Rapid acquisition of linezolid resistance in methicillin-resistant staphylococcus Aureus: Role of hypermutation and homologous recombination

PLoS ONE

Volumn 11, Issue 5, 2016, Pages

  Iguchi, Shigekazu ^a,b   Mizutani, Tomonori ^a   Hiramatsu, Keiichi ^a   Kikuchi, Ken ^a,b  

^a JUNTENDO UNIVERSITY   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LINEZOLID; RECQ HELICASE; RNA 23S; ANTIINFECTIVE AGENT; RIBOSOMAL SPACER DNA; RIBOSOME RNA;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENOME; BACTERIAL STRAIN; BACTERIUM ISOLATE; CONTROLLED STUDY; GENE; GENE LOCUS; GENETIC VARIATION; GENOME ANALYSIS; HOMOLOGOUS RECOMBINATION; IN VITRO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MISSENSE MUTATION; MUTATION RATE; MUTATIONAL ANALYSIS; NEXT GENERATION SEQUENCING; NONHUMAN; PHYLOGENETIC TREE; RECQ GENE; RNA SEQUENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC HYPERMUTATION; CLASSIFICATION; DRUG EFFECTS; GENETICS; GENOMICS; HUMAN; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MUTATION; PHYLOGENY; PROCEDURES; STAPHYLOCOCCAL INFECTIONS;

ANTI-BACTERIAL AGENTS; DNA, RIBOSOMAL SPACER; DRUG RESISTANCE, BACTERIAL; GENOME, BACTERIAL; GENOMICS; HOMOLOGOUS RECOMBINATION; HUMANS; LINEZOLID; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MUTATION; MUTATION RATE; PHYLOGENY; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, RIBOSOMAL; STAPHYLOCOCCAL INFECTIONS;

EID: 84969718266     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0155512     Document Type: Article

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