-
1
-
-
33845882484
-
Biologic therapies in rheumatology: lessons learned, future directions
-
Strand, V, Kimberly, R, Isaacs, JD, Biologic therapies in rheumatology: lessons learned, future directions. Nat Rev Drug Discov 6 (2007), 75–92 10.1038/nrd2196.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 75-92
-
-
Strand, V.1
Kimberly, R.2
Isaacs, J.D.3
-
2
-
-
0032980855
-
Conceptual issues in scoring radiographic progression in rheumatoid arthritis
-
Kirwan, JR, Conceptual issues in scoring radiographic progression in rheumatoid arthritis. J Rheumatol 26 (1999), 720–725.
-
(1999)
J Rheumatol
, vol.26
, pp. 720-725
-
-
Kirwan, J.R.1
-
3
-
-
33846693507
-
Mortality in rheumatoid arthritis. Increased in the early course of disease, in ischaemic heart disease and in pulmonary fibrosis
-
Young, A, Koduri, G, Batley, M, et al. Mortality in rheumatoid arthritis. Increased in the early course of disease, in ischaemic heart disease and in pulmonary fibrosis. Rheumatology 46 (2007), 350–357 10.1093/rheumatology/kel253.
-
(2007)
Rheumatology
, vol.46
, pp. 350-357
-
-
Young, A.1
Koduri, G.2
Batley, M.3
-
4
-
-
78650048259
-
Long-term impact of delay in assessment of patients with early arthritis
-
van der Linden, MP, le Cessie, S, Raza, K, et al. Long-term impact of delay in assessment of patients with early arthritis. Arthritis Rheumatol 62 (2010), 3537–3546 10.1002/art.27692.
-
(2010)
Arthritis Rheumatol
, vol.62
, pp. 3537-3546
-
-
van der Linden, M.P.1
le Cessie, S.2
Raza, K.3
-
5
-
-
3242677099
-
Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial
-
Grigor, C, Capell, H, Stirling, A, et al. Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial. Lancet 364 (2004), 263–269 10.1016/S0140-6736(04)16676-2.
-
(2004)
Lancet
, vol.364
, pp. 263-269
-
-
Grigor, C.1
Capell, H.2
Stirling, A.3
-
6
-
-
84893772728
-
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update
-
Smolen, JS, Landewe, R, Breedveld, FC, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Ann Rheum Dis 73 (2014), 492–509 10.1136/annrheumdis-2013-204573.
-
(2014)
Ann Rheum Dis
, vol.73
, pp. 492-509
-
-
Smolen, J.S.1
Landewe, R.2
Breedveld, F.C.3
-
7
-
-
0035056003
-
Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?
-
Feldmann, M, Maini, RN, Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?. Ann Rev Immunol 19 (2001), 163–196 10.1146/annurev.immunol.19.1.163.
-
(2001)
Ann Rev Immunol
, vol.19
, pp. 163-196
-
-
Feldmann, M.1
Maini, R.N.2
-
8
-
-
0033611472
-
A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate
-
Weinblatt, ME, Kremer, JM, Bankhurst, AD, et al. A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. N Engl J Med 340 (1999), 253–259 10.1056/NEJM199901283400401.
-
(1999)
N Engl J Med
, vol.340
, pp. 253-259
-
-
Weinblatt, M.E.1
Kremer, J.M.2
Bankhurst, A.D.3
-
9
-
-
0034735842
-
Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group
-
Lipsky, PE, van der Heijde, DM, St Clair, EW, et al. Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. N Engl J Med 343 (2000), 1594–1602 10.1056/NEJM200011303432202.
-
(2000)
N Engl J Med
, vol.343
, pp. 1594-1602
-
-
Lipsky, P.E.1
van der Heijde, D.M.2
St Clair, E.W.3
-
10
-
-
2342658406
-
Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: a randomized, placebo-controlled, 52-week trial
-
Keystone, EC, Kavanaugh, AF, Sharp, JT, et al. Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: a randomized, placebo-controlled, 52-week trial. Arthritis Rheumatol 50 (2004), 1400–1411 10.1002/art.20217.
-
(2004)
Arthritis Rheumatol
, vol.50
, pp. 1400-1411
-
-
Keystone, E.C.1
Kavanaugh, A.F.2
Sharp, J.T.3
-
11
-
-
85027951851
-
Outcomes of early rheumatoid arthritis – the WHO ICF framework
-
Verstappen, SM, Outcomes of early rheumatoid arthritis – the WHO ICF framework. Best Prac Res Clin Rheumatol 27 (2013), 555–570 10.1016/j.berh.2013.09.004.
-
(2013)
Best Prac Res Clin Rheumatol
, vol.27
, pp. 555-570
-
-
Verstappen, S.M.1
-
12
-
-
84899707304
-
Hand and foot surgery rates in rheumatoid arthritis have declined from 1986 to 2011, but large-joint replacement rates remain unchanged: results from two UK inception cohorts
-
Nikiphorou, E, Carpenter, L, Morris, S, et al. Hand and foot surgery rates in rheumatoid arthritis have declined from 1986 to 2011, but large-joint replacement rates remain unchanged: results from two UK inception cohorts. Arth Rheumatol 66 (2014), 1081–1089 10.1002/art.38344.
-
(2014)
Arth Rheumatol
, vol.66
, pp. 1081-1089
-
-
Nikiphorou, E.1
Carpenter, L.2
Morris, S.3
-
13
-
-
84883472050
-
The decline in joint replacement surgery in rheumatoid arthritis is associated with a concomitant increase in the intensity of anti-rheumatic therapy: a nationwide register-based study from 1995 through 2010
-
Jamsen, E, Virta, LJ, Hakala, M, Kauppi, MJ, Malmivaara, A, Lehto, MU, The decline in joint replacement surgery in rheumatoid arthritis is associated with a concomitant increase in the intensity of anti-rheumatic therapy: a nationwide register-based study from 1995 through 2010. Acta Orthopaedica 84 (2013), 331–337 10.3109/17453674.2013.810519.
-
(2013)
Acta Orthopaedica
, vol.84
, pp. 331-337
-
-
Jamsen, E.1
Virta, L.J.2
Hakala, M.3
Kauppi, M.J.4
Malmivaara, A.5
Lehto, M.U.6
-
15
-
-
79951712039
-
Anti-TNF therapy is -associated with an increased risk of serious infections in patients with rheumatoid arthritis especially in the first 6 months of treatment: updated results from the British Society for Rheumatology Biologics Register with special emphasis on risks in the elderly
-
Galloway, JB, Hyrich, KL, Mercer, LK, et al. Anti-TNF therapy is -associated with an increased risk of serious infections in patients with rheumatoid arthritis especially in the first 6 months of treatment: updated results from the British Society for Rheumatology Biologics Register with special emphasis on risks in the elderly. Rheumatology (Oxford) 50 (2011), 124–131 10.1093/rheumatology/keq242.
-
(2011)
Rheumatology (Oxford)
, vol.50
, pp. 124-131
-
-
Galloway, J.B.1
Hyrich, K.L.2
Mercer, L.K.3
-
16
-
-
0035846326
-
Tuberculosis associated with -infliximab, a tumor necrosis factor alpha-neutralizing agent
-
Keane, J, Gershon, S, Wise, RP, et al. Tuberculosis associated with -infliximab, a tumor necrosis factor alpha-neutralizing agent. N Engl J Med 345 (2001), 1098–1104 10.1056/NEJMoa011110.
-
(2001)
N Engl J Med
, vol.345
, pp. 1098-1104
-
-
Keane, J.1
Gershon, S.2
Wise, R.P.3
-
17
-
-
80053565309
-
Malignancies -associated with tumour necrosis factor inhibitors in registries and prospective observational studies: a systematic review and -meta-analysis
-
Mariette, X, Matucci-Cerinic, M, Pavelka, K, et al. Malignancies -associated with tumour necrosis factor inhibitors in registries and prospective observational studies: a systematic review and -meta-analysis. Ann Rheum Dis 70 (2011), 1895–1904 10.1136/ard.2010.149419.
-
(2011)
Ann Rheum Dis
, vol.70
, pp. 1895-1904
-
-
Mariette, X.1
Matucci-Cerinic, M.2
Pavelka, K.3
-
18
-
-
33746961890
-
Rituximab for -rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, -placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks
-
Cohen, SB, Emery, P, Greenwald, MW, et al. Rituximab for -rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, -placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheumatol 54 (2006), 2793–2806 10.1002/art.22025.
-
(2006)
Arthritis Rheumatol
, vol.54
, pp. 2793-2806
-
-
Cohen, S.B.1
Emery, P.2
Greenwald, M.W.3
-
19
-
-
84881475884
-
Long-term safety of rituximab in rheumatoid arthritis: 9.5-year follow-up of the global clinical trial programme with a focus on adverse events of interest in RA patients
-
van Vollenhoven, RF, Emery, P, Bingham, CO, et al. Long-term safety of rituximab in rheumatoid arthritis: 9.5-year follow-up of the global clinical trial programme with a focus on adverse events of interest in RA patients. Ann Rheum Dis 72 (2013), 1496–1502 10.1136/annrheumdis-2012-201956.
-
(2013)
Ann Rheum Dis
, vol.72
, pp. 1496-1502
-
-
van Vollenhoven, R.F.1
Emery, P.2
Bingham, C.O.3
-
20
-
-
84865315420
-
Progressive multifocal leukoencephalopathy associated with immunosuppressive therapy in rheumatic diseases: evolving role of biologic therapies
-
Molloy, ES, Calabrese, LH, Progressive multifocal leukoencephalopathy associated with immunosuppressive therapy in rheumatic diseases: evolving role of biologic therapies. Arthritis Rheumatol 64 (2012), 3043–3051 10.1002/art.34468.
-
(2012)
Arthritis Rheumatol
, vol.64
, pp. 3043-3051
-
-
Molloy, E.S.1
Calabrese, L.H.2
-
21
-
-
33646483031
-
The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: results of a phase IIB randomized, double-blind, placebo-controlled, dose-ranging trial
-
Emery, P, Fleischmann, R, Filipowicz-Sosnowska, A, et al. The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: results of a phase IIB randomized, double-blind, placebo-controlled, dose-ranging trial. Arthritis Rheumatol 54 (2006), 1390–1400 10.1002/art.21778.
-
(2006)
Arthritis Rheumatol
, vol.54
, pp. 1390-1400
-
-
Emery, P.1
Fleischmann, R.2
Filipowicz-Sosnowska, A.3
-
22
-
-
24944498854
-
Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition
-
Genovese, MC, Becker, JC, Schiff, M, et al. Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition. N Engl J Med 353 (2005), 1114–1123 10.1056/NEJMoa050524.
-
(2005)
N Engl J Med
, vol.353
, pp. 1114-1123
-
-
Genovese, M.C.1
Becker, J.C.2
Schiff, M.3
-
23
-
-
33745291091
-
Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: a randomized trial
-
Kremer, JM, Genant, HK, Moreland, LW, et al. Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: a randomized trial. Ann Internal Med 144 (2006), 865–876 10.7326/0003-4819-144-12-200606200-00003.
-
(2006)
Ann Internal Med
, vol.144
, pp. 865-876
-
-
Kremer, J.M.1
Genant, H.K.2
Moreland, L.W.3
-
24
-
-
79952026221
-
Abatacept treatment for rheumatoid arthritis
-
Schiff, M, Abatacept treatment for rheumatoid arthritis. Rheumatology 50 (2011), 437–449 10.1093/rheumatology/keq287.
-
(2011)
Rheumatology
, vol.50
, pp. 437-449
-
-
Schiff, M.1
-
25
-
-
84904977067
-
-Long-term safety of subcutaneous abatacept in rheumatoid arthritis: Integrated analysis of clinical trial data of up to 4.75 years of treatment
-
Alten, R, Kaine, J, Keystone, E, Nash, P, Delaet, I, Genovese, MC, -Long-term safety of subcutaneous abatacept in rheumatoid arthritis: Integrated analysis of clinical trial data of up to 4.75 years of treatment. Arthritis Rheumatol 66 (2014), 1987–1997 10.1002/art.38687.
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 1987-1997
-
-
Alten, R.1
Kaine, J.2
Keystone, E.3
Nash, P.4
Delaet, I.5
Genovese, M.C.6
-
26
-
-
84878631800
-
Safety of abatacept administered intravenously in treatment of rheumatoid arthritis: integrated analyses of up to 8 years of treatment from the abatacept clinical trial program
-
Weinblatt, ME, Moreland, LW, Westhovens, R, et al. Safety of abatacept administered intravenously in treatment of rheumatoid arthritis: integrated analyses of up to 8 years of treatment from the abatacept clinical trial program. J Rheumatol 40 (2013), 787–797 10.3899/jrheum.120906.
-
(2013)
J Rheumatol
, vol.40
, pp. 787-797
-
-
Weinblatt, M.E.1
Moreland, L.W.2
Westhovens, R.3
-
27
-
-
52149099504
-
IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial
-
Emery, P, Keystone, E, Tony, HP, et al. IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial. Ann Rheum Dis 67 (2008), 1516–1523 10.1136/ard.2008.092932.
-
(2008)
Ann Rheum Dis
, vol.67
, pp. 1516-1523
-
-
Emery, P.1
Keystone, E.2
Tony, H.P.3
-
28
-
-
40749114497
-
Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, -randomised trial
-
Smolen, JS, Beaulieu, A, Rubbert-Roth, A, et al. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, -randomised trial. Lancet 371 (2008), 987–997 10.1016/S0140-6736(08)60453-5.
-
(2008)
Lancet
, vol.371
, pp. 987-997
-
-
Smolen, J.S.1
Beaulieu, A.2
Rubbert-Roth, A.3
-
29
-
-
85189807743
-
Tocilizumab improves hemoglobin levels and FACIT-Fatigue scores in patients with rheumatoid arthritis - Poster Presentation
-
29 Smolen JS, Ramos-Remus CR, Mysler EF, Day B, Wiese C, Alten R,. Tocilizumab improves hemoglobin levels and FACIT-Fatigue scores in patients with rheumatoid arthritis - Poster Presentation. Ann Rheum Dis.
-
Ann Rheum Dis
-
-
Smolen, J.S.1
Ramos-Remus, C.R.2
Mysler, E.F.3
Day, B.4
Wiese, C.5
Alten, R.6
-
30
-
-
80052137402
-
Integrated safety in tocilizumab clinical trials
-
Schiff, MH, Kremer, JM, Jahreis, A, Vernon, E, Isaacs, JD, van Vollenhoven, RF, Integrated safety in tocilizumab clinical trials. Arthritis Res Ther, 13, 2011, R 10.1186/ar3455.
-
(2011)
Arthritis Res Ther
, vol.13
, pp. R
-
-
Schiff, M.H.1
Kremer, J.M.2
Jahreis, A.3
Vernon, E.4
Isaacs, J.D.5
van Vollenhoven, R.F.6
-
31
-
-
77954937171
-
The changing face of rheumatoid arthritis: sustained remission for all?
-
Isaacs, JD, The changing face of rheumatoid arthritis: sustained remission for all?. Nat Rev Immunol 10 (2010), 605–611 10.1038/nri2804.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 605-611
-
-
Isaacs, J.D.1
-
32
-
-
1042290337
-
Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors
-
Nielen, MM, van Schaardenburg, D, Reesink, HW, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheumatol 50 (2004), 380–386 10.1002/art.20018.
-
(2004)
Arthritis Rheumatol
, vol.50
, pp. 380-386
-
-
Nielen, M.M.1
van Schaardenburg, D.2
Reesink, H.W.3
|