Intraventricular methotrexate as part of primary therapy for children with infant and/or metastatic medulloblastoma: Feasibility, acute toxicity and evidence for efficacy

European Journal of Cancer

Volumn 51, Issue 17, 2015, Pages 2634-2642

  Pompe, Raisa S ^a   Von Bueren, André O ^a,b   Mynarek, Martin ^a   Von Hoff, Katja ^a   Friedrich, Carsten ^a,c   Kwiecien, Robert ^d   Treulieb, Wiebke ^a   Lindow, Christine ^a   Deinlein, Frank ^e   Fleischhack, Gudrun ^f   Kuehl, Joachim ^e   Rutkowski, Stefan ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^c UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^d UNIVERSITY OF MÜNSTER   (Germany)

^e UNIVERSITY OF WÜRZBURG   (Germany)

^f UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Brain tumours; Chemotherapy; Intraventricular; Medulloblastoma; Methotrexate; Treatment

Indexed keywords

METHOTREXATE; ANTINEOPLASTIC AGENT;

ADOLESCENT; ADULT; ARTICLE; BRAIN EDEMA; CANCER CHEMOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; CHILD; DEVICE INFECTION; DEVICE REMOVAL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DOSE REDUCTION; DRUG EFFICACY; EVENT FREE SURVIVAL; FEASIBILITY STUDY; FEMALE; HUMAN; INFANT; INFECTION; INTRAVENTRICULAR ACCESS DEVICE; MAJOR CLINICAL STUDY; MALE; MEDULLOBLASTOMA; METASTATIC MEDULLOBLASTOMA; MULTICENTER STUDY; MULTIPLE CYCLE TREATMENT; NEUROTOXICITY; OMMAYA RESERVOIR; PRIORITY JOURNAL; SEIZURE; SURVIVAL RATE; VASCULAR ACCESS DEVICE; CEREBELLAR NEOPLASMS; CHEMORADIOTHERAPY; CLINICAL TRIAL; DISEASE FREE SURVIVAL; DOSE RESPONSE; DRUG ADMINISTRATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; METASTASIS; MULTIVARIATE ANALYSIS; OUTCOME ASSESSMENT; PATHOLOGY; PRESCHOOL CHILD; PROCEDURES; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; STATISTICS AND NUMERICAL DATA; YOUNG ADULT;

ADOLESCENT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CEREBELLAR NEOPLASMS; CHEMORADIOTHERAPY; CHILD; CHILD, PRESCHOOL; DISEASE-FREE SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEASIBILITY STUDIES; FEMALE; HUMANS; INFANT; INFECTION; INJECTIONS, INTRAVENTRICULAR; MALE; MEDULLOBLASTOMA; METHOTREXATE; MULTIVARIATE ANALYSIS; NEOPLASM METASTASIS; OUTCOME ASSESSMENT (HEALTH CARE); PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84969812436     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2015.08.009     Document Type: Article

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