Level of pregnancy-Associated plasma protein-A correlates with coronary thin-cap fibroatheroma burden in patients with coronary artery disease: Novel findings from 3-vessel virtual histology intravascular ultrasound assessment

Medicine (United States)

Volumn 95, Issue 3, 2016, Pages

  Wu, Xiao Fan ^a   Yang, Min ^b   Qu, Ai Juan ^c   Mintz, Gary S ^d   Yang, Ya ^a   Shang, Yun Peng ^e   Gao, Hai ^a   Zhang, Yu Chen ^a   Ge, Chang Jiang ^a   Wang, Lu Ya ^b   Wang, Lin ^f   Pu, Jun ^f  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b BEIJING INSTITUTE OF HEART   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d CARDIOVASCULAR RESEARCH FOUNDATION   (United States)

^e ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^f HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BIOLOGICAL MARKER; CLOPIDOGREL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLYCERYL TRINITRATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PREGNANCY ASSOCIATED PLASMA PROTEIN A;

ADULT; ARTICLE; ATHEROMA; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CORONARY THIN CAP FIBROATHEROMA; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; ENZYME IMMUNOASSAY; EVENT FREE SURVIVAL; FEMALE; HISTOLOGY; HISTOPATHOLOGY; HUMAN; INTRAVASCULAR ULTRASOUND; INTRAVASCULAR ULTRASOUND SYSTEM; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NON ST SEGMENT ELEVATION ACUTE CORONARY SYNDROME; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; STABLE ANGINA PECTORIS; VIRTUAL REALITY; BLOOD; CORONARY ARTERY DISEASE; CORONARY BLOOD VESSEL; ECHOGRAPHY; PATHOLOGY; SEVERITY OF ILLNESS INDEX;

CORONARY ARTERY DISEASE; CORONARY VESSELS; FEMALE; HUMANS; MALE; MIDDLE AGED; PLAQUE, ATHEROSCLEROTIC; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A; SEVERITY OF ILLNESS INDEX;

EID: 84973488218     PISSN: 00257974     EISSN: 15365964     Source Type: Journal    
DOI: 10.1097/MD.0000000000002563     Document Type: Article

References (34)

1. Lin TM, Galbert SP, Kiefer D, et al. Characterization of four human pregnancy-Associated plasma proteins. Am J Obstet Gynecol. 1974;118:223-236.
2. Bayes-Genis A, Conover CA, Overgaard MT, et al. Pregnancyassociated plasma protein A as a marker of acute coronary syndromes. N Engl J Med. 2001;345:1022-1029.
3. Lund J, Qin QP, Ilva T, et al. Circulating pregnancy-Associated plasma protein A predicts outcome in patients with acute coronary syndrome but no troponin I elevation. Circulation. 2003;108: 1924-1926.
4. Heeschen C, Dimmeler S, Hamm CW, et al., CAPTURE Study Investigators. Pregnancy associated plasma protein-A levels in patients with acute coronary syndromes: comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis. J Am Coll Cardiol. 2005;45:229-237.
5. Virmani R, Burke AP, Farb A, et al. Pathology of the vulnerable plaque. J Am Coll Cardiol. 2006;47:C13-C18.
6. Pu J, Mintz GS, Biro S, et al. Insights into echo-Attenuated plaques, echolucent plaques, and plaques with spotty calcification: novel findings from comparisons among intravascular ultrasound, nearinfrared spectroscopy, and pathological histology in 2294 human coronary artery segments. J Am Coll Cardiol. 2014;63:2220-2233.
7. Liu X, Ni M, Ma L, et al. Targeting blood thrombogenicity precipitates atherothrombotic events in a mouse model of plaque destabilization. Sci Rep. 2015;5:10225.
8. Stone GW, Maehara A, Lansky AJ, et al., PROSPECT Investigators. A prospective natural-history study of coronary atherosclerosis. N Engl J Med. 2011;364:226-235.
9. Calvert PA, Obaid DR, OSullivan M, et al. Association between IVUS findings and adverse outcomes in patients with coronary artery disease: The VIVA (VH-IVUS in vulnerable atherosclerosis) Study. JACC Cardiovasc Imaging. 2011;4:894-901.
10. Cheng JM, Garcia-Garcia HM, de Boer SP, et al. In vivo detection of high-risk coronary plaques by radiofrequency intravascular ultrasound and cardiovascular outcome: results of the ATHEROREMOIVUS study. Eur Heart J. 2014;35:639-647.
11. Sangiorgi G, Mauriello A, Bonanno E, et al. Pregnancy-Associated plasma protein-A is markedly expressed by monocytemacrophage cells in vulnerable and ruptured carotid atherosclerotic plaques: A link between inflammation and cerebrovascular events. J Am Coll Cardiol. 2006;47:2201-2211.
12. Wu X, Maehara A, Mintz GS, et al. Virtual histology intravascular ultrasound analysis of non-culprit attenuated plaque detected by grayscale intravascular ultrasound in patients with acute coronary syndromes. Am J Cardiol. 2010;105:48-53.
13. Pu J, Mintz GS, Brilakis ES, et al. In vivo characterization of coronary plaques: novel findings from comparing greyscale and virtual histology intravascular ultrasound and near-infrared spectroscopy. Eur Heart J. 2012;33:372-383.
14. Hájek P, Macek M Sr, Pešková M, et al. High positive predictive value of PAPP-A for acute coronary syndrome diagnosis in heparinnai ve patients. J Thromb Thrombolysis. 2012;34:99-105.
15. Lund J, Qin QP, Ilva T, et al. Circulating pregnancy-Associated plasma protein-A predicts outcome in patients with acute coronary syndrome but no troponin I elevation. Circulation. 2003;108:1924-1926.
16. Heeschen C, Dimmeler S, Hamm CW, et al. Pregnancy-Associated plasma protein-A levels in patients with acute coronary syndromes: comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis. J Am Coll Cardiol. 2005;45:229-237.
17. Wang G, Zhang A, Han X, et al. Effect of routine heparins treatment in acute coronary syndrome on serum pregnancy-Associated plasma protein a concentration. Ann Clin Lab Sci. 2013;43:274-277.
18. Rossen M, Iversen K, Teisner A, et al. Optimisation of sandwich ELISA based on monoclonal antibodies for the specific measurement of pregnancy-Associated plasma protein (PAPP-A) in acute coronary syndrome. Clin Biochem. 2007;40:478-484.
19. Ding S, Li Z, Ge H, et al. Impact of early ST-segment changes on cardiac magnetic resonance-verified intramyocardial haemorrhage and microvascular obstruction in st-elevation myocardial infarction patients. Medicine (Baltimore). 2015;94:e1438.
20. De Metrio M, Milazzo V, Rubino M, et al. Vitamin D plasma levels and in-hospital and 1-year outcomes in acute coronary syndromes: A prospective study. Medicine (Baltimore). 2015;94:e857.
21. Bonaca MP, Scirica BM, Sabatine MS, et al. Prospective evaluation of pregnancy associated plasma protein-A and outcomes in patients with acute coronary syndromes. J Am Coll Cardiol. 2012;60:332-338.
22. Iversen KK, Teisner B, Winkel P, et al., CLARICOR Trial Group. Pregnancy associated plasma protein-A as a marker for myocardial infarction and death in patients with stable coronary artery disease: A prognostic study within the CLARICOR Trial. Atherosclerosis. 2011;214:203-208.
23. Conover CA, Mason MA, Bale LK, et al. Transgenic overexpression of pregnancy-Associated plasma protein-A in murine arterial smooth muscle accelerates atherosclerotic lesion development. Am J Physiol Heart Circ Physiol. 2010;299:H284-H291.
24. Harrington SC, Simari RD, Conover CA. Genetic deletion of pregnancy-Associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet. Circ Res. 2007;100:1696-1702.
25. Tang SL, Chen WJ, Yin K, et al. PAPP-A negatively regulates ABCA1, ABCG1 and SR-B1 expression by inhibiting LXRa through the IGF-I-mediated signaling pathway. Atherosclerosis. 2012;222:344-354.
26. Renier G, Clement I, Desfaits AC, et al. Direct stimulatory effect of insulin-like growth factor-I on monocyte and macrophage tumor necrosis factor-Alpha production. Endocrinology. 1996;137:4611-4618.
27. Jones JI, Prevette T, Gockerman A, et al. Ligand occupancy of the V3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor. Proc Natl Acad Sci USA. 1996;93:2482-2487.
28. Wu X, Liu X, Dong J, et al. Pregnancy associated plasma protein-A as a marker of culprit lesion instability in unstable angina patients: An intravascular ultrasound study. Cardiology. 2013;126:244-251.
29. Wu X, Mintz GS, Kubo T, et al. Relationship between attenuated plaque identified by intravascular ultrasound and no-reflow after stenting in acute myocardial infarction. J Am Coll Cardiol Intv. 2011;4:495-502.
30. Yang Y, Sun Y, Yi W, et al. A review of melatonin as a suitable antioxidant against myocardial ischemia-reperfusion injury and clinical heart diseases. J Pineal Res. 2014;57:357-366.
31. Nair A, Margolis MP, Kuban BD, et al. Automated coronary plaque characterisation with intravascular ultrasound backscatter: ex vivo validation. Euro Intervention. 2007;3:113-120.
32. Brown AJ, Obaid DR, Costopoulos C, et al. Direct comparison of virtual-histology intravascular ultrasound and optical coherence tomography imaging for identification of thin-cap fibroatheroma. Circ Cardiovasc Imaging. 2015;8:e003487.
33. Obaid DR, Calvert PA, Gopalan D, et al. Atherosclerotic plaque composition and classification identified by coronary computed tomography: Assessment of computed tomography-generated plaque maps compared with virtual histology intravascular ultrasound and histology. Circ Cardiovasc Imaging. 2013;6:655-664.
34. Sawada T, Shite J, Garcia-Garcia HM, et al. Feasibility of combined use of intravascular ultrasound radiofrequency data analysis and optical coherence tomography for detecting thin-cap fibroatheroma. Eur Heart J. 2008;29:1136-1146.