Ex-vivo characterization of circulating colon cancer cells distinguished in stem and differentiated subset provides useful biomarker for personalized metastatic risk assessment

Journal of Translational Medicine

Volumn 14, Issue 1, 2016, Pages

  Malara, Natalia ^a   Trunzo, Valentina ^a   Foresta, Umberto ^b   Amodio, Nicola ^b   De Vitis, Stefania ^a   Roveda, Laura ^b   Fava, Mariagiovanna ^b   Coluccio, MariaLaura ^a   Macrì, Roberta ^a   Di Vito, Anna ^a   Costa, Nicola ^a   Mignogna, Chiara ^a   Britti, Domenico ^a   Palma, Ernesto ^a   Mollace, Vincenzo ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b Dipartimento di Medicina Sperimentale e Clinica   (Italy)

Author keywords

Circulating colon tumor differentiated stem cells; Metastatic risk stratification

Indexed keywords

CD133 ANTIGEN; CD45 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CYTOKERATIN 20; INTERLEUKIN 6; INTERLEUKIN 8; STROMAL CELL DERIVED FACTOR 1; CYTOKINE; TUMOR MARKER;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER PROGNOSIS; CANCER RISK; CANCER STEM CELL; CANCER SURVIVAL; CELL DIFFERENTIATION; CELL EXPANSION; CELL PROLIFERATION; CELL SELECTION; CIRCULATING TUMOR CELL; CLINICAL ARTICLE; COLON CANCER; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MALE; METASTASIS POTENTIAL; MOUSE; NONHUMAN; OVERALL SURVIVAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEOMICS; RISK ASSESSMENT; TUMOR XENOGRAFT; WESTERN BLOTTING; ANIMAL; CELL ADHESION; CELL CYCLE; CELL SHAPE; CELL SURVIVAL; COLON TUMOR; DRUG SCREENING; METABOLISM; METASTASIS; MIDDLE AGED; PATHOLOGY; PERSONALIZED MEDICINE; SCID MOUSE; TUMOR EMBOLISM;

ADULT; AGED; ANIMALS; BIOMARKERS, TUMOR; CELL ADHESION; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; COLONIC NEOPLASMS; CYTOKINES; FEMALE; HUMANS; MALE; MICE, SCID; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASTIC CELLS, CIRCULATING; NEOPLASTIC STEM CELLS; PRECISION MEDICINE; RISK ASSESSMENT; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84971325358     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-016-0876-y     Document Type: Article

References (22)

1. Powell AA, Talasaz AH, Zhang H, Coram MA, Reddy A, Deng G, Telli ML, Advani RH, Carlson RW, Mollick JA, Sheth S, Kurian AW, Ford JM, Stockdale FE, Quake SR, Pease RF, Mindrinos MN, Bhanot G, Dairkee SH, Davis RW, Jeffrey SS. Single cell profiling of circulating tumor cells: transcriptional heterogeneity and diversity from breast cancer cell lines. PLoS One. 2012;7(5):e33788.
2. Kim MY, Oskarsson T, Acharyya S, Nguyen DX, Zhang XHF, Norton L, Massague J. Tumor self-seeding by circulating cancer cells. Cell. 2009;139(7):1315-26.
3. Marusyk A, Polyak K. Tumor heterogeneity: causes and consequences. BBA-Rev. Biochim Biophys Acta. 2010;1805(1):105-17.
4. Shackleton M, Quintana E, Fearon ER, Morrison SJ. Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell. 2009;138(5):822-9.
5. English D, Andersen BR. Single-step separation of red blood cells. Granulocytes and mononuclear leukocytes on discontinuous density gradients of Ficoll-Hypaque. J Immunol Methods. 1974;5:249-52.
6. Malara NM, Givigliano F, Trunzo V, Macrina L, Raso C, Amodio N, Aprigliano S, Minniti AM, Russo V, Roveda L, Coluccio ML, Fini M, Voci P, Prati U, Di Fabrizio E, Mollace V. In vitro expansion of tumour cells derived from blood and tumour tissue is useful to redefine personalized treatment in non-small cell lung cancer patients. J Biol Regul Homeost Agents. 2014;28(4):717-31.
7. Malara N, Coluccio ML, Limongi T, Asande M, Trunzo V, Cojoc G, Raso C, Calderolo P, Perozziello G, Raimondo R, De Vitis S, Roveda L, Renne M, Prati U, Mollace V, Di Fabrizio E. Folic acid functionalized surface highlights 5-methylcytosine-genomic content within circulating tumor cells. Small. 2014;10(21):4324-31.
8. Li M, Zhang B, Zhang Z, Liu X, Qi X, Zhao J, Jiang Y, Zhai H, Ji Y, Luo D. Stem cell-like circulating tumor cells indicate poor prognosis in gastric cancer. Biomed Res Int. 2014;2014:981261.
9. Iinuma H, Watanabe T, Mimori K, Adachi M, Hayashi N, Tamura J, Matsuda K, Fukushima R, Okinaga K, Sasako M, Mori M. Clinical significance of circulating tumor cells, including cancer stem-like cells, in peripheral blood for recurrence and prognosis in patients with Dukes' stage B and C colorectal cancer. J Clin Oncol. 2011;29(12):1547-55.
10. General Assembly of the World Medical Association. World medical association declaration of Helsinki: ethical principles for medical research involving human subjects.
11. Simone G, Malara N, Trunzo V, Perozziello G, Neuzil P, Francardi M, Roveda L, Renne M, Prati U, Mollace V, Manz A, Di Fabrizio E. Protein-carbohydrate complex reveals circulating metastatic cells in a microfluidic assay. Small. 2013;9(12):2152-61.
12. Lakshmikuttyamma A, Selvakumar P, Kanthan R, Kanthan SC, Sharma RK. Overexpression of m-calpain in human colorectal adenocarcinomas. Cancer Epidemiol Biomark Prev. 2004;13(10):1604-9.
13. Malara N, Focà D, Casadonte F, Sesto MF, Macrina L, Santoro L, Scaramuzzino M, Terracciano R, Savino R. Simultaneous inhibition of the constitutively activated nuclear factor kappaB and of the interleukin-6 pathways is necessary and sufficient to completely overcome apoptosis resistance of human U266 myeloma cells. Cell Cycle. 2008;7(20):3235-45.
14. Malara NM, Sgambato A, Granone P, Flamini G, Margaritora S, Boninsegna A, Cesario A, Galetta D, Yang Q, Cittadini A. Biological characterization of central and peripheral primary non-small cell lung cancers (NSCLC). Anticancer Res. 1999;19(3B):2249-52.
15. Diamond E, Lee GY, Akhtar NH, Kirby BJ, Giannakakou P, Tagawa ST, Nanus DM. Isolation and characterization of circulating tumor cells in prostate cancer. Front Oncol. 2012;11(2):131.
16. Kucia M, Reca R, Miekus K, Wanzeck J, Wojakowski W, Janowska-Wieczorek A, Ratajczak J, Ratajczak MZ. Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis. Stem Cells. 2005;23(7):879-94.
17. Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, McClanahan T, Murphy E, Yuan W, Wagner SN, Barrera JL, Mohar A, Verástegui E, Zlotnik A. Involvement of chemokine receptors in breast cancer metastasis. Nature. 2001;410(6824):50-6.
18. Zeelenberg IS, Ruuls-Van Stalle L, Roos E. The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases. Cancer Res. 2003;63(13):3833-9.
19. Lupu CM, Eisenbach C, Kuefner MA, Schmidt J, Lupu AD, Stremmel W, Encke J. An orthotopic colon cancer model for studying the B7-H3 antitumor effect in vivo. J Gastrointest Surg. 2006;10(5):635-45.
20. Cohen SJ, Alpaugh RK, Gross S, O'Hara SM, Smirnov DA, Terstappen LW, Allard WJ, Bilbee M, Cheng JD, Hoffman JP, Lewis NL, Pellegrino A, Rogatko A, Sigurdson E, Wang H, Watson JC, Weiner LM, Meropol NJ. Isolation and characterization of circulating tumor cells in patients with metastatic colorectal cancer. Clin Colorectal Cancer. 2006;6(2):125-32.
21. Sastre J, Maestro ML, Puente J, Veganzones S, Alfonso R, Rafael S, García-Saenz JA, Vidaurreta M, Martín M, Arroyo M, Sanz-Casla MT, Díaz-Rubio E. Circulating tumor cells in colorectal cancer: correlation with clinical and pathological variables. Ann Oncol. 2008;19(5):935-8.
22. Tang DG. Understanding cancer stem cell heterogeneity and plasticity. Cell Res. 2012;22(3):457-72.