Biorheology of Platelet Activation in the Bloodstream Distal to Thrombus Formation

Cellular and Molecular Bioengineering

Volumn 9, Issue 4, 2016, Pages 496-508

  Zilberman Rudenko, Jevgenia ^a   Itakura, Asako ^b,c   Maddala, Jeevan ^a,d   Baker Groberg, Sandra M ^a   Vetter, Ralf ^c   Tucker, Erik I ^a,e   Gruber, András ^a,e,f   Gerdes, Christoph ^c   McCarty, Owen J T ^a,b,e  

^a Oregon Health and Science University Department of Biomedical Engineering   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c BAYER PHARMA AG   (Germany)

^d West Virginia University   (United States)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^f Aronora Inc   (United States)

Author keywords

Biophysics; Factor X; Factor XI; Physical biology; Platelets; Shear; Thrombin

Indexed keywords

BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 11; COLLAGEN; THROMBIN;

ARTICLE; BLOOD CLOTTING; BLOOD FLOW; BLOOD RHEOLOGY; CONTROLLED STUDY; FLOW KINETICS; HEMOSTASIS; HUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; PROTEIN TRANSPORT; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

EID: 84971643840     PISSN: 18655025     EISSN: 18655033     Source Type: Journal    
DOI: 10.1007/s12195-016-0448-5     Document Type: Article

References (23)

1. Abulencia, J. P., N. Tien, O. J. McCarty, D. Plymire, S. A. Mousa, and K. Konstantopoulos. Comparative antiplatelet efficacy of a novel, nonpeptide GPIIb/IIIa antagonist (XV454) and abciximab (c7E3) in flow models of thrombosis. Arterioscler. Thromb. Vasc. Biol. 21:149–156, 2001.
2. Andrews, R. K., and M. C. Berndt. Platelet physiology and thrombosis. Thromb. Res. 114:447–453, 2004.
3. Baker, S. M., K. G. Phillips, and O. J. T. McCarty. Development of a label-free imaging technique for the quantification of thrombus formation. Cell. Mol. Bioeng. 5:488–492, 2012.
4. Baker-Groberg, S. M., F. A. Cianchetti, K. G. Phillips, and O. J. McCarty. Development of a method to quantify platelet adhesion and aggregation under static conditions. Cell. Mol. Bioeng. 7:285–290, 2014.
5. Chang, J. Y. Thrombin specificity. Requirement for apolar amino acids adjacent to the thrombin cleavage site of polypeptide substrate. Eur. J. Biochem. 151:217–224, 1985.
6. Cheng, Q., et al. A role for factor XIIa–mediated factor XI activation in thrombus formation in vivo. Blood 116:3981–3989, 2010.
7. Fogelson, A. L., and K. B. Neeves. Fluid mechanics of blood clot formation. Annu. Rev. Fluid Mech. 47:377–403, 2015.
8. Goodeve, A. C., A. Pavlova, and J. Oldenburg. Genomics of bleeding disorders. Haemoph. Off. J. World Fed. Hemoph. 20(Suppl 4):50–53, 2014.
9. Hathcock, J. J. Flow effects on coagulation and thrombosis. Arterioscler. Thromb. Vasc. Biol. 26:1729–1737, 2006.
10. Itakura, A., et al. Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes. J. Leukoc. Biol. 90:923–927, 2011.
11. Jones, C. M., et al. Measurement science in the circulatory system. Cell. Mol. Bioeng. 7:1–14, 2014.
12. Jonnalagadda, D., L. T. Izu, and S. W. Whiteheart. Platelet secretion is kinetically heterogeneous in an agonist-responsive manner. Blood 120:5209–5216, 2012.
13. Kravtsov, D. V., et al. Factor XI contributes to thrombin generation in the absence of factor XII. Blood 114:452–458, 2009.
14. Lee, A. M., G. W. Tormoen, E. Kanso, O. J. McCarty, and P. K. Newton. Modeling and simulation of procoagulant circulating tumor cells in flow. Front. Oncol. 2:108, 2012.
15. McCarty, O. J., J. P. Abulencia, S. A. Mousa, and K. Konstantopoulos. Evaluation of platelet antagonists in in vitro flow models of thrombosis. Methods Mol. Med. 93:21–34, 2004.
16. McCarty, O. J., et al. Dimensional analysis and scaling relevant to flow models of thrombus formation: communication from the SSC of the ISTH. J. Thromb. Haemost. 14:619–622, 2016.
17. Mousa, S. A., J. P. Abulencia, O. J. McCarty, N. A. Turner, and K. Konstantopoulos. Comparative efficacy between the glycoprotein IIb/IIIa antagonists roxifiban and orbofiban in inhibiting platelet responses in flow models of thrombosis. J. Cardiovasc. Pharmacol. 39:552–560, 2002.
18. Puy, C., et al. Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates. J. Thromb. Haemost. 11:1341–1352, 2013.
19. Roehrig, S., et al. Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor. J. Med. Chem. 48:5900–5908, 2005.
20. Samuel, M., R. A. Pixley, M. A. Villanueva, R. W. Colman, and G. B. Villanueva. Human factor XII (Hageman factor) autoactivation by dextran sulfate. Circular dichroism, fluorescence, and ultraviolet difference spectroscopic studies. J. Biol. Chem. 267:19691–19697, 1992.
21. Tormoen, G. W., S. Rugonyi, A. Gruber, and O. J. McCarty. The role of carrier number on the procoagulant activity of tissue factor in blood and plasma. Phys. Biol. 8:066005, 2011.
22. White-Adams, T. C., et al. Laminin promotes coagulation and thrombus formation in a factor XII-dependent manner. J. Thromb. Haemost. 8:1295–1301, 2010.
23. Zilberman-Rudenko, J., et al. Coagulation factor XI promotes distal platelet activation and single platelet consumption in the bloodstream under shear flow. Arterioscler. Thromb. Vasc. Biol. 36:510–517, 2016.