The significance of phosphorylated heat shock protein 27 on the prognosis of pancreatic cancer

Oncotarget

Volumn 7, Issue 12, 2016, Pages 14291-14299

  Okuno, Mitsuru ^a   Yasuda, Ichiro ^a   Adachi, Seiji ^a   Nakashima, Masanori ^a   Kawaguchi, Junji ^a   Doi, Shinpei ^a   Iwashita, Takuji ^a   Hirose, Yoshinobu ^b   Kozawa, Osamu ^a   Yoshimi, Naoki ^c   Shimizu, Masahito ^a   Moriwaki, Hisataka ^a  

^a GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA MEDICAL COLLEGE   (Japan)

^c UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

HSP27; Pancreatic cancer; Phosphorylation; Prognosis

Indexed keywords

GEMCITABINE; HEAT SHOCK PROTEIN 27; ANTINEOPLASTIC ANTIMETABOLITE; DEOXYCYTIDINE; HSPB1 PROTEIN, HUMAN; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER PROGNOSIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PANCREAS BIOPSY; PANCREAS CANCER; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RETROSPECTIVE STUDY; TREATMENT RESPONSE; ANALOGS AND DERIVATIVES; CANCER STAGING; FOLLOW UP; METABOLISM; METASTASIS; MIDDLE AGED; PANCREAS TUMOR; PATHOLOGY; PHOSPHORYLATION; PROGNOSIS; SURVIVAL RATE; TUMOR INVASION; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTIMETABOLITES, ANTINEOPLASTIC; BIOMARKERS, TUMOR; DEOXYCYTIDINE; FEMALE; FOLLOW-UP STUDIES; HSP27 HEAT-SHOCK PROTEINS; HUMANS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM STAGING; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 84971646926     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.7424     Document Type: Article

References (21)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. A cancer journal for clinicians. 2011; 61:69-90.
2. Burris HA, 3rd, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, Cripps MC, Portenoy RK, Storniolo AM, Tarassoff P, Nelson R, Dorr FA, Stephens CD, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. Journal of clinical oncology. 1997; 15:2403-2413.
3. Plunkett W, Huang P, Searcy CE, Gandhi V. Gemcitabine: preclinical pharmacology and mechanisms of action. Seminars in oncology. 1996; 23:3-15.
4. Habiro A, Tanno S, Koizumi K, Izawa T, Nakano Y, Osanai M, Mizukami Y, Okumura T, Kohgo Y. Involvement of p38 mitogen-activated protein kinase in gemcitabine-induced apoptosis in human pancreatic cancer cells. Biochemical and biophysical research communications. 2004; 316:71-77.
5. Lindquist S, Craig EA. The heat-shock proteins. Annual review of genetics. 1988; 22:631-677.
6. Freeman BC, Yamamoto KR. Disassembly of transcriptional regulatory complexes by molecular chaperones. Science. 2002; 296:2232-2235.
7. Mymrikov EV, Seit-Nebi AS, Gusev NB. Large potentials of small heat shock proteins. Physiological reviews. 2011; 91:1123-1159.
8. Katsogiannou M, Andrieu C, Rocchi P. Heat shock protein 27 phosphorylation state is associated with cancer progression. Frontiers in genetics. 2014; 5:346.
9. Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kawaguchi J, Itani M, Yoshioka T, Matsushima-Nishiwaki R, Hirose Y, Kozawa O, Moriwaki H. Phosphorylation status of heat shock protein 27 plays a key role in gemcitabine-induced apoptosis of pancreatic cancer cells. Cancer letters. 2011; 313:218-225.
10. Rouse J, Cohen P, Trigon S, Morange M, Alonso-Llamazares A, Zamanillo D, Hunt T, Nebreda AR. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell. 1994; 78:1027-1037.
11. Benjamin IJ, McMillan DR. Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease. Circulation research. 1998; 83:117-132.
12. Yasuda E, Kumada T, Takai S, Ishisaki A, Noda T, Matsushima-Nishiwaki R, Yoshimi N, Kato K, Toyoda H, Kaneoka Y, Yamaguchi A, Kozawa O. Attenuated phosphorylation of heat shock protein 27 correlates with tumor progression in patients with hepatocellular carcinoma. Biochemical and biophysical research communications. 2005; 337:337-342.
13. Matsushima-Nishiwaki R, Takai S, Adachi S, Minamitani C, Yasuda E, Noda T, Kato K, Toyoda H, Kaneoka Y, Yamaguchi A, Kumada T, Kozawa O. Phosphorylated heat shock protein 27 represses growth of hepatocellular carcinoma via inhibition of extracellular signal-regulated kinase. The Journal of biological chemistry. 2008; 283:18852-18860.
14. Matsunaga A, Ishii Y, Tsuruta M, Okabayashi K, Hasegawa H, Kitagawa Y. Inhibition of heat shock protein 27 phosphorylation promotes sensitivity to 5-fluorouracil in colorectal cancer cells. Oncology letters. 2014; 8:2496-2500.
15. Stope MB, Weiss M, Preuss M, Streitborger A, Ritter CA, Zimmermann U, Walther R, Burchardt M. Immediate and transient phosphorylation of the heat shock protein 27 initiates chemoresistance in prostate cancer cells. Oncology reports. 2014; 32:2380-2386.
16. Mori-Iwamoto S, Kuramitsu Y, Ryozawa S, Mikuria K, Fujimoto M, Maehara S, Maehara Y, Okita K, Nakamura K, Sakaida I. Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine. International journal of oncology. 2007; 31:1345-1350.
17. Taba K, Kuramitsu Y, Ryozawa S, Yoshida K, Tanaka T, Maehara S, Maehara Y, Sakaida I, Nakamura K. Heat-shock protein 27 is phosphorylated in gemcitabine-resistant pancreatic cancer cells. Anticancer research. 2010; 30:2539-2543.
18. Tsiaousidou A, Lambropoulou M, Chatzitheoklitos E, Tripsianis G, Tsompanidou C, Simopoulos C, Tsaroucha AK. B7H4, HSP27 and DJ-1 molecular markers as prognostic factors in pancreatic cancer. Pancreatology. 2013; 13:564-569.
19. Zhong Y, Naito Y, Cope L, Naranjo-Suarez S, Saunders T, Hong SM, Goggins MG, Herman JM, Wolfgang CL, Iacobuzio-Donahue CA. Functional p38 MAPK identified by biomarker profiling of pancreatic cancer restrains growth through JNK inhibition and correlates with improved survival. Clinical cancer research. 2014; 20:6200-6211.
20. Kang D, Choi HJ, Kang S, Kim SY, Hwang YS, Je S, Han Z, Kim JH, Song JJ. Ratio of phosphorylated HSP27 to nonphosphorylated HSP27 biphasically acts as a determinant of cellular fate in gemcitabine-resistant pancreatic cancer cells. Cellular signalling. 2015; 27:807-817.
21. McCarty KS, Jr., Miller LS, Cox EB, Konrath J, McCarty KS, Sr. Estrogen receptor analyses. Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies. Archives of pathology & laboratory medicine. 1985; 109:716-721.