Hospital-Use Pharmaceuticals in Swiss Waters Modeled at High Spatial Resolution

Environmental Science and Technology

Volumn 50, Issue 9, 2016, Pages 4742-4751

  Kuroda, Keisuke ^a,b,c   Itten, René ^a   Kovalova, Lubomira ^a   Ort, Christoph ^a   Weissbrodt, David G ^a   McArdell, Christa S ^a  

^a SWISS FEDERAL INSTITUTE OF AQUATIC SCIENCE AND TECHNOLOGY   (Switzerland)

^b UNIVERSITY OF TOKYO   (Japan)

^c NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CATCHMENTS; COMPUTERIZED TOMOGRAPHY; CONTRAST MEDIA; EFFLUENTS; GADOLINIUM; GEOGRAPHICAL DISTRIBUTION; IMAGE RESOLUTION; MAGNETIC RESONANCE IMAGING; MASS TRANSFER; POPULATION STATISTICS; RIVERS; SEWAGE TREATMENT PLANTS;

CONTRAST MEDIUM; DIVERSE RANGE; FIELD MEASUREMENT; GENERAL POPULATION; HIGH SPATIAL RESOLUTION; IODINATED X-RAY CONTRAST MEDIA; POPULATION SIZES; SULFAMETHOXAZOLE;

HOSPITALS;

CARBAMAZEPINE; CYCLOPHOSPHAMIDE; DICLOFENAC; GADOLINIUM; SULFAMETHOXAZOLE; WATER; DRUG; SEWAGE; WATER POLLUTANT;

CATCHMENT; CONCENTRATION (COMPOSITION); DRUG; EFFLUENT; GEOGRAPHICAL DISTRIBUTION; HOSPITAL SECTOR; HYDROLOGICAL MODELING; POPULATION SIZE; RIVER WATER; SEWAGE TREATMENT; SPATIAL RESOLUTION;

ARTICLE; CANCER CHEMOTHERAPY; CATCHMENT; COMPUTER ASSISTED TOMOGRAPHY; GEOGRAPHIC DISTRIBUTION; HOSPITAL; HOSPITAL BED; HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POPULATION SIZE; RIVER; SEWAGE TREATMENT; SEWAGE TREATMENT PLANT; SWITZERLAND; WATER SAMPLING; ENVIRONMENTAL MONITORING; SEWAGE; WATER POLLUTANT;

SWITZERLAND;

ENVIRONMENTAL MONITORING; PHARMACEUTICAL PREPARATIONS; RIVERS; SEWAGE; WATER; WATER POLLUTANTS, CHEMICAL;

EID: 84968902255     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/acs.est.6b00653     Document Type: Article

References (50)

1. Weissbrodt, D.; Kovalova, L.; Ort, C.; Pazhepurackel, V.; Moser, R.; Hollender, J.; Siegrist, H.; McArdell, C. S. Mass flows of X-ray contrast media and cytostatics in hospital wastewater Environ. Sci. Technol. 2009, 43 (13) 4810-4817 10.1021/es8036725
2. Verlicchi, P.; Galletti, A.; Petrovic, M.; Barceló, D. Hospital effluents as a source of emerging pollutants: An overview of micropollutants and sustainable treatment options J. Hydrol. 2010, 389 (3-4) 416-428 10.1016/j.jhydrol.2010.06.005
3. Santos, L. H. M. L. M.; Gros, M.; Rodriguez-Mozaz, S.; Delerue-Matos, C.; Pena, A.; Barceló, D.; Montenegro, M. C. B. S. M. Contribution of hospital effluents to the load of pharmaceuticals in urban wastewaters: Identification of ecologically relevant pharmaceuticals Sci. Total Environ. 2013, 461-462, 302-316 10.1016/j.scitotenv.2013.04.077
4. Carraro, E.; Bonetta, S.; Bertino, C.; Lorenzi, E.; Bonetta, S.; Gilli, G. Hospital effluents management: Chemical, physical, microbiological risks and legislation in different countries J. Environ. Manage. 2016, 168, 185-199 10.1016/j.jenvman.2015.11.021
5. Ort, C.; Lawrence, M. G.; Reungoat, J.; Eaglesham, G.; Carter, S.; Keller, J. Determining the fraction of pharmaceutical residues in wastewater originating from a hospital Water Res. 2010, 44 (2) 605-615 10.1016/j.watres.2009.08.002
6. Escher, B. I.; Baumgartner, R.; Koller, M.; Treyer, K.; Lienert, J.; McArdell, C. S. Environmental toxicology and risk assessment of pharmaceuticals from hospital wastewater Water Res. 2011, 45 (1) 75-92 10.1016/j.watres.2010.08.019
7. Le Corre, K. S.; Ort, C.; Kateley, D.; Allen, B.; Escher, B. I.; Keller, J. Consumption-based approach for assessing the contribution of hospitals towards the load of pharmaceutical residues in municipal wastewater Environ. Int. 2012, 45, 99-111 10.1016/j.envint.2012.03.008
8. Al Aukidy, M.; Verlicchi, P.; Voulvoulis, N. A framework for the assessment of the environmental risk posed by pharmaceuticals originating from hospital effluents Sci. Total Environ. 2014, 493, 54-64 10.1016/j.scitotenv.2014.05.128
9. Daouk, S.; Chèvre, N.; Vernaz, N.; Widmer, C.; Daali, Y.; Fleury-Souverain, S. Dynamics of active pharmaceutical ingredients loads in a Swiss university hospital wastewaters and prediction of the related environmental risk for the aquatic ecosystems Sci. Total Environ. 2016, 547, 244-253 10.1016/j.scitotenv.2015.12.117
10. Hospital beds (per 1,000 people). World Bank Open Data; http://data.worldbank.org/indicator/SH.MED.BEDS.ZS?page=1. Accessed: 2015-03-09. (Archived by WebCite® at http://www.webcitation.org/6WtAd0sR8).
11. Thomas, K. V.; Dye, C.; Schlabach, M.; Langford, K. H. Source to sink tracking of selected human pharmaceuticals from two Oslo city hospitals and a wastewater treatment works J. Environ. Monit. 2007, 9 (12) 1410-1418 10.1039/b709745j
12. Verlicchi, P.; Al Aukidy, M.; Galletti, A.; Petrovic, M.; Barceló, D. Hospital effluent: Investigation of the concentrations and distribution of pharmaceuticals and environmental risk assessment Sci. Total Environ. 2012, 430, 109-118 10.1016/j.scitotenv.2012.04.055
13. Heberer, T.; Feldmann, D. Contribution of effluents from hospitals and private households to the total loads of diclofenac and carbamazepine in municipal sewage effluents-modeling versus measurements J. Hazard. Mater. 2005, 122 (3) 211-218 10.1016/j.jhazmat.2005.03.007
14. Emmanuel, E.; Perrodin, Y.; Keck, G.; Blanchard, J. M.; Vermande, P. Ecotoxicological risk assessment of hospital wastewater: a proposed framework for raw effluents discharging into urban sewer network J. Hazard. Mater. 2005, 117 (1) 1-11 10.1016/j.jhazmat.2004.08.032
15. Orias, F.; Perrodin, Y. Characterisation of the ecotoxicity of hospital effluents: A review Sci. Total Environ. 2013, 454-455, 250-276 10.1016/j.scitotenv.2013.02.064
16. Ternes, T. A.; Hirsch, R. Occurrence and behavior of X-ray contrast media in sewage facilities and the aquatic environment Environ. Sci. Technol. 2000, 34 (13) 2741-2748 10.1021/es991118m
17. Kümmerer, K.; Haiß, A.; Schuster, A.; Hein, A.; Ebert, I. Antineoplastic compounds in the environment-substances of special concern Environ. Sci. Pollut. Res. 2014, 1-14 10.1007/s11356-014-3902-8
18. Watkinson, A. J.; Murby, E. J.; Kolpin, D. W.; Costanzo, S. D. The occurrence of antibiotics in an urban watershed: From wastewater to drinking water Sci. Total Environ. 2009, 407 (8) 2711-2723 10.1016/j.scitotenv.2008.11.059
19. Michael, I.; Rizzo, L.; McArdell, C. S.; Manaia, C. M.; Merlin, C.; Schwartz, T.; Dagot, C.; Fatta-Kassinos, D. Urban wastewater treatment plants as hotspots for the release of antibiotics in the environment: A review Water Res. 2013, 47 (3) 957-995 10.1016/j.watres.2012.11.027
20. Joss, A.; Keller, E.; Alder, A. C.; Göbel, A.; McArdell, C. S.; Ternes, T.; Siegrist, H. Removal of pharmaceuticals and fragrances in biological wastewater treatment Water Res. 2005, 39 (14) 3139-3152 10.1016/j.watres.2005.05.031
21. Göbel, A.; Thomsen, A.; McArdell, C. S.; Joss, A.; Giger, W. Occurrence and sorption behavior of sulfonamides, macrolides, and trimethoprim in activated sludge treatment Environ. Sci. Technol. 2005, 39, 3981-3989 10.1021/es048550a
22. Pauwels, B.; Verstraete, W. The treatment of hospital wastewater: an appraisal J. Water Health 2006, 4, 405-416
23. Lienert, J.; Koller, M.; Konrad, J.; McArdell, C. S.; Schuwirth, N. Multiple-criteria decision analysis reveals high stakeholder preference to remove pharmaceuticals from hospital wastewater Environ. Sci. Technol. 2011, 45 (9) 3848-3857 10.1021/es1031294
24. Hollender, J.; Zimmermann, S. G.; Koepke, S.; Krauss, M.; McArdell, C. S.; Ort, C.; Singer, H.; von Gunten, U.; Siegrist, H. Elimination of organic micropollutants in a municipal wastewater treatment plant upgraded with a full-scale post-ozonation followed by sand filtration Environ. Sci. Technol. 2009, 43 (20) 7862-7869 10.1021/es9014629
25. Reungoat, J.; Escher, B. I.; Macova, M.; Argaud, F. X.; Gernjak, W.; Keller, J. Ozonation and biological activated carbon filtration of wastewater treatment plant effluents Water Res. 2012, 46 (3) 863-872 10.1016/j.watres.2011.11.064
26. Margot, J.; Kienle, C.; Magnet, A.; Weil, M.; Rossi, L.; de Alencastro, L. F.; Abegglen, C.; Thonney, D.; Chèvre, N.; Schärer, M.; Barry, D. A. Treatment of micropollutants in municipal wastewater: Ozone or powdered activated carbon? Sci. Total Environ. 2013, 461-462, 480-498 10.1016/j.scitotenv.2013.05.034
27. Mikroverunreinigungen: Massnahmen bei der Abwasserreinigung (Micropollutants: measures in wasteater treatment). Federal Office for Environment (FOEN), Switzerland, Website (in German), http://www.bafu.admin.ch/gewaesserschutz/03716/index.html?lang=en. Accessed: 2015-03-09. (Archived by WebCite® at http://www.webcitation.org/6WtI9NAAf).
28. Eggen, R. I. L.; Hollender, J.; Joss, A.; Schärer, M.; Stamm, C. Reducing the discharge of micropollutants in the aquatic environment: The benefits of upgrading wastewater treatment plants Environ. Sci. Technol. 2014, 48 (14) 7683-7689 10.1021/es500907n
29. Ort, C.; Hollender, J.; Schaerer, M.; Siegrist, H. Model-based evaluation of reduction strategies for micropollutants from wastewater treatment plants in complex river networks Environ. Sci. Technol. 2009, 43 (9) 3214-3220 10.1021/es802286v
30. Verlicchi, P.; Al Aukidy, M.; Jelic, A.; Petrović, M.; Barceló, D. Comparison of measured and predicted concentrations of selected pharmaceuticals in wastewater and surface water: A case study of a catchment area in the Po Valley (Italy) Sci. Total Environ. 2014, 470-471, 844-854 10.1016/j.scitotenv.2013.10.026
31. Kehrein, N.; Berlekamp, J.; Klasmeier, J. Modeling the fate of down-the-drain chemicals in whole watersheds: New version of the GREAT-ER software Environ. Modell. Softw. 2015, 64, 1-8 10.1016/j.envsoft.2014.10.018
32. Price, O. R.; Williams, R. J.; Zhang, Z.; van Egmond, R. Modelling concentrations of decamethylcyclopentasiloxane in two UK rivers using LF2000-WQX Environ. Pollut. 2010, 158 (2) 356-360 10.1016/j.envpol.2009.09.013
33. Coppens, L. J. C.; van Gils, J. A. G.; ter Laak, T. L.; Raterman, B. W.; van Wezel, A. P. Towards spatially smart abatement of human pharmaceuticals in surface waters: Defining impact of sewage treatment plants on susceptible functions Water Res. 2015, 81, 356-365 10.1016/j.watres.2015.05.061
34. Knodel, J.; Geißen, S. U.; Broll, J.; Dünnbier, U. Simulation and source identification of X-ray contrast media in the water cycle of Berlin J. Environ. Manage. 2011, 92 (11) 2913-2923 10.1016/j.jenvman.2011.07.004
35. Van Boeckel, T. P.; Gandra, S.; Ashok, A.; Caudron, Q.; Grenfell, B. T.; Levin, S. A.; Laxminarayan, R. Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data Lancet Infect. Dis. 2014, 14 (8) 742-750 10.1016/S1473-3099(14)70780-7
36. Ort, C.; Lawrence, M. G.; Reungoat, J.; Mueller, J. F. Sampling for PPCPs in wastewater systems: Comparison of different sampling modes and optimization strategies Environ. Sci. Technol. 2010, 44 (16) 6289-6296 10.1021/es100778d
37. Lawrence, M. G.; Ort, C.; Keller, J. Detection of anthropogenic gadolinium in treated wastewater in South East Queensland, Australia Water Res. 2009, 43 (14) 3534-3540 10.1016/j.watres.2009.04.033
38. Verplanck, P. L.; Furlong, E. T.; Gray, J. L.; Phillips, P. J.; Wolf, R. E.; Esposito, K. Evaluating the behavior of gadolinium and other rare earth elements through large metropolitan sewage treatment plants Environ. Sci. Technol. 2010, 44 (10) 3876-3882 10.1021/es903888t
39. Janna, H.; Scrimshaw, M. D.; Williams, R. J.; Churchley, J.; Sumpter, J. P. From dishwasher to tap? Xenobiotic substances benzotriazole and tolyltriazole in the environment Environ. Sci. Technol. 2011, 45 (9) 3858-3864 10.1021/es103267g
40. Kovalova, L.; Siegrist, H.; Singer, H.; Wittmer, A.; McArdell, C. S. Hospital wastewater treatment by membrane bioreactor: Performance and efficiency for organic micropollutant elimination Environ. Sci. Technol. 2012, 46 (3) 1536-1545 10.1021/es203495d
41. Batt, A. L.; Kim, S.; Aga, D. S. Enhanced biodegradation of iopromide and trimethoprim in nitrifying activated sludge Environ. Sci. Technol. 2006, 40 (23) 7367-7373 10.1021/es060835v
42. Ternes, T. A.; Bonerz, M.; Herrmann, N.; Teiser, B.; Andersen, H. R. Irrigation of treated wastewater in Braunschweig, Germany: An option to remove pharmaceuticals and musk fragrances Chemosphere 2007, 66 (5) 894-904 10.1016/j.chemosphere.2006.06.035
43. Kormos, J. L.; Schulz, M.; Ternes, T. A. Occurrence of iodinated X-ray contrast media and their biotransformation products in the urban water cycle Environ. Sci. Technol. 2011, 45 (20) 8723-8732 10.1021/es2018187
44. Menz, J.; Schneider, M.; Kümmerer, K. Usage pattern-based exposure screening as a simple tool for the regional priority-setting in environmental risk assessment of veterinary antibiotics: A case study of north-western Germany Chemosphere 2015, 127, 42-48 10.1016/j.chemosphere.2014.12.091
45. Kovalova, L.; Siegrist, H.; Von Gunten, U.; Eugster, J.; Hagenbuch, M.; Wittmer, A.; Moser, R.; McArdell, C. S. Elimination of micropollutants during post-treatment of hospital wastewater with powdered activated carbon, ozone and UV Environ. Sci. Technol. 2013, 47 (14) 7899-7908 10.1021/es400708w
46. Kuroda, K.; Murakami, M.; Oguma, K.; Muramatsu, Y.; Takada, H.; Takizawa, S. Assessment of groundwater pollution in Tokyo using PPCPs as sewage markers Environ. Sci. Technol. 2012, 46 (3) 1455-1464 10.1021/es202059g
47. Phillips, P. J.; Chalmers, A. T.; Gray, J. L.; Kolpin, D. W.; Foreman, W. T.; Wall, G. R. Combined sewer overflows: An environmental source of hormones and wastewater micropollutants Environ. Sci. Technol. 2012, 46 (10) 5336-5343 10.1021/es3001294
48. Buerge, I. J.; Buser, H.-R.; Poiger, T.; Müller, M. D. Occurrence and fate of the cytostatic drugs cyclophosphamide and ifosfamide in wastewater and surface waters Environ. Sci. Technol. 2006, 40 (23) 7242-7250 10.1021/es0609405
49. Luo, Y.; Guo, W.; Ngo, H. H.; Nghiem, L. D.; Hai, F. I.; Zhang, J.; Liang, S.; Wang, X. C. A review on the occurrence of micropollutants in the aquatic environment and their fate and removal during wastewater treatment Sci. Total Environ. 2014, 473-474, 619-641 10.1016/j.scitotenv.2013.12.065
50. Deblonde, T.; Cossu-Leguille, C.; Hartemann, P. Emerging pollutants in wastewater: A review of the literature Int. J. Hyg. Environ. Health 2011, 214 (6) 442-448 10.1016/j.ijheh.2011.08.002