Mapping the specific amino acid residues that make hamster DPP4 functional as a receptor for Middle East respiratory syndrome coronavirus

Journal of Virology

Volumn 90, Issue 11, 2016, Pages 5499-5502

  van Doremalen, Neeltje ^a   Miazgowicz, Kerri L ^a,b   Munster, Vincent J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; AMINO ACID; DPP4 PROTEIN, HUMAN; PROTEIN BINDING; VIRUS RECEPTOR;

AMINO ACID ANALYSIS; ANIMAL CELL; ARTICLE; CASE FATALITY RATE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; VIRUS REPLICATION; VIRUS STRAIN; ANIMAL; CHEMISTRY; CORONAVIRUS INFECTION; DISEASE MODEL; GENETICS; HAMSTER; METABOLISM; MOLECULAR MODEL; PHYSIOLOGY; VIROLOGY; VIRUS ENTRY;

AMINO ACIDS; ANIMALS; CORONAVIRUS INFECTIONS; CRICETINAE; DIPEPTIDYL PEPTIDASE 4; DISEASE MODELS, ANIMAL; HUMANS; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MODELS, MOLECULAR; PROTEIN BINDING; RECEPTORS, VIRUS; VIRUS INTERNALIZATION; VIRUS REPLICATION;

EID: 84971483715     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.03267-15     Document Type: Article

References (17)

1. WHO. Middle East respiratory syndrome coronavirus. WHO, Geneva, Switzerland. http://www.who.int/emergencies/mers-cov/en/.
2. Falzarano D, de Wit E, Feldmann F, Rasmussen AL, Okumura A, Peng X, Thomas MJ, van Doremalen N, Haddock E, Nagy L, LaCasse R, Liu T, Zhu J, McLellan JS, Scott DP, Katze MG, Feldmann H, Munster VJ. 2014. Infection with MERS-CoV causes lethal pneumonia in the common marmoset. PLoS Pathog 10:e1004250. http://dx.doi.org/10.1371/journal.ppat.1004250.
3. de Wit E, Rasmussen AL, Falzarano D, Bushmaker T, Feldmann F, Brining DL, Fischer ER, Martellaro C, Okumura A, Chang J, Scott D, Benecke AG, Katze MG, Feldmann H, Munster VJ. 2013. Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques. Proc Natl Acad Sci U S A 110:16598-16603. http://dx.doi.org/10.1073/pnas.1310744110.
4. Yao Y, Bao L, Deng W, Xu L, Li F, Lv Q, Yu P, Chen T, Xu Y, Zhu H, Yuan J, Gu S, Wei Q, Chen H, Yuen KY, Qin C. 2014. An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus. J Infect Dis 209:236-242. http://dx.doi.org/10.1093/infdis/jit590.
5. Adney DR, van Doremalen N, Brown VR, Bushmaker T, Scott D, de Wit E, Bowen RA, Munster VJ. 2014. Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels. Emerg Infect Dis 20:1999-2005. http://dx.doi.org/10.3201/eid2012.141280.
6. Zhao J, Li K, Wohlford-Lenane C, Agnihothram SS, Fett C, Zhao J, Gale MJ, Jr, Baric RS, Enjuanes L, Gallagher T, McCray PB, Jr, Perlman S. 2014. Rapid generation of a mouse model for Middle East respiratory syndrome. Proc Natl Acad Sci U S A 111:4970-4975. http://dx.doi.org/10.1073/pnas.1323279111.
7. Agrawal AS, Garron T, Tao X, Peng BH, Wakamiya M, Chan TS, Couch RB, Tseng CT. 2015. Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease. J Virol 89: 3659-3670. http://dx.doi.org/10.1128/JVI.03427-14.
8. Pascal KE, Coleman CM, Mujica AO, Kamat V, Badithe A, Fairhurst J, Hunt C, Strein J, Berrebi A, Sisk JM, Matthews KL, Babb R, Chen G, Lai KM, Huang TT, Olson W, Yancopoulos GD, Stahl N, Frieman MB, Kyratsous CA. 2015. Pre-and postexposure efficacy of fully human antibodies against spike protein in a novel humanized mouse model of MERSCoVinfection. Proc Natl Acad SciUSA112:8738-8743. http://dx.doi.org/10.1073/pnas.1510830112.
9. Fan Z, Li W, Lee SR, Meng Q, Shi B, Bunch TD, White KL, Kong IK, Wang Z. 2014. Efficient gene targeting in golden Syrian hamsters by the CRISPR/Cas9 system. PLoS One 9:e109755. http://dx.doi.org/10.1371/journal.pone.0109755.
10. Gao M, Zhang B, Liu J, Guo X, Li H, Wang T, Zhang Z, Liao J, Cong N, Wang Y, Yu L, Zhao D, Liu G. 2014. Generation of transgenic golden Syrian hamsters. Cell Res 24:380-382. http://dx.doi.org/10.1038/cr.2014.2.
11. Lu G, Hu Y, Wang Q, Qi J, Gao F, Li Y, Zhang Y, Zhang W, Yuan Y, Bao J, Zhang B, Shi Y, Yan J, Gao GF. 2013. Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature 500:227-231. http://dx.doi.org/10.1038/nature12328.
12. Wang N, Shi X, Jiang L, Zhang S, Wang D, Tong P, Guo D, Fu L, Cui Y, Liu X, Arledge KC, Chen YH, Zhang L, Wang X. 2013. Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4. Cell Res 23:986-993. http://dx.doi.org/10.1038/cr.2013.92.
13. van Doremalen N, Miazgowicz KL, Milne-Price S, Bushmaker T, Robertson S, Scott D, Kinne J, McLellan JS, Zhu J, Munster VJ. 2014. Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4. J Virol 88:9220-9232. http://dx.doi.org/10.1128/JVI.00676-14.
14. Finney DJ. 1964. Statistical method in biological assay. Hafner Publishing Co, New York, NY.
15. Schrödinger. The PyMOL molecular graphics system, v1.7.4. Schrödinger, New York, NY.
16. Cockrell AS, Peck KM, Yount BL, Agnihothram SS, Scobey T, Curnes NR, Baric RS, Heise MT. 2014. Mouse dipeptidyl peptidase 4 is not a functional receptor for Middle East respiratory syndrome coronavirus infection. J Virol 88:5195-5199. http://dx.doi.org/10.1128/JVI.03764-13.
17. Peck KM, Cockrell AS, Yount BL, Scobey T, Baric RS, Heise MT. 2015. Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection. J Virol 89:4696-4699. http://dx.doi.org/10.1128/JVI.03445-14.