipocalin (NGAL) in predicting worsening renal function in acute decompensated heart failure. J Card Fail 2010; 16: 49-54.
35. Maisel A, Mueller C, Fitzgerald R, Brikhan R, Hiestand BC, Iqbal N, Clopton P, van Veldhuisen DJ: Prognostic utility of plasma neutrophil gelatinase-Associated lipocalin in patients with acute heart failure the NGAL evaluation along B-Type natriuretic peptide in acutely decompensated heart failure (GALLANT) trial. Eur J Heart Fail 2011; 13: 846-851.
36. Alvelos M, Lourenco P, Dias C, Amorim M, Rema J, Leite AB, Guimaraes JT, Almeida P, Bettencourt P: Prognostic value of neutrophil gelatinase-Associated lipocalin in acute heart failure. Int J Cardiol 2013; 165: 51-55.
37. Palazzuoli A, Ruocco G, Beltrami M, Franci B, Pellegrini M, Lucani B, Nuti R, Ronco C: Admission plasma neutrophil gelatinase associated lipocalin (NGAL) predicts worsening renal function during hospitalization and post discharge outcome in patients with acute heart failure. Acute Card Care 2014; 16: 93-101.
38. Breidthardt T, Socrates T, Drexler B, Noveanu M, Heinisch C, Arenja N, Klima T, Zösli C, Reichlin T, Potocki M, Twerenbold R, Steiger J, Mueller C: Plasma neutrophil gelatinase-Associated lipocalin for the prediction of acute kidney injury in acute heart failure. Crit Care 2012; 16:R2.
39. Palazzuoli A, Beltrami M, Pellegrini M, Nuti R: Natriuretic peptides and NGAL in heart failure: does a link exist? Clin Chim Acta 2012; 413: 1832-1838.
40. Felker MG: Biomarkers as a surrogate end points in heart failure trials. Heart Fail Clin 2011; 7: 501-507.