MiR-195 Suppresses Cervical Cancer Migration and Invasion Through Targeting Smad3

International Journal of Gynecological Cancer

Volumn 26, Issue 5, 2016, Pages 817-824

  Zhou, Quan ^a   Han, Ling R ^a   Zhou, Yang X ^a   Li, Yan ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

Cervical cancer; Metastasis; miR 195; Smad3

Indexed keywords

MICRORNA; MICRORNA 195; SMAD3 PROTEIN; UNCLASSIFIED DRUG; MIRN195 MICRORNA, HUMAN; SMAD3 PROTEIN, HUMAN;

ADULT; ARTICLE; CELL INVASION; CELL MIGRATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE METASTASIS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; UTERINE CERVIX CANCER; BIOSYNTHESIS; CELL MOTION; DISEASE COURSE; GENETICS; HELA CELL LINE; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; UTERINE CERVIX TUMOR;

ADULT; CELL LINE, TUMOR; CELL MOVEMENT; DISEASE PROGRESSION; FEMALE; HELA CELLS; HUMANS; MICRORNAS; SMAD3 PROTEIN; UTERINE CERVICAL NEOPLASMS;

EID: 84973369736     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1097/IGC.0000000000000686     Document Type: Article

References (32)

1. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin. 2011;61:69-90.
2. Arbyn M, Castellsague X, de Sanjose S, et al.Worldwide burden of cervical cancer in 2008. Ann Oncol. 2011;22:2675-2686.
3. Duenas-Gonzalez A, Cetina L, Mariscal I, et al. Modern management of locally advanced cervical carcinoma. Cancer Treat Rev. 2003;29:389-399.
4. Glick SB, Clarke AR, Blanchard A, et al. Cervical cancer screening, diagnosis and treatment interventions for racial and ethnic minorities: a systematic review. J Gen Intern Med. 2012;27:1016-1032.
5. Wilting SM, Snijde rs PJ, Verlaat W, et al. Altered microRNA expression associated with chromosomal changes contributes to cervical carcinogenesis. Oncogene. 2013;32:106-116.
6. Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet. 2008;9:102-114.
7. Mukherji S, Ebert MS, Zheng GX, et al. MicroRNAs can generate thresholds in target gene expression. Nat Genet. 2011;43:854e859.
8. Tsai WC,Hsu SD,Hsu CS,et al. MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis J Clin Invest. 2012 122 2884-2897.
9. Yang P, Li QJ, F eng Y, et al. TGF-A-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma. Cancer Cell. 2012;22:291-303.
10. Krzeszinski JY, Wei W, Huynh H, et al. miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2. Nature. 2014;512:431-435.
11. Ventura A, Jacks T. MicroRNAs and cancer: short RNAs go a long way. Cell. 2009;136:586-591.
12. Song L, Liu S, Zeng S, et al. miR-375 modulates radiosensitivity of HR-HPV-positive cervical cancer cells by targeting UBE3A through the p53 pathway. Med Sci Monit. 2015;21:2210-2217.
13. Ye C, Sun NX, Ma Y, et al. MicroRNA-145 contributes to enhancing radiosensitivity of cervical cancer cells. FEBS Lett. 2015;589:702-709.
14. Banno K, Iida M, Yanokura M, et al. MicroRNA in cervical cancer: OncomiRs and tumor suppressor miRs in diagnosis and treatment. Scientific World Journal. 2014;2014:178075.
15. Park H, Lee MJ, Jeong JY, et al. Dysregulated microRNA expression in adenocarcinoma of the uterine cervix: clinical impact of miR-363-3p. Gynecol Oncol. 2014;135:565-572.
16. Zeng K, Zhe ng W, Mo X, et al. Dysregulated microRNAs involved in the progression of cervical neoplasm. Arch Gynecol Obstet. 2015;292:905-913.
17. Liu B, Qu J, Xu F, et al. MiR-195 suppresses non-small cell lung cancer by targeting CHEK1. Oncotarget. 2015;6:9445-9456.
18. Yang Y, Li M, Chang S, et al. MicroRNA-195 acts as a tumor suppressor by directly targeting Wnt3a in HepG2 hepatocellular carcinoma cells. Mol Med Rep. 2014;10:2643-2648.
19. Wang L, Qian L, Li X, et al. MicroRNA-195 inhibits colorectal cancer cell proliferation, colony-formation and invasion through targeting CARMA3. Mol Med Rep. 2014;10:473-478.
20. Wang N, Zhou Y, Zheng L, et al. MiR-31 is an independent prognostic factor and functions as an oncomir in cervical cancer via targeting ARID1A. Gyn ecol Oncol. 2014;134:129-137.
21. Wang N, Zhan T, Ke T, et al. Increased expression of RRM2 by human papillomavirus E7 oncoprotein promotes angiogenesis in cervical cancer. Br J Cancer. 2014;110:1034-1044.
22. Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer. 2006;6:857-866.
23. Rao Q, Shen Q, Zhou H, et al. Aberrant microRNA expression in human cervical carcinomas. Med Oncol. 2012;29:1242-1248.
24. Chen B, Zhang C, Dong P, et al. Molecular regulation of cervical cancer growth and invasion by VEGFA. Tumor Biol. 2014;35:11587-11593.
25. Setoodeh R, Hakam A, Shan Y. Cerebral metastasis of cervical cancer, report of two cases and reviewof the literature. Int J Clin Exp Pathol. 2012;5:710-714.
26. Sun N, Ye L, Chang T, et al. MicroRNA-195-Cdc42 axis acts as a prognostic factor of esophageal squamous cell carcinoma. Int J Clin Exp Pathol. 2014;7:6871-6879.
27. Han K, Chen X, Bian N, et al. MicroRNA profiling identifies MiR-195 suppresses osteosarcoma cell metastasis by targeting CCND1. Oncotarget. 2015;6:8875-8889.
28. Yang B, Tan Z, Song Y. Study on the molecular regulatory mechanism of MicroRNA-195 in the invasion and metastasis of colorectal carcinoma. Int J Clin Exp Med. 2015;8:3793-3800.
29. MassaguéJ. TGFA signaling in context Nat Rev Mol Cell Biol. 2012 13 616-630.
30. Xia Q, Li C, Bian P, et al. Targeting SMAD3 for inhibiting prostate cancer metastasis. Tumor Biol. 2014;35:8537-8541.
31. Y amazaki K, Masugi Y, Effendi K, et al. Upregulated SMAD3 promotes epithelial-mesenchymal transition and predicts poor prognosis in pancreatic ductal adenocarcinoma. Lab Invest. 2014 ;94:683-691.
32. Fan Q, Qiu MT, Zhu Z, et al. Twist induces epithelial-mesenchymal transition in cervical carcinogenesis by regulating the TGF-A/Smad3 signaling pathway. Oncol Rep. 2015;34:1787-1794.