Unraveling the paradox of selective insulin resistance in the liver: The brain-liver connection

Diabetes

Volumn 65, Issue 6, 2016, Pages 1481-1483

  Ferris, Heather A ^a   Kahn, C Ronald ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; INSULIN; INSULIN RECEPTOR; INSULIN SENSITIZING AGENT; TRIACYLGLYCEROL; TYLOXAPOL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ALZHEIMER DISEASE; BRAIN; CHOLESTEROL LIVER LEVEL; GLUCONEOGENESIS; GLUCOSE TRANSPORT; HUMAN; HYPERGLYCEMIA; INSULIN RELEASE; INSULIN RESISTANCE; LIPID ABSORPTION; LIPOGENESIS; LIPOLYSIS; LIVER; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NOTE; PRIORITY JOURNAL; STEATOSIS;

BRAIN; HUMANS; INSULIN; INSULIN RESISTANCE; LIVER;

EID: 84969787249     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/dbi16-0010     Document Type: Note

References (17)

1. Kleinridders A, Ferris HA, Cai W, Kahn CR. Insulin action in brain regulates systemic metabolism and brain function. Diabetes 2014;63:2232-2243
2. McEwen BS, Reagan LP. Glucose transporter expression in the central nervous system: relationship to synaptic function. Eur J Pharmacol 2004;490:13-24
3. Woods SC, Lotter EC, McKay LD, Porte D Jr. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 1979;282:503-505
4. Brüning JC, Gautam D, Burks DJ, et al. Role of brain insulin receptor in control of body weight and reproduction. Science 2000;289:2122-2125
5. Fisher SJ, Brüning JC, Lannon S, Kahn CR. Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia. Diabetes 2005;54:1447-1451
6. Obici S, Feng Z, Karkanias G, Baskin DG, Rossetti L. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci 2002;5:566-572
7. Klöckener T, Hess S, Belgardt BF, et al. High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nat Neurosci 2011;14:911-918
8. McNay EC, Ong CT, McCrimmon RJ, Cresswell J, Bogan JS, Sherwin RS. Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance. Neurobiol Learn Mem 2010;93:546-553
9. Suzuki R, Lee K, Jing E, et al. Diabetes and insulin in regulation of brain cholesterol metabolism. Cell Metab 2010;12:567-579
10. Heni M, Hennige AM, Peter A, et al. Insulin promotes glycogen storage and cell proliferation in primary human astrocytes. PLoS One 2011;6:e21594
11. Biddinger SB, Hernandez-Ono A, Rask-Madsen C, et al. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab 2008;7:125-134
12. Brown MS, Goldstein JL. Selective versus total insulin resistance: a pathogenic paradox. Cell Metab 2008;7:95-96
13. Miao J, Haas JT, Manthena P, et al. Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins. J Lipid Res 2014;55:659-667
14. Vatner DF, Majumdar SK, Kumashiro N, et al. Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids. Proc Natl Acad Sci U S A 2015;112:1143-1148
15. Scherer T, Lindtner C, O'Hare J, et al. Insulin regulates hepatic triglyceride secretion and lipid content via signaling in the brain. Diabetes 2016;65:1511-1520
16. Lam TK, Gutierrez-Juarez R, Pocai A, et al. Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins. Nat Med 2007;13:171-180
17. Gancheva S, Koliaki C, Bierwagen A, et al. Effects of intranasal insulin on hepatic fat accumulation and energy metabolism in humans. Diabetes 2015;64:1966-1975