The avascular zone and neuronal remodeling of the fovea in Parkinson disease

Annals of Clinical and Translational Neurology

Volumn 2, Issue 2, 2015, Pages 196-201

  Miri, Shahnaz ^a   Shrier, Eric M ^b,c   Glazman, Sofya ^a   Ding, Yin ^d   Selesnick, Ivan ^d   Kozlowski, Piotr B ^e,f   Bodis Wollner, Ivan ^a,b,c  

^a Downstate Health Sciences University   (United States)

^b SUNY DOWNSTATE MEDICAL CENTER   (United States)

^c SUNY EYE INSTITUTE   (United States)

^d NEW YORK UNIVERSITY   (United States)

^e NEUROMEDLAB   (United States)

^f TOURO COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; BIOLOGICAL MARKER;

ANGIOGENESIS; ANGIOGRAPHY; ARTICLE; AVASCULAR ZONE; CAPILLARY; CLINICAL ARTICLE; CONTROLLED STUDY; CORNEAL ENDOTHELIAL CELL LOSS; DISEASE DURATION; DOPAMINERGIC ACTIVITY; HOEHN AND YAHR SCALE; HUMAN; MACULAR THICKNESS; MOTOR PERFORMANCE; NERVE CELL; NEUROLOGIC EXAMINATION; NEURONAL REMODELING; OPTICAL COHERENCE TOMOGRAPHY; PARKINSON DISEASE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETINA FLUORESCEIN ANGIOGRAPHY; RETINA FOVEA; RETINAL THICKNESS; UNIFIED PARKINSON DISEASE RATING SCALE;

EID: 84973291253     PISSN: None     EISSN: 23289503     Source Type: Journal    
DOI: 10.1002/acn3.146     Document Type: Article

References (23)

1. Xu J, Kao SY, Lee FJ, et al. Dopamine-dependent neurotoxicity of α-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat Med 2002;8:600–606.
2. Braak H, de Vos RA, Bohl J, Del Tredici K. Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci Lett 2006;396:67–72.
3. Bodis-Wollner I, Kozlowski PB, Glazman S, Miri S. α-synuclein in the inner retina in parkinson disease. Ann Neurol 2014;75:964–966.
4. Beach TG, Carew J, Serrano G, et al. Phosphorylated α-synuclein-immunoreactive retinal neuronal elements in Parkinson's disease subjects. Neurosci Lett 2014;571:34–38.
5. Spund B, Ding Y, Liu T, et al. Remodeling of the fovea in Parkinson disease. J Neural Transm 2013;120:745–753.
6. Bodis-Wollner I, Miri S, Glazman S. Venturing into the no-man's land of the retina in Parkinson disease. Mov Disord 2014;29:15–22.
7. Savy C, Simon A, Nguyen-Legros J. Spatial geometry of the dopamine innervation in the avascular area of the human fovea. Vis Neurosci 1991;7:487–498.
8. Adams JD, Pickford MS, Wong CG. The acute retinal histopathology of MPTP. Neurotoxicology 1992;13:541–549.
9. Djamgoz MBA, Hankins MW, Hirano J, Archer SN. Neurobiology of retinal dopamine in relation to degenerative states of the tissue. Vision Res 1997;37:3509–3529.
10. Arend O, Remky A, Plange N, et al. Capillary density and retinal diameter measurements and their impact on altered retinal circulation in glaucoma: a digital fluorescein angiographic study. Br J Ophthalmol 2002;86:429–433.
11. Finley KH. Angio-architecture of the substantia nigra and its pathogenic significance. Arch Neurol Psych 1936;36:118–127.
12. Penfold PL, Provis JM. Antibodies to human leucocyte antigens indicate subpopulations of microglia in human retina. Vis Neurosci 1991;7:383–388.
13. Faucheux BA, Bonnet AM, Agid Y, Hirsch EC. Blood vessels change in the mesencephalon of patients with Parkinson's disease. Lancet 1999;353:981–982.
14. Barcia C, Bautista V, Sanchez-Bahillo A, et al. Changes in vascularization in substantia nigra pars compacta of monkeys rendered Parkinsonian. J Neural Transm 2005;112:1237–1248.
15. Farkas E, De Jong GI, de Vos RA, et al. Pathological features of cerebral cortical capillaries are doubled in Alzheimer's disease and Parkinson's disease. Acta Neuropathol 2000;100:395–402.
16. Desai Bradaric B, Patel A, Schneider JA, et al. Evidence for angiogenesis in Parkinson's disease, incidental Lewy body disease, and progressive supranuclear palsy. J Neural Transm 2012;119:59–71.
17. Wada K, Arai H, Takanashi M, et al. Expression levels of vascular endothelial growth factor and its receptors in Parkinson's disease. NeuroReport 2006;17:705–709.
18. Cuenca N, Fernández-Sánchez L, Campello L, et al. Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases. Prog Retin Eye Res 2014;43C:17–75.
19. Dubis AM, Hansen BR, Cooper RF, et al. Relationship between the foveal avascular zone and foveal pit morphology. Invest Ophthalmol Vis Sci 2012;53:1628–1636.
20. Chui TY, Zhong Z, Song H, Burns SA. Foveal avascular zone and its relationship to foveal pit shape. Optom Vis Sci 2012;89:602.
21. Conrath J, Giorgi R, Raccah D, Ridings B. Foveal avascular zone in diabetic retinopathy: quantitative vs qualitative assessment. Eye 2004;19:322–326.
22. Frost S, Kanagasingam Y, Sohrabi H, et al. Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease. Transl Psychiatry 2013;3:e233.
23. Cheung N, Liew G, Lindley RI, et al. Retinal fractals and acute lacunar stroke. Ann Neurol 2010;68:107–111.