The diagnostic value of circulating brain-specific microRNAs for ischemic stroke

Internal Medicine

Volumn 55, Issue 10, 2016, Pages 1279-1286

  Yang, Zhong Bao ^a   Li, Ting Bo ^a   Zhang, Zhen ^b   Ren, Kai Di ^a   Zheng, Zhao Feng ^a   Peng, Jun ^a   Luo, Xiu Ju ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Biomarkers; Circulating miRNAs; Diagnosis; Ischemia stroke

Indexed keywords

MICRORNA; MICRORNA 107; MICRORNA 128B; MICRORNA 137; MICRORNA 153; UNCLASSIFIED DRUG; BIOLOGICAL MARKER;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOCHEMISTRY; BRAIN ISCHEMIA; CONTROLLED STUDY; DIAGNOSTIC VALUE; FEMALE; GENE EXPRESSION; HUMAN; MAJOR CLINICAL STUDY; MALE; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; REAL TIME POLYMERASE CHAIN REACTION; RECEIVER OPERATING CHARACTERISTIC; RNA ISOLATION; SENSITIVITY AND SPECIFICITY; BLOOD; BRAIN; DIAGNOSTIC IMAGING; METABOLISM; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PROSPECTIVE STUDY;

BIOMARKERS; BRAIN; BRAIN ISCHEMIA; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MICRORNAS; MIDDLE AGED; PROSPECTIVE STUDIES; REAL-TIME POLYMERASE CHAIN REACTION; ROC CURVE;

EID: 84968807181     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.55.5925     Document Type: Article

References (33)

1. Mozaffarian D, Benjamin EJ, Go AS, et al. Heart disease and stroke statistics-2015 update: a report from the American Heart Association. Circulation 131: e29-e322, 2015.
2. Wang W, Sun G, Zhang L, Shi L, Zeng Y. Circulating microRNAs as novel potential biomarkers for early diagnosis of acute stroke in humans. J Stroke Cerebrovasc Dis 23: 2607-2613, 2014.
3. Sepramaniam S, Tan JR, Tan KS, et al. Circulating microRNAs as biomarkers of acute stroke. Int J Mol Sci 15: 1418-1432, 2014.
4. Zhan X, Jickling GC, Tian Y, et al. Transient ischemic attacks characterized by RNA profiles in blood. Neurology 77: 1718-1724, 2011.
5. Cox C, Sharp FR. RNA-based blood genomics as an investigative tool and prospective biomarker for ischemic stroke. Neurol Res 35: 457-464, 2013.
6. Sharp FR, Jickling GC, Stamova B, et al. RNA expression profiles from blood for the diagnosis of stroke and its causes. J Child Neurol 26: 1131-1136, 2011.
7. Ameres SL, Zamore PD. Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol 14: 475-488, 2013.
8. Vidigal JA, Ventura A. The biological functions of miRNAs: lessons from in vivo studies. Trends Cell Biol 25: 137-147, 2015.
9. Yang ZB, Zhang Z, Li TB, et al. Up-regulation of brain-enriched miR-107 promotes excitatory neurotoxicity through down-regulation of glutamate transporter-1 expression following ischaemic stroke. Clin Sci (Lond) 127: 679-689, 2014.
10. Vickers KC, Palmisano BT, Shoucri BM, Shamburek RD, Remaley AT. MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol 13: 423-433, 2011.
11. Zampetaki A, Willeit P, Drozdov I, Kiechl S, Mayr M. Profiling of circulating microRNAs: from single biomarkers to re-wired networks. Cardiovasc Res 93: 555-562, 2012.
12. Kroh EM, Parkin RK, Mitchell PS, Tewari M. Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR). Methods 50: 298-301, 2010.
13. Chevillet JR, Lee I, Briggs HA, He Y, Wang K. Issues and prospects of microRNA-based biomarkers in blood and other body fluids. Molecules 19: 6080-6105, 2014.
14. Schwarzenbach H, Nishida N, Calin GA, Pantel K. Clinical relevance of circulating cell-free microRNAs in cancer. Nat Rev Clin Oncol 11: 145-156, 2014.
15. Grasedieck S, Sorrentino A, Langer C, et al. Circulating microRNAs in hematological diseases: principles, challenges, and perspectives. Blood 121: 4977-4984, 2013.
16. Adlakha YK, Saini N. Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128. Mol Cancer 13: 33, 2014.
17. Zhao L, Li H, Guo R, et al. miR-137, a new target for post-stroke depression? Neural Regen Res 8: 2441-2448, 2013.
18. Duan X, Zhan Q, Song B, et al. Detection of platelet microRNA expression in patients with diabetes mellitus with or without ischemic stroke. J Diabetes Complications 28: 705-710, 2014.
19. Jauch EC, Lindsell C, Broderick J, Fagan SC, Tilley BC, Levine SR. Association of serial biochemical markers with acute ischemic stroke: the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator Stroke Study. Stroke 37: 2508-2513, 2006.
20. Dassan P, Keir G, Brown MM. Criteria for a clinically informative serum biomarker in acute ischaemic stroke: a review of S100B. Cerebrovasc Dis 27: 295-302, 2009.
21. Al-Rawi NH, Atiyah KM. Salivary neuron specific enolase: an indicator for neuronal damage in patients with ischemic stroke and stroke-prone patients. Clin Chem Lab Med 47: 1519-1524, 2009.
22. An SA, Kim J, Kim OJ, et al. Limited clinical value of multiple blood markers in the diagnosis of ischemic stroke. Clin Biochem 46: 710-715, 2013.
23. Liu DZ, Tian Y, Ander BP, et al. Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J Cereb Blood Flow Metab 30: 92-101, 2010.
24. Fichtlscherer S, Zeiher AM, Dimmeler S. Circulating microRNAs: biomarkers or mediators of cardiovascular diseases? Arterioscler Thromb Vasc Biol 31: 2383-2390, 2011.
25. Nishiguchi T, Imanishi T, Akasaka T. MicroRNAs and cardiovascular diseases. Biomed Res Int 2015: 682857, 2015.
26. Jeyaseelan K, Lim KY, Armugam A. MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion. Stroke 39: 959-966, 2008.
27. Tan KS, Armugam A, Sepramaniam S, et al. Expression profile of MicroRNAs in young stroke patients. PLoS One 4: e7689, 2009.
28. Tan JR, Tan KS, Koo YX, et al. Blood microRNAs in low or no risk ischemic stroke patients. Int J Mol Sci 14: 2072-2084, 2013.
29. Gan CS, Wang CW, Tan KS. Circulatory microRNA-145 expression is increased in cerebral ischemia. Genet Mol Res 11: 147-152, 2012.
30. Selvamani A, Williams MH, Miranda RC, Sohrabji F. Circulating miRNA profiles provide a biomarker for severity of stroke outcomes associated with age and sex in a rat model. Clin Sci (Lond) 127: 77-89, 2014.
31. Rothstein JD, Dykes-Hoberg M, Pardo CA, et al. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16: 675-686, 1996.
32. Ketheeswaranathan P, Turner NA, Spary EJ, Batten TF, McColl BW, Saha S. Changes in glutamate transporter expression in mouse forebrain areas following focal ischemia. Brain Res 1418: 93-103, 2011.
33. Liu L, Sun T, Liu Z, et al. Traumatic brain injury dysregulates microRNAs to modulate cell signaling in rat hippocampus. PLoS One 9: e103948, 2014.