GWAS analysis of suicide attempt in schizophrenia: Main genetic effect and interaction with early life trauma

Neuroscience Letters

Volumn 622, Issue , 2016, Pages 102-106

  Bani Fatemi, Ali ^a   Graff, Ariel ^a,b   Zai, Clement ^a,b   Strauss, John ^a,b   De Luca, Vincenzo ^a,b  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

CTQ; Genetics; GWAS; Schizophrenia; Suicide

Indexed keywords

ADULT; ARTICLE; CHILDHOOD INJURY; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; FEMALE; GENE FREQUENCY; GENE INTERACTION; GENETIC MARKER; GENETIC MODEL; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HEREDITY; HUMAN; LIFESPAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; SUICIDAL IDEATION; SUICIDE ATTEMPT; ADOLESCENT; AGED; COHORT ANALYSIS; GENETICS; MIDDLE AGED; PSYCHOLOGY; PSYCHOTRAUMA; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; COHORT STUDIES; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHOLOGICAL TRAUMA; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SUICIDE, ATTEMPTED; YOUNG ADULT;

EID: 84973131423     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2016.04.043     Document Type: Article

References (20)

1. Laursen T.M., Nordentoft M., Mortensen P.B. Excess early mortality in schizophrenia. Annu. Rev. Clin. Psychol. 2014, 10:425-448.
2. Alaraisanen A., Miettunen J., Rasanen P., et al. Suicide rate in schizophrenia in the Northern Finland 1966 birth cohort. Soc. Psychiatry Psychiatr. Epidemiol. 2009, 44:1107-1110.
3. Beck A.T., Steer R.A., et al. Panic disorder and suicidal ideation and behavior: discrepant findings in psychiatric outpatients. Am. J. Psychiatry 1991, 148:1195-1199.
4. Bernstein D.P., Fink L., et al. Initial reliability and validity of a new retrospective measure of child abuse and neglect. Am. J. Psychiatry 1994, 151:1132-1136.
5. Bondy B., Buettner A., Zill P. Genetics of suicide. Mol. Psychiatry 2006, 11:336-351.
6. Brent D.A., Mann J.J. Family genetic studies, suicide, and suicidal behavior. Am. J. Med. Genet. C Semin. Med. Genet. 2005, 133C:13-24.
7. Dutta R., Murray R.M., Hotopf M., et al. Reassessing the long-term risk of suicide after a first episode of psychosis. Arch. Gen. Psychiatry 2010, 67:1230-1237.
8. First Michael B., Spitzer Robert L., Miriam Gibbon, Williams Janet B.W. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I/P) 2002, Biometrics Research New York State Psychiatric Institute, New York, November.
9. Hawton K., Sutton L., Haw C., et al. Schizophrenia and suicide: systematic review of risk factors. The British journal of psychiatry. J. Mental Sci. 2005, 187:9-20.
10. McGirr A., Seguin M., Renaud J., et al. Gender and risk factors for suicide: evidence for heterogeneity in predisposing mechanisms in a psychological autopsy study. J. Clin. Psychiatry 2006, 67:1612-1617.
11. Melhem N.M., Brent D.A., Ziegler M., et al. Familial pathways to early-onset suicidal behavior: familial and individual antecedents of suicidal behavior. Am. J. Psychiatry 2007, 164:1364-1370.
12. Montross L.P., Zisook S., Kasckow J. Suicide among patients with schizophrenia: a consideration of risk and protective factors. Ann. Clin. Psychiatry 2005, 17:173-182.
13. Perlis R.H., Huang J., et al. Genome-wide association study of suicide attempts in mood disorder patients. Am. J. Psychiatry 2010, 167:1499-1507.
14. Palmer B.A., Pankratz V.S., Bostwick J.M. The lifetime risk of suicide in schizophrenia: a reexamination. Arch. Gen. Psychiatry 2005, 62:247-253.
15. Posner K., Brown G.K., et al. The Columbia-suicide severity rating scale: initial validity and internal consistency findings from three multisite studies with adolescents and adults. Am. J. Psychiatry 2011, 168:1266-1277.
16. Roy A., Segal N.L. Suicidal behavior in twins: a replication. J. Affect Disord. 2001, 66:71-74.
17. Roy A., Segal N.L., Sarchiapone M. Attempted suicide among living co-twins of twin suicide victims. Am. J. Psychiatry 1995, 152:1075-1076.
18. Schosser A., Butler A.W., et al. Genomewide association scan of suicidal thoughts and behaviour in major depression. PLoS One 2011, 6:e20690.
19. Willour V.L., Seifuddin F., Mahon P.B., et al. A genome-wide association study of attempted suicide. Mol. Psychiatry 2012, 17:433-444.
20. Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M.A.R., Bender D., Maller J., Sklar P., de Bakker P.I.W., Daly M.J., Sham P.C. PLINK: a toolset for whole-genome association and population-based linkage analysis. Am. J. Hum. Genet. 2007, 81.