Antibiotic-Resistant Neisseria gonorrhoeae Spread Faster with More Treatment, Not More Sexual Partners

PLoS Pathogens

Volumn 12, Issue 5, 2016, Pages

  Fingerhuth, Stephanie M ^a,b   Bonhoeffer, Sebastian ^a   Low, Nicola ^b   Althaus, Christian L ^b  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CEFIXIME; CIPROFLOXACIN; ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; ARTICLE; DISEASE DURATION; DISEASE SURVEILLANCE; DISEASE TRANSMISSION; GONORRHEA; HETEROSEXUAL MALE; HUMAN; MATHEMATICAL MODEL; MEN WHO HAVE SEX WITH MEN; NEISSERIA GONORRHOEAE; PREVALENCE; SEXUAL BEHAVIOR; TREATMENT OUTCOME; ADULT; DRUG EFFECTS; FEMALE; INCIDENCE; MALE; SEXUALITY; THEORETICAL MODEL; TRANSMISSION;

ADULT; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, MICROBIAL; FEMALE; GONORRHEA; HUMANS; INCIDENCE; MALE; MODELS, THEORETICAL; NEISSERIA GONORRHOEAE; PREVALENCE; SEXUAL PARTNERS;

EID: 84973320242     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005611     Document Type: Article

References (42)

1. Unemo M, Shafer WM, Antimicrobial Resistance in Neisseria gonorrhoeae in the 21st Century: Past, Evolution, and Future. Clin Microbiol Rev. 2014jul;27(3):587–613. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24982323. doi: 10.1128/CMR.00010-1424982323
2. Centers for Disease Control and PreventionSexually Transmitted Disease Surveillance 2012. Atlanta: U.S. Department of Health and Human Services; 2014.
3. Public Health England. GRASP 2013 Report The Gonococcal Resistance to Antimicrobials Surveillance Programme (England and Wales); 2014.
4. Davies S, Fowler T, Watson J, Livermore D, Walker D, Annual Report of the Chief Medical Officer: infection and the rise of antimicrobial resistance. Lancet. 2013;381:1606–1609. Available from: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)60604-2/abstract. doi: 10.1016/S0140-6736(13)60604-223489756
5. Ison CA, Town K, Obi C, Chisholm S, Hughes G, Livermore D, et al. Decreased susceptibility to cephalosporins among gonococci: data from the Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP) in England and Wales, 2007–2011. Lancet Infect Dis. 2013sep;13(9):762–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23764300. doi: 10.1016/S1473-3099(13)70143-923764300
6. Tapsall J, World Health Organization. Antimicrobial resistance in Neisseria gonorrhoeae; 2001. Available from: http://www.who.int/entity/csr/resources/publications/drugresist/Neisseria_gonorrhoeae.pdf.
7. Bignell C, Unemo M, 2012 European Guideline on the Diagnosis and Treatment of Gonorrhoea in Adults. Int J STD AIDS. 2013feb;24(2):85–92. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24400344. doi: 10.1177/095646241247283724400344
8. Kirkcaldy RD, Weinstock HS, Moore PC, Philip SS, Wiesenfeld HC, Papp JR, et al. The Efficacy and Safety of Gentamicin Plus Azithromycin and Gemifloxacin Plus Azithromycin as Treatment of Uncomplicated Gonorrhea. Clin Infect Dis. 2014oct;59(8):1083–91. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25031289. doi: 10.1093/cid/ciu52125031289
9. Campos-Outcalt D, CDC update on gonorrhea: Expand treatment to limit resistance. J Fam Practice. 2011;60(12):736–739.
10. Centers for Disease Control and PreventionCephalosporin-resistant Neisseria gonorrhoeae Public Health Response Plan; 2012. Available from: http://www.cdc.gov/std/treatment/ceph-r-responseplanjuly30-2012.pdf.
11. Yorke J, Hethcote H, Nold A, Dynamics and Control of the Transmission of Gonorrhea. Sex Transm Dis. 1978;5(2):51–56. Available from: http://journals.lww.com/stdjournal/Abstract/1978/04000/Dynamics_and_Control_of_the_Transmission_of.3.aspx. 10328031
12. Chan CH, McCabe CJ, Fisman DN, Core groups, antimicrobial resistance and rebound in gonorrhoea in North America. Sex Transm Infect. 2012apr;88(3):200–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22169277. doi: 10.1136/sextrans-2011-05004922169277
13. Xiridou M, Soetens LC, Koedijk FDH, van der Sande MAB, Wallinga J, Public health measures to control the spread of antimicrobial resistance in Neisseria gonorrhoeae in men who have sex with men. Epidemiol Infect. 2015oct;143(8):1575–1584. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25275435. doi: 10.1017/S095026881400251925275435
14. Hui BB, Ryder N, Su JY, Ward J, Chen MY, Donovan B, et al. Exploring the Benefits of Molecular Testing for Gonorrhoea Antibiotic Resistance Surveillance in Remote Settings. PloS One. 2015;10(7):e0133202. doi: 10.1371/journal.pone.013320226181042
15. Health Protection AgencyGRASP 2011 Report: The Gonococcal Resistance to Antimicrobials Surveillance Programme. 2012;p. 12. Available from: http://webarchive.nationalarchives.gov.uk/20140714084352/http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1317136030908.
16. Health Protection AgencyGRASP 2011 Report: The Gonococcal Resistance to Antimicrobials Surveillance Programme. 2012;p. 14. Available from: http://webarchive.nationalarchives.gov.uk/20140714084352/http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1317136030908.
17. Centers for Disease Control and PreventionSexually Transmitted Disease Surveillance 2011. 2012;p. 54. Available from: http://www.cdc.gov/std/stats11/surv2011.pdf.
18. Plot Digitizer 2.6.6. 2014;Available from: http://plotdigitizer.sourceforge.net/.
19. R Core TeamR: A Language and Environment for Statistical Computing. Vienna, Austria; 2015. Available from: http://www.r-project.org/.
20. Romero-Severson EO, Alam SJ, Volz EM, Koopman JS, Heterogeneity in Number and Type of Sexual Contacts in a Gay Urban Cohort. Stat Commun Infect Dis. 2012;4(1). Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3639013&tool=pmcentrez&rendertype=abstract.
21. Garnett GP, Swinton J, Brunham RC, Anderson RM, The influence of heterogeneity in sexual behaviour. IMA J Math Appl Med Biol. 1992;9(2):127–144. doi: 10.1093/imammb/9.2.1271517674
22. Johnson AM, Mercer CH, Erens B, Copas AJ, McManus S, Wellings K, et al. Sexual behaviour in Britain: Partnerships, practices, and HIV risk behaviours. Lancet. 2001;358(9296):1835–1842. doi: 10.1016/S0140-6736(01)06883-011741621
23. Althaus CL, Heijne JCM, Herzog SA, Roellin A, Low N, Individual and Population Level Effects of Partner Notification for Chlamydia trachomatis. PloS One. 2012jan;7(12):e51438. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3520891&tool=pmcentrez&rendertype=abstract. doi: 10.1371/journal.pone.005143823251534
24. Soetaert, K. rootSolve: Nonlinear root finding, equilibrium and steady-state analysis of ordinary differential equations; 2009. Available from: https://cran.r-project.org/web/packages/rootSolve/.
25. Garnett GP, Mertz KJ, Finelli L, Levine WC, Louis ME, StThe transmission dynamics of gonorrhoea: modelling the reported behaviour of infected patients from Newark, New Jersey. Philos Trans R Soc Lond B Biol Sci. 1999apr;354(1384):787–97. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1692556&tool=pmcentrez&rendertype=abstract. doi: 10.1098/rstb.1999.043110365404
26. Datta SD, Sternberg M, Johnson RE, Berman S, Papp JR, McQuillan G, et al. Gonorrhea and Chlamydia in the United States among Persons 14 to 39 Years of Age, 1999 to 2002. Ann Intern Med. 2007;147(2):89–96. doi: 10.7326/0003-4819-147-2-200707170-0000717638719
27. Centers for Disease Control and PreventionSexually Transmitted Disease Surveillance 2013. Atlanta: U.S. Department of Health and Human Services; 2014.
28. Jin F, Prestage GP, Mao L, Kippax SC, Pell CM, Donovan B, et al. Incidence and risk factors for urethral and anal gonorrhoea and chlamydia in a cohort of HIV-negative homosexual men: the Health in Men Study. Sex Transm Infect. 2007;83(2):113–119. doi: 10.1136/sti.2006.02191517005541
29. Jin F. Personal Communication. 2015 may.
30. Althaus CL, Choisy M, Alizon S, CSF groupNumber of sex acts matters for heterosexual transmission and control of Chlamydia trachomatis. PeerJ PrePrints. 2015;3:e1164. Available from: https://dx.doi.org/10.7287/peerj.preprints.940v1.
31. Grad YH, Goldstein E, Lipsitch M, White PJ, Improving Control of Antibiotic-Resistant Gonorrhea by Integrating Research Agendas Across Disciplines: Key Questions Arising From Mathematical Modeling. J Infect Dis. 2016;213(6):883–890. Available from: http://jid.oxfordjournals.org/content/213/6/883. doi: 10.1093/infdis/jiv51726518045
32. Lynn F, Hobbs MM, Zenilman JM, Behets FMTF, Van Damme K, Rasamindrakotroka A, et al. Genetic typing of the porin protein of Neisseria gonorrhoeae from clinical noncultured samples for strain characterization and identification of mixed gonococcal infections. J Clin Microbiol. 2005;43(1):368–375. doi: 10.1128/JCM.43.1.368-375.200515634996
33. Renton A, Whitaker L, Ison C, Wadsworth J, Harris JRW, Estimating the sexual mixing patterns in the general population from those in people acquiring gonorrhoea infection: theoretical foundation and empirical findings. J Epidemiol Community Health. 1995apr;49(2):205–213. Available from: http://jech.bmj.com/cgi/doi/10.1136/jech.49.2.205. doi: 10.1136/jech.49.2.2057798052
34. Farley TA, Cohen DA, Elkins W, Asymptomatic sexually transmitted diseases: the case for screening. Prev Med. 2003;36(4):502–509. Available from: http://www.sciencedirect.com/science/article/pii/S0091743502000580. doi: 10.1016/S0091-7435(02)00058-012649059
35. Buimer M, van Doornum GJ, Ching S, Peerbooms PG, Plier PK, Ram D, et al. Detection of Chlamydia trachomatis and Neisseria gonorrhoeae by ligase chain reaction-based assays with clinical specimens from various sites: implications for diagnostic testing and screening. J Clin Microbiol. 1996;34(10):2395–400. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=229278&tool=pmcentrez&rendertype=abstract. 8880487
36. Chen MI, Ghani AC, Edmunds WJ, A metapopulation modelling framework for gonorrhoea and other sexually transmitted infections in heterosexual populations. J R Soc Interface. 2009sep;6(38):775–791. Available from: http://rsif.royalsocietypublishing.org/cgi/doi/10.1098/rsif.2008.0394. doi: 10.1098/rsif.2008.039418986961
37. Hethcote H, Yorke J, Gonorrhea Transmission Dynamics and Control. Lecture Notes in Bioinformatics. 1984;56. doi: 10.1007/978-3-662-07544-9
38. Swinton J, Garnett GP, Brunham RC, Anderson RM, Gonococcal infection, infertility, and population growth: I. Endemic states in behaviourally homogeneous growing populations. IMA J Math Appl Med Biol. 1992;9(2):107–126. doi: 10.1093/imammb/9.2.1071517673
39. Bracher M, Watkins S, Santow G, “Moving” and Marrying: Modelling HIV Infection among Newly-weds in Malawi. Demogr Res. 2003sep;Special 1:207–246. Available from: http://www.demographic-research.org/special/1/7/. doi: 10.4054/DemRes.2003.S1.7
40. Bonhoeffer S, Lipsitch M, Levin BR, Evaluating treatment protocols to prevent antibiotic resistance. Proc Natl Acad Sci USA. 1997oct;94(22):12106–11. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9342370. doi: 10.1073/pnas.94.22.121069342370
41. Huijben S, Bell AS, Sim DG, Tomasello D, Mideo N, Day T, et al. Aggressive Chemotherapy and the Selection of Drug Resistant Pathogens. PLoS Pathog. 2013sep;9(9):e1003578. doi: 10.1371/journal.ppat.100357824068922
42. Shimuta K, Unemo M, Nakayama SI, Morita-Ishihara T, Dorin M, Kawahata T, et al. Antimicrobial Resistance and Molecular Typing of Neisseria gonorrhoeae Isolates in Kyoto and Osaka, Japan, 2010 to 2012: Intensified Surveillance after Identification of the First Strain (H041) with High-Level Ceftriaxone Resistance. Antimicrob Agents Chemother. 2013nov;57(11):5225–32. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23939890http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC3811299. doi: 10.1128/AAC.01295-1323939890