Bisphenol A glucuronide/sulfate diconjugate in perfused liver of rats

Journal of Veterinary Medical Science

Volumn 78, Issue 5, 2016, Pages 733-737

  Inoue, Hiroki ^a   Kemanai, Shino ^a   Sano, Chie ^a   Kato, Seiyu ^a   Yokota, Hiroshi ^a   Iwano, Hidetomo ^a  

^a RAKUNO GAKUEN UNIVERSITY   (Japan)

Author keywords

Bisphenol A; Diconjugation; Glucuronide conjugation; Liver perfusion; Sulfate conjugation

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; BENZHYDRYL DERIVATIVE; BISPHENOL A GLUCURONIDE; GLUCURONIDE; PHENOL DERIVATIVE; SULFATE;

ANIMAL; CHEMISTRY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER; MALE; METABOLISM; PERFUSION; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; BENZHYDRYL COMPOUNDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; GLUCURONIDES; LIVER; MALE; PERFUSION; PHENOLS; RATS; RATS, SPRAGUE-DAWLEY; SULFATES;

EID: 84971468283     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.15-0573     Document Type: Article

References (23)

1. Bock, K. W. 2003. Vertebrate UDP-glucuronosyltransferases: functional and evolutionary aspects. Biochem. Pharmacol. 66: 691–696. [Medline] [CrossRef]
2. Brotons, J. A., Olea-Serrano, M. F., Villalobos, M., Pedraza, V. and Olea, N. 1995. Xenoestrogens released from lacquer coatings in food cans. Environ. Health Perspect. 103: 608–612. [Medline] [CrossRef]
3. Calafat, A. M., Kuklenyik, Z., Reidy, J. A., Caudill, S. P., Ekong, J. and Needham, L. L. 2005. Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population. Environ. Health Perspect. 113: 391–395. [Medline] [CrossRef]
4. Inoue, H., Tsuruta, A., Kudo, S., Ishii, T., Fukushima, Y., Iwano, H., Yokota, H. and Kato, S. 2005. Bisphenol A glucuronidation and excretion in liver of pregnant and nonpregnant female rats. Drug Metab. Dispos. 33: 55–59. [Medline] [CrossRef]
5. Inoue, H., Yokota, H., Makino, T., Yuasa, A. and Kato, S. 2001. Bisphenol A glucuronide, a major metabolite in rat bile after liver perfusion. Drug Metab. Dispos. 29: 1084–1087. [Medline]
6. Klaassen, C. D., Liu, L. and Dunn, R. T. 1998. Regulation of sulfotransferase mRNA expression in male and female rats of various ages. Chem. Biol. Interact. 109: 299–313. [Medline] [CrossRef]
7. Krishnan, A. V., Stathis, P., Permuth, S. F., Tokes, L. and Feldman, D. 1993. Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology 132: 2279–2286. [Medline]
8. Kurebayashi, H., Nagatsuka, S., Nemoto, H., Noguchi, H. and Ohno, Y. 2005. Disposition of low doses of 14C-bisphenol A in male, female, pregnant, fetal, and neonatal rats. Arch. Toxicol. 79: 243–252. [Medline] [CrossRef]
9. Mackenzie, P. I., Owens, I. S., Burchell, B., Bock, K. W., Bairoch, A., Belanger, A., Fournel-Gigleux, S., Green, M., Hum, D. W., Iyanagi, T., Lancet, D., Louisot, P., Magdalou, J., Chowdhury, J. R., Ritter, J. K., Schachter, H., Tephly, T. R., Tipton, K. F. and Nebert, D. W. 1997. The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. Pharmacogenetics 7: 255–269. [Medline] [CrossRef]
10. National Toxicology Program. 1982. Carcinogenesis Bioassay of Bisphenol A (CAS No. 80-05-7) in F344 Rats and B6C3F1 Mice (Feed Study). Technical Report Series, 215.
11. Nishikawa, M., Iwano, H., Yanagisawa, R., Koike, N., Inoue, H. and Yokota, H. 2010. Placental transfer of conjugated bisphenol A and subsequent reactivation in the rat fetus. Environ. Health Perspect. 118: 1196–1203. [Medline] [CrossRef]
12. Nishiyama, T., Ogura, K., Nakano, H., Kaku, T., Takahashi, E., Ohkubo, Y., Sekine, K., Hiratsuka, A., Kadota, S. and Watabe, T. 2002. Sulfation of environmental estrogens by cytosolic human sulfotransferases. Drug Metab. Pharmacokinet. 17: 221–228. [Medline] [CrossRef]
13. Pottenger, L. H., Domoradzki, J. Y., Markham, D. A., Hansen, S. C., Cagen, S. Z. and Waechter, J. M. Jr.. 2000. The relative bioavailability and metabolism of bisphenol A in rats is dependent upon the route of administration. Toxicol. Sci. 54: 3–18. [Medline] [CrossRef]
14. Pritchett, J. J., Kuester, R. K. and Sipes, I. G. 2002. Metabolism of bisphenol a in primary cultured hepatocytes from mice, rats, and humans. Drug Metab. Dispos. 30: 1180–1185. [Medline] [CrossRef]
15. Sakamoto, H., Yokota, H., Kibe, R., Sayama, Y. and Yuasa, A. 2002. Excretion of bisphenol A-glucuronide into the small intestine and deconjugation in the cecum of the rat. Biochim. Biophys. Acta 1573: 171–176. [Medline] [CrossRef]
16. Shelby, M. K., Cherrington, N. J., Vansell, N. R. and Klaassen, C. D. 2003. Tissue mRNA expression of the rat UDP-glucuronosyltransferase gene family. Drug Metab. Dispos. 31: 326–333. [Medline] [CrossRef]
17. Shimizu, M., Ohta, K., Matsumoto, Y., Fukuoka, M., Ohno, Y. and Ozawa, S. 2002. Sulfation of bisphenol A abolished its estrogenicity based on proliferation and gene expression in human breast cancer MCF-7 cells. Toxicol. In Vitro 16: 549–556. [Medline] [CrossRef]
18. Ugele, B., St-Pierre, M. V., Pihusch, M., Bahn, A. and Hantschmann, P. 2003. Characterization and identification of steroid sulfate transporters of human placenta. Am. J. Physiol. Endocrinol. Metab. 284: E390–398. [Medline] [CrossRef]
19. vom Saal, F. S. and Hughes, C. 2005. An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment. Environ. Health Perspect. 113: 926–933. [Medline] [CrossRef]
20. Yokota, H., Iwano, H., Endo, M., Kobayashi, T., Inoue, H., Ikushiro, S. and Yuasa, A. 1999. Glucuronidation of the environmental oestrogen bisphenol A by an isoform of UDP-glucuronosyltransferase, UGT2B1, in the rat liver. Biochem. J. 340: 405–409. [Medline] [CrossRef]
21. Zamek-Gliszczynski, M. J., Day, J. S., Hillgren, K. M. and Phillips, D. L. 2011. Efflux transport is an important determinant of ethinylestradiol glucuronide and ethinylestradiol sulfate pharmacokinetics. Drug Metab. Dispos. 39: 1794–1800. [Medline] [CrossRef]
22. Zamek-Gliszczynski, M. J., Hoffmaster, K. A., Humphreys, J. E., Tian, X., Nezasa, K. and Brouwer, K. L. 2006. Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat. J. Pharmacol. Exp. Ther. 319: 459–467. [Medline] [Cross- Ref]
23. Zhou, F., Tanaka, K., Soares, M. J. and You, G. 2003. Characterization of an organic anion transport system in a placental cell line. Am. J. Physiol. Endocrinol. Metab. 285: E1103–1109. [Medline] [CrossRef]