Metallothionein structure and reactivity

Metallothioneins in Biochemistry and Pathology

Volumn , Issue , 2008, Pages 3-26

  Vašák, Milan ^a   Meloni, Gabriele ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Copper; Metal cluster reactivity; Metal thiolate cluster; Metallothionein; Structure dynamics; Three dimensional structure; Zinc

Indexed keywords

EID: 84969662816     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1142/9789812778949_0001     Document Type: Chapter

References (89)

1. Arseniev A, Schultze P, Wörgötter E, et al. Three-dimensional structure of rabbit liver Cd7metallothionein-2a in aqueous solution determined by nuclear magnetic resonance. J Mol Biol 1988; 201: 637-657.
2. Bertini I, Luchinat C, Messori L, Vašák M. Proton NMR studies of the cobalt(II)- metallothionein system. J Am Chem Soc 1989; 111: 7296-7300.
3. Berweger CD, Thiel W, van Gunsteren WF. Molecular-dynamics simulation of the beta domain of metallothionein with a semi-empirical treatment of the metal core. Proteins 2000; 41: 299-315.
4. Binz PA, Kägi JHR. Metallothionein: Molecular evolution and classification. In: Klaassen C (ed.), Metallothionein IV, Birkhäuser Verlag, Basel, 1999, pp. 7-13.
5. Bogumil R, Faller P, Binz PA, et al. Structural characterization of Cu(I) and Zn(II) sites in neuronal-growth-inhibitory factor by extended X-ray absorption fine structure (EXAFS). Eur J Biochem 1998; 255: 172-177.
6. Braun W, Vašák M, Robbins AH, et al. Comparison of the NMR solution structure and the X-ray crystal structure of rat metallothionein-2. Proc Natl Acad Sci USA 1992; 89: 10124-10128.
7. Calderone V, Dolderer B, Hartmann HJ, et al. The crystal structure of yeast copper thionein: The solution of a long-lasting enigma. Proc Natl Acad Sci USA 2005; 102: 51-56.
8. Chen Y, Irie Y, Keung WM, Maret WS. Nitrosothiols react preferentially with zinc thiolate clusters of metallothionein III through transnitrosation. Biochemistry 2002; 41: 8360-8367.
9. Cherian G, Jayasurya A, Bay BH. Metallothioneins in human tumors and potential roles in carcinogenesis. Mutat Res 2003; 533: 201-209.
10. Ding ZC, Teng XC, Cai B, et al. Mutation at Glu23 eliminates the neuron growth inhibitory activity of human metallothionein-3. Biochem Biophys Res Commun 2006; 349: 674-682.
11. Ding ZC, Zheng Q, Cai B, et al. Effect of alpha-domain substitution on the structure, property and function of human neuronal growth inhibitory factor. J Biol Inorg Chem 2007; 12: 1173-1179.
12. Dolderer B, Echner H, Beck A, et al. Coordination of three and four Cu(I) to the α- and ß- domain of vertebrate Zn-metallothionein-1, respectively, induces significant structural changes. FEBS J 2007; 274: 2349-2362.
13. El Ghazi I, Martin BL, Armitage IM. Metallothionein-3 is a component of a multiprotein complex in the mouse brain. Exp Biol Med (Maywood) 2006; 231: 1500-1506.
14. Erickson JC, Sewell AK, Jensen LT, et al. Enhanced neurotrophic activity in Alzheimer’s disease cortex is not associated with down-regulation of metallothionein-III (GIF). Brain Res 1994; 649: 297-304.
15. Fabisiak JP, Borisenko GG, Liu SX, et al. Redox sensor function of metallothioneins. Methods Enzymol 2002; 353: 268-281.
16. Faller P, Hasler DW, Zerbe O, et al. Evidence for a dynamic structure of human neuronal growth inhibitory factor and for major rearrangements of its metal-thiolate clusters. Biochemistry 1999; 38: 10158-10167.
17. Faller P, Vašák M. Distinct metal-thiolate clusters in the N-terminal domain of neuronal growth inhibitory factor. Biochemistry 1997; 36: 13341-13348.
18. -metallothionein with EDTA. A reappraisal. J Biol Chem 1995; 270: 5339-5345.
19. 113Cd NMR studies on metal-thiolate cluster formation in rabbit Cd(II)-metallothionein: Evidence for a pH dependence. Biochemistry 1988; 27: 7163-7166.
20. Good M, Hollenstein R, Vašák M. Metal selectivity of clusters in rabbit liver metallothionein. Eur J Biochem 1991; 197: 655-659.
21. 2-. Inorg Chem 1982; 21: 3928-3936.
22. Hasler DW, Faller P, Vašák M. Metal-thiolate clusters in the C-terminal domain of human neuronal growth inhibitory factor (GIF). Biochemistry 1998; 37: 14966-14973.
23. Hasler DW, Jensen LT, Zerbe O, et al. Effect of the two conserved prolines of human growth inhibitory factor (metallothionein-3) on its biological activity and structure fluctuation: Comparison with a mutant protein. Biochemistry 2000; 39: 14567-14575.
24. Heuchel R, Radtke F, Georgiev O, et al. The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression. EMBO J 1994; 13: 2870-2875.
25. Hidalgo J, Aschner M, Zatta P, Vašák M. Roles of the metallothionein family of proteins in the central nervous system. Brain Res Bull 2001; 55: 133-145.
26. Irie Y, Mori F, Keung WM, et al. Expression of neuronal growth inhibitory factor (metallothionein-III) in the salivary gland. Physiol Res 2004; 53: 719-723.
27. Jacob C, Maret W, Vallee BL. Control of zinc transfer between thionein, metallothionein, and zinc proteins. Proc Natl Acad Sci USA 1998; 95: 3489-3494.
28. Jiang LJ, Maret W, Vallee BL. The glutathione redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase. Proc Natl Acad Sci USA 1998; 95: 3483-3488.
29. Kägi JHR, Schaffer A. Biochemistry of metallothionein. Biochemistry 1988; 27: 8509-8515.
30. Kägi JHR, Vallee B. Metallothionein: A cadmium- and zinc-containing protein from equine renal cortex. J Biol Chem 1960; 235: 3460-3465.
31. Kelley SL, Basu A, Teicher BA, et al. Overexpression of metallothionein confers resistance to anticancer drugs. Science 1988; 241: 1813-1815.
32. 2] anticancer complexes: trans-Pt(II) complexes retain their N-donor ligands. J Med Chem 2007; 50: 4075-4086.
33. Knipp M, Meloni G, Roschitzki B, Vašák M. Zn7metallothionein-3 and the synaptic vesicle cycle: Interaction of metallothionein-3 with the small GTPase Rab3A. Biochemistry 2005; 44: 3159-3165.
34. Kre¸z˙el A, Hao Q, Maret W. The zinc/thiolate redox biochemistry of metallothionein and the control of zinc ion fluctuations in cell signaling. Arch Biochem Biophys 2007; 463: 188-200.
35. Kre¸z˙el A, Maret W. Dual nanomolar and picomolar Zn(II) binding properties of metallothionein. JAm Chem Soc 2007; 129: 10911-10921.
36. Kroncke KD, Fehsel K, Schmidt T, et al. Nitric oxide destroys zinc-sulfur clusters inducing zinc release from metallothionein and inhibition of the zinc finger-type yeast transcription activator LAC9. Biochem Biophys Res Commun 1994; 200: 1105-1110.
37. Laib JE, Shaw CF, Petering DH, et al. Formation and characterization of aurothioneins: Au, Zn, Cd-thionein, Au, Cd-thionein, and (thiomalato-Au)chi-thionein. Biochemistry 1985; 24: 1977-1986.
38. 2+ removal from Zn metallothionein by nitrilotriacetate are associated with differential reactivity of the two metal clusters. J Inorg Biochem 1998; 70: 187-194.
39. Liang L, Fu K, Lee DK, et al. Activation of the complete mouse metallothionein gene locus in the maternal deciduum. Mol Reprod Dev 1996; 43: 25-37.
40. Maret W. The function of zinc metallothionein: A link between cellular zinc and redox state. JNutr 2000; 130: 1455S-1458S.
41. Maret W, Vallee BL. Thiolate ligands in metallothionein confer redox activity on zinc clusters. Proc Natl Acad Sci USA 1998; 95: 3478-3482.
42. Margoshes M, Vallee BL. A cadmium protein from equine kidney cortex. JAm Chem Soc 1957; 79: 4813-4814.
43. Martell AE, Hancock RD, Motekaitis RJ. Factors affecting stabilities of chelate, macrocyclic and macrobicyclic complexes in solution. Coord Chem Rev 1994; 133: 39-65.
44. Masters BA, Quaife J, Erickson JC, et al. Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles. J Neuro sci 1994; 14: 5844-5857.
45. 2+ ions. J Biol Chem 2007; 282: 16068-16078.
46. Meloni G, Zovo K, Kazantseva J, et al. Organization and assembly of metal-thiolate clusters in epithelium-specific metallothionein-4. J Biol Chem 2006; 281: 14588-14595.
47. Mercogliano CP, DeRosier DJ. Gold nanocluster formation using metallothionein: Mass spectrometry and electron microscopy. J Mol Biol 2006; 355: 211-223.
48. Messerle BA, Bos M, Schaffer A, et al. Amide proton exchange in human metallothionein-2 measured by nuclear magnetic resonance spectroscopy. J Mol Biol 1990a; 214: 781-786.
49. 113Cd7]metallothionein-2 in solution determined by nuclear magnetic resonance spectroscopy. J Mol Biol 1990b; 214:765-779.
50. Miles AT, Hawksworth GM, Beattie JH, Rodilla V. Induction, regulation, degradation, and biological significance of mammalian metallothioneins. Crit Rev Biochem Mol Biol 2000; 35: 35-70.
51. '- dithio-bis(2-nitrobenzoate) (DTNB) and aurothiomalate (AuSTm). Inorg Chem 1999; 38: 5655-5659.
52. Nartey NO, Banerjee D, Cherian MG. Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of fetal human liver and kidney and its changes during development. Pathology 1987; 19: 233-238.
53. Ni FY, Cai B, Ding ZC, et al. Structural prediction of the beta-domain of metallothionein-3 by molecular dynamics simulation. Proteins 2007; 68: 255-266.
54. Nielson KB, Atkin CL, Winge DR. Distinct metal-binding configurations in metallothionein. J Biol Chem 1985; 260: 5342-5350.
55. Nielson KB, Winge DR. Order of metal binding in metallothionein. J Biol Chem 1983; 258: 13063-13069.
56. Nielson KB, Winge DR. Preferential binding of copper to the beta domain of metallothionein. JBiol Chem 1984; 259: 4941-4946.
57. Otvos JD, Armitage IM. Structure of the metal clusters in rabbit liver metallothionein. Proc Natl Acad Sci USA 1980; 77: 7094-7098.
58. Otvos JD, Liu X, Li H, et al. Dynamic aspects of metallothionein structure. In: Suzuki KT, Imura N, Kimura M (eds.), Metallothionein III, Birkhäuser Verlag, Basel, 1993, pp. 57-74.
59. Öz G, Zangger K, Armitage IM. Three-dimensional structure and dynamics of a brain specific growth inhibitory factor: Metallothionein-3. Biochemistry 2001; 40: 11433-11441.
60. Palmiter RD. The elusive function of metallothioneins. Proc Natl Acad Sci USA 1998; 95: 8428-8430.
61. Palumaa P, Eriste E, Njunkova O, et al. Brain-specific metallothionein-3 has higher metalbinding capacity than ubiquitous metallothioneins and binds metals noncooperatively. Biochemistry 2002; 41: 6158-6163.
62. Petering DH, Krezoski S, Chen P, et al. Kinetic reactivity of metallothioneins. In: Stillman MJ, Shaw IIICF, Suzuki KT (eds.), Metallothioneins - Synthesis, Structure and Properties of Metallothioneins, Phytochelatins and Metal-Thiolate Complexes, VCH Publishers, New York, 1992, pp. 164-183.
63. 4-thiolate clusters. Biochemistry 1994; 33: 9699-9705.
64. Pountney DL, Vašák M. Spectroscopic studies on metal distribution in Co(II)/Zn(II) mixed-metal clusters in rabbit liver metallothionein 2. Eur J Biochem 1992; 209: 335-341.
65. Quaife CJ, Findley SD, Erickson JC, et al. Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia. Biochemistry 1994; 33: 7250-7259.
66. Robbins AH, McRee DE, Williamson M, et al. Refined crystal structure of Cd, Zn metallothionein at 2.0 Â resolution. J Mol Biol 1991; 221: 1269-1293.
67. Roesijadi G, Bogumil R, Vašák M. Kägi JH. Modulation of DNA binding of a Tramtrack zinc finger peptide by the metallothionein-thionein conjugate pair. J Biol Chem 1998; 273: 17425-17432.
68. Romero-Isart N, Vašák M. Advances in the structure and chemistry of metallothioneins. J Inorg Biochem 2002; 88: 388-396.
69. Roschitzki B, Vašák M. A distinct Cu4-thiolate cluster of human metallothionein-3 is located in the N-terminal domain. J Biol Inorg Chem 2002; 7: 611-616.
70. Roschitzki B, Vašák M. Redox labile site in a Zn4 cluster of Cu4, Zn4-metallothionein-3. Biochemistry 2003; 42: 9822-9828.
71. Schlake T, Boehm T. Expression domains in the skin of genes affected by the nude mutation and identified by gene expression profiling. Mech Dev 2001; 109: 419-422.
72. Schultze P, Wörgötter E, Braun W, et al. Conformation of Cd7-metallothionein-2 from rat liver in aqueous solution determined by nuclear magnetic resonance spectroscopy. J Mol Biol 1988; 203: 251-268.
73. Shaw III CF, Savas MM, Petering DH. Ligand substitution and sulfhydryl reactivity of metallothionein. Methods Enzymol 1991; 205: 401-414.
74. Sogawa CA, Asanuma M, Sogawa N, et al. Localization, regulation, and function of metallothionein-III/growth inhibitory factor in the brain. Acta Med Okayama 2001; 55: 1-9.
75. Stillman MJ. Metallothioneins. Coord Chem Rev 1995; 144: 461-511.
76. Tapiero H, Townsend DM, Tew KD. Trace elements in human physiology and pathology, Copper. Biomed Pharmacother 2003; 57: 386-398.
77. Theocharis SE, Margeli AP, Klijanienko JT, Kouraklis GP. Metallothionein expression in human neoplasia. Histopathology 2004; 45: 103-118.
78. Thornalley PJ, Vašák M. Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals. Biochim Biophys Acta 1985; 827: 36-44.
79. Tio L, Villarreal L, Atrian S, Capdevila M. Functional differentiation in the mammalian metallothionein gene family: Metal binding features of mouse MT4 and comparison with its paralog MT1. J Biol Chem 2004; 279: 24403-24413.
80. Uchida Y, Takio K, Titani K, et al. The growth inhibitory factor that is deficient in the Alzheimer’s disease brain is a 68 amino acid metallothionein-like protein. Neuron 1991; 7: 337-347.
81. Vašák M. Spectroscopic studies on cobalt(II) metallothionein: Evidence for pseudotetrahedral coordination. J Am Chem Soc 1980; 102: 3953-3955.
82. Vašák M. Kagi JH. Metal thiolate clusters in cobalt(II)-metallothionein. Proc Natl Acad Sci USA 1981; 78: 6709-6713.
83. Vašák M. Romero-Isart N. Metallothioneins. In: King RB (ed.), Encyclopedia of Inorganic Chemistry, 2nd ed., John Wiley & Sons, New York, 2005, pp. 3208-3221.
84. Wang H, Zhang Q, Cai B, et al. Solution structure and dynamics of human metallothionein-3 (MT-3). FEBS Lett 2006; 580: 795-800.
85. Winge DR, Miklossy KA. Domain nature of metallothionein. J Biol Chem 1982; 257: 3471-3476.
86. Yu X, Wu Z, Fenselau C. Covalent sequestration of melphalan by metallothionein and selective alkylation of cysteines. Biochemistry 1995; 34: 3377-3385.
87. Zaia J, Jiang LC, Han MS, et al. A binding site for chlorambucil on metallothionein. Biochemistry 1996; 35: 2830-2835.
88. Zangger K, Öz G, Haslinger E, et al. Nitric oxide selectively releases metals from the aminoterminal domain of metallothioneins: Potential role at inflammatory sites. FASEB J 2001; 15: 1303-1305.
89. Zangger K, Öz G, Otvos JD, Armitage IM. Three-dimensional solution structure of mouse Cd7-metallothionein-1 by homonuclear and heteronuclear NMR spectroscopy. Protein Sci 1999; 8: 2630-2638.