The value of SHOX2 methylation test in peripheral blood samples used for the differential diagnosis of lung cancer and other lung disorders

Neoplasma

Volumn 63, Issue 2, 2016, Pages 246-253

  Konecny, M ^a   Markus, J ^a   Waczulikova, I ^b   Dolesova, L ^b   Kozlova, R ^a   Repiska, V ^b   Novosadova, H ^c   Majer, I ^c  

^a ST ELIZABETH CANCER INSTITUTE   (Slovakia)

^b Faculty of Natural Sciences   (Slovakia)

^c UNIVERSITY HOSPITAL BRATISLAVA   (Slovakia)

Author keywords

Blood plasma; Bronchial lavage; DNA methylation test; Lung cancer; SHOX2

Indexed keywords

ADENOCARCINOMA; ADULT; ARTICLE; BRONCHOPNEUMONIA; BRONCHOSCOPY; CASE CONTROL STUDY; CONTROLLED STUDY; CYTOLOGY; DIAGNOSTIC TEST ACCURACY STUDY; DIFFERENTIAL DIAGNOSIS; FEMALE; GENE; HISTOLOGY; HUMAN; HUMAN TISSUE; LARGE CELL CARCINOMA; LUNG CANCER; LUNG DISEASE; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MESOTHELIOMA; METASTASIS; METHYLATION; MIDDLE AGED; NON SMALL CELL LUNG CANCER; OBSERVATIONAL STUDY; PREDICTIVE VALUE; REAL TIME POLYMERASE CHAIN REACTION; SARCOIDOSIS; SENSITIVITY AND SPECIFICITY; SHORT STATURE HOMEOBOX GENE 2; SMALL CELL CARCINOMA; SMALL CELL LUNG CANCER; SMOKING; SQUAMOUS CELL CARCINOMA; TRACHEOBRONCHIAL TOILET; TUBERCULOSIS; BLOOD; CROSS-SECTIONAL STUDY; DNA METHYLATION; EARLY CANCER DIAGNOSIS; GENETIC EPIGENESIS; GENETICS; LUNG SARCOIDOSIS; LUNG TUBERCULOSIS; LUNG TUMOR; PATHOLOGY; POLYMERASE CHAIN REACTION; PROCEDURES;

HOMEODOMAIN PROTEIN; SHOX2 PROTEIN, HUMAN; TUMOR MARKER;

BIOMARKERS, TUMOR; BRONCHOPNEUMONIA; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; DIAGNOSIS, DIFFERENTIAL; DNA METHYLATION; EARLY DETECTION OF CANCER; EPIGENESIS, GENETIC; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; LUNG NEOPLASMS; LYMPHOMA; MALE; MESOTHELIOMA; MIDDLE AGED; POLYMERASE CHAIN REACTION; SARCOIDOSIS, PULMONARY; TUBERCULOSIS, PULMONARY;

EID: 84969632435     PISSN: 00282685     EISSN: 13384317     Source Type: Journal    
DOI: 10.4149/210_150419N208     Document Type: Article

References (26)

1. MOLINA JR, YANG P, CASSIVI SD, SCHILD SE, ADJEI AA. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc. 2008; 83: 584-94. doi: 10.4065/83.5.584. http://dx.doi.org/10.4065/83.5.584
2. KHUDER SA. Effect of cigarette smoking on major histological types of lung cancer: a meta-analysis. Lung Cancer. 2001; 31: 139-48. http://dx.doi.org/10.1016/S0169-5002-(00)00181-1
3. U.S. Department of Health and Human Services. The Health Consequences of Smoking: A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2004.
4. PETO R, LOPEZ AD, BOREHAM J, et al. Mortality from Smoking in Developed Countries, 1950-2000: Indirect Estimates from National Vital Statistics. New York, NY: Oxford University Press, 1994.
5. KAVCOVA E, ONDRUSOVA M, DZIAN A. Karcinom pl'úc prekročil hranice tretieho milénia-1. čast', In: Via Practica. Roč. 7, č. 5 (2010), s. 215-221
6. TRAVIS WD, TRAVIS LB, DEVESA SS. Lung cancer. Cancer. 1995; 75(1 Suppl): 191-202. Erratum in: Cancer 1995; 75: 2979. http://dx.doi.org/10.1002/1097-0142-(19950101)75:1+<191::AID-CNCR2820751307>3.0.CQ;2-Y
7. SCHWARTZ AG, PRYSAK GM, BOCK CH, COTE ML. The molecular epidemiology of lung cancer. Carcinogenesis. 2007; 28: 507-18. Epub 2006 Dec 20. http://dx.doi.org/10.1093/ carcin/bgl253
8. HOFFMAN PC , MAUER AM, VOKES EE. Lung cancer. Lancet 2000; 355: 479-85. http://dx.doi.org/10.1016/S0140-6736(00)82038-3
9. PETO R, DARBY S, DEO H, SILCOCKS P, WHITLEY E, et al. Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies. BMJ. 2000; 321: 323-9. http://dx.doi. org/10.1136/bmj.321.7257.323
10. ROBERTSON KD. DNA methylation and human disease. Nat Rev Genet. 2005 Aug; 6(8): 597-610. http://dx.doi. org/10.1038/nrg1655
11. PALMISANO WA, DIVINE KK, SACCOMANNO G, GILLILAND FD, BAYLIN SB, et al. Predicting lung cancer by detecting aberrant promoter methylation in sputum. Cancer Res. 2000; 60: 5954-8.
12. BALGKOURANIDOU I, LILOGLOU T, LIANIDOU ES. Lung cancer epigenetics: emerging biomarkers. Biomark Med. 2013; 7: 49-58. doi: 10.2217/bmm.12.111. http://dx.doi. org/10.2217/bmm.12.111
13. BELINSKY SA, KLINGE DM, DEKKER JD, SMITH MW, BOCKLAGE TJ, et al. Gene promoter methylation in plasma and sputum increases with lung cancer risk. Clin Cancer Res. 2005; 11: 6505-11. http://dx.doi.org/10.1158/1078-0432.CCR-05-0625
14. LENG S, DO K, YINGLING CM, PICCHI MA, WOLF HJ, et al. Defining a gene promoter methylation signature in sputum for lung cancer risk assessment. Clin Cancer Res. 2012; 18: 3387-95. doi: 10.1158/1078-0432.CCR-11-3049. Epub 2012 Apr 17. http://dx.doi.org/10.1158/1078-0432.CCR-11-3049
15. DIETRICH D, KNEIP C, RAJI O, LILOGLOU T, SEEGEBARTH A, et al. Performance evaluation of the DNA methylation biomarker SHOX2 for the aid in diagnosis of lung cancer based on the analysis of bronchial aspirates. Int J Oncol. 2012; 40: 825-32. doi: 10.3892/ijo.2011.1264. Epub 2011 Nov 16. http://dx.doi.org/10.3892/ijo.2011.1264
16. SIMKIN M, ABDALLA M, EL-MOGY M, HAJ-AHMAD Y. Differences in the quantity of DNA found in the urine and saliva of smokers versus non-smokers: implications for the timing of epigenetic events. Epigenomics. 2012; 4: 343-52. doi: 10.2217/epi.12.24. http://dx.doi.org/10.2217/epi.12.24
17. BLASCHKE RJ, MONAGHAN AP, SCHILLER S, SCHECHINGER B, RAO E, et al. SHOT, a SHOX-related homeobox gene, is implicated in craniofacial, brain, heart, and limb development. Proc Natl Acad Sci U S A. 1998; 95: 2406-11. http://dx.doi.org/10.1073/pnas.95.5.2406
18. BLASCHKE RJ, HAHURIJ ND, KUIJPER S, JUST S, WISSE LJ, et al. Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development. Circulation. 2007; 115: 1830-8. Epub 2007 Mar 19. http://dx.doi.org/10.1161/ CIRCULATIONAHA.106.637819
19. SMITH TM, LOZANOFF S, IYYANAR PP, NAZARALI AJ. Molecular signaling along the anterior-posterior axis of early palate development. Front Physiol. 2013; 3: 488. doi: 10.3389/fphys.2012.00488. eCollection 2012. http://dx.doi. org/10.3389/fphys.2012.00488
20. DIETRICH D, HASINGER O, LIEBENBERG V, FIELD JK, KRISTIANSEN G, SOLTERMANN A. DNA methylation of the homeobox genes PITX2 and SHOX2 predicts outcome in non-small-cell lung cancer patients. Diagn Mol Pathol. 2012; 21: 93-104. doi: 10.1097/PDM.0b013e318240503b. http:// dx.doi.org/10.1097/PDM.0b013e318240503b
21. KNEIP C, SCHMIDT B, SEEGEBARTH A, WEICK-MANN S, FLEISCHHACKER M, et al. SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer in plasma. J Thorac Oncol. 2011; 6: 1632-8. doi: 10.1097/JTO.0b013e318220ef9a. http://dx.doi.org/10.1097/ TTO.0b013e318220ef9a
22. BEGUM S, BRAIT M, DASGUPTA S, OSTROW KL, ZAHURAK M, et al. An epigenetic marker panel for detection of lung cancer using cell-free serum DNA. Clin Cancer Res. 2011; 17: 4494-503. doi: 10.1158/1078-0432.CCR-10-3436. Epub 2011 May 24. http://dx.doi.org/10.1158/1078-0432. CCR-10-3436
23. SCHNEIDER KU, DIETRICH D, FLEISCHHACKER M, LESCHBER G, MERK J, et al. Correlation of SHOX2 gene amplification and DNA methylation in lung cancer tumors. BMC Cancer. 2011;11: 102. doi: 10.1186/1471-2407-11-102. http://dx.doi.org/10.1186/1471-2407-11-102
24. SCHMIDT B, LIEBENBERG V, DIETRICH D, SCHLEGEL T, KNEIP C, et al. SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer based on bronchial aspirates. BMC Cancer. 2010; 10: 600. doi: 10.1186/1471-2407-10-600. http://dx.doi.org/10.1186/1471-2407-10-600
25. ILSE P, BIESTERFELD S, POMJANSKI N, FINK C, SCHRAMM M. SHOX2 DNA methylation is a tumour marker in pleural effusions. Cancer Genomics Proteomics. 2013; 10: 217-23.
26. DIETRICH D, JUNG M, PUETZER S, LEISSE A, HOLMES EE, et al. Diagnostic and prognostic value of SHOX2 and SEPT9 DNA methylation and cytology in benign, paramalignant and malignant pleural effusions. PLoS One. 2013 Dec 27; 8(12): e84225. doi: 10.1371/journal.pone.0084225. eCollection 2013. http://dx.doi.org/10.1371/journal. pone.0084225