A 3-day randomised clinical study investigating the efficacy of two toothpastes, designed to occlude dentine tubules, for the treatment of dentine hypersensitivity

Journal of Dentistry

Volumn 41, Issue 2, 2013, Pages 187-194

  West, N ^a   Newcombe, R G ^c   Hughes, N ^b   Mason, S ^b   Maggio, B ^b   Sufi, F ^b   Claydon, N ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Arginine; Dentine hypersensitivity; Pain; Strontium

Indexed keywords

ACETATE STRONTIUM; ACETIC ACID DERIVATIVE; ANTICARIES AGENT; ARGININE; CALCIUM CARBONATE; DESENSITIZING AGENT; DIAGNOSTIC AGENT; FLUORIDE; FLUOROPHOSPHATE; PHOSPHATE; SILICON DIOXIDE; SODIUM FLUORIDE; STRONTIUM; TOOTHPASTE;

ADULT; ARTICLE; COLD; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DENTIN; DENTIN SENSITIVITY; DESICCATION; DRUG EFFECT; FEMALE; HUMAN; MALE; PAIN ASSESSMENT; PAIN THRESHOLD; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; STIMULATION; TOUCH; TREATMENT OUTCOME; ULTRASTRUCTURE;

ACETATES; ADULT; ARGININE; CALCIUM CARBONATE; CARIOSTATIC AGENTS; COLD TEMPERATURE; DENTIN; DENTIN DESENSITIZING AGENTS; DENTIN SENSITIVITY; DESICCATION; FEMALE; FLUORIDES; HUMANS; MALE; PAIN MEASUREMENT; PAIN THRESHOLD; PHOSPHATES; PHYSICAL STIMULATION; SILICON DIOXIDE; SINGLE-BLIND METHOD; SODIUM FLUORIDE; STRONTIUM; TOOTHPASTES; TOUCH; TREATMENT OUTCOME;

EID: 84873710797     PISSN: 03005712     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdent.2012.11.007     Document Type: Article

References (48)

1. O.V. Boiko, S.R. Baker, B.J. Gibson, D. Locker, F. Sufi, and A.P.S. Barlow Construction and validation of the quality of life measure for dentine hypersensitivity (DHEQ) Journal of Clinical Periodontology 37 2010 973 980
2. C. Fischer, R.G. Fischer, and A. Wennberg Prevalence and distribution of cervical dentine hypersensitivity in a population in Rio de Janeiro, Brazil Journal of Dentistry 20 1992 272 276
3. M. Addy Dentine hypersensitivity: definition, prevalence, distribution and aetiology M. Addy, G. Embery, M. Edgar, R. Orchardson, Tooth Wear and Sensitivity 2000 Martin Dunitz London 239 248
4. Canadian Advisory Board on Dentin Hypersensitivity Consensus-based recommendations for the diagnosis and management of dentine hypersensitivity Journal of the Canadian Dental Association 69 2003 221 226
5. Blum M. German anonymous. Artzney buch wider Allerbi. Krancheyton und Gebrechen der Tzeen 1530.
6. M. Addy, and E. Urquart Dentine hypersensitivity: its prevalence, aetiology and clinical management Dental Update 12 1992 407 412
7. N.X. West, M. Addy, R.J. Jackson, and B.D. Ridge Dentine hypersensitivity: controls and placebo response. A comparison of the effect of strontium acetate and potassium nitrate toothpastes on dentine hypersensitivity Journal of Clinical Periodontology 4 1997 209 216
8. N.X. West Dentine hypersensitivity A. Lussi, Dental erosion: from diagnosis to therapy. Monograph of oral science vol. 20 2006 Karger Basel 173 189
9. D.G. Gillam, and R. Orchardson Advances in the treatment of root dentine sensitivity: mechanisms and treatment principles Endodontic Topics 13 2006 13 33
10. M. Addy, and N.X. West Dentinal sensitivity S.J. Daniel, S.A. Harfst, Mosby's dental hygiene: concepts, cases and competencies 2nd ed. 2007 Elsevier Amsterdam 623 640
11. Poulsen S, Errboe M, Lescay Mevil Y, Glenny AM. Potassium containing toothpastes for dentine hypersensitivity. The Cochrane Database System Review, The Cochrane Library; 2006 http://onlinelibrary.wiley.com/doi/10.1002/14651858. CD001476.pub2/pdf [accessed 18.10.12].
12. D.G. Gillam, J.S. Bulman, R.J. Jackson, and H.N. Newman Comparison of 2 desensitising dentifrices with a commercially available fluoride dentifrice in alleviating cervical dentine sensitivity Journal of Periodontology 67 1996 737 742
13. N.X. West, M. Addy, R.J. Jackson, and D.B. Ridge Dentine hypersensitivity and the placebo response. A comparison of the effect of strontium acetate, potassium nitrate and fluoride toothpastes Journal of Clinical Periodontology 24 1997 209 215
14. F. Ayad, R. Berta, W. De Vizio, J. McCool, M.E. Petrone, and A.R. Volpe Comparative study of two dentifrices containing 5% potassium nitrate on dentinal sensitivity: a twelve week clinical study Journal of Clinical Dentistry 5 1994 97 101
15. T. Schiff, M. Dotson, S. Cohen, W. De Vizio, J. McCool, and A. Volpe Efficacy of a dentifrice containing potassium nitrate, soluble pyrophosphate, PVM/MA copolymer, and sodium fluoride on dentinal hypersensitivity: a twelve-week clinical study Journal of Clinical Dentistry 5 1994 87 92
16. E.G. Absi, M. Addy, and D. Adams Dentine hypersensitivity: a study of the patency of dentinal tubules in sensitive and nonsensitive cervical dentine Journal of Clinical Periodontology 14 1987 280 284
17. A. Gysi An attempt to explain the sensitiveness of dentin British Journal of Dental Science 43 1900 865 868
18. M. Brännström A hydrodynamic mechanism in the transmission of pain producing stimuli through the dentine D.J. Anderson, Sensory mechanism in dentine 1963 Pergammon Press Oxford 73 79
19. E.G. Absi, M. Addy, and D. Adams Dentine hypersensitivity: the development and evaluation of a replica technique to study sensitive and nonsensitive cervical dentine Journal of Clinical Periodontology 16 1989 190 195
20. Q. Du Min, Z. Bian, H. Jiang, D.C. Greenspan, A.K. Burwell, and J. Zhong Clinical evaluation of a dentifrice containing calcium sodium phosphosilicate (novamin) for the treatment of dentin hypersensitivity American Journal of Dentistry 21 2008 210 214
21. L. Kun Biophysical study of the modification of dental tissues caused by local application of strontium Swiss Monthly Review of Odontostomatology 86 1976 661 676
22. P. Dowell, and M. Addy Dentine hypersensitivity. A quantitative comparison of the uptake of metal salts and fluoride by dentine and hydroxyapatite Journal of Periodontal Research 19 1984 530 539
23. A. Curtis, N.X. West, and B. Su Synthesis of nanobioglass and formation of apatite rods to occlude exposed dentine tubules and eliminate hypersensitivity Acta Biomaterials 6 2010 3740 3746
24. I. Gedalia, L. Brayer, N. Kalter, M. Richter, and A. Stabholz The effect of fluoride and strontium application on dentine: in vivo and in vitro studies Journal of Periodontology 49 1978 269 272
25. N. Banfield, and M. Addy Dentine hypersensitivity: development and evaluation of a model in situ to study tubule patency Journal of Clinical Periodontology 31 2004 325 335
26. N.X. West, J.A. Hughes, and M. Addy Dentine hypersensitivity: the effects of brushing toothpaste on etched and unetched dentine in vitro Journal of Oral Rehabilitation 29 2002 167 174
27. C. Parkinson, A. Butler, and R. Willson Development of an acid challenge based in-vitro dentin disc occlusion model Journal of Clinical Dentistry 21 2010 31 36
28. N.C.A. Claydon, M. Addy, E.L. MacDonald, N.X. West, B. Maggio, and A. Barlow Development of an in situ methodology for the clinical evaluation of dentine hypersensitivity occlusion ingredients Journal of Clinical Dentistry 20 2009 158 166
29. C. Parkinson, and R. Willson Dentine tubule occlusion under acid challenge conditions: an in-vitro study Journal of Dental Research 89 special issue B 2010 4780 www.dentalresearch.org
30. M. Davies, E.M. Paice, S.B. Jones, S. Leary, A.R. Curtis, and N.X. West Efficacy of desensitising dentifrices to occlude dentinal tubules European Journal of Oral Science 119 2011 497 503
31. I. Petrou, R. Heu, M. Stranick, S. Lavender, L. Zaidel, and D. Cummins A breakthrough therapy for dentin hypersensitivity: how dental products containing 8% arginine and calcium carbonate work to deliver effective relief of sensitive teeth Journal of Clinical Dentistry 20 2009 23 31
32. S. Mason, N. Hughes, F. Sufi, L. Bannon, B. Maggio, and M. North A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentine hypersensitivity Journal of Clinical Dentistry 21 2010 42 48
33. S. Nathoo, E. Delgado, Y.P. Zhang, W. DeVizio, D. Cummins, and L.R. Mateo Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride relative to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride, and to a control toothpaste with 1450 ppm fluoride: a three-day clinical study in New Jersey, USA Journal of Clinical Dentistry 20 2009 123 130
34. F. Ayad, N. Ayad, E. Delgado, Y.P. Zhang, W. DeVizio, and D. Cummins Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride, and to a control toothpaste with 1450 ppm fluoride: a three-day clinical study in Mississauga, Canada Journal of Clinical Dentistry 20 2009 115 122
35. N. Hughes, S. Mason, P. Jeffery, H. Welton, M. Tobin, and C. O'Shea A comparative clinical study investigating the efficacy of a test dentifrice containing 8% strontium acetate and 1040 ppm sodium fluoride versus a marketed control dentifrice containing 8% arginine, calcium carbonate, and 1450 ppm sodium monofluorophosphate in reducing dentinal hypersensitivity Journal of Clinical Dentistry 21 2010 49 55
36. R. Docimo, L. Montesani, P. Maturo, M. Costacurta, M. Bartolino, and Y.P. Zhang Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark commercial desensitizing toothpaste containing 2% potassium ion: an eight-week clinical study in Rome, Italy Journal of Clinical Dentistry 20 2009 137 143
37. J. Seong, E. Macdonald, R.G. Newcombe, M. Davies, S.B. Jones, and S. Johnson In situ randomised trial to investigate the occluding properties of two desensiting toothpastes on dentine after subsequent acid challenge Clinical Oral Investigations 2012 10.1007/s00784-012-0683-7
38. G.E. Clark, and E.S. Troullos Designing hypersensitivity clinical studies Dental Clinics of North America 34 1990 531 544
39. H. Loe, and J. Silness Periodontal Disease in Pregnancy (I). Prevalence and severity Acta Odontologica Scandinavica 21 1963 533 551
40. F.A. Curro, M. Friedman, and R.S. Leight Design and conduct of clinical trials on dentine hypersensitivity M. Addy, G. Embery, W.M. Edgar, R. Orchardson, Tooth wear and sensitivity 2000 Martin Dunitz London 299 314
41. L.E. Grossman A systematic method for the treatment of hypersensitive dentine Journal of the American Dental Association 22 1935 592 602
42. K. Marvowitz, and D.H. Pashley Discovering new treatments for sensitive teeth. The long path from biology to therapy Journal of Oral Rehabilitation 35 2008 300 315
43. M. Al-Sabbagh, E. Harrison, and M.V. Thomas Patient applied treatment of dentinal hypersensitivity Dental Clinics of North America 53 2009 61 70
44. M. Addy, and P. Dowell Dentine hypersensitivity-a review: clinical and in vitro evaluation of treatment agents Journal of Clinical Periodontology 10 1983 351 363
45. G.R. Holland, M.N. Nähri, M. Addy, L. Gangarosa, and R. Orchardson Guidelines for the design and conduct of clinical trials on dentine hypersensitivity Journal of Clinical Periodontology 24 1997 808 813
46. D.G. Gillam, R. Orchardson, M.V.O. Närhi, and V. Kontturi-Nahri Present and future methods for the evaluation of pain associated with dentine hypersensitivity M. Addy, G. Embery, W.M. Edgar, R. Orchardson, Tooth wear and sensitivity 2000 Martin Dunitz London 283 299
47. R.J. Jackson Potential modalities for dentine hypersensitivity: home use products M. Addy, G. Embery, W.M. Edgar, R. Orchardson, Tooth wear and sensitivity 2012 Martin Dunitz London 327 339
48. D. Schwarz, and J. Lellouch Explanatory and pragmatic attitudes in therapeutical trials Journal of Chronic Diseases 20 1967 637 648