Physical activity and gastric residuals as biomarkers for region-specific NEC lesions in preterm neonates

Neonatology

Volumn 110, Issue 4, 2016, Pages 241-247

  Cao, Muqing ^a   Andersen, Anders D ^b,c   Li, Yanqi ^b,c   Thymann, Thomas ^b,c   Jing, Jin ^a   Sangild, Per T ^b,c,d  

^a SUN YAT SEN UNIVERSITY   (China)

^b Exercise and Sports   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d University of Copenhagen   (Denmark)

Author keywords

Animal model; Biomarker; Necrotizing enterocolitis; Piglet; Stomach

Indexed keywords

BIOLOGICAL MARKER;

ABDOMINAL DISTENSION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APATHY; ARTICLE; CESAREAN SECTION; CLINICAL ASSESSMENT; COLON; CONTROLLED STUDY; DIARRHEA; DIGESTIVE TRACT PARAMETERS; EUTHANASIA; FEMALE; GASTRIC RESIDUAL; NECROTIZING ENTEROCOLITIS; NEWBORN; NONHUMAN; NUTRITIONAL INTOLERANCE; PARENTERAL NUTRITION; PHYSICAL ACTIVITY; PREMATURITY; PRIORITY JOURNAL; RESPIRATORY DISTRESS; SKIN DISCOLORATION; SMALL INTESTINE; SOW (SWINE); STOMACH; WELLBEING; ANIMAL; DISEASE MODEL; ENTEROCOLITIS, NECROTIZING; HUMAN; MOTOR ACTIVITY; NUTRITIONAL SUPPORT; PATHOLOGY; PIG; STOMACH EMPTYING; TIME FACTOR;

ANIMALS; ANIMALS, NEWBORN; BIOMARKERS; COLON; DISEASE MODELS, ANIMAL; ENTEROCOLITIS, NECROTIZING; GASTRIC EMPTYING; HUMANS; INFANT, NEWBORN; INTESTINE, SMALL; MOTOR ACTIVITY; NUTRITIONAL SUPPORT; PREMATURE BIRTH; SWINE; TIME FACTORS;

EID: 84973539328     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000445707     Document Type: Article

References (26)

1. Obladen M: Necrotizing enterocolitis-150 years of fruitless search for the cause. Neonatology 2009; 96: 203-210.
2. Walsh MC, Kliegman RM: Necrotizing enterocolitis: treatment based on staging criteria. Pediatr Clin North Am 1986; 33: 179-201.
3. Oh S, Young C, Gravenstein N, Islam S, Neu J: Monitoring technologies in the neonatal intensive care unit: implications for the detection of necrotizing enterocolitis. J Perinatol 2010; 30: 701-708.
4. Jiang P, Jensen ML, Cilieborg MS, Thymann T, Wan JM, Sit W, Tipoe GL, Sangild PT: Antibiotics increase gut metabolism and antioxidant proteins and decrease acute phase response and necrotizing enterocolitis in preterm neonates. PLoS One 2012; 7:e44929.
5. Grave GD, Nelson SA, Walker WA, Moss RL, Dvorak B, Hamilton FA, Higgins R, Raju TNK: New therapies and preventive approaches for necrotizing enterocolitis: report of a research planning workshop. Pediatr Res 2007; 62: 510-514.
6. Morison SJ, Holsti L, Grunau RE, Whitfield MF, Oberlander TF, Chan HW, Williams L: Are there developmentally distinct motor indicators of pain in preterm infants? Early Hum Dev 2003; 72: 131-146.
7. Shattuck EC, Muehlenbein MP: Mood, behavior, testosterone, cortisol, and interleukin-6 in adults during immune activation: a pilot study to assess sickness behaviors in humans. Am J Hum Biol 2015; 27: 133-135.
8. Torrazza RM, Parker LA, Li Y, Talaga E, Shuster J, Neu J: The value of routine evaluation of gastric residuals in very low birth weight infants. J Perinatol 2015; 35: 57-60.
9. Ghoneim N, Bauchart-Thevret C, Oosterloo B, Stoll B, Kulkarni M, de Pipaon MS, Zamora IJ, Olutoye OO, Berg B, Wittke A, Burrin DG: Delayed initiation but not gradual advancement of enteral formula feeding reduces the incidence of necrotizing enterocolitis (NEC) in preterm pigs. PLoS One 2014; 9: e106888.
10. Shen RL, Thymann T, Ostergaard MV, Støy ACF, Krych L, Nielsen DS, Lauridsen C, Hartmann B, Holst JJ, Burrin DG, Sangild PT: Early gradual feeding with bovine colostrum improves gut function and NEC resistance relative to infant formula in preterm pigs. Am J Physiol Gastrointest Liver Physiol 2015; 309: G310-G323.
11. Cao M, Andersen AD, Van Ginneken C, Shen RL, Petersen SO, Thymann T, Jing J, Sangild PT: Physical activity level is impaired and diet dependent in preterm newborn pigs. Pediatr Res 2015; 78: 137-144.
12. Cilieborg MS, Boye M, Thymann T, Jensen BB, Sangild PT: Diet-dependent effects of minimal enteral nutrition on intestinal function and necrotizing enterocolitis in preterm pigs. JPEN J Parenter Enteral Nutr 2011; 35: 32-42.
13. Bjornvad CR, Thymann T, Deutz NE, Burrin DG, Jensen SK, Jensen BB, Mølbak L, Boye M, Larsson LI, Schmidt M, Michaelsen KF, Sangild PT: Enteral feeding induces diet-dependent mucosal dysfunction, bacterial proliferation, and necrotizing enterocolitis in preterm pigs on parenteral nutrition. Am J Physiol Gastrointest Liver Physiol 2008; 295:G1092-G1103.
14. Siggers J, Ostergaard MV, Siggers RH, Skovgaard K, Mølbak L, Thymann T, Schmidt M, Møller HK, Purup S, Fink LN, Frøkiaer H, Boye M, Sangild PT, Bering SB: Postnatal amniotic fluid intake reduces gut inflammatory responses and necrotizing enterocolitis in preterm neonates. Am J Physiol Gastrointest Liver Physiol 2013; 304:G864-G875.
15. Cilieborg MS, Boye M, Mølbak L, Thymann T, Sangild PT: Preterm birth and necrotizing enterocolitis alter gut colonization in pigs. Pediatr Res 2011; 69: 10-16.
16. Cilieborg MS, Thymann T, Siggers R, Boye M, Bering SB, Jensen BB, Sangild PT: The incidence of necrotizing enterocolitis is increased following probiotic administration to preterm pigs. J Nutr 2011; 141: 223-230.
17. Fiset C, Rioux FM, Surette ME, Fiset S: Prenatal iron deficiency in guinea pigs increases locomotor activity but does not influence learning and memory. PLoS One 2015; 10:e133168.
18. Doheny KK, Palmer C, Browning KN, Jairath P, Liao D, He F, Travagli RA: Diminished vagal tone is a predictive biomarker of necrotizing enterocolitis-risk in preterm infants. Neurogastroenterol Motil 2014; 26: 832-840.
19. Bertino E, Giuliani F, Prandi G, Coscia A, Martano C, Fabris C: Necrotizing enterocolitis: risk factor analysis and role of gastric residuals in very low birth weight infants. J Pediatr Gastroenterol Nutr 2009; 48: 437-442.
20. Dolgin SE, Shlasko E, Levitt MA, Hong AR, Brillhart S, Rynkowski M, Holzman I: Alterations in respiratory status: early signs of severe necrotizing enterocolitis. J Pediatr Surg 1998; 33: 856-858.
21. Garzoni L, Faure C, Frasch MG: Fetal cholinergic anti-inflammatory pathway and necrotizing enterocolitis: the brain-gut connection begins in utero. Front Integr Neurosci 2013; 7: 57.
22. Bjornvad CR, Thymann T, Deutz NE, Burrin DG, Jensen SK, Jensen BB, Mølbak L, Boye M, Larsson LI, Schmidt M, Michaelsen KF, Sangild PT: Enteral feeding induces diet-dependent mucosal dysfunction, bacterial proliferation, and necrotizing enterocolitis in preterm pigs on parenteral nutrition. Am J Physiol Gastrointest Liver Physiol 2008; 295: G1092-G1103.
23. Thymann T, Burrin DG, Tappenden KA, Bjornvad CR, Jensen SK, Sangild PT: Formula-feeding reduces lactose digestive capacity in neonatal pigs. Br J Nutr 2006; 95: 1075-1081.
24. Clark DA, Munshi UK: Feeding associated neonatal necrotizing enterocolitis (primary NEC) is an inflammatory bowel disease. Pathophysiology 2014; 21: 29-34.
25. Shen RL, Thymann T, Ostergaard MV, Støy ACF, Krych L, Nielsen DS, Lauridsen C, Hartmann B, Holst JJ, Burrin DG, Sangild PT: Early gradual feeding with bovine colostrum improves gut function and NEC resistance relative to infant formula in preterm pigs. Am J Physiol Gastrointest Liver Physiol 2015; 309: G310-G323.
26. Gay AN, Lazar DA, Stoll B, Naik-Mathuria B, Mushin OP, Rodriguez MA, Burrin DG, Olutoye OO: Near-infrared spectroscopy measurement of abdominal tissue oxygenation is a useful indicator of intestinal blood flow and necrotizing enterocolitis in premature piglets. J Pediatr Surg 2011; 46: 1034-1040.