αB-crystallin interacts with Nav1.5 and regulates ubiquitination and internalization of cell surface Nav1.5

Journal of Biological Chemistry

Volumn 291, Issue 21, 2016, Pages 11030-11041

  Huang, Yuan ^a   Wang, Zhijie ^a   Liu, Yinan ^a   Xiong, Hongbo ^a   Zhao, Yuanyuan ^a   Wu, Ling ^b,c   Yuan, Chao ^a   Wang, Longfei ^a   Hou, Yuxi ^d   Yu, Gang ^a   Huang, Zhengrong ^d   Xu, Chengqi ^a   Chen, Qiuyun ^b   Wang, Qing K ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b LERNER RESEARCH INSTITUTE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CELLS; CYTOLOGY; HEART; PROTEINS;

CARDIAC ACTION POTENTIAL; CARDIAC ARRHYTHMIA; CELL SURFACE EXPRESSION; CO-IMMUNOPRECIPITATIONS; COIMMUNOPRECIPITATION ANALYSIS; INITIATION AND PROPAGATION; MOLECULAR MECHANISM; PROTEIN-PROTEIN INTERACTIONS;

SODIUM;

ALPHA CRYSTALLIN; NEDD4-2 PROTEIN; SODIUM CHANNEL NAV1.5; UBIQUITIN PROTEIN LIGASE NEDD4; UNCLASSIFIED DRUG; CRYAB PROTEIN, HUMAN; ESCRT PROTEIN; MUTANT PROTEIN; NEDD4 UBIQUITIN PROTEIN LIGASES; PROTEIN BINDING; RECOMBINANT PROTEIN; SCN5A PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL SURFACE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INTERNALIZATION; NEWBORN; NONHUMAN; NONSENSE MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; SODIUM CURRENT; UBIQUITINATION; UPREGULATION; WHOLE CELL PATCH CLAMP; ANIMAL; CARDIAC MUSCLE; CELL LINE; CELL MEMBRANE; CHEMISTRY; GENE SILENCING; GENETICS; HEK293 CELL LINE; METABOLISM; PROTEIN DOMAIN; PROTEIN STABILITY; PROTEIN TRANSPORT;

ALPHA-CRYSTALLIN B CHAIN; ANIMALS; CELL LINE; CELL MEMBRANE; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; MUTANT PROTEINS; MYOCARDIUM; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STABILITY; PROTEIN TRANSPORT; RATS; RECOMBINANT PROTEINS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84971449979     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.695080     Document Type: Article

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