Role of TFEB Mediated Autophagy, Oxidative Stress, Inflammation, and Cell Death in Endotoxin Induced Myocardial Toxicity of Young and Aged Mice

Oxidative Medicine and Cellular Longevity

Volumn 2016, Issue , 2016, Pages

  Li, Fang ^a   Lang, Fangfang ^a   Zhang, Huilin ^a   Xu, Liangdong ^a   Wang, Yidan ^a   Hao, Enkui ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOLOGY; CELL DEATH; HEART; OXIDATIVE STRESS; PATHOLOGY;

CARDIAC FUNCTIONS; CARDIOPROTECTION; EJECTION FRACTION; LACTATE DEHYDROGENASE; LEFT VENTRICULAR; MYOCARDIAL INJURY; MYOSIN LIGHT CHAINS; THERAPEUTIC STRATEGY;

MAMMALS;

CARDIAC MYOSIN; CREATINE KINASE; ENDOTOXIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HISTONE H3; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; LIPOPOLYSACCHARIDE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; MYOSIN LIGHT CHAIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB; TROPONIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; TCFEB PROTEIN, MOUSE;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CARDIOTOXICITY; CELL DEATH; CONTROLLED STUDY; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE VOLUME; HEART MUSCLE INJURY; HEART PROTECTION; INFLAMMATION; MALE; MOUSE; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; SEPSIS; ANIMAL; C57BL MOUSE; CARDIAC MUSCLE; DRUG EFFECTS; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

AGING; ANIMALS; AUTOPHAGY; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; ENDOTOXINS; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MICE, INBRED C57BL; MYOCARDIUM; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

EID: 84971385315     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2016/5380319     Document Type: Article

References (47)

1. R. Umberger, B. Callen, and M. L. Brown, "Severe sepsis in older adults, " Critical Care Nursing Quarterly, vol. 38, no. 3, pp. 259-270, 2015.
2. J. Carbajal-Guerrero, A. Cayuela-Domínguez, E. Fernández-García et al., "Epidemiology and long-term outcome of sepsis in elderly patients, " Medicina Intensiva, vol. 38, no. 1, pp. 21-32, 2014.
3. P. Nasa, D. Juneja, and O. Singh, "Severe sepsis and septic shock in the elderly: an overview, "World Journal of Critical Care Medicine, vol. 1, no. 1, pp. 23-30, 2012.
4. H. Palomba, T. D. Corrêa, E. Silva, A. Pardini, and M. S. de Assuncao, "Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients, " Einstein, vol. 13, no. 3, pp. 357-363, 2015.
5. D. Heymann, "Autophagy: a protective mechanism in response to stress and inflammation, " Current Opinion in Investigational Drugs, vol. 7, no. 5, pp. 443-450, 2006.
6. D. C. Rubinsztein, G. Mariño, and G. Kroemer, "Autophagy and aging, " Cell, vol. 146, no. 5, pp. 682-695, 2011.
7. L. Knuppertz and H. D. Osiewacz, "Orchestrating the network of molecular pathways affecting aging: role of nonselective autophagy and mitophagy, " Mechanisms of Ageing and Development, vol. 153, pp. 30-40, 2016.
8. L. J. Leon and A. B. Gustafsson, "Staying young at heart: autophagy and adaptation to cardiac aging, " Journal of Molecular and Cellular Cardiology, 2015.
9. C. Settembre and A. Ballabio, "TFEB regulates autophagy: an integrated coordination of cellular degradation and recycling processes, " Autophagy, vol. 7, no. 11, pp. 1379-1381, 2011.
10. M. Palmieri, S. Impey, H. Kang et al., "Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways, " Human Molecular Genetics, vol. 20, no. 19, Article ID ddr306, pp. 3852-3866, 2011.
11. J. Wu, S. Xia, B. Kalionis, W. Wan, and T. Sun, "The role of oxidative stress and inflammation in cardiovascular aging, " BioMed Research International, vol. 2014, Article ID 615312, 13 pages, 2014.
12. D.-F. Dai and P. S. Rabinovitch, "Cardiac aging in mice and humans: the role of mitochondrial oxidative stress, " Trends in Cardiovascular Medicine, vol. 19, no. 7, pp. 213-220, 2009.
13. P. Pacher, J. S. Beckman, and L. Liaudet, "Nitric oxide and peroxynitrite in health and disease, " Physiological Reviews, vol. 87, no. 1, pp. 315-424, 2007.
14. E. Hao, F. Lang, Y. Chen et al., "Resveratrol alleviates endotoxininduced myocardial toxicity via the Nrf2 transcription factor, " PLoS ONE, vol. 8, no. 7, Article ID e69452, 2013.
15. E. Hao, P. Mukhopadhyay, Z. Cao et al., "Cannabidiol protects against doxorubicin-induced cardiomyopathy by modulating mitochondrial function and biogenesis, " Molecular Medicine, vol. 21, pp. 38-45, 2015.
16. T. D. Schmittgen and K. J. Livak, "Analyzing real-time PCR data by the comparative CT method, " Nature Protocols, vol. 3, no. 6, pp. 1101-1108, 2008.
17. F. Lang, Z. Qin, F. Li, H. Zhang, Z. Fang, and E. Hao, "Apoptotic cell death induced by resveratrol is partially mediated by the autophagy pathway in human ovarian cancer cells, " PLoS ONE, vol. 10, no. 6, Article ID e0129196, 2015.
18. M. K. ElZarrad, P. Mukhopadhyay, N. Mohan et al., "Trastuzumab alters the expression of genes essential for cardiac function and induces ultrastructural changes of cardiomyocytes in mice, " PLoS ONE, vol. 8, no. 11, Article ID e79543, 2013.
19. S. Bátkai, M. Rajesh, P. Mukhopadhyay et al., "Decreased agerelated cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase, " American Journal of Physiology-Heart andCirculatory Physiology, vol. 293, no. 2, pp. H909-H918, 2007.
20. K. Boengler, A. Buechert, Y. Heinen et al., "Cardioprotection by ischemic postconditioning is lost in aged and STAT3-deficient mice, " Circulation Research, vol. 102, no. 1, pp. 131-135, 2008.
21. R. M. Grocott-Mason and A. M. Shah, "Cardiac dysfunction in sepsis: new theories and clinical implications, " Intensive Care Medicine, vol. 24, no. 4, pp. 286-295, 1998.
22. A. F. Suffredini, R. E. Fromm, M. M. Parker et al., "The cardiovascular response of normal humans to the administration of endotoxin, " The New England Journal of Medicine, vol. 321, no. 5, pp. 280-287, 1989.
23. S.-Y. Li, M. Du, E. K. Dolence et al., "Aging induces cardiac diastolic dysfunction, oxidative stress, accumulation of advanced glycation endproducts and protein modification, " Aging Cell, vol. 4, no. 2, pp. 57-64, 2005.
24. J. M. Capasso, T. Palackal, G. Olivetti, and P. Anversa, "Severe myocardial dysfunction induced by ventricular remodeling in aging rat hearts, " American Journal of Physiology-Heart and Circulatory Physiology, vol. 259, no. 4, pp. H1086-H1096, 1990.
25. J. L. Fleg, "Normative aging changes in cardiovascular structure and function, "TheAmerican Journal ofGeriatricCardiology, vol. 5, pp. 7-15, 1996.
26. E. G. Lakatta, "Changes in cardiovascular function with aging, " European Heart Journal, vol. 11, pp. 22-29, 1990.
27. M. D. Cheitlin, "Cardiovascular physiology-changes with aging, " The American Journal of Geriatric Cardiology, vol. 12, no. 1, pp. 9-13, 2003.
28. R. S. Whelan, V. Kaplinskiy, and R. N. Kitsis, "Cell death in the pathogenesis of heart disease: mechanisms and significance, " Annual Review of Physiology, vol. 72, pp. 19-44, 2009.
29. S. L. Fink and B. T. Cookson, "Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells, " Infection and Immunity, vol. 73, no. 4, pp. 1907-1916, 2005.
30. R. S. Vasan, L. M. Sullivan, R. Roubenoff et al., "Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study, " Circulation, vol. 107, no. 11, pp. 1486-1491, 2003.
31. J. Baynes and D. B. Murray, "Cardiac and renal function are progressively impaired with aging in Zucker diabetic fatty type II diabetic rats, " OxidativeMedicine and Cellular Longevity, vol. 2, no. 5, pp. 328-334, 2009.
32. M. Coggins and A. Rosenzweig, "The fire within: cardiac inflammatory signaling in health and disease, " Circulation Research, vol. 110, no. 1, pp. 116-125, 2012.
33. J. W. Gordon, J. A. Shaw, and L. A. Kirshenbaum, "Multiple facets of NF-B in the heart: to be or not to NF-B, " Circulation Research, vol. 108, no. 9, pp. 1122-1132, 2011.
34. Q. S. Zang, S. E. Wolf, and J. P. Minei, "Sepsis-induced cardiac mitochondrial damage and potential therapeutic interventions in the elderly, " Aging and Disease, vol. 5, no. 2, pp. 137-149, 2014.
35. R. Radi, "Nitric oxide, oxidants, and protein tyrosine nitration, " Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 12, pp. 4003-4008, 2004.
36. M. M. Elahi, Y. X. Kong, and B. M. Matata, "Oxidative stress as a mediator of cardiovascular disease, " Oxidative Medicine and Cellular Longevity, vol. 2, no. 5, pp. 259-269, 2009.
37. P. Mukhopadhyay, M. Rajesh, S. Bátkai et al., "Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro, " American Journal of Physiology- Heart and Circulatory Physiology, vol. 296, no. 5, pp. H1466-H1483, 2009.
38. K. Nishida, M. Taneike, and K. Otsu, "The role of autophagic degradation in the heart, " Journal of Molecular and Cellular Cardiology, vol. 78, pp. 73-79, 2015.
39. C. Settembre, C. Di Malta, V. A. Polito et al., "TFEB links autophagy to lysosomal biogenesis, " Science, vol. 332, no. 6036, pp. 1429-1433, 2011.
40. E. E. Essick and F. Sam, "Oxidative stress and autophagy in cardiac disease, neurological disorders, aging and cancer, " OxidativeMedicine and Cellular Longevity, vol. 3, no. 3, pp. 168-177, 2010.
41. A. B. Gustafsson and R. A. Gottlieb, "Recycle or die: the role of autophagy in cardioprotection, " Journal of Molecular and Cellular Cardiology, vol. 44, no. 4, pp. 654-661, 2008.
42. C. Huang, S. Yitzhaki, C. N. Perry et al., "Autophagy induced by ischemic preconditioning is essential for cardioprotection, " Journal of Cardiovascular Translational Research, vol. 3, no. 4, pp. 365-373, 2010.
43. A. Nakai, O. Yamaguchi, T. Takeda et al., "The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress, " Nature Medicine, vol. 13, no. 5, pp. 619-624, 2007.
44. E. J. Feeney, C. Spampanato, R. Puertollano, A. Ballabio, G. Parenti, and N. Raben, "What else is in store for autophagy? Exocytosis of autolysosomes as a mechanism of TFEB-mediated cellular clearance in Pompe disease, " Autophagy, vol. 9, no. 7, pp. 1117-1118, 2013.
45. M. Decressac, B. Mattsson, P. Weikop, M. Lundblad, J. Jakobsson, and A. Björklund, "TFEB-mediated autophagy rescues midbrain dopamine neurons from-synuclein toxicity, " Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 19, pp. E1817-E1826, 2013.
46. A. Terman and U. T. Brunk, "Autophagy in cardiac myocyte homeostasis, aging, and pathology, " Cardiovascular Research, vol. 68, no. 3, pp. 355-365, 2005.
47. S. Kostin, L. Pool, A. Elsässer et al., "Myocytes die by multiple mechanisms in failing human hearts, " Circulation Research, vol. 92, no. 7, pp. 715-724, 2003.