Synthesis and biological evaluation of novel resveratrol-NSAID derivatives as anti-inflammatory agents

Chemical and Pharmaceutical Bulletin

Volumn 64, Issue 6, 2016, Pages 609-615

  Peng, Wei ^a   Ma, Yan Yan ^a,b   Zhang, Kun ^a,b   Zhou, Ai Yu ^a   Zhang, Yu ^b   Wang, Huaqian ^a   Du, Zhiyun ^a   Zhao, Deng Gao ^a,b  

^a GUANGDONG UNIVERSITY OF TECHNOLOGY   (China)

^b Wuyi University   (China)

Author keywords

Ester derivative; Nonsteroidal antiinflammatory drug (NSAID); Resveratrol

Indexed keywords

4 (3,5 DIHYDROXYSTYRYL)PHENYL 2 (3 BENZOYLPHENYL) PROPANOATE; 4 (3,5 DIHYDROXYSTYRYL)PHENYL 2 (4 ISOBUTYLPHENYL)PROPANOATE; 4 (3,5 DIHYDROXYSTYRYL)PHENYL 2 (6 METHOXYNAPHTHALEN 2 YL)PROPANOATE; 4 (3,5 DIHYDROXYSTYRYL)PHENYL 2 [(2,3 DIMETHYLPHENYL)AMINO]BENZOATE; 4 [3,5 BIS [(TRIISOPROPYLSILYL)OXY]STYRYL]PHENYL 2 (6 METHOXYNAPHTHALEN 2 YL)PROPANOATE; 4 [3,5 BIS[(TRIISOPROPYLSILYL)OXY]STYRYL]PHENYL 2 (3 BENZOYLPHENYL)PROPANOATE; 4 [3,5 BIS[(TRIISOPROPYLSILYL)OXY]STYRYL]PHENYL 2 [(2,3 DIMETHYLPHENYL)AMINO]BENZOATE; 5 [4 [2 [1 (4 CHLOROBENZOYL) 5 METHOXY 2 METHYL 1H INDOL 3 YL]ACETOXY]STYRYL] 1,3 PHENYLENE BIS([2 [1 (4 CHLOROBENZOYL) 5 METHOXY 2 METHYL 1H INDOL 3 YL]ACETATE]; 5 [4 [[2 (3 BENZOYLPHENYL)PROPANOYL]OXY]STYRYL] 1,3 PHENYLENE BIS[2 (3 BENZOYLPHENYL)PROPANOATE]; 5 [4 [[2 (3 BENZOYLPHENYL)PROPANOYL]OXY]STYRYL] 1,3 PHENYLENE BIS[2 [(2,3 DIMETHYLPHENYL)AMINO]BENZOATE]; 5 [4 [[2 (4 ISOBUTYLPHENYL)PROPANOYL]OXY]STYRYL] 1,3 PHENYLENE BIS[2 (3 ISOBUTYLPHENYL)PROPANOATE]; 5 [4 [[2 (6 METHOXYNAPHTHALEN 2 YL)PROPANOYL]OXY]STYRYL] 1,3 PHENYLENE BIS[2 (6 METHOXYNAPHTHALEN 2 YL)PROPANOATE]; 5 [4 [[2 [(3 CHLORO 2 METHYLPHENYL)AMINO]BENZOYL]OXY]STYRYL] 1,3 PHENYLENE BIS[2 [(3 CHLORO 2 MERTHYLPHENYL)AMINO]BENZOATE]; ANTIINFLAMMATORY AGENT; DEXAMETHASONE; IBUPROFEN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; NITRIC OXIDE; RESVERATROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; NONSTEROID ANTIINFLAMMATORY AGENT; STILBENE DERIVATIVE; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFECT; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY; KUNMING MOUSE; MACROPHAGE; MORTALITY; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SEPTIC SHOCK; STOMACH MUCOSA LESION; SURVIVAL RATE; ANIMAL; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; METABOLISM; RAW 264.7 CELL LINE; STOMACH MUCOSA; SYNTHESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL SURVIVAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GASTRIC MUCOSA; IBUPROFEN; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE; RAW 264.7 CELLS; STILBENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84971510698     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c16-00030     Document Type: Article

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