High throughput cell-free extraction of plasma by an integrated microfluidic device combining inertial microfluidics and membrane

ASME 2016 5th International Conference on Micro/Nanoscale Heat and Mass Transfer, MNHMT 2016

Volumn 1, Issue , 2016, Pages

  Zhang, Jun ^a   Yan, Sheng ^a   Yuan, Dan ^a   Alici, Gursel ^a   Nguyen, Nam Trung ^b   Li, Weihua ^a  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b GRIFFITH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHIPS; BLOOD; CENTRIFUGATION; EXTRACTION; FILTERS (FOR FLUIDS); FLUIDIC DEVICES; HEAT TRANSFER; MASS TRANSFER; MEMBRANE TECHNOLOGY; MICROFILTRATION; NUCLEIC ACIDS; THROUGHPUT;

CONVENTIONAL METHODS; HIGH THROUGHPUT; INERTIAL MICROFLUIDICS; INTEGRATED DEVICE; INTEGRATED MICROFLUIDIC DEVICES; MEMBRANE FILTERS; MEMBRANE FILTRATIONS; PLASMA EXTRACTIONS;

MICROFLUIDICS;

EID: 84968813474     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1115/MNHMT2016-6717     Document Type: Conference Paper

References (29)

1. M. Toner and D. Irimia, "Blood-on-a-chip," Annual review of biomedical engineering, vol. 7, pp. 77-103, 2005.
2. K. Aran, A. Fok, L. A. Sasso, N. Kamdar, Y. Guan, Q. Sun, et al., "Microfiltration platform for continuous blood plasma protein extraction from whole blood during cardiac surgery," Lab on a Chip, vol. 11, pp. 2858-2868, 2011.
3. F. Petersson, L. Aberg, A.-M. Sward-Nilsson, and T. Laurell, "Free flow acoustophoresis: Microfluidic-based mode of particle and cell separation," Analytical Chemistry, vol. 79, pp. 5117-5123, Jul 15 2007.
4. M. Kersaudy-Kerhoas and E. Sollier, "Micro-scale blood plasma separation: from acoustophoresis to egg-beaters," Lab on a Chip, vol. 13, pp. 3323-3346, 2013.
5. M. Li, S. Li, W. Li, W. Wen, and G. Alici, "Continuous manipulation and separation of particles using combined obstacle and curvature induced direct current dielectrophoresis," Electrophoresis, vol. 34, pp. 952-960, 2013.
6. B. Çetin and D. Li, "Dielectrophoresis in microfluidics technology," Electrophoresis, vol. 32, pp. 2410-2427, 2011.
7. N. Pamme and C. Wilhelm, "Continuous sorting of magnetic cells via onchip free-flow magnetophoresis," Lab Chip, vol. 6, pp. 974-980, 2006.
8. Y. Gao, Y. Jian, L. Zhang, and J. Huang, "Magnetophoresis of nonmagnetic particles in ferrofluids," The Journal of Physical Chemistry C, vol. 111, pp. 10785-10791, 2007.
9. L. R. Huang, E. C. Cox, R. H. Austin, and J. C. Sturm, "Continuous particle separation through deterministic lateral displacement," Science, vol. 304, pp. 987-990, 2004.
10. Z. Liu, F. Huang, J. Du, W. Shu, H. Feng, X. Xu, et al., "Rapid isolation of cancer cells using microfluidic deterministic lateral displacement structure," Biomicrofluidics, vol. 7, p. 011801, 2013.
11. J. V. Green, M. Radisic, and S. K. Murthy, "Deterministic lateral displacement as a means to enrich large cells for tissue engineering," Analytical chemistry, vol. 81, pp. 9178-9182, 2009.
12. S. Choi, S. Song, C. Choi, and J. K. Park, "Sheathless focusing of microbeads and blood cells based on hydrophoresis," Small, vol. 4, pp. 634-641, 2008.
13. S. Yan, J. Zhang, G. Alici, H. Du, Y. Zhu, and W. Li, "Isolating plasma from blood using a dielectrophoresis-active hydrophoretic device," Lab on a Chip, vol. 14, pp. 2993-3003, 2014.
14. D. Di Carlo, "Inertial microfluidics," Lab on a Chip, vol. 9, pp. 3038-3046, 2009 2009.
15. J. Zhang, S. Yan, R. Sluyter, W. Li, G. Alici, and N.-T. Nguyen, "Inertial particle separation by differential equilibrium positions in a symmetrical serpentine micro-channel," Scientific reports, vol. 4, p. Art No. 4527, 2014.
16. H. Amini, W. Lee, and D. Di Carlo, "Inertial microfluidic physics," Lab on a Chip, vol. 14, pp. 2739-2761, 2014.
17. A. R. C. B. Service. (2015, 27 JUL). Blood components. Available: http://www.donateblood.com.au/about-blood/components
18. J. Zhang, S. Yan, W. Li, G. Alici, and N.-T. Nguyen, "High throughput extraction of plasma using a secondary flow-aided inertial microfluidic device," RSC Advances, vol. 4, pp. 33149-33159, 2014.
19. J. Moorthy and D. J. Beebe, "In situ fabricated porous filters for microsystems," Lab on a Chip, vol. 3, pp. 62-66, 2003.
20. W. Gan, B. Zhuang, P. Zhang, J. Han, C.-X. Li, and P. Liu, "A filter paperbased microdevice for low-cost, rapid, and automated DNA extraction and amplification from diverse sample types," Lab on a Chip, vol. 14, pp. 3719-3728, 2014.
21. S. Wang, D. Sarenac, M. Chen, S.-H. Huang, F. F. Giguel, D. R. Kuritzkes, et al., "Simple filter microchip for rapid separation of plasma and viruses from whole blood," 2012.
22. J. H. Son, S. H. Lee, S. Hong, S.-m. Park, J. Lee, A. M. Dickey, et al., "Hemolysis-free blood plasma separation," Lab on a Chip, vol. 14, pp. 2287-2292, 2014.
23. C. Liu, M. Mauk, R. Gross, F. D. Bushman, P. H. Edelstein, R. G. Collman, et al., "Membrane-based, sedimentation-assisted plasma separator for point-of-care applications," Analytical chemistry, vol. 85, pp. 10463-10470, 2013.
24. X. Li, W. Chen, G. Liu, W. Lu, and J. Fu, "Continuous-flow microfluidic blood cell sorting for unprocessed whole blood using surfacemicromachined microfiltration membranes," Lab on a Chip, vol. 14, pp. 2565-2575, 2014.
25. G. Késmárky, P. Kenyeres, M. Rábai, and K. Tóth, "Plasma viscosity: a forgotten variable," Clinical hemorheology and microcirculation, vol. 39, pp. 243-246, 2008.
26. J. Kim, R. Surapaneni, and B. K. Gale, "Rapid prototyping of microfluidic systems using a PDMS/polymer tape composite," Lab on a Chip, vol. 9, pp. 1290-1293, 2009.
27. H. Y. Tan, W. K. Loke, and N.-T. Nguyen, "A reliable method for bonding polydimethylsiloxane (PDMS) to polymethylmethacrylate (PMMA) and its application in micropumps," Sensors and Actuators B: Chemical, vol. 151, pp. 133-139, 2010.
28. Syringe-filters.com. (2015). Membrane Selection Guide. Available: http://www.syringe-filters.com/membrane-selection-guide.php
29. Labhut.com. (2015, 31 Jul). Syringe Filter Chemical Compatibility Guide. Available: http://www.labhut.com/syringe-filter-chemical-compatibilityguide/