Additive genetic contribution to symptom dimensions in major depressive disorder

Journal of Abnormal Psychology

Volumn 125, Issue 4, 2016, Pages 495-501

  Pearson, Rahel ^a   Palmer, Rohan H C ^b,c   Brick, Leslie A ^b   McGeary, John E ^d   Knopik, Valerie S ^b,c   Beevers, Christopher G ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b RHODE ISLAND HOSPITAL   (United States)

^c BROWN UNIVERSITY   (United States)

^d PROVIDENCE VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Depression; Genetics; Greml; Symptom dimensions

Indexed keywords

ADULT; ANHEDONIA; ANXIETY; APPETITE; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; HAMILTON DEPRESSION RATING SCALE; HERITABILITY; HUMAN; INSOMNIA; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PRINCIPAL COMPONENT ANALYSIS; SAMPLE SIZE; SINGLE NUCLEOTIDE POLYMORPHISM; SYMPTOM; CLINICAL TRIAL; COMPLICATION; DEPRESSION; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; MENTAL HEALTH; MIDDLE AGED; PSYCHOLOGICAL RATING SCALE; STATISTICAL MODEL;

ADULT; DEPRESSION; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LIKELIHOOD FUNCTIONS; MALE; MENTAL STATUS SCHEDULE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHIATRIC STATUS RATING SCALES;

EID: 84973097780     PISSN: 0021843X     EISSN: 19391846     Source Type: Journal    
DOI: 10.1037/abn0000161     Document Type: Article

References (34)

1. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
2. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: Author.
3. Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H.,... Poulton, R. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386-389. http://dx.doi.org/10.1126/science.1083968
4. Cichon, S., Craddock, N., Daly, M., Faraone, S. V., Gejman, P. V., Kelsoe, J.,... the Psychiatric GWAS Consortium Coordinating Committee. (2009). Genomewide association studies: History, rationale, and prospects for psychiatric disorders. The American Journal of Psychiatry, 166, 540-556. http://dx.doi.org/10.1176/appi.ajp.2008.08091354
5. Dunn, E. C., Brown, R. C., Dai, Y., Rosand, J., Nugent, N. R., Amstadter, A. B., & Smoller, J. W. (2015). Genetic determinants of depression: Recent findings and future directions. Harvard Review of Psychiatry, 23, 1-18. http://dx.doi.org/10.1097/HRP.0000000000000054
6. Eichler, E. E., Flint, J., Gibson, G., Kong, A., Leal, S. M., Moore, J. H., & Nadeau, J. H. (2010). Missing heritability and strategies for finding the underlying causes of complex disease. Nature Reviews Genetics, 11, 446-450. http://dx.doi.org/10.1038/nrg2809
7. Fergusson, D. M., Horwood, L. J., Miller, A. L., & Kennedy, M. A. (2011). Life stress, 5-HTTLPR and mental disorder: Findings from a 30-year longitudinal study. The British Journal of Psychiatry, 198, 129-135. http://dx.doi.org/10.1192/bjp.bp.110.085993
8. Fried, E. I., & Nesse, R. M. (2015). Depression is not a consistent syndrome: An investigation of unique symptom patterns in the STAR*D study. Journal of Affective Disorders, 172C, 96-102.
9. Galbaud du Fort, G., Newman, S. C., Boothroyd, L. J., & Bland, R. C. (1999). Treatment seeking for depression: Role of depressive symptoms and comorbid psychiatric diagnoses. Journal of Affective Disorders, 52, 31-40. http://dx.doi.org/10.1016/S0165-0327(98)00052-4
10. Greenberg, P. E., & Birnbaum, H. G. (2005). The economic burden of depression in the US: Societal and patient perspectives. Expert Opinion on Pharmacotherapy, 6, 369-376. http://dx.doi.org/10.1517/14656566.6.3.369
11. Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery & Psychiatry, 23, 56-62. http://dx.doi.org/10.1136/jnnp.23.1.56
12. Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K.,... Wang, P. (2010). Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders. The American Journal of Psychiatry, 167, 748-751. http://dx.doi.org/10.1176/appi.ajp.2010.09091379
13. Jang, K. L., Livesley, W. J., Taylor, S., Stein, M. B., & Moon, E. C. (2004). Heritability of individual depressive symptoms. Journal of Affective Disorders, 80, 125-133. http://dx.doi.org/10.1016/S0165-0327(03)00108-3
14. Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: Evidence of genetic moderation. Archives of General Psychiatry, 68, 444-454. http://dx.doi.org/10.1001/archgenpsychiatry.2010.189
15. Kendler, K. S., Aggen, S. H., & Neale, M. C. (2013). Evidence for multiple genetic factors underlying DSM-IV criteria for major depression. Journal of the American Medical Association Psychiatry, 70, 599-607. http://dx.doi.org/10.1001/jamapsychiatry.2013.751
16. Kendler, K. S., Walters, E. E., Truett, K. R., Heath, A. C., Neale, M. C., Martin, N. G., & Eaves, L. J. (1995). A twin-family study of self-report symptoms of panic-phobia and somatization. Behavior Genetics, 25, 499-515. http://dx.doi.org/10.1007/BF02327574
17. Knesevich, J. W., Biggs, J. T., Clayton, P. J., & Ziegler, V. E. (1977). Validity of the Hamilton Rating Scale for depression. The British Journal of Psychiatry, 131, 49-52. http://dx.doi.org/10.1192/bjp.131.1.49
18. Korszun, A., Moskvina, V., Brewster, S., Craddock, N., Ferrero, F., Gill, M.,... McGuffin, P. (2004). Familiality of symptom dimensions in depression. Archives of General Psychiatry, 61, 468-474. http://dx.doi.org/10.1001/archpsyc.61.5.468
19. Lee, S. H., Ripke, S., Neale, B. M., Faraone, S. V., Purcell, S. M., Perlis, R. H.,... Wray, N. R. (2013). Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics, 45, 984-994. http://dx.doi.org/10.1038/ng.2711
20. Leek, J. T., Scharpf, R. B., Bravo, H. C., Simcha, D., Langmead, B., Johnson, W. E.,... Irizarry, R. A. (2010). Tackling the widespread and critical impact of batch effects in high-throughput data. Nature Reviews Genetics, 11, 733-739. http://dx.doi.org/10.1038/nrg2825
21. Lubke, G. H., Hottenga, J. J., Walters, R., Laurin, C., de Geus, E. J. C., Willemsen, G.,... Boomsma, D. I. (2012). Estimating the genetic variance of major depressive disorder due to all single nucleotide polymorphisms. Biological Psychiatry, 72, 707-709. http://dx.doi.org/10.1016/j.biopsych.2012.03.011
22. Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J.,... Visscher, P. M. (2009). Finding the missing heritability of complex diseases. Nature, 461, 747-753. http://dx.doi.org/10.1038/nature08494
23. McMahon, F. J., Buervenich, S., Charney, D., Lipsky, R., Rush, A. J., Wilson, A. F.,... Manji, H. (2006). Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment. American Journal of Human Genetics, 78, 804-814. http://dx.doi.org/10.1086/503820
24. Palmer, R. H. C., Brick, L., Nugent, N. R., Bidwell, L. C., McGeary, J. E., Knopik, V. S., & Keller, M. C. (2015). Examining the role of common genetic variants on alcohol, tobacco, cannabis and illicit drug dependence: Genetics of vulnerability to drug dependence. Addiction, 110, 530-537. http://dx.doi.org/10.1111/add.12815
25. Power, R. A., Keers, R., Ng, M. Y., Butler, A. W., Uher, R., Cohen-Woods, S.,... Lewis, C. M. (2012). Dissecting the genetic heterogeneity of depression through age at onset. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 159B, 859-868.
26. Risch, N., Herrell, R., Lehner, T., Liang, K. Y., Eaves, L., Hoh, J.,... Merikangas, K. R. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: A meta-analysis. JAMA: Journal of the American Medical Association, 301, 2462-2471. http://dx.doi.org/10.1001/jama.2009.878
27. Rush, A. J., Fava, M., Wisniewski, S. R., Lavori, P. W., Trivedi, M. H., Sackeim, H. A.,... for the STAR*D Investigators Group. (2004). Sequenced treatment alternatives to relieve depression (STAR*D): Rationale and design. Controlled Clinical Trials, 25, 119-142. http://dx.doi.org/10.1016/S0197-2456(03)00112-0
28. Shafer, A. B. (2006). Meta-analysis of the factor structures of four depression questionnaires: Beck, CES-D, Hamilton, and Zung. Journal of Clinical Psychology, 62, 123-146. http://dx.doi.org/10.1002/jclp.20213
29. Sherbourne, C. D., Wells, K. B., Hays, R. D., Rogers, W., Burnam, M. A., & Judd, L. L. (1994). Subthreshold depression and depressive disorder: Clinical characteristics of general medical and mental health specialty outpatients. The American Journal of Psychiatry, 151, 1777-1784. http://dx.doi.org/10.1176/ajp.151.12.1777
30. Smoller, J. W., Kendler, K. S., Craddock, N., Lee, P., Neale, B. M., Nurnberger, J. I.,... Thapar, A. (2013). Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics, 45, 984-994. http://dx.doi.org/10.1038/ng.2711
31. Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000). Genetic epidemiology of major depression: Review and meta-analysis. The American Journal of Psychiatry, 157, 1552-1562. http://dx.doi.org/10.1176/appi.ajp.157.10.1552
32. Tansey, K. E., Guipponi, M., Hu, X., Domenici, E., Lewis, G., Malafosse, A.,... Uher, R. (2013). Contribution of common genetic variants to antidepressant response. Biological Psychiatry, 73, 679-682. http://dx.doi.org/10.1016/j.biopsych.2012.10.030
33. Trajković, G., Starčević, V., Latas, M., Leštarević, M., Ille, T., Bukumirić, Z., & Marinković, J. (2011). Reliability of the Hamilton Rating Scale for Depression: A meta-analysis over a period of 49 years. Psychiatry Research, 189, 1-9. http://dx.doi.org/10.1016/j.psychres.2010.12.007
34. Yang, J., Lee, S. H., Goddard, M. E., & Visscher, P. M. (2011). GCTA: A tool for genome-wide complex trait analysis. American Journal of Human Genetics, 88, 76-82. http://dx.doi.org/10.1016/j.ajhg.2010.11.011