Troponin elevation in heart failure: Prevalence, mechanisms, and clinical implications

Journal of the American College of Cardiology

Volumn 56, Issue 14, 2010, Pages 1071-1078

  Kociol, Robb D ^a   Pang, Peter S ^b   Gheorghiade, Mihai ^b   Fonarow, Gregg C ^c   O'Connor, Christopher M ^a   Felker, G Michael ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

biomarkers; heart failure; outcomes

Indexed keywords

BIOLOGICAL MARKER; MILRINONE; TROPONIN; VALSARTAN;

HEART FAILURE; HEART MUSCLE INJURY; HUMAN; OUTCOME ASSESSMENT; PHYSICIAN; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROGNOSIS; REVIEW; RISK ASSESSMENT; ACUTE DISEASE; BLOOD; CHRONIC DISEASE; FEMALE; MALE; PREVALENCE; SENSITIVITY AND SPECIFICITY; SURVIVAL;

ACUTE DISEASE; BIOLOGICAL MARKERS; CHRONIC DISEASE; FEMALE; HEART FAILURE; HUMANS; MALE; PREVALENCE; PROGNOSIS; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SURVIVAL ANALYSIS; TROPONIN;

EID: 77957204899     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2010.06.016     Document Type: Review

References (59)

1. W. Rosamond, K. Flegal, and K. Furie Heart disease and stroke statistics2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee Circulation 117 2008 e25 e146
2. E. Braunwald Biomarkers in heart failure N Engl J Med 358 2008 2148 2159
3. A.S. Maisel, P. Krishnaswamy, and R.M. Nowak Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure N Engl J Med 347 2002 161 167
4. I.S. Anand, L.D. Fisher, and Y.T. Chiang Changes in brain natriuretic peptide and norepinephrine over time and mortality and morbidity in the Valsartan Heart Failure Trial (Val-HeFT) Circulation 107 2003 1278 1283
5. K. Thygesen, J.S. Alpert, and H.D. White Universal definition of myocardial infarction Circulation 116 2007 2634 2653 (Pubitemid 350182388)
6. F.G. Kushner, M. Hand, and S.C. Smith Jr. 2009 focused updates: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (updating the 2004 guideline and 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention (updating the 2005 guideline and 2007 focused update) a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines J Am Coll Cardiol 54 2009 2205 2241
7. C.V. Pollack Jr., and E. Braunwald 2007 update to the ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction: implications for emergency department practice Ann Emerg Med 51 2008 591 606
8. C.H. Del Carlo, A.C. Pereira-Barretto, C. Cassaro-Strunz, R. Latorre Mdo, and J.A. Ramires Serial measure of cardiac troponin T levels for prediction of clinical events in decompensated heart failure J Card Fail 10 2004 43 48
9. W.A. Gattis, C.M. O'Connor, V. Hasselblad, K.F. Adams Jr., I. Kobrin, and M. Gheorghiade Usefulness of an elevated troponin-I in predicting clinical events in patients admitted with acute heart failure and acute coronary syndrome (from the RITZ-4 trial) Am J Cardiol 93 2004 1436 1437
10. M. Gheorghiade, W. Gattis Stough, K.F. Adams Jr., A.S. Jaffe, V. Hasselblad, and C.M. O'Connor The Pilot Randomized Study of Nesiritide Versus Dobutamine in Heart Failure (PRESERVD-HF) Am J Cardiol 96 2005 18G 25G
11. T.B. Horwich, J. Patel, W.R. MacLellan, and G.C. Fonarow Cardiac troponin I is associated with impaired hemodynamics, progressive left ventricular dysfunction, and increased mortality rates in advanced heart failure Circulation 108 2003 833 838
12. M.P. Hudson, C.M. O'Connor, and W.A. Gattis Implications of elevated cardiac troponin T in ambulatory patients with heart failure: a prospective analysis Am Heart J 147 2004 546 552
13. Y. Kuwabara, Y. Sato, and T. Miyamoto Persistently increased serum concentrations of cardiac troponin in patients with acutely decompensated heart failure are predictive of adverse outcomes Circ J 71 2007 1047 1051
14. L. La Vecchia, G. Mezzena, and L. Zanolla Cardiac troponin I as diagnostic and prognostic marker in severe heart failure J Heart Lung Transplant 19 2000 644 652
15. R. Latini, S. Masson, and I.S. Anand Prognostic value of very low plasma concentrations of troponin T in patients with stable chronic heart failure Circulation 116 2007 1242 1249
16. D. Logeart, P. Beyne, and C. Cusson Evidence of cardiac myolysis in severe nonischemic heart failure and the potential role of increased wall strain Am Heart J 141 2001 247 253
17. W.L. Miller, K.A. Hartman, and M.F. Burritt Serial biomarker measurements in ambulatory patients with chronic heart failure: the importance of change over time Circulation 116 2007 249 257
18. N. Parenti, S. Bartolacci, F. Carle, and F. Angelo Cardiac troponin I as prognostic marker in heart failure patients discharged from emergency department Intern Emerg Med 3 2008 43 47
19. W.F. Peacock, T. De Marco, and G.C. Fonarow Cardiac troponin and outcome in acute heart failure N Engl J Med 358 2008 2117 2126
20. E.R. Perna, S.M. Macin, and J.P. Canella Ongoing myocardial injury in stable severe heart failure: value of cardiac troponin T monitoring for high-risk patient identification Circulation 110 2004 2376 2382
21. E.R. Perna, S.M. Macin, and J.P. Cimbaro Canella Minor myocardial damage detected by troponin T is a powerful predictor of long-term prognosis in patients with acute decompensated heart failure Int J Cardiol 99 2005 253 261
22. C.H. Del Carlo, and C.M. O'Connor Cardiac troponins in congestive heart failure Am Heart J 138 1999 646 653
23. J.E. Adams III, G.S. Bodor, and V.G. Davila-Roman Cardiac troponin I A marker with high specificity for cardiac injury Circulation 88 1993 101 106
24. G.S. Bodor, D. Porterfield, E.M. Voss, S. Smith, and F.S. Apple Cardiac troponin-I is not expressed in fetal and healthy or diseased adult human skeletal muscle tissue Clin Chem 41 1995 1710 1715
25. T.W. Wallace, S.M. Abdullah, and M.H. Drazner Prevalence and determinants of troponin T elevation in the general population Circulation 113 2006 1958 1965
26. E. Missov, C. Calzolari, and B. Pau Circulating cardiac troponin I in severe congestive heart failure Circulation 96 1997 2953 2958
27. E. Missov, and J. Mair A novel biochemical approach to congestive heart failure: cardiac troponin T Am Heart J 139 1999 95 99
28. M. Metra, S. Nodari, and G. Parrinello The role of plasma biomarkers in acute heart failure Serial changes and independent prognostic value of NT-proBNP and cardiac troponin-T Eur J Heart Fail 9 2007 776 786
29. M. Panteghini, F. Pagani, and K.T. Yeo Evaluation of imprecision for cardiac troponin assays at low-range concentrations Clin Chem 50 2004 327 332
30. A.H. Wu, S.J. Agee, Q.A. Lu, J. Todd, and A.S. Jaffe Specificity of a high-sensitivity cardiac troponin I assay using single-molecule-counting technology Clin Chem 55 2009 196 198
31. D.A. Morrow, and E.M. Antman Evaluation of high-sensitivity assays for cardiac troponin Clin Chem 55 2009 5 8
32. L.S. Rosenbaum, and J.L. Januzzi Moving troponin testing into the 21st century: will greater sensitivity be met with greater sensibility? Cardiovasc Hematol Disord Drug Targets 8 2008 118 126
33. B. Levine, J. Kalman, L. Mayer, H.M. Fillit, and M. Packer Elevated circulating levels of tumor necrosis factor in severe chronic heart failure N Engl J Med 323 1990 236 241
34. J. Narula, N. Haider, and R. Virmani Apoptosis in myocytes in end-stage heart failure N Engl J Med 335 1996 1182 1189
35. G. Olivetti, R. Abbi, and F. Quaini Apoptosis in the failing human heart N Engl J Med 336 1997 1131 1141
36. Y. Sato, T. Kita, Y. Takatsu, and T. Kimura Biochemical markers of myocyte injury in heart failure Heart 90 2004 1110 1113
37. M.H. Hessel, D.E. Atsma, E.J. van der Valk, W.H. Bax, M.J. Schalij, and A. van der Laarse Release of cardiac troponin I from viable cardiomyocytes is mediated by integrin stimulation Pflugers Arch 455 2008 979 986
38. J. Feng, B.J. Schaus, J.A. Fallavollita, T.C. Lee, and J.M. Canty Jr. Preload induces troponin I degradation independently of myocardial ischemia Circulation 103 2001 2035 2037
39. J. Sundstrom, E. Ingelsson, and L. Berglund Cardiac troponin-I and risk of heart failure: a community-based cohort study Eur Heart J 30 2009 773 781
40. T.J. Wang, M.G. Larson, and D. Levy Plasma natriuretic peptide levels and the risk of cardiovascular events and death N Engl J Med 350 2004 655 663
41. J.J. You, P.C. Austin, D.A. Alter, D.T. Ko, and J.V. Tu Relation between cardiac troponin I and mortality in acute decompensated heart failure Am Heart J 153 2007 462 470
42. W.L. Miller, K.A. Hartman, M.F. Burritt, D.E. Grill, and A.S. Jaffe Profiles of serial changes in cardiac troponin T concentrations and outcome in ambulatory patients with chronic heart failure J Am Coll Cardiol 54 2009 1715 1721
43. C.M. O'Connor, W.T. Abraham, and N.M. Albert Predictors of mortality after discharge in patients hospitalized with heart failure: an analysis from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF) Am Heart J 156 2008 662 673
44. W.T. Abraham, G.C. Fonarow, and N.M. Albert Predictors of in-hospital mortality in patients hospitalized for heart failure: insights from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF) J Am Coll Cardiol 52 2008 347 356
45. A. Biolo, M. Fisch, and J. Balog Episodes of acute heart failure syndrome are associated with increased levels of troponin and extracellular matrix markers Circ Heart Fail 3 2010 44 50
46. S. Eriksson, J. Hellman, and K. Pettersson Autoantibodies against cardiac troponins N Engl J Med 352 2005 98 100
47. T. Okazaki, Y. Tanaka, and R. Nishio Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice Nat Med 9 2003 1477 1483
48. Z. Kaya, S. Goser, and S.J. Buss Identification of cardiac troponin I sequence motifs leading to heart failure by induction of myocardial inflammation and fibrosis Circulation 118 2008 2063 2072
49. M. Gheorghiade, K.F. Adams, and J.G. Cleland Phase III clinical trial end points in acute heart failure syndromes: a virtual roundtable with the Acute Heart Failure Syndromes International Working Group Am Heart J 157 2009 957 970
50. M.R. Mehra, P.A. Uber, and G.S. Francis Heart failure therapy at a crossroad: are there limits to the neurohormonal model? J Am Coll Cardiol 41 2003 1606 1610
51. G.M. Felker, R.L. Benza, and A.B. Chandler Heart failure etiology and response to milrinone in decompensated heart failure: results from the OPTIME-CHF study J Am Coll Cardiol 41 2003 997 1003
52. B.R. Berridge, S. Pettit, and D.B. Walker A translational approach to detecting drug-induced cardiac injury with cardiac troponins: consensus and recommendations from the Cardiac Troponins Biomarker Working Group of the Health and Environmental Sciences Institute Am Heart J 158 2009 21 29
53. M. Gheorghiade, J.E. Blair, and G.S. Filippatos Hemodynamic, echocardiographic, and neurohormonal effects of istaroxime, a novel intravenous inotropic and lusitropic agent: a randomized controlled trial in patients hospitalized with heart failure J Am Coll Cardiol 51 2008 2276 2285
54. The SOLVD Investigators Studies of left ventricular dysfunction (SOLVD)rationale, design and methods: two trials that evaluate the effect of enalapril in patients with reduced ejection fraction Am J Cardiol 66 1990 315 322
55. R. Alcalai, D. Planer, A. Culhaoglu, A. Osman, A. Pollak, and C. Lotan Acute coronary syndrome vs nonspecific troponin elevation: clinical predictors and survival analysis Arch Intern Med 167 2007 276 281
56. G. Fonarow, W.F. Peacock, and T.B. Horwich Usefulness of B-type natriuretic peptide and cardiac troponin levels to predict in-hospital mortality from ADHERE Am J Cardiol 101 2008 231 237
57. T.J. Wang Significance of circulating troponins in heart failure: if these walls could talk Circulation 116 2007 1217 1220
58. T. Niizeki, Y. Takeishi, and T. Arimoto Heart-type fatty acid-binding protein is more sensitive than troponin T to detect the ongoing myocardial damage in chronic heart failure patients J Card Fail 13 2007 120 127
59. T. Niizeki, Y. Takeishi, and T. Arimoto Persistently increased serum concentration of heart-type fatty acid-binding protein predicts adverse clinical outcomes in patients with chronic heart failure Circ J 72 2008 109 114