A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure

Journal of Genetics and Genomics

Volumn 43, Issue 5, 2016, Pages 307-318

  Ear, Jason ^a   Hsueh, Jessica ^a   Nguyen, Melinda ^a   Zhang, QingHua ^a   Sung, Victoria ^b   Chopra, Rajesh ^b   Sakamoto, Kathleen M ^c   Lin, Shuo ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CELGENE CORPORATION   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5q syndrome; Myelodysplastic syndrome; Ribosomopathy; RPS14

Indexed keywords

DEXAMETHASONE; LEUCINE; PROTEIN P53; RIBOSOME PROTEIN; RIBOSOMAL PROTEIN S14;

5Q- SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BONE MARROW DEPRESSION; CONTROLLED STUDY; CRISPR CAS SYSTEM; EMBRYO; ERYTHROCYTE DISORDER; ERYTHROID FAILURE; ERYTHROPOIESIS; GENE; GENE DISRUPTION; GENE MAPPING; GENE MUTATION; MACROCYTIC ANEMIA; NONHUMAN; PHENOTYPE; RPS14 GENE; UPREGULATION; ZEBRA FISH; ANEMIA; ANIMAL; BLOOD; CHROMOSOME 5; CHROMOSOME DELETION; COMPLICATION; DEFICIENCY; DISEASE MODEL; ERYTHROID CELL; GENE EDITING; GENETICS; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE;

ANEMIA; ANEMIA, MACROCYTIC; ANIMALS; BASE SEQUENCE; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 5; CRISPR-CAS SYSTEMS; DISEASE MODELS, ANIMAL; ERYTHROID CELLS; GENE EDITING; MUTATION; RIBOSOMAL PROTEINS; TUMOR SUPPRESSOR PROTEIN P53; ZEBRAFISH;

EID: 84969497796     PISSN: 16738527     EISSN: 18735533     Source Type: Journal    
DOI: 10.1016/j.jgg.2016.03.007     Document Type: Article

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