Identification of a human monoclonal antibody to replace equine diphtheria antitoxin for treatment of diphtheria intoxication

Infection and Immunity

Volumn 81, Issue 11, 2013, Pages 3992-4000

  Sevigny, Leila M ^a,b   Booth, Brian J ^a,c   Rowley, Kirk J ^a,e   Leav, Brett A ^a,d   Cheslock, Peter S ^a   Garrity, Kerry A ^a,f   Sloan, Susan E ^a,e   Thomas Jr , William ^a   Babcock, Gregory J ^a,e   Wang, Yang ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b SANOFI   (France)

^c AbVitro Inc   (United States)

^d NOVARTIS   (United States)

^e VISTERRA INC   (United States)

^f BLUEBIRD BIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHTHERIA ANTIBODY; DIPHTHERIA TOXIN; EPITOPE; GENOMIC DNA; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; HUMAN MONOCLONAL ANTIBODY; HUMAN MONOCLONAL ANTIBODY 315C4; POLYCLONAL ANTIBODY; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; CORYNEBACTERIUM DIPHTHERIAE; CORYNEBACTERIUM INFECTION; CYTOTOXICITY; DIPHTHERIA; DRUG EFFICACY; DRUG SAFETY; ENZYME LINKED IMMUNOSORBENT ASSAY; GUINEA PIG; HUMAN; HUMAN CELL; IMMUNIZATION; IN VITRO STUDY; INTOXICATION; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PURIFICATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VERO CELL;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE; CORYNEBACTERIUM DIPHTHERIAE; DIPHTHERIA; DIPHTHERIA ANTITOXIN; DIPHTHERIA TOXIN; DISEASE MODELS, ANIMAL; EPITOPE MAPPING; GUINEA PIGS; HEALTHY VOLUNTEERS; HUMANS; IMMUNOTHERAPY; NEUTRALIZATION TESTS; PROTEIN BINDING; SURVIVAL ANALYSIS;

EID: 84886777353     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00462-13     Document Type: Article

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