Three randomized clinical trials to assess the short-term efficacy of anhydrous 0.454% w/w stannous fluoride dentifrices for the relief of dentin hypersensitivity

American Journal of Dentistry

Volumn 29, Issue 1, 2016, Pages 25-32

  Parkinson, Charles R ^a   Hughes, Nathan ^b   Hall, Claire ^b   Whelton, Helen ^c,d   Gallob, John ^e,f,g   Mason, Stephen ^b  

^a Gum Health and Family Oral Health   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c UNIVERSITY COLLEGE CORK   (Ireland)

^d UNIVERSITY OF LEEDS   (United Kingdom)

^e BioSci Research Group   (United States)

^f UNIVERSITY OF NEVADA   (United States)

^g Silverstone Research Group   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DESENSITIZING AGENT; TIN FLUORIDE; TOOTHPASTE;

ADOLESCENT; ADULT; AGED; AIR; COMPARATIVE STUDY; CONTROLLED STUDY; DENTIN SENSITIVITY; FEMALE; FOLLOW UP; HUMAN; INTENTION TO TREAT ANALYSIS; MALE; MIDDLE AGED; PAIN MEASUREMENT; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; STIMULATION; TOOTH BRUSHING; TOUCH; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AIR; DENTIFRICES; DENTIN DESENSITIZING AGENTS; DENTIN SENSITIVITY; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTENTION TO TREAT ANALYSIS; MALE; MIDDLE AGED; PAIN MEASUREMENT; PHYSICAL STIMULATION; SINGLE-BLIND METHOD; TIN FLUORIDES; TOOTHBRUSHING; TOUCH; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84969203979     PISSN: 08948275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Cunha-Cruz J, Wataha JC. The burden of dentine hypersensitivity. In: The everyday impact of dentine sensitivity: Personal and functional aspects. In: Robinson PG. Dentine hypersensitivity. Developing a person-centred approach to oral health. Oxford: Academic Press, 2014, Ch 3.
2. Addy M. Etiology and clinical implications of dentine hypersensitivity. Dent Clin North Am 1990;34:503-514.
3. Brännström M, Linden LA, Astrom A. The hydrodynamics of the dental tubule and of pulp fluid. A discussion of its significance in relation to dentinal sensitivity. Caries Res 1967;1:310-317.
4. Brännström M. The hydrodynamic theory of dentinal pain: Sensation in preparations, caries and the dentinal crack syndrome. J Endod 1986;12:453-457.
5. Gysi A. An attempt to explain the sensitiveness of dentin. Br J Dent Sci 1900;43:864-868.
6. Gibson B, Boiko OV, Baker S, Robinson PG, Barlow A, Player, T, Locker D. The everyday impact of dentine sensitivity: Personal and functional aspects. Soc Sci Dent 2010;1:11-20.
7. Ling TY, Gillam DG. The effectiveness of desensitizing agents for the treatment of cervical dentine sensitivity (CDS) - A review. J West Soc Periodontal Periodontal Abstr 1996;44:5-12.
8. Markowitz K. The original desensitizers: Strontium and potassium salts. J Clin Dent 2009;20:145-151.
9. Miller S, Truong T, Heu R, Stranick M, Bouchard D, Gaffar A. Recent advances in stannous fluoride technology: Antibacterial efficacy and mechanism of action towards hypersensitivity. Int Dent J 1994;44:83-98.
10. Earl JS, Langford RM. Physical and chemical characterization of the surface layers formed on dentin following treatment with an experimental anhydrous stannous fluoride dentifrice. Am J Dent 2013;26:19A-24A.
11. Makin SA Stannous fluoride dentifrices. Am J Dent 2013;26 (Sp Is A):3A-9A.
12. Schiff T, He T, Sagel L, Baker R. Efficacy and safety of a novel stabilized stannous fluoride and sodium hexametaphosphate dentifrice for dentinal hypersensitivity. J Contemp Dent Pract 2006;7:1-10.
13. Schiff T, Saletta L, Baker R, Winston JL, He T. Desensitizing effect of a stabilized stannous fluoride/sodium hexametaphosphate dentifrice. Compendium Contin Educ Dent 2005;26:35-40.
14. Parkinson C, Hughes N, Jeffrey P, Jain R, Kennedy L, Qaqish J, Gallob JT, Mason S. The efficacy of an experimental dentifrice containing 0.454% w/w stannous fluoride in providing relief from the pain of dentin hypersensitivity: An 8-week clinical study. Am J Dent 2013;26 (Sp Is A):25A-31A.
15. Parkinson C, Jeffery P, Milleman JL, Milleman KR, Mason S. Confirmation of efficacy in providing relief from the pain of dentin hypersensitivity of an anhydrous dentifrice containing 0.454% w/w stannous fluoride in an 8-week randomized clinical trial. Am J Dent, 2015;28:190-196.
16. He T, Chang J, Cheng R, Li X, Sun L, Biesbrock AR. Clinical evaluation of the fast onset and sustained sensitivity relief of a 0.454% stannous fluoride, dentifrice compared to an 8.0% arginine-calcium carbonatesodium monofluorophosphate dentifrice. Am J Dent 2011;24:336-340.
17. He T, Barker ML, Qaqish J, Sharma N. Fast onset sensitivity relief of a 0.454% stannous fluoride dentifrice. J Clin Dent 2011;22:46-50.
18. He T, Cheng R, Biesbrock AP, Chang A, Sun L. Rapid desensitizing efficacy of a stannous-containing sodium fluoride dentifrice. J Clin Dent 2011;22:40-45.
19. Nathoo S, Delgado E, Zhang YP, DeVizio W, Cummins D, Mateo LR. Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new dentifrice containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark desensitizing dentifrice containing 2% potassium ion and 1450 ppm fluoride and to a control dentifrice with 1450 ppm fluoride: A three-day clinical study in New Jersey, USA. J Clin Dent 2009;20:123-130.
20. Ayad F, Ayad N, Delgado E, Zhang YP, DeVizio W, Cummins D, Mateo LR. Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new dentifrice containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride, and to a control dentifrice with 1450 ppm fluoride: A three-day clinical study in Mississauga, Canada. J Clin Dent 2009; 20:115-122.
21. Mason S, Hughes N, Sufi F, Bannon L, Maggio B, North M, Holt J. A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentine hypersensitivity. J Clin Dent 2010;21:42-48.
22. West N, Newcombe RG, Hughes N, Mason S, Maggio B, Sufi F, Claydon N. A 3-day randomized clinical study investigating the efficacy of two toothpastes, designed to occlude dentine tubules, for the treatment of dentine hypersensitivity. J Dent 2013;41:187-194.
23. Holland GR, Narhi MN, Addy M, Gangarosa L, Orchardson R. Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. J Clin Periodontal 1997;24:808-813.
24. World Medical Association Declaration of Helsinki, 59th General Assembly, Seoul 2008.
25. GSK Clinical Study Register. Study 1: http://www.gsk-clinicalstudyregister.com/study/Z7871335?study-ids=Z7871335#ps
26. GSK Clinical Study Register. Study 2: http://www.gsk-clinicalstudyregister.com/study/RH01324?study-ids=RH01324#ps
27. GSK Clinical Study Register. Study 3: http://www.gsk-clinicalstudyregister.com/study/RH01327?study-ids=RH01327#ps
28. Yeaple Probe. http://yeapleprobe.com/Yeaple-Probe.html
29. Barker ML, Sharma N, Qaqish J, Biesbrock AR, He T. RCT evaluating onset of sensitivity relief for stannous fluoride dentifrice. Oral Presentation 2991, IADR San Diego, CA, USA, March 19,2011.
30. Schiff T, Dodson M, Cohen S, DeVizio W, McCool J, Volpe A. Efficacy of a dentifrice containing potassium nitrate, soluble pyrophosphate, PVM/MA copolymer and sodium fluoride on dentinal hypersensitivity: A twelve-week clinical study. J Clin Dent 1994;5:87-92.
31. Gillam DG, Seo HS, Bulman JS, Newman HN. Perceptions of dentine hypersensitivity in a general practice population. J Oral Rehabil 1999;26:710-714.
32. Canadian Advisory Board on Dentin Hypersensitivity. Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity. / Can Dent Assoc 2003;69:221-226.
33. Schmidlin PR, Sahramm P. Current management of dentin hypersensitivity. Clin Orallnvestig 2013;17 Suppl 1:S55-S59.