Cardiac troponins and volatile anaesthetics in coronary artery bypass graft surgery

European Journal of Anaesthesiology

Volumn 33, Issue 6, 2016, Pages 396-407

  Straarup, Therese S ^a   Hausenloy, Derek J ^b   Rolighed Larsen, Jens K ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIAC TROPONIN I; CARDIAC TROPONIN T; INHALATION ANESTHETIC AGENT; TROPONIN I; TROPONIN T; UNCLASSIFIED DRUG; TROPONIN;

ARTICLE; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY BYPASS SURGERY; HEART PROTECTION; HUMAN; META ANALYSIS; OFF PUMP CORONARY SURGERY; ON PUMP CORONARY ARTERY BYPASS GRAFT; RANDOMIZED CONTROLLED TRIAL (TOPIC); REPERFUSION INJURY; SYSTEMATIC REVIEW; CARDIAC MUSCLE; INHALATION ANESTHESIA; METABOLISM; POSTOPERATIVE COMPLICATION; PROCEDURES;

ANESTHESIA, INHALATION; ANESTHETICS, INHALATION; CORONARY ARTERY BYPASS; HUMANS; MYOCARDIUM; POSTOPERATIVE COMPLICATIONS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TROPONIN;

EID: 84969765692     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1097/EJA.0000000000000397     Document Type: Article

References (103)

1. Symons JA, Myles PS. myocardial protection with volatile anesthetic agents during coronary artery bypass surgery: a meta-analysis. BJA 2006; 97:127-136.
2. Brener SJ, Lytle BW, Schneider JP, et al. Association between CK-MB elevation after percutaneous or surgical revascularization and three-year mortality. J Am Coll Cardiol 2002; 40:1961-1967.
3. Mohammed AA, Agnihotri AK, van Kimmenade RR, et al. Prospective, comprehensive assessment of cardiac troponin T testing after coronary artery bypass graft surgery. Circulation 2009; 120:843-850.
4. Wang TK, Stewart RA, Ramanathan T, et al. Diagnosis of MI after CABG with high-sensitivity troponin T and new ECG or echocardiogram changes: relationship with mortality and validation of the universal definition of MI. Eur Heart J Acute Cardiovasc Care 2013; 2: 323-333.
5. Croal BL, Hillis GS, Gibson PH, et al. Relationship between postoperative cardiac troponin I levels and outcome of cardiac surgery. Circulation 2006; 114:1468-1475.
6. Muehlschlegel JD, Perry TE, Liu KY, et al. Troponin is superior to electrocardiogram and creatinine kinase MB for predicting clinically significant myocardial injury after coronary artery bypass grafting. Eur Heart J 2009; 30:1574-1583.
7. Newall N, Oo AY, Palmer ND, et al. Intermediate and high peri-operative cardiac enzyme release following isolated coronary artery bypass surgery are independently associated with higher one-year mortality. J Cardiothorac Surg 2006; 1:20.
8. Soraas CL, Friis C, Engebretsen KV, et al. Troponin T is a better predictor than creatine kinase-MB of long-term mortality after coronary artery bypass graft surgery. Am Heart J 2012; 164:779-785.
9. Apple FS, Wu AHB, Jaffe AS. European Society of Cardiology and American College Of Cardiology guidelines for redefinition of myocardial infarction: how to use existing assays clinically and for clinical trials. Am Heart J 2002; 144:981-986.
10. Moller CH, Penninga L, Wetterslev J, et al. Off-pump versus on-pump coronary artery bypass grafting for ischaemic heart disease. Cochrane Database Syst Rev 2012.
11. Mcpherson K. Statistics: the problem of examining accumulating data more than once. N Engl J Med 1974; 290:501-502.
12. Brok J, Thorlund K, Gluud C, et al. Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses. J Clin Epidemiol 2008; 61:763-769.
13. Bignami E, Greco T, Barile L, et al. The effect of isoflurane on survival and myocardial infarction: a meta-analysis of randomized controlled studies. J Cardiothorac Vasc Anesth 2013; 27:50-58.
14. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996; 17:1-12.
15. ORourke K. Mixed means and medians: a unified approach to deal with disparate outcome summaries. In: Proceedings of the Symposium on Systematic Reviews: Pushing the Boundaries. Oxford: 2002; 49
16. Wetterslev J, Thorlund K, Brok J, et al. Estimating required information size by quantifying diversity in random-effects model meta-analyses. BMC Med Res Methodol 2009; 9:86.
17. Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ 2003; 327:557-560.
18. Borenstein M, Hedges LV, Higgins JPT, et al. Introduction to metaanalysis. Chichester, UK: Wiley; 2009.
19. Thorlund K, Imberger G, Walsh M, et al. The number of patients and events required to limit the risk of overestimation of intervention effects in meta-analysis: a simulation study. PLoS One 2011; 6:e25491.
20. Brok J, Thorlund K, Wetterslev J, et al. Apparently conclusive meta-analyses maybe inconclusive: trial sequential analysis adjustment of randomerror risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses. Int J Epidemiol 2009; 38:287-298.
21. Wetterslev J, Thorlund K, Brok J, et al. Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis. J Clin Epidemiol 2008; 61:64-75.
22. Thorlund K, Devereaux PJ, Wetterslev J, et al. Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses? Int J Epidemiol 2009; 38:276-286.
23. Thorlund K, Engstrom J, Wetterslev J, et al. User manual for trial sequential analysis (TSA) Copenhagen Trial Unit. Copenhagen, Denmark: Centre for Clinical Intervention Research; 2011; pp 1-115.
24. Conzen PF, Fischer S, Detter C, et al. Sevoflurane provides greater protection of themyocardium than propofol in patients undergoing off-pump coronary artery bypass surgery. Anesthesiology 2003; 99:826-833.
25. Kendall JB, Russell GN, Scawn ND, et al. A prospective, randomised, single-blind pilot study to determine the effect of anesthetic technique on troponin T release after off-pump coronary artery surgery. Anesthesia 2004; 59:545-549.
26. Wang J, Zheng H, Chen CL, et al. Sevoflurane at 1 MAC provides optimal myocardial protection during off-pump CABG. Scand Cardiovasc J 2013; 47:175-184.
27. Guarracino F, Landoni G, Tritapepe L, et al. Myocardial damage prevented by volatile anesthetics: a multicenter randomized controlled study. J Cardiothorac Vasc Anesth 2006; 20:477-483.
28. Lucchinetti E, Hofer C, Bestmann L, et al. Gene regulatory control of myocardial energy metabolism predicts postoperative cardiac function in patients undergoing off-pump coronary artery bypass graft surgery: inhalational versus intravenous. Anesthesiology 2007; 106:444-457.
29. Xu ZD, Jin M, He WX, et al. Remifentanil preconditioning lowers cardiac troponin I levels in patients undergoing off-pump coronary artery bypass graft surgery [Article in Chinese]. Nan Fang Yi Ke Da Xue Xue Bao 2009; 29:1554-1556.
30. Tempe DK, Dutta D, Garg M, et al. Myocardial protection with isoflurane during off-pump coronary artery bypass grafting: a randomized trial. Cardiothorac Vasc Anesth 2011; 25:59-65.
31. Kim TY, Kim DK, Yoon TG, et al. Myocardial injury in remifentanil-based anesthesia for off-pump coronary artery bypass surgery: an equipotent dose of sevoflurane versus propofol. Anaesth Intensive Care 2011; 39:418-425.
32. Suryaprakash S, Chakravarthy M, Muniraju G, et al. Myocardial protection during off pump coronary artery bypass surgery: a comparison of inhalational anesthesia with sevoflurane or desflurane and total intravenous anesthesia. Ann Card Anaesth 2013; 16:4-8.
33. Guerrero Orriach JL, Galan Ortega M, Ramirez Aliaga M, et al. Prolonged sevoflurane administration in the off-pump coronary artery bypass graft surgery: beneficial effects. J Crit Care 2013; 28:879; e13-8.
34. Mrozinski P, Lango R, Biedrzycka A, et al. Comparison of haemodynamics and myocardial injury markers under desflurane vs. propofol anaesthesia for off-pump coronary surgery. A prospective randomised trial. Anaesthesiol Intensive Ther 2014; 46:4-13.
35. Bein B, Renner J, Caliebe D, et al. Sevoflurane but not propofol preserves myocardial function during minimally invasive direct coronary artery bypass surgery. Anesth Analg 2005; 100:610-616.
36. Malagon I, Hogenbirk K, Van Pelt J, et al. Effect of three different anesthetic agents on the postoperative production of cardiac troponin T in paediatric cardiac surgery. Br J Anaesth 2005; 94:805-809.
37. Cromheecke S, Pepermans V, Hendrickx E, et al. Cardioprotective properties of sevoflurane in patients undergoing aortic valve replacement with cardiopulmonary bypass. Anesth Analg 2006; 103:289-296.
38. Landoni G, Calabro Mg, Marchetti C, et al. Desflurane versus propofol in patients undergoing mitral valve surgery. J Cardiothorac Vasc Anesth 2007; 21:672-677.
39. Jovic M, Stancic A, Nenadic D, et al. Mitochondrial molecular basis of sevoflurane and propofol cardioprotection in patients undergoing aortic valve replacement with cardiopulmonary bypass. Cell Physiol Biochem 2012; 29:131-142.
40. Bignami E, Landoni G, Gerli C, et al. Sevoflurane vs. propofol in patients with coronary disease undergoing mitral surgery: a randomised study. Acta Anaesthesiol Scand 2012; 56:482-490.
41. Erol DD, Ozen I. Is general anesthesia a risk for myocardium? Effect of anesthesia on myocardial function as assessed by cardiac troponin-I in two different groups (isofluranN2O Inhalation and propofolfentanyl iv anesthesia). Vasc Health Risk Manag 2007; 3:755-758.
42. Zhang YL, Guan CY, Hu SF, et al. Effect of long-term sevoflurane anesthesia on markers of myocardial damage [Article in Chinese]. Zhonghua Yi Xue Za Zhi 2009; 89:1916-1918.
43. Lurati Buse GA, Schumacher P, Seeberger E, et al. Randomized comparison of sevoflurane versus propofol to reduce perioperative myocardial ischemia in patients undergoing noncardiac surgery. Circulation 2012; 126:2696-2704.
44. Zangrillo A, Testa V, Aldrovandi V, et al. Volatile agents for cardiac protection in noncardiac surgery: a randomized controlled study. J Cardiothorac Vasc Anesth 2011; 25:902-907.
45. YuJB,GongLR,WangJ, et al.Effect ofsevoflurane combination withepidural anesthesia on myocardial injury in patients with coronary artery disease undergoing non-cardiac surgery. Saudi Med J 2011; 32:1009-1016.
46. Barbagallo M, Casati A, Spadini E, et al. Early increases in cardiac troponin levels after major vascular surgery is associated with an increased frequency of delayed cardiac complications. J Clin Anesth 2006; 18:280-285.
47. Landoni G, Zangrillo A, Fochi O, et al. Cardiac protection with volatile anesthetics in stenting procedures. J Cardiothorac Vasc Anesth 2008; 22:543-547.
48. Lavi S, Bainbridge D, DAlfonso S, et al. Sevoflurane in acute myocardial infarction: a pilot randomized study. Am Heart J 2014; 168:776-783.
49. Delphin E, Jackson D, Gubenko Y, et al. Sevoflurane provides earlier tracheal extubation and assessment of cognitive recovery than isoflurane in patients undergoing off-pump coronary artery bypass surgery. J Cardiothorac Vasc Anesth 2007; 21:690-695.
50. Cardioprotective properties of sevoflurane in coronary bypass surgery with extracorporeal circulation [Article in Russian]. Anesteziol Reanimatol 2011; 6:13-16.
51. Zadorozhny MV, Iavorovski AG, Ziuliaeva TP, et al. Method of pharmacological myocardial preconditioning with halogen-containing anesthetics in cardiosurgical patients [Article in Russian]. Anesteziol Reanimatol 2008; 5:4-8.
52. Ceyhan D, Tanriverdi B, Bilir A. Comparison of the effects of sevoflurane and isoflurane on myocardial protection in coronary bypass surgery [Article in Russian]. Anadolu Kardiyol Derg 2011; 11:257-262.
53. Karuppasamy P, Chaubey S, Dew T, et al. Remote intermittent ischemia before coronary artery bypass graft surgery: a strategy to reduce injury and inflammation? Basic Res Cardiol 2011; 106:511-519.
54. Hemmerling T, Olivier JF, Le N, et al. Myocardial protection by isoflurane vs. sevoflurane in ultra-fast-track anesthesia for off-pump aortocoronary bypass grafting. Eur J Anaesthesiol 2008; 25:230-236.
55. Hong DM, Mint JJ, Kim JH, et al. The effect of remote ischaemic preconditioning on myocardial injury in patients undergoing off-pump coronary artery bypass graft surgery. Anaesth Intensive Care 2010; 38:924-929.
56. Lucchinetti E, Bestmann L, Feng J, et al. Remote ischemic preconditioning applied during isoflurane inhalation provides no benefit to the myocardium of patients undergoing on-pump coronary artery bypass graft surgery: lack of synergy or evidence of antagonism in cardioprotection? Anesthesiology 2012; 116:296-310.
57. Belhomme D, Peynet J, Louzy M, et al. Evidence for preconditioning by isoflurane in coronary artery bypass graft surgery. Circulation 1999; 100 (19 Suppl):II340-II344.
58. Tomai F, De Paulis R, Penta De Peppo A, et al. Beneficial impact of isoflurane during coronary bypass surgery on troponin I release. G Ital Cardiol 1999; 29:1007-1014.
59. Pouzet B, Lecharny Jb, Dehoux M, et al. Is there a place for preconditioning during cardiac operations in humans? Ann Thorac Surg 2002; 73:843-848.
60. De Hert SG, ten Broecke PW, Mertens E, et al. Sevoflurane but not propofol preserves myocardial function in coronary surgery patients. Anesthesiology 2002; 97:42-49.
61. De Hert SG, Cromheecke S, ten Broecke PW, et al. Effects of propofol, desflurane, and sevoflurane on recovery of myocardial function after coronary surgery in elderly high-risk patients. Anesthesiology 2003; 99:314-323.
62. Julier K, Da Silva R, Garcia C, et al. Preconditioning by sevoflurane decreases biochemical markers for myocardial and renal dysfunction in coronary artery bypass graft surgery: a double-blinded, placebo-controlled, multicenter study. Anesthesiology 2003; 98:1315-1327.
63. Nader ND, Li CM, Khadra WZ, et al. Anesthetic myocardial protection with sevoflurane. J Cardiothorac Vasc Anesth 2004; 18:269-274.
64. De Hert SG, Van Der Linden PJ, Cromheecke S, et al. Cardioprotective properties of sevoflurane in patients undergoing coronary surgery with cardiopulmonary bypass are related to the modalities of its administration. Anesthesiology 2004; 101:299-310.
65. De Hert SG, Van der Linden PJ, Cromheecke S, et al. Choice of primary anesthetic regimen can influence intensive care unit length of stay after coronary surgery with cardiopulmonary bypass. Anesthesiology 2004; 101:9-20.
66. Forlani S, Tomai F, De Paulis R, et al. Preoperative shift from glibenclamide to insulin is cardioprotective in diabetic patients undergoing coronary artery bypass surgery. J Cardiovasc Surg (Torino) 2004; 45:117-122.
67. Wang X, Ja rvinen O, Kuukasja rvi P, et al. Isoflurane produces only minor preconditioning in coronary artery bypass grafting. Scand Cardiovasc J 2004; 38:287-292.
68. Xia Z, Huang Z, Ansley DM. Large-dose propofol during cardiopulmonary bypass decreases biochemical markers of myocardial injury in coronary surgery patients: a comparison with isoflurane. Anesth Analg 2006; 103:527-532.
69. Lee Mc, Chen Ch, Kuo Mc, et al. Isoflurane preconditioning-induced cardio protection in patients undergoing coronary artery bypass grafting. Eur J Anaesthesiol 2006; 23:841-847.
70. Kawamura T, Kadosaki M, Nara N, et al. Effects of sevoflurane on cytokine balance in patients undergoing coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth 2006; 20:503-508.
71. Piriou V, Mantz J, Goldfarb G, et al. Sevoflurane preconditioning at 1 mac only provides limited protection in patients undergoing coronary artery bypass surgery: a randomized bi-centre trial. Br J Anaesth 2007; 99:624-631.
72. Ndoko SK, Tual L, Ait Mamar B, et al. Isoflurane, 0.5 minimum alveolar concentration administered through the precardiopulmonary bypass period, reduces postoperative dobutamine requirements of cardiac surgery patients: a randomized study. J Cardiothorac Vasc Anesth 2007; 21:683-689.
73. Meco M, Cirri S, Gallazzi C, et al. Desflurane preconditioning in coronary artery bypass graft surgery: a double-blinded, randomised and placebocontrolled study. Eur J Cardiothorac Surg 2007; 32:319-325.
74. Tritapepe L, Landoni G, Guarracino F, et al. Cardiac protection by volatile anesthetics: a multicentre randomized controlled study in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass. Eur J Anaesthesiol 2007; 24:323-331.
75. De Hert S, Vlasselaers D, BarbeR, et al. A comparison of volatile and non volatile agents for cardioprotection during on-pump coronary surgery. Anaesthesia 2009; 64:953-960.
76. Frassdorf J, Borowski A, Ebel D, et al. Impact of preconditioning protocol on anesthetic-induced cardioprotection in patients having coronary artery bypass surgery. J Thorac Cardiovasc Surg 2009; 137:1436-1442.
77. Yildirim V, Doganci S, Aydin A, et al. Cardioprotective effects of sevoflurane, isoflurane, and propofol in coronary surgery patients: a randomized controlled study. Heart Surg Forum 2009; 12:E1-E9.
78. Flier S, Post J, Concepcion An, et al. Influence of propofol-opioid vs isoflurane-opioid anesthesia on postoperative troponin release in patients undergoing coronary artery bypass grafting. Br J Anaesth 2010; 105:122-130.
79. Amr Ym, Yassin Im. Cardiac protection during on-pump coronary artery bypass grafting: ischemic versus isoflurane preconditioning. Semin Cardiothorac Vasc Anesth 2010; 14:205-211.
80. Huang Z, Zhong X, Irwin Mg, et al. Synergy of isoflurane preconditioning and propofol postconditioning reduces myocardial reperfusion injury in patients. Clin Sci (Lond) 2011; 121:57-69.
81. Hellstrom J, O wall A, Bergstrom J, et al. Cardiac outcome after sevoflurane versus propofol sedation following coronary bypass surgery: a pilot study. Acta Anaesthesiol Scand 2011; 55:460-467.
82. Kottenberg E, Thielmann M, Bergmann L, et al. Protection by remote ischemic preconditioning during coronary artery bypass graft surgery with isoflurane but not propofol: a clinical trial. Acta Anaesthesiol Scand 2012; 56:30-38.
83. Soro M, Gallego L, Silva V, et al. Cardioprotective effect of sevoflurane and propofol during anesthesia and the postoperative period in coronary bypass graft surgery: a double-blind randomised study. Eur J Anaesthesiol 2012; 29:561-569.
84. Sirvinskas E, Kinderyte A, Trumbeckaite S, et al. Effects of sevoflurane vs. propofol on mitochondrial functional activity after ischemia-reperfusion injury and the influence on clinical parameters in patients undergoing CABG surgery with cardiopulmonary bypass. Perfusion 2015.
85. Bein B, Renner J, Caliebe D, et al. The effects of interrupted or continuous administration of sevoflurane on preconditioning before cardio-pulmonary bypass in coronary artery surgery: comparison with continuous propofol. Anaesthesia 2008; 63:1046-1055.
86. Imantalab V, Nejad AS, Mansouri AM, et al. A comparative study of cardioprotective effect of three anesthetic agents by measuring serum level of troponin-T after coronary artery bypass grafting. Int Cardiovasc Res J 2012; 6:70-74.
87. Bland JHL, Lowenstein E. Halothane-induced decrease in experimental myocardial ischemia in the nonfailing canine heart. Anesthesiology 1976; 45:287-293.
88. Kersten JR, Schmeling TJ, Pagel PS, et al. Isoflurane mimics ischemic preconditioning via activation of k(atp) channels: reduction of myocardial infarct size with an acute memory phase. Anesthesiology 1997; 87:361-370.
89. Cason B, Gamperl A, Slocum RE, et al. Anesthetic-induced preconditioning: previous administration of isoflurane decreases myocardial infarct size in rabbits. Anesthesiology 1997; 87:1182-1190.
90. Lehrke S, Steen H, Sievers HH, et al. Cardiac troponin T for prediction of short- and long-term morbidity and mortality after elective open heart surgery. Clin Chem 2004; 50:1560-1567.
91. Greenson N, Macoviak J, Krishnaswamy P, et al. Usefulness of cardiac troponin I in patients undergoing open heart surgery. Am Heart J 2001; 141:447-455.
92. Fellahi JL, GueX, Richomme X, et al. Short- and long-term prognostic value of postoperative cardiac troponin I concentration in patients undergoing coronary artery bypass grafting. Anesthesiology 2003; 99:270-274.
93. Kathiresan S, Servoss SJ, Newell JB, et al. Cardiac troponin T elevation after coronary artery bypass grafting is associated with increased oneyear mortality. Am J Cardiol 2004; 94:879-881.
94. Hausenloy DJ, Mwamure PK, Venugopal V, et al. Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial. Lancet 2007; 370:575-579.
95. Swyers T, Redford D, Larson DF. Volatile anesthetic-induced preconditioning. Perfusion 2014; 29:10-15.
96. Tanaka K, Ludwig LM, Kersten JR, et al. Mechanisms of cardioprotection by volatile anesthetics. Anesthesiology 2004; 100:707-721.
97. Landoni G, Greco T, Biondi-Zoccai G, et al. Anaesthetic drugs and survival: a Bayesian network meta-analysis of randomized trials in cardiac surgery. Br J Anaesth 2013; 111:886-896.
98. Landoni G. Volatile anesthetics to reduce mortality in cardiac surgery. https://clinicaltrials.gov/ct2/show/NCT02105610?term= NCT02105610&rank=1. [Accessed October 2015].
99. Jakobsen CJ, Berg H, Hindsholm KB, et al. The influence of propofol versus sevoflurane anesthesia on outcome in 10 535 cardiac surgical procedures. J Cardiothorac Vasc Anesth 2007; 21:664-671.
100. Larsen JR, Aagaard S, Lie RH, et al. Sevoflurane improves myocardial ischaemic tolerance in a closed-chest porcine model. Acta Anaesthesiol Scand 2008; 52:1400-1410.
101. Hausenloy DJ, Tsang A, Mocanu MM, et al. Ischemic preconditioning protects by activating prosurvival kinases at reperfusion. Am J Physiol Heart Circ Physiol 2005; 288:H971-H976.
102. Hausenloy DJ, Baxter G, Bell R, et al. Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations. Basic Res Cardiol 2010; 105:677-686.
103. Zaugg M, Lucchinetti E, Uecker M, et al. Anaesthetics and cardiac preconditioning. Part I. Signalling and cytoprotective mechanisms. Br J Anaesth 2003; 91:551-565.