Preparation procedure and pharmacokinetic study of water-in-oil nanoemulsion of panax notoginseng saponins for improving the oral bioavailability

Current Drug Delivery

Volumn 13, Issue 4, 2016, Pages 600-610

  Liu, Zhidong ^a   Zhang, Qian ^a,b   Ding, Lingling ^a   Li, Chunhua ^a   Yin, Zhongpeng ^a,c   Yan, Guoqiang ^b   Pi, Jiaxin ^a   Li, Jiawei ^a   Li, Nan ^a   Qi, Dongli ^a  

^a TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Department of Radiotherapy   (China)

^c People's Hospital of Cangzhou   (China)

Author keywords

Drug release; Formulation optimizing; Nanoemulsion; Oral bioavailability; Pharmacokinetic study; PNS

Indexed keywords

GINSENG SAPONIN; GINSENG SAPONIN RB1; GINSENG SAPONIN RG1; SANCHINOSIDE R1; UNCLASSIFIED DRUG; EMULSION; OIL; SAPONIN; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG RELEASE; HYPERBARISM; IN VITRO STUDY; INTESTINE ABSORPTION; MALE; NANOEMULSION; NONHUMAN; PANAX NOTOGINSENG; PARTICLE SIZE; PH; PRECIPITATION; PRIORITY JOURNAL; RAT; REFRACTION INDEX; SUSTAINED DRUG RELEASE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; BIOAVAILABILITY; CHEMISTRY; EMULSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NANOTECHNOLOGY; ORAL DRUG ADMINISTRATION; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EMULSIONS; MALE; NANOTECHNOLOGY; OILS; PANAX NOTOGINSENG; RATS; RATS, SPRAGUE-DAWLEY; SAPONINS; WATER;

EID: 84973594562     PISSN: 15672018     EISSN: 18755704     Source Type: Journal    
DOI: 10.2174/1567201812666150608095517     Document Type: Article

References (28)

1. Kang, J.K.; Gao, C.J.; Ma, K.Q.; Hao, J.J.; Wang, Z.Q. Effects of panax notoginseng spaponins on diet induced metabolic dysfunction and expression of in flammatory cytokines in adipose tissue of obese mice. J. Chongqing Med. Univ., 2012, 37, 949-952.
2. Li, J.S. Authentication of Traditional Chinese Medicine. Shanghai: Shanghai Sci. Tech. Publis., 1998, 132.
3. Feng, L.; Jiang, X.H. Study on the pharmacokinetic behavior of Panax notoginseng saponions in rat. West China J. Pharm. Sci., 2010, 25, 46-49.
4. Ma, Q.H. Nanometric Chinese preparation for antineoplastic. J. Jixi Univ., 2012, 12, 155-156.
5. Shi, Y.J.; Cheng, G. Review on the research of biological safety evaluation for nanopreparations. J. Shenyang Pharm. Univ., 2010, 27, 987-992.
6. Lawrencem, J.; Reesg, D. Nanoemulsion-based media as novel drug delivery systems. Adv. Drug Deliv. Rev., 2000, 45, 89-121.
7. Talegaonkar, S.; Azeem, A.; Ahmad, F. J.; Khar, R. K.; Pathan, S. A.; Khan, Z. I. Microemulsions: a novel approach to enhanced drug delivery. Rec. Patents Drug Deliv. Formul., 2008, 2(3), 238-257.
8. Liu, L.F.; Zhang, D.Y. Progress in medicine nanoemulsion. Guiding J. Tradit. Chinese Med. Pharm., 2010, 16, 112-114.
9. Pan, G.L.; Jia, X. B.; Wei, H. H.; Wang, Y. Comparison among Several Preparation Methods for Pseudo-ternary Phase Diagrams of Pharmaceutical Nanoemulsions. China Pharm., 2006, 17, 21-23.
10. Baheti, A.; Srivastava, S.; Sahoo, D.; Lowalekar, R.; Panda, B. P.; Padhi, B. K.; Raghuvanshi, R. Development and Pharmacokinetic Evaluation of Industrially Viable Selfmicroemulsifying Drug Delivery Systems (SMEDDS) for Terbinafine. Curr. Drug Deliv., 2015, 13(1) 65-75.
11. Palanuwech, J.; Potineni, R.; Roberts, R. F.; Coupland, J. N. A method to determine free fat in emulsions. Food Hydrocolloids, 2003, 17, 55-62.
12. Patel, A., Shelat, P.; Lalwani, A. Development and optimization of solid self nanoemulsifying drug delivery (S-SNEDDS) using Doptimal design for improvement of oral bioavailability of amiodarone hydrochloride. Curr. Drug Deliv., 2015, 12, 745-760.
13. Xie, J.C.; Liu, Z.D.; Wang, X.Y. Intestinal absorption kinetics of mangiferin in rats in vivo. Central South Pharm., 2010, 8, 340-343.
14. Alany, R. G.; Rades, T.; Agatonovic-Kustrin, S.; Davies, N. M.; Tucker, I. G. Effects of alcohols and diols on the phase behaviour of quaternary systems. Int. J. Pharm., 2000, 196, 141-145.
15. Li, W.H.; He, Y. Preparation and intestinal absorption effect of 5-Fluorouracil nanoemulsion in rats. China Pharm., 2008, 19, 501-503.
16. Avramiotis, S.; Bekiari, V.; Lianos, P.; Xenakis, A. Structural and dynamic properties of lecithin-alcohol based w/o nanoemulsions: a luminescence quenching study. J. Colloid Interface Sci., 1997, 194, 326-331.
17. Reza, A.; David, J.B.; Mjayne, L. Particle size analysis of concentrated phospholipid nanoemulsions: I. total intensity light scattering. AAPS Pharm. Sci., 2000, 2(2), 27-39.
18. Reza, A.; David, J.B.; Mjayne, L. Particle size analysis of concentrated phospholipid nanoemulsions: II photon correlation spectroscopy. AAPS Pharm. Sci., 2000, 2, 1-10.
19. Shinoda, K.; Araki, M.; Sadaghiani, A.; Khan, A.; Lindman, B. Lecithin-based nanoemulsions: phase behavior and microstructure. J. Phys. Chem., 1991, 95, 989-993.
20. Schurtenberger, P.; Peng, Q.; Leser, M. E.; Luisi, P. L. Structure and phase behavior of lecithin-based nanoemulsions: a study of the chain length dependence. J. Colloid Interface Sci., 1993, 156, 43-51.
21. Pan, Y.; Li, C.S.; Guo, Y.H.; Li, T.F. Preparation and determination of oral matrine nanoemulsion. J. Shenyang Pharm. Univ., 2010, 28, 177-181.
22. Binks, B.P.; Meunier, J.; Langevin, D. Characteristic size, film rigidity and interfacial tensions in nanoemulsion systems. Prog. Colloid Polym. Sci., 1989, 79, 208-213.
23. Chu, M.Q.; Gu, H.C.; Liu, G.J. Study on the preparation of tanshinone proliposomes by spray drying method. Chin. Pharm. J., 2002, 37, 32-35.
24. Moghimipour, E., Salimi, A., Karami, M., Isazadeh, S. Preparation and characterization of dexamethasone microemulsion based on pseudoternary phase diagram. Jundishapur J. Nat. Pharm. Products, 2013, 8(3), 105.
25. Li, J.W.; Guo, X.J.; Liu, Z.D.; Okeke, C. I.; Li, N.; Zhao, H.N.; Aggrey, M. O.; Pan, W.S.; Wu, T. Preparation and evaluation of charged solid lipid nanoparticles of tetrandrine for ocular drug delivery system: pharmacokinetics, cytotoxicity and cellular uptake studies. Drug Dev. Ind. Pharm., 2013, 40(7), 980-987.
26. Aihua, Y.; Guangxi, Z.; Fengliang, C.; Jun, Y.; Peixue, L.; Hongxiang, L. Studies on Absorption K inetics of PuerarinM icroemulsion in Rat Intestine. Chin. Pharm. J., 2007, 42(9), 692-695.
27. Ling, L.; Huagang, L.; Yane, Q.; Shihua, L.; Li, W.; Ming, C.; Guanping, L. Effects of absorption enhancers on small intestinal absorption of panax notoginseng saponins. Chin. J. New Drugs, 2011, 20(10), 909-913.
28. Jiangchun, X.; Zhidong, L.; Xiaoyu, W. Intestinal absorption kinetics of mangiferin in rats in vivo. Central South Pharm., 2010, 8(5), 340-343.