Interaction between rs10830963 polymorphism in MTNR1B and lifestyle intervention on occurrence of gestational diabetes

Diabetologia

Volumn 59, Issue 8, 2016, Pages 1655-1658

  Grotenfelt, Nora E ^a   Wasenius, Niko S ^a,b   Rönö, Kristiina ^b   Laivuori, Hannele ^a,b   Stach Lempinen, Beata ^c   Orho Melander, Marju ^d   Schulz, Christina Alexandra ^d   Kautiainen, Hannu ^b,e   Koivusalo, Saila B ^b   Eriksson, Johan G ^a,b,f  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c SOUTH KARELIA CENTRAL HOSPITAL   (Finland)

^d LUND UNIVERSITY   (Sweden)

^e UNIVERSITY OF EASTERN FINLAND   (Finland)

^f NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Clinical trial; Diabetes; Gestational; Melatonin; MT2; Polymorphism; Pregnancy; Prevalence; Public health; Receptor; Single nucleotide

Indexed keywords

GLUCOSE; MELATONIN RECEPTOR; MELATONIN RECEPTOR 1B; UNCLASSIFIED DRUG; MELATONIN 2 RECEPTOR; MTNR1B PROTEIN, HUMAN;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; DIET; FEMALE; FINLAND; GENE FREQUENCY; GENE INTERACTION; GENETIC POLYMORPHISM; GENETIC VARIATION; GENOTYPE; GESTATIONAL AGE; GLUCOSE BLOOD LEVEL; HETEROZYGOTE; HIGH RISK PREGNANCY; HOMOZYGOTE; HUMAN; LIFESTYLE MODIFICATION; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PATIENT COUNSELING; PHYSICAL ACTIVITY; PREGNANCY; PREGNANCY DIABETES MELLITUS; PRENATAL CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SECONDARY ANALYSIS; WEIGHT CONTROL; ALLELE; GENETICS; LIFESTYLE; RANDOMIZED CONTROLLED TRIAL;

ADULT; ALLELES; BODY MASS INDEX; DIABETES, GESTATIONAL; FEMALE; FINLAND; HETEROZYGOTE; HUMANS; LIFE STYLE; POLYMORPHISM, GENETIC; PREGNANCY; RECEPTOR, MELATONIN, MT2;

EID: 84969835042     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-3989-1     Document Type: Article

References (10)

1. Ferrara A (2007) Increasing prevalence of gestational diabetes mellitus: a public health perspective. Diabetes Care 30(Suppl 2):S141–S146
2. Catalano PM, McIntyre HD, Cruickshank JK et al (2012) The Hyperglycemia and Adverse Pregnancy Outcome Study: associations of GDM and obesity with pregnancy outcomes. Diabetes Care 35:780–786
3. Lowe WL Jr, Karban J (2014) Genetics, genomics and metabolomics: new insights into maternal metabolism during pregnancy. Diabet Med 31:254–262
4. Huopio H, Cederberg H, Vangipurapu J et al (2013) Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes. Eur J Endocrinol 169:291–297
5. Lyssenko V, Nagorny CL, Erdos MR et al (2009) Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet 41:82–88
6. Peschke E, Bahr I, Muhlbauer E (2013) Melatonin and pancreatic islets: interrelationships between melatonin, insulin and glucagon. Int J Mol Sci 14:6981–7015
7. Oteng-Ntim E, Varma R, Croker H, Poston L, Doyle P (2012) Lifestyle interventions for overweight and obese pregnant women to improve pregnancy outcome: systematic review and meta-analysis. BMC Med 10:47. doi:10.1186/1741-7015-10-47
8. Koivusalo SB, Rono K, Klemetti MM et al (2016) Gestational diabetes mellitus can be prevented by lifestyle intervention: The Finnish Gestational Diabetes Prevention Study (RADIEL): a randomized controlled trial. Diabetes Care 39:24–30
9. Jonsson A, Ladenvall C, Ahluwalia TS et al (2013) Effects of common genetic variants associated with type 2 diabetes and glycemic traits on alpha- and beta-cell function and insulin action in humans. Diabetes 62:2978–2983
10. Goni L, Cuervo M, Milagro FI, Martinez JA (2014) Gene-gene interplay and gene-diet interactions involving the MTNR1B rs10830963 variant with body weight loss. J Nutrigenet Nutrigenomics 7:232–242