메뉴 건너뛰기




Volumn 91, Issue 7, 2016, Pages 681-686

Epidemiology and clinical relevance of mutations in postpolycythemia vera and postessential thrombocythemia myelofibrosis: A study on 359 patients of the AGIMM group

(24)  Rotunno, Giada a   Pacilli, Annalisa a   Artusi, Valentina b   Rumi, Elisa c,d   Maffioli, Margherita e   Delaini, Federica f   Brogi, Giada a   Fanelli, Tiziana a,g   Pancrazzi, Alessandro a   Pietra, Daniela c   Bernardis, Isabella b   Belotti, Clara f   Pieri, Lisa a   Sant'Antonio, Emanuela a   Salmoiraghi, Silvia f   Cilloni, Daniela h   Rambaldi, Alessandro f   Passamonti, Francesco e   Barbui, Tiziano f   Manfredini, Rossella b   more..


Author keywords

[No Author keywords available]

Indexed keywords

CALRETICULIN; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2; JANUS KINASE 2; TRANSCRIPTION FACTOR EZH2;

EID: 84973882745     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.24377     Document Type: Article
Times cited : (84)

References (38)
  • 1
    • 34248364065 scopus 로고    scopus 로고
    • Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), post essential thrombocythemia myelofibrosis (post-ET MF), blast phase PMF (PMF-BP): Consensus on terminology by the international working group for myelofibrosis research and treatment (IWG-MRT)
    • Mesa RA, Verstovsek S, Cervantes F, et al. Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), post essential thrombocythemia myelofibrosis (post-ET MF), blast phase PMF (PMF-BP): Consensus on terminology by the international working group for myelofibrosis research and treatment (IWG-MRT). Leuk Res 2007;31:737–740.
    • (2007) Leuk Res , vol.31 , pp. 737-740
    • Mesa, R.A.1    Verstovsek, S.2    Cervantes, F.3
  • 2
    • 84947228713 scopus 로고    scopus 로고
    • Blast transformation and fibrotic progression in polycythemia vera and essential thrombocythemia: A literature review of incidence and risk factors
    • Cerquozzi S, Tefferi A. Blast transformation and fibrotic progression in polycythemia vera and essential thrombocythemia: A literature review of incidence and risk factors. Blood Cancer J 2015; 5:e366
    • (2015) Blood Cancer J , vol.5 , pp. e366
    • Cerquozzi, S.1    Tefferi, A.2
  • 3
    • 39149105615 scopus 로고    scopus 로고
    • Proposed criteria for the diagnosis of post-polycythemia vera and post-essential thrombocythemia myelofibrosis: A consensus statement from the international working group for myelofibrosis research and treatment
    • Barosi G, Mesa RA, Thiele J, et al. Proposed criteria for the diagnosis of post-polycythemia vera and post-essential thrombocythemia myelofibrosis: A consensus statement from the international working group for myelofibrosis research and treatment. Leukemia 2008;22:437–438.
    • (2008) Leukemia , vol.22 , pp. 437-438
    • Barosi, G.1    Mesa, R.A.2    Thiele, J.3
  • 4
    • 84876790720 scopus 로고    scopus 로고
    • The clinical benefit of ruxolitinib across patient subgroups: Analysis of a placebo-controlled, phase III study in patients with myelofibrosis
    • Verstovsek S, Mesa RA, Gotlib J, et al. The clinical benefit of ruxolitinib across patient subgroups: Analysis of a placebo-controlled, phase III study in patients with myelofibrosis. Br J Haematol 2013.
    • (2013) Br J Haematol
    • Verstovsek, S.1    Mesa, R.A.2    Gotlib, J.3
  • 5
    • 84891303523 scopus 로고    scopus 로고
    • Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis
    • Cervantes F, Vannucchi AM, Kiladjian J-J, et al. Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis. Blood 2013;122:4047–4053.
    • (2013) Blood , vol.122 , pp. 4047-4053
    • Cervantes, F.1    Vannucchi, A.M.2    Kiladjian, J.-J.3
  • 6
    • 84964694744 scopus 로고    scopus 로고
    • Safety and efficacy of fedratinib in patients with primary or secondary myelofibrosis: A randomized clinical trial
    • Pardanani A, Harrison C, Cortes JE, et al. Safety and efficacy of fedratinib in patients with primary or secondary myelofibrosis: A randomized clinical trial. JAMA Oncol 2015;1:643–651.
    • (2015) JAMA Oncol , vol.1 , pp. 643-651
    • Pardanani, A.1    Harrison, C.2    Cortes, J.E.3
  • 7
    • 84928901823 scopus 로고    scopus 로고
    • Results of a phase 2 study of pacritinib (SB1518), a JAK2/JAK2(V617F) inhibitor, in patients with myelofibrosis
    • Komrokji RS, Seymour JF, Roberts AW, et al. Results of a phase 2 study of pacritinib (SB1518), a JAK2/JAK2(V617F) inhibitor, in patients with myelofibrosis. Blood 2015;125:2649–2655.
    • (2015) Blood , vol.125 , pp. 2649-2655
    • Komrokji, R.S.1    Seymour, J.F.2    Roberts, A.W.3
  • 8
    • 84897414330 scopus 로고    scopus 로고
    • The International Prognostic Scoring System does not accurately discriminate different risk categories in patients with post-essential thrombocythemia and post-polycythemia vera myelofibrosis
    • Hernandez-Boluda J-C, Pereira A, Gomez M, et al. The International Prognostic Scoring System does not accurately discriminate different risk categories in patients with post-essential thrombocythemia and post-polycythemia vera myelofibrosis. Haematologica 2014;99:e55–e57.
    • (2014) Haematologica , vol.99 , pp. e55-e57
    • Hernandez-Boluda, J.-C.1    Pereira, A.2    Gomez, M.3
  • 9
    • 81055126771 scopus 로고    scopus 로고
    • EZH2 mutational status predicts poor survival in myelofibrosis
    • Guglielmelli P, Biamonte F, Score J, et al. EZH2 mutational status predicts poor survival in myelofibrosis. Blood 2011;118:5227–5234.
    • (2011) Blood , vol.118 , pp. 5227-5234
    • Guglielmelli, P.1    Biamonte, F.2    Score, J.3
  • 10
    • 84869786872 scopus 로고    scopus 로고
    • SRSF2 mutations in primary myelofibrosis: Significant clustering with IDH mutations and independent association with inferior overall and leukemia-free survival
    • Lasho TL, Jimma T, Finke CM, et al. SRSF2 mutations in primary myelofibrosis: Significant clustering with IDH mutations and independent association with inferior overall and leukemia-free survival. Blood 2012;120:4168–4171.
    • (2012) Blood , vol.120 , pp. 4168-4171
    • Lasho, T.L.1    Jimma, T.2    Finke, C.M.3
  • 11
    • 84905990634 scopus 로고    scopus 로고
    • Clinical effect of driver mutations of JAK2, CALR or MPL in primary myelofibrosis
    • Rumi E, Pietra D, Pascutto C, et al. Clinical effect of driver mutations of JAK2, CALR or MPL in primary myelofibrosis. Blood 2014;124:1062–1069.
    • (2014) Blood , vol.124 , pp. 1062-1069
    • Rumi, E.1    Pietra, D.2    Pascutto, C.3
  • 12
    • 84883742034 scopus 로고    scopus 로고
    • Mutations and prognosis in primary myelofibrosis
    • Vannucchi AM, Lasho TL, Guglielmelli P, et al. Mutations and prognosis in primary myelofibrosis. Leukemia 2013;27:1861–1869.
    • (2013) Leukemia , vol.27 , pp. 1861-1869
    • Vannucchi, A.M.1    Lasho, T.L.2    Guglielmelli, P.3
  • 13
    • 84904056081 scopus 로고    scopus 로고
    • CALR and ASXL1 mutations-based molecular prognostication in primary myelofibrosis: An international study of 570 patients
    • Tefferi A, Guglielmelli P, Lasho TL, et al. CALR and ASXL1 mutations-based molecular prognostication in primary myelofibrosis: An international study of 570 patients. Leukemia 2014;28:1494–1500.
    • (2014) Leukemia , vol.28 , pp. 1494-1500
    • Tefferi, A.1    Guglielmelli, P.2    Lasho, T.L.3
  • 14
    • 84904046605 scopus 로고    scopus 로고
    • Type 1 vs type 2 calreticulin mutations in primary myelofibrosis: Differences in phenotype and prognostic impact
    • Tefferi A, Lasho TL, Finke C, et al. Type 1 vs type 2 calreticulin mutations in primary myelofibrosis: Differences in phenotype and prognostic impact. Leukemia 2014;28:1568–1570.
    • (2014) Leukemia , vol.28 , pp. 1568-1570
    • Tefferi, A.1    Lasho, T.L.2    Finke, C.3
  • 15
    • 84904042955 scopus 로고    scopus 로고
    • CALR vs JAK2 vs MPL mutated or triple-negative myelofibrosis: Clinical, cytogenetic and molecular comparisons
    • Tefferi A, Lasho TL, Finke CM, et al. CALR vs JAK2 vs MPL mutated or triple-negative myelofibrosis: Clinical, cytogenetic and molecular comparisons. Leukemia 2014;28:1472–1477.
    • (2014) Leukemia , vol.28 , pp. 1472-1477
    • Tefferi, A.1    Lasho, T.L.2    Finke, C.M.3
  • 16
    • 84989952230 scopus 로고    scopus 로고
    • Validation of the differential prognostic impact of type 1/type 1-like versus type 2/type 2-like CALR mutations in myelofibrosis
    • Guglielmelli P, Rotunno G, Fanelli T, et al. Validation of the differential prognostic impact of type 1/type 1-like versus type 2/type 2-like CALR mutations in myelofibrosis. Blood Cancer J 2015;2015;e360.
    • (2015) Blood Cancer J , vol.2015 , pp. e360
    • Guglielmelli, P.1    Rotunno, G.2    Fanelli, T.3
  • 17
    • 84899056972 scopus 로고    scopus 로고
    • Impact of mutational status on outcomes in myelofibrosis patients treated with ruxolitinib in the COMFORT-II Study
    • Guglielmelli P, Biamonte F, Rotunno G, et al. Impact of mutational status on outcomes in myelofibrosis patients treated with ruxolitinib in the COMFORT-II Study. Blood 2014;123:2157–2160.
    • (2014) Blood , vol.123 , pp. 2157-2160
    • Guglielmelli, P.1    Biamonte, F.2    Rotunno, G.3
  • 18
    • 84908275738 scopus 로고    scopus 로고
    • The number of prognostically detrimental mutations and prognosis in primary myelofibrosis: An international study of 797 patients
    • Guglielmelli P, Lasho TL, Rotunno G, et al. The number of prognostically detrimental mutations and prognosis in primary myelofibrosis: An international study of 797 patients. Leukemia 2014;28:1804–1810, 1804
    • (2014) Leukemia , vol.28 , pp. 1804-1810
    • Guglielmelli, P.1    Lasho, T.L.2    Rotunno, G.3
  • 19
    • 84899065964 scopus 로고    scopus 로고
    • Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms
    • Lundberg P, Karow A, Nienhold R, et al. Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms. Blood 2014;123:2220–2228.
    • (2014) Blood , vol.123 , pp. 2220-2228
    • Lundberg, P.1    Karow, A.2    Nienhold, R.3
  • 20
    • 84925038218 scopus 로고    scopus 로고
    • A compendium of cytogenetic abnormalities in myelofibrosis: molecular and phenotypic correlates in 826 patients
    • Wassie E, Finke C, Gangat N, et al. A compendium of cytogenetic abnormalities in myelofibrosis: molecular and phenotypic correlates in 826 patients. Br J Haematol 2015;169:71–76.
    • (2015) Br J Haematol , vol.169 , pp. 71-76
    • Wassie, E.1    Finke, C.2    Gangat, N.3
  • 21
    • 84897568260 scopus 로고    scopus 로고
    • Impact of calreticulin mutations on clinical and hematological phenotype and outcome in essential thrombocythemia
    • Rotunno G, Mannarelli C, Guglielmelli P, et al. Impact of calreticulin mutations on clinical and hematological phenotype and outcome in essential thrombocythemia. Blood 2014;123:1552–1555.
    • (2014) Blood , vol.123 , pp. 1552-1555
    • Rotunno, G.1    Mannarelli, C.2    Guglielmelli, P.3
  • 22
    • 84908065771 scopus 로고    scopus 로고
    • The prognostic advantage of calreticulin mutations in myelofibrosis might be confined to type 1 or type 1-like CALR variants
    • Tefferi A, Lasho TL, Tischer A, et al. The prognostic advantage of calreticulin mutations in myelofibrosis might be confined to type 1 or type 1-like CALR variants. Blood 2014;124:2465–2466.
    • (2014) Blood , vol.124 , pp. 2465-2466
    • Tefferi, A.1    Lasho, T.L.2    Tischer, A.3
  • 23
    • 63849328927 scopus 로고    scopus 로고
    • New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment
    • Cervantes F, Dupriez B, Pereira A, et al. New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment. Blood 2009;113:2895–2901.
    • (2009) Blood , vol.113 , pp. 2895-2901
    • Cervantes, F.1    Dupriez, B.2    Pereira, A.3
  • 24
    • 84863393110 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
    • Verstovsek S, Mesa RA, Gotlib J, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med 2012;366:799–807.
    • (2012) N Engl J Med , vol.366 , pp. 799-807
    • Verstovsek, S.1    Mesa, R.A.2    Gotlib, J.3
  • 25
    • 84857837774 scopus 로고    scopus 로고
    • JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis
    • Harrison C, Kiladjian JJ, Al-Ali HK, et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med 2012;366:787–798.
    • (2012) N Engl J Med , vol.366 , pp. 787-798
    • Harrison, C.1    Kiladjian, J.J.2    Al-Ali, H.K.3
  • 26
    • 84940912122 scopus 로고    scopus 로고
    • A pooled analysis of overall survival in COMFORT-I and COMFORT-II, 2 randomized phase 3 trials of ruxolitinib for the treatment of myelofibrosis
    • Vannucchi AM, Kantarjian HM, Kiladjian J-J, et al. A pooled analysis of overall survival in COMFORT-I and COMFORT-II, 2 randomized phase 3 trials of ruxolitinib for the treatment of myelofibrosis. Haematologica 2015;100:1139–1145.
    • (2015) Haematologica , vol.100 , pp. 1139-1145
    • Vannucchi, A.M.1    Kantarjian, H.M.2    Kiladjian, J.-J.3
  • 27
    • 84920596808 scopus 로고    scopus 로고
    • Differential association of calreticulin type 1 and type 2 mutations with myelofibrosis and essential thrombocytemia: Relevance for disease evolution
    • Cabagnols X, Defour JP, Ugo V, et al. Differential association of calreticulin type 1 and type 2 mutations with myelofibrosis and essential thrombocytemia: Relevance for disease evolution. Leukemia 2015;29:249–252.
    • (2015) Leukemia , vol.29 , pp. 249-252
    • Cabagnols, X.1    Defour, J.P.2    Ugo, V.3
  • 28
    • 84959370553 scopus 로고    scopus 로고
    • Differential clinical effects of different mutation subtypes in CALR-mutant myeloproliferative neoplasms
    • Pietra D, Rumi E, Ferretti VV, et al. Differential clinical effects of different mutation subtypes in CALR-mutant myeloproliferative neoplasms. Leukemia 2016; 30:431–438.
    • (2016) Leukemia , vol.30 , pp. 431-438
    • Pietra, D.1    Rumi, E.2    Ferretti, V.V.3
  • 29
    • 84960864909 scopus 로고    scopus 로고
    • Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis
    • Marty C, Pecquet C, Nivarthi H, et al. Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis. Blood 2016;127:1317–1324.
    • (2016) Blood , vol.127 , pp. 1317-1324
    • Marty, C.1    Pecquet, C.2    Nivarthi, H.3
  • 30
    • 84908459025 scopus 로고    scopus 로고
    • Calreticulin mutations in Chinese with primary myelofibrosis
    • Li B, Xu J, Wang J, et al. Calreticulin mutations in Chinese with primary myelofibrosis. Haematologica 2014;99:1697–1700.
    • (2014) Haematologica , vol.99 , pp. 1697-1700
    • Li, B.1    Xu, J.2    Wang, J.3
  • 31
    • 50949127379 scopus 로고    scopus 로고
    • Characteristics and clinical correlates of MPL 515W>L/K mutation in essential thrombocythemia
    • Vannucchi AM, Antonioli E, Guglielmelli P, et al. Characteristics and clinical correlates of MPL 515W>L/K mutation in essential thrombocythemia. Blood 2008;112:844–847.
    • (2008) Blood , vol.112 , pp. 844-847
    • Vannucchi, A.M.1    Antonioli, E.2    Guglielmelli, P.3
  • 32
    • 84897517940 scopus 로고    scopus 로고
    • JAK2 or CALR mutation status defines subtypes of essential thrombocythemia with substantially different clinical course and outcomes
    • Rumi E, Pietra D, Ferretti V, et al. JAK2 or CALR mutation status defines subtypes of essential thrombocythemia with substantially different clinical course and outcomes. Blood 2014;123:1544–1551.
    • (2014) Blood , vol.123 , pp. 1544-1551
    • Rumi, E.1    Pietra, D.2    Ferretti, V.3
  • 33
    • 84962858012 scopus 로고    scopus 로고
    • Calreticulin (CALR) variant stratified driver mutational status and prognosis in essential thrombocythemia
    • Elala YC, Lasho TL, Gangat N, et al. Calreticulin (CALR) variant stratified driver mutational status and prognosis in essential thrombocythemia. Am J Hematol 2016.
    • (2016) Am J Hematol
    • Elala, Y.C.1    Lasho, T.L.2    Gangat, N.3
  • 34
    • 34547953018 scopus 로고    scopus 로고
    • Clinical profile of homozygous JAK2V617F mutation in patients with polycythemia vera or essential thrombocythemia
    • Vannucchi AM, Antonioli E, Guglielmelli P, et al. Clinical profile of homozygous JAK2V617F mutation in patients with polycythemia vera or essential thrombocythemia. Blood 2007;110:840–846.
    • (2007) Blood , vol.110 , pp. 840-846
    • Vannucchi, A.M.1    Antonioli, E.2    Guglielmelli, P.3
  • 35
    • 77956439565 scopus 로고    scopus 로고
    • A prospective study of 338 patients with polycythemia vera: the impact of JAK2 (V617F) allele burden and leukocytosis on fibrotic or leukemic disease transformation and vascular complications
    • Passamonti F, Rumi E, Pietra D, et al. A prospective study of 338 patients with polycythemia vera: the impact of JAK2 (V617F) allele burden and leukocytosis on fibrotic or leukemic disease transformation and vascular complications. Leukemia 2010;24:1574–1579.
    • (2010) Leukemia , vol.24 , pp. 1574-1579
    • Passamonti, F.1    Rumi, E.2    Pietra, D.3
  • 36
    • 78751706637 scopus 로고    scopus 로고
    • JAK2V617F allele burden in polycythemia vera correlates with grade of myelofibrosis, but is not substantially affected by therapy
    • Silver RT, Vandris K, Wang YL, et al. JAK2V617F allele burden in polycythemia vera correlates with grade of myelofibrosis, but is not substantially affected by therapy. Leuk Res 2011;35:177–182.
    • (2011) Leuk Res , vol.35 , pp. 177-182
    • Silver, R.T.1    Vandris, K.2    Wang, Y.L.3
  • 37
    • 84857997263 scopus 로고    scopus 로고
    • IDH mutations in primary myelofibrosis predict leukemic transformation and shortened survival: Clinical evidence for leukemogenic collaboration with JAK2V617F
    • Tefferi A, Jimma T, Sulai NH, et al. IDH mutations in primary myelofibrosis predict leukemic transformation and shortened survival: Clinical evidence for leukemogenic collaboration with JAK2V617F. Leukemia 2012; 26:475–480.
    • (2012) Leukemia , vol.26 , pp. 475-480
    • Tefferi, A.1    Jimma, T.2    Sulai, N.H.3
  • 38
    • 84973883494 scopus 로고    scopus 로고
    • Prognostic interactions between SRSF2, ASXL1, and IDH mutations in primary myelofibrosis and determination of added value to cytogenetic risk stratification and DIPSS-Plus
    • Lasho TL, Gangat N, Finke C, et al. Prognostic interactions between SRSF2, ASXL1, and IDH mutations in primary myelofibrosis and determination of added value to cytogenetic risk stratification and DIPSS-Plus. ASH Annual Meeting Abstracts 2012;120:430.
    • (2012) ASH Annual Meeting Abstracts , vol.120 , pp. 430
    • Lasho, T.L.1    Gangat, N.2    Finke, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.