Interaction of Vitamin E isoforms on asthma and allergic airway disease

Thorax

Volumn 71, Issue 10, 2016, Pages 954-956

  Cook Mills, Joan ^a   Gebretsadik, Tebeb ^b   Abdala Valencia, Hiam ^a   Green, Jeremy ^a   Larkin, Emma K ^b   Dupont, William D ^b   Shu, Xiao Ou ^b   Gross, Myron ^c   Bai, Chunxue ^d   Gao, Yu Tang ^e   Hartman, Terryl J ^f   Rosas Salazar, Christian ^b   Hartert, Tina ^b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^d FUDAN UNIVERSITY   (China)

^e SHANGHAI CANCER INSTITUTE   (China)

^f EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; EOTAXIN; EOTAXIN 2; GAMMA TOCOPHEROL; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; ISOPROTEIN;

ALLERGIC AIRWAY INFLAMMATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; COHORT ANALYSIS; CONTROLLED STUDY; DERMATOPHAGOIDES; DIET SUPPLEMENTATION; HUMAN; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; VITAMIN BLOOD LEVEL; ANIMAL; BLOOD; RESPIRATORY TRACT ALLERGY;

ALPHA-TOCOPHEROL; ANIMALS; ASTHMA; GAMMA-TOCOPHEROL; HUMANS; MICE; PROTEIN ISOFORMS; RESPIRATORY HYPERSENSITIVITY;

EID: 84973320500     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2016-208494     Document Type: Article

References (19)

1. Hartert TV, Deng X, Hartman TJ, et al. The Shanghai Women?s Asthma and Allergy Study: objectives, design, and recruitment results. Am J Epidemiol 2008; 167: 1387-96
2. Larkin EK, Gao YT, Gebretsadik T, et al. New risk factors for adult-onset incident asthma. A nested case-control study of host antioxidant defense. Am J Respir Crit Care Med 2015; 191: 45-53
3. Abdala-Valencia H, Berdnikovs S, Cook-Mills JM. Vitamin E isoforms differentially regulate intercellular adhesion molecule-1 activation of PKCa in human microvascular endothelial cells. PLoS ONE 2012; 7: e41054
4. Berdnikovs S, Abdala-Valencia H, McCary C, et al. Isoforms of vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment. J Immunol 2009; 182: 4395-405
5. McCary CA, Abdala-Valencia H, Berdnikovs S, et al. Supplemental and highly elevated tocopherol doses differentially regulate allergic inflammation: reversibility of alpha-tocopherol and gamma-tocopherol?s effects. J Immunol 2011; 186: 3674-85
6. McCary CA, Yoon Y, Panagabko C, et al. Vitamin E isoforms directly bind PKCa and differentially regulate activation of PKCa. Biochem J 2012; 441: 189-98
7. Cook-Mills JM, Avila PC. Vitamin E and D regulation of allergic asthma immunopathogenesis. Int Immunopharmacol 2014; 23: 364-72
8. Marchese ME, Kumar R, Colangelo LA, et al. The vitamin E isoforms alpha-tocopherol and gamma-tocopherol have opposite associations with spirometric parameters: the CARDIA study. Respir Res 2014; 15: 31
9. Abdala-Valencia H, Cook-Mills JM. VCAM-1 signals activate endothelial cell protein kinase Calpha via oxidation. J Immunol 2006; 177: 6379-87
10. Cook-Mills JM. Isoforms of Vitamin E Differentially Regulate PKCa and Inflammation: A Review. J Clin Cell Immunol 2013; 4
11. Peh HY, Ho WE, Cheng C, et al. Vitamin E Isoform gamma-Tocotrienol Downregulates House Dust Mite-Induced Asthma. J Immunol 2015; 195: 437-44
12. Wagner JG, Jiang Q, Harkema JR, et al. Gamma-tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma. Clin Exp Allergy 2008; 38: 501-11
13. Tsuchiya K, Siddiqui S, Risse PA, et al. The presence of LPS in OVA inhalations affects airway inflammation and AHR but not remodeling in a rodent model of asthma. Am J Physiol Lung Cell Mol Physiol 2012; 303: L54-63
14. Hamahata A, Enkhbaatar P, Kraft ER, et al. gamma-Tocopherol nebulization by a lipid aerosolization device improves pulmonary function in sheep with burn and smoke inhalation injury. Free Radic Biol Med 2008; 45: 425-33
15. Fakhrzadeh L, Laskin JD, Laskin DL. Ozone-induced production of nitric oxide and TNF-Alpha and tissue injury are dependent on NF-kappaB p50. Am J Physiol Lung Cell Mol Physiol 2004; 287: L279-85
16. He Y, Franchi L, Núñez G. The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages. Eur J Immunol 2013; 43: 1147-52
17. Christen S, Woodall AA, Shigenaga MK, et al. gamma-tocopherol traps mutagenic electrophiles such as NO(X) and complements alpha-tocopherol: physiological implications. Proc Natl Acad Sci USA 1997; 94: 3217-22
18. Patel A, Liebner F, Netscher T, et al. Vitamin E chemistry. Nitration of non-Alpha-tocopherols: products and mechanistic considerations. J Org Chem 2007; 72: 6504-12
19. Wolf G. gamma-Tocopherol: an efficient protector of lipids against nitric oxide-initiated peroxidative damage. Nutr Rev 1997; 55: 376-8