Excretion of bisphenol A-glucuronide into the small intestine and deconjugation in the cecum of the rat

Biochimica et Biophysica Acta - General Subjects

Volumn 1573, Issue 2, 2002, Pages 171-176

  Sakamoto, Hirokazu ^a   Yokota, Hiroshi ^a   Kibe, Ryoko ^a   Sayama, Yoshikatu ^b   Yuasa, Akira ^a  

^a RAKUNO GAKUEN UNIVERSITY   (Japan)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Bisphenol A; Deconjugation; Digestive tract; Glucuronidation; UDP glucuronosyltransferase

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; BACTERIAL ENZYME; BETA GASE; BETA GLUCURONIDASE; ENZYME ANTIBODY; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; UNCLASSIFIED DRUG;

ABSORPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CECUM; CONJUGATION; CONTROLLED STUDY; ENTEROHEPATIC CIRCULATION; ENZYME ACTIVITY; HYDROLYSIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMALL INTESTINE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CECUM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FECES; GASTROINTESTINAL CONTENTS; GLUCURONIDASE; GLUCURONIDES; INTESTINE, SMALL; MALE; PHENOLS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0037078915     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4165(02)00418-X     Document Type: Article

References (32)

1. Kirach K.S. Editorial: suprising places of estrogenic activity. Endocrinology. 132:1993;2277-2278.
2. Stone R. Environmental estrogens stir debate. Science. 265:1994;308-310.
3. Lazear N.R. Polycarbonate: high-performance resin. Adv. Mater. Process. 417:1994;43-45.
4. Ben-Jonathan N., Steinmetz R. Xenoestrogens: the emerging story of bisphenol A. Trends Endocrinol. Metab. 9:1998;124-128.
5. Howdeshell K.L., Hotchkiss A.K., Thayer K.A., Vandenbergh J.G., vom Saal F.S. Exposure to bisphenol A advances puberty. Nature. 401(6755):1999;763-764.
6. Knaak J.B., Sullivan L.J. Metabolism of bisphenol A in the rat. Toxicol. Appl. Pharmacol. 8(2):1966;175-184.
7. Yokota H., Iwano H., Endo M., Kobayashi T., Inoue H., Ikushiro S., Yuasa A. Glucuronidation of the environmental oestrogen bisphenol A by an isoform of UDP-glucuronosyltransferase, UGT2B1, in the rat liver. Biochem. J. 340(Pt. 2):1999;405-409.
8. Inoue H., Yokota H., Makino T., Yuasa A., Kato S. Bisphenol A glucuronide, a major metabolite in rat bile after liver perfusion. Drug Metab. Dispos. 29(8):2001;1084-1087.
9. Matsumoto J., Yokota H., Yuasa A. Developmental increase in rat hepatic microsomal UDP-glucuronosyltransferase activities toward xenoestrogens and decrease during pregnancy. Environ. Health Perspect. 110(2):2002;193-196.
10. Goldwin B.R., Gorbach S.L. The relationship between diet and rat fecal bacterial enzymes implicated in colon cancer. J. Natl. Cancer Inst. 57(2):1976;371-375.
11. Howe J.G., Hershey J.W. A sensitive immunoblotting method for measuring protein synthesis initiation factor levels in lysates of Escherichia coli. J. Biol. Chem. 256(24):1981;12836-12839.
12. Yokota H., Yuasa A. Increase of a form of UDP-glucuronyltransferase glucuronizing various phenolic xenobiotics and the corresponding translatable mRNA in 3-methylcholanthrene-treated rat liver. J. Biochem. (Tokyo). 107(1):1990;92-96.
13. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
14. Himeno M., Nishimura Y., Tsuji H., Kato K. Purification and characterization of microsomal and lysosomal b-glucuronidase from rat liver by use of immunoaffinity chromatography. Eur. J. Biochem. 70:1976;349-359.
15. Hawksworth G., Drasar B.S., Hill M.J. Intestinal bacteria and the hydrolysis of glycosidic bonds. Med. Microbiol. 4:1971;451-459.
16. Upmerier A., Degen G.H., Michna P.D.H., Bolt H.M. Toxicokinetics of bisphenol A in female DA/Han rats after a single i.v. and oral administration. Arch. Toxicol. 74:2000;431-436.
17. Pottenger L.H., Domoradzki J.Y., Markham D.A., Hansen S.C., Cagen S.Z., Waechter J.M. Jr. The relative bioavailability and metabolism of bisphenol A in rats is dependent upon the route of administration. Toxicol. Sci. 54:2000;3-18.
18. Levine W.G. Biliary excretion of drugs and other xenobiotics. Annu. Rev. Pharmacol. Toxicol. 18:1978;81-96.
19. Rollins D.E., Klaassen C.D. Biliary excretion of drugs in man. Clin. Pharmacokinet. 4:1979;368-379.
20. Ramos J.G., Varayoud J., Sonnenschein C., Soto A.M., Munoz De Toro M., Luque E.H. Prenatal exposure to low doses of bisphenol A alters the periductal stroma and glandular cell function in the rat ventral prostate. Biol. Reprod. 65:2001;1271-1277.
21. Rubin B.S., Murray M.K., Damassa D.A., King J.C., Soto A.M. Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels. Environ. Health Perspect. 109:2001;675-680.
22. Cagen S.Z., Waechter J.M. Jr., Dimond S.S., Breslin W.J., Butala J.H., Jekat F.W., Joiner R.L., Shiotsuka R.N., Veenstra G.E., Harris L.R. Normal reproductive organ development in Wistar rats exposed to bisphenol A in the drinking water. Regul. Toxicol. Pharmacol. 30:1999;130-139.
23. Ema M., Fujii S., Furukawa M., Kiguchi M., Ikka T., Harazono A. Rat two-generation reproductive toxicity study of bisphenol A. Reprod. Toxicol. 15:2001;505-523.
24. Rowland I.R., Mallett A.K., Bearne C.A., Farthing M.J. Enzyme activities of the hindgut microflora of laboratory animals and man. Xenobiotica. 16:1986;519-523.
25. Rowland I.R. Factors affecting metabolic activity of the intestinal microflora. Drug Metab. Rev. 19:1988;243-261.
26. Goldin B.R., Gorbach S.L. The relationship between diet and rat fecal bacterial enzymes implicated in colon cancer. J. Natl. Cancer Inst. 57:1976;371-375.
27. Lidbeck A., Nord C.E., Gustafsson J.A., Rafter J. Lactobacilli, anticarcinogenic activities and human intestinal microflora. Eur. J. Cancer Prev. 1:1992;341-353.
28. Goldin B.R., Gorbach S.L. Effect of Lactobacillus acidophilus dietary supplements on 1,2-dimethylhydrazine dihydrochloride-induced intestinal cancer in rats. J. Natl. Cancer Inst. 64:1980;263-265.
29. Goldin B.R., Gorbach S.L. The effect of milk and lactobacillus feeding on human intestinal bacterial enzyme activity. Am. J. Clin. Nutr. 39:1984;756-761.
30. Eriyamremu G.E., Osagie V.E., Alufa O.I., Osaghae M.O., Oyibu F.A. Early biochemical events in mice exposed to cycas and fed a Nigerian-like diet. Ann. Nutr. Metab. 39:1995;42-51.
31. Reddy B.S., Mangat S., Weisburger J.H., Wynder E.L. Effect of high-risk diets for colon carcinogenesis on intestinal mucosal and bacterial beta-glucuronidase activity in F344 rats. Cancer Res. 37:1977;3533-3536.
32. McIntosh G.H., Royle P.J., Pointing G. Wheat aleurone flour increases cecal beta-glucuronidase activity and butyrate concentration and reduces colon adenoma burden in azoxymethane-treated rats. J. Nutr. 131:2001;127-131.