Potency of a human monoclonal antibody to diphtheria toxin relative to equine diphtheria anti-toxin in a guinea pig intoxication model

Virulence

Volumn 7, Issue 6, 2016, Pages 660-668

  Smith, Heidi L ^a   Cheslock, Peter ^a   Leney, Mark ^a   Barton, Bruce ^a   Molrine, Deborah C ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

anti toxin; diphtheria; monoclonal antibody; potency

Indexed keywords

DIPHTHERIA TOXIN; DIPHTHERIA VACCINE; IMMUNOGLOBULIN G1 ANTIBODY; DIPHTHERIA ANTIBODY; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY;

ANAPHYLAXIS; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIPHTHERIA; EFFECTIVE DOSE (PHARMACOLOGY); FEMALE; NONHUMAN; OVERALL SURVIVAL; SERUM SICKNESS; WEIGHT GAIN; ANIMAL; ANTIBODY AFFINITY; COMPLICATION; DISEASE MODEL; GUINEA PIG; HORSE; HUMAN; IMMUNOLOGY; PARALYSIS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; DIPHTHERIA; DIPHTHERIA ANTITOXIN; DIPHTHERIA TOXIN; DISEASE MODELS, ANIMAL; GUINEA PIGS; HORSES; HUMANS; IMMUNOGLOBULIN G; PARALYSIS;

EID: 84973879888     PISSN: 21505594     EISSN: 21505608     Source Type: Journal    
DOI: 10.1080/21505594.2016.1171436     Document Type: Article

References (30)

1. P.Beh, R.W.Byard. Diphtheria and lethal upper airway obstruction. Forensic Sci Med Pathol 2015; 11:133-5; PMID:25332174; http://dx.doi.org/10.1007/s12024-014-9623-y
2. A.K.Kole, R.Roy. Images in clinical medicine. Respiratory diphtheria. N Engl J Med 2013; 369:1544; PMID:24131179; http://dx.doi.org/10.1056/NEJMicm1309222
3. I.Logina, M.Donaghy. Diphtheritic polyneuropathy:a clinical study and comparison with Guillain-Barré syndrome. J Neurol Neurosurg Psychiatry 1999; 67:433-8; PMID:10486387; http://dx.doi.org/10.1136/jnnp.67.4.433
4. M.J.Varghese, S.Ramakrishnan, S.S.Kothari, A.Parashar, R.Juneja, A.Saxena. Complete heart block due to diphtheritic myocarditis in the present era. Ann Pediatr Cardiol 2013; 6:34-8; PMID:23626433; http://dx.doi.org/10.4103/0974-2069.107231
5. S.Bhagat, S.S.Grover, N.Gupta, R.D.Roy, S.Khare. Persistence of Corynebacterium diphtheriae in Delhi & National Capital Region (NCR). Indian J Med Res 2015; 142:459-61; PMID:26609038
6. L.S.Santos, L.O.Sant'anna, J.N.Ramos, E.M.Ladeira, R.Stavracakis-Peixoto, L.L.G.Borges, C.S.Santos, F.Napoleão, T.C.F.Camello, G.A.Pereira, et al. Diphtheria outbreak in Maranhão, Brazil:microbiological, clinical and epidemiological aspects. Epidemiol Infect 2015; 143:791-8; PMID:25703400; http://dx.doi.org/10.1017/S0950268814001241
7. S.Bitragunta, M.V.Murhekar, Y.J.Hutin, P.P.Penumur, M.D.Gupte. Persistence of diphtheria, Hyderabad, India, 2003–2006. Emerg Infect Dis 2008; 14:1144-6; PMID:18598644; http://dx.doi.org/10.3201/eid1407.071167
8. WHO | Diphtheria [Internet]. WHO [cited 2015 Dec 11]; Available from:http://www.who.int/immunization/monitoring_surveillance/burden/diphtheria/en/
9. Centers for Disease Control and Prevention. Diphtheria:Haiti Pre-decision Brief for Public Health Action [Internet]. [cited 2013 Aug 28]; Available from:http://emergency.cdc.gov/disasters/earthquakes/haiti/diphtheria_pre-decision_brief.asp
10. N.C.Besa, M.E.Coldiron, A.Bakri, A.Raji, M.J.Nsuami, C.Rousseau, N.Hurtado, K.Porten. Diphtheria outbreak with high mortality in northeastern Nigeria. Epidemiol Infect 2013; 142(4):1-6
11. National Institute for Communicable Diseases. Update on the diphtheria outbreak in KwaZulu-Natal [Internet]. 2015 [cited 2015 Dec 11]; Available from:http://www.nicd.ac.za/?page=alerts&id=5&rid=572
12. G.J.Hughes, A.F.W.Mikhail, D.Husada, E.Irawan, G.Kafatos, S.Bracebridge, R.Pebody, A.Efstratiou. Seroprevalence and Determinants of Immunity to Diphtheria for Children Living in Two Districts of Contrasting Incidence During an Outbreak in East Java, Indonesia. Pediatr Infect Dis J 2015; 34:1152-6; PMID:26226444; http://dx.doi.org/10.1097/INF.0000000000000846
13. N.Nanthavong, A.P.Black, P.Nouanthong, C.Souvannaso, K.Vilivong, C.P.Muller, S.Goossens, F.Quet, Y.Buisson. Diphtheria in Lao PDR:insufficient coverage or ineffective vaccine? PLoS ONE 2015; 10:e0121749; PMID:25909365; http://dx.doi.org/10.1371/journal.pone.0121749
14. M.Jhancy, A.Satyavani, D.Manikyamba, K.Tulasi Deepthi. Re-emergence of diphtheria – An outbreak from east Godavari District, Andhra Pradesh. Pediatr Infect Dis 2015; 7(2):33-35; Available online 12 September 2015
15. European Centre for Disease Prevention and Control. Rapid risk assessment:a case of diphtheria in Spain, 15 June 2015 [Internet]. Stockholm:ECDC; 2015 [cited 2015 Jul 23]. Available from:http://ecdc.europa.eu/en/publications/Publications/diphtheria-spain-rapid-risk-assessment-june-2015.pdf
16. T.Tiwari. Diphtheria. In:Manual for the surveillance of vaccine-preventable diseases. Atlanta, GA:Centers for Disease Control and Prevention; 2011.
17. European Centre for Disease Prevention and Control. Rapid risk assessment:cutaneous diphtheria among recently arrived refugees and asylum seekers in the EU [Internet]. 2015 [cited 2015 Dec 11]; Available from:http://ecdc.europa.eu/en/publications/Publications/Diphtheria-cutaneous-EU-July-2015.pdf
18. L.Both, J.White, S.Mandal, A.Efstratiou. Access to diphtheria antitoxin for therapy and diagnostics. Euro Surveill 2014; 19:pii:20830; http://dx.doi.org/10.2807/1560-7917.ES2014.19.24.20830
19. K.S.Wagner, P.Stickings, J.M.White, S.Neal, N.S.Crowcroft, D.Sesardic, A.Efstratiou. A review of the international issues surrounding the availability and demand for diphtheria antitoxin for therapeutic use. Vaccine 2009; 28:14-20; PMID:19818425; http://dx.doi.org/10.1016/j.vaccine.2009.09.094
20. Centers for Disease Control and Prevention (CDC). Use of Diphtheria Antitoxin (DAT) for Suspected Diphtheria Cases BB IND 11184 [Internet]. [cited 2015 Dec 11]; Available from:http://www.cdc.gov/diphtheria/downloads/protocol.pdf
21. L.M.Sevigny, B.J.Booth, K.J.Rowley, B.A.Leav, P.S.Cheslock, K.A.Garrity, S.E.Sloan, W.ThomasJr, G.J.Babcock, Y.Wang. Identification of a human monoclonal antibody to replace equine diphtheria antitoxin for treatment of diphtheria intoxication. Infect Immun 2013; 81:3992-4000; PMID:23940209; http://dx.doi.org/10.1128/IAI.00462-13
22. A.Tasman, J.E.Minkenhof, H.H.Vink, A.C.Brandwijk, L.Smith. Importance of intravenous injection of diphtheria antiserum. Lancet 1958; 1:1299-304; PMID:13550990; http://dx.doi.org/10.1016/S0140-6736(58)92061-0
23. US Department of Health, Education and Welfare Public Health Service, National Institute of Health. Minimum Requirements:Diphtheria Toxoid. Fourth revision. 1947;
24. A.Tasman, J.E.Minkenhof, H.H.Vink, A.C.Brandwijk, L.Smith. On the pathogenesis of diphtheria. V. Importance of intravenous injection of diphtheria serum. Antonie Van Leeuwenhoek 1958; 24:161-86; PMID:13595643; http://dx.doi.org/10.1007/BF02548444
25. D.E.Pleasure, B.Feldman, D.J.Prockop. Diphtheria toxin inhibits the synthesis of myelin proteolipid and basic proteins by peripheral nerve in vitro. J Neurochem 1973; 20:81-90; PMID:4687209; http://dx.doi.org/10.1111/j.1471-4159.1973.tb12106.x
26. A.H.Pullen. Neurofilament reorganisation and neurofilament antigen redistribution in spinal motoneurones following retrograde axonal transport of diphtheria toxin. Acta Neuropathol (Berl) 1994; 87:32-46; http://dx.doi.org/10.1007/BF00386252
27. G.Ramon. Sur une technique de titrage in vitro du sérum antidiphthérique. CRSocBiol 1923; 86:711-2
28. M.E.Stokes, C.S.Davis, G.G.Koch. Categorical Data Analysis using the SAS System. 1995; Pp. 287-292.
29. G.Zerbe. On Fieller's theorem and the general linear model. Am Stat 1978; 32:102-5
30. B.F.Kurland, L.L.Johnson, B.L.Egleston, P.H.Diehr. Longitudinal Data with Follow-up Truncated by Death:Match the Analysis Method to Research Aims. Stat Sci Rev J Inst Math Stat 2009; 24:211