Inflammation in Alcoholic and Nonalcoholic Fatty Liver Disease: Friend or Foe?

Gastroenterology

Volumn 150, Issue 8, 2016, Pages 1704-1709

  Gao, Bin ^a   Tsukamoto, Hidekazu ^b,c  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

Alcoholic Hepatitis; Macrophages; NASH; Neutrophils

Indexed keywords

ADIPONECTIN; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C5; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 22; INTERLEUKIN 6; INTERLEUKIN 8; LEPTIN; MACROPHAGE MIGRATION INHIBITION FACTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; OSTEOPONTIN; TUMOR NECROSIS FACTOR ALPHA; AUTACOID;

ALCOHOLIC FATTY LIVER; HUMAN; INFLAMMATION; MACROPHAGE; NATURAL KILLER CELL; NATURAL KILLER T CELL; NEUTROPHIL; NONALCOHOLIC FATTY LIVER; NOTE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; TH1 CELL; TH17 CELL; TH2 CELL; ANIMAL; IMMUNOLOGY; LIVER; LYMPHOCYTE; METABOLISM; PROGNOSIS; RISK ASSESSMENT; RISK FACTOR; SIGNAL TRANSDUCTION;

ANIMALS; FATTY LIVER, ALCOHOLIC; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; LIVER; LYMPHOCYTES; MACROPHAGES; NON-ALCOHOLIC FATTY LIVER DISEASE; PROGNOSIS; RISK ASSESSMENT; RISK FACTORS; SIGNAL TRANSDUCTION;

EID: 84971228888     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2016.01.025     Document Type: Article

References (20)

1. M.M. Yeh, and E.M. Brunt Pathological features of fatty liver disease Gastroenterology 147 2014 754 764
2. Y. Adachi, B.U. Bradford, W. Gao, and et al. Inactivation of Kupffer cells prevents early alcohol-induced liver injury Hepatology 20 1994 453 460
3. N. Lanthier, O. Molendi-Coste, P.D. Cani, and et al. Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat diet FASEB J 25 2011 4301 4311
4. N.C. Boetticher, C.J. Peine, P. Kwo, and et al. A randomized, double-blinded, placebo-controlled multicenter trial of etanercept in the treatment of alcoholic hepatitis Gastroenterology 135 2008 1953 1960
5. J. Xu, F. Chi, T. Guo, and et al. NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation J Clin Invest 125 2015 1579 1590
6. M. Wang, Q. You, K. Lor, and et al. Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice J Leukoc Biol 96 2014 657 665
7. T. Asanuma, M. Ono, K. Kubota, and et al. Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease Gut 59 2010 258 266
8. N. Lanthier, L. Rubbia-Brandt, N. Lin-Marq, and et al. Hepatic cell proliferation plays a pivotal role in the prognosis of alcoholic hepatitis J Hepatol 63 2015 609 621
9. T.G. Bird, W.Y. Lu, L. Boulter, and et al. Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling Proc Natl Acad Sci U S A 110 2013 6542 6547
10. C.L. Elsegood, C.W. Chan, M.A. Degli-Esposti, and et al. Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration Hepatology 62 2015 1272 1284
11. S.K. Ramaiah, and H. Jaeschke Role of neutrophils in the pathogenesis of acute inflammatory liver injury Toxicol Pathol 35 2007 757 766
12. B. Chang, M.J. Xu, Z. Zhou, and et al. Short- or long-term high-fat diet feeding plus acute ethanol binge synergistically induce acute liver injury in mice: an important role for CXCL1 Hepatology 62 2015 1070 1085
13. M. Dominguez, R. Miquel, J. Colmenero, and et al. Hepatic expression of CXC chemokines predicts portal hypertension and survival in patients with alcoholic hepatitis Gastroenterology 136 2009 1639 1650
14. J. Altamirano, R. Miquel, A. Katoonizadeh, and et al. A histologic scoring system for prognosis of patients with alcoholic hepatitis Gastroenterology 146 2014 1231 1239 e1-6
15. V.L. Gadd, R. Skoien, E.E. Powell, and et al. The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease Hepatology 59 2014 1393 1405
16. E. Liaskou, E.K. Henriksen, K. Holm, and et al. High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires Hepatology 63 2016 1608 1619
17. S. Sutti, A. Jindal, I. Locatelli, and et al. Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH Hepatology 59 2014 886 897
18. L.J. Markwick, A. Riva, J.M. Ryan, and et al. Blockade of PD1 and TIM3 restores innate and adaptive immunity in patients with acute alcoholic hepatitis Gastroenterology 148 2015 590 602 e10
19. J. Michelena, J. Altamirano, J.G. Abraldes, and et al. Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis Hepatology 62 2015 762 772
20. R. Lazaro, R. Wu, S. Lee, and et al. Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice Hepatology 61 2015 129 140