메뉴 건너뛰기




Volumn 33, Issue 6, 2016, Pages 718-722

Drug development from the bench to the pharmacy: With special reference to dipeptidyl peptidase-4 inhibitor development

(1)  Carr, R D a  


Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCAGON LIKE PEPTIDE 1;

EID: 84968739538     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/dme.13066     Document Type: Review
Times cited : (10)

References (32)
  • 1
    • 84903597977 scopus 로고    scopus 로고
    • Tamoxifen as the first targeted long term adjuvant therapy for breast cancer
    • Jordan VC. Tamoxifen as the first targeted long term adjuvant therapy for breast cancer. Endocr Relat Cancer 2014; 21: R235-R246.
    • (2014) Endocr Relat Cancer , vol.21 , pp. R235-R246
    • Jordan, V.C.1
  • 3
    • 0023104829 scopus 로고
    • Truncated glucagon-like peptide I, an insulin-releasing hormone from the distil gut
    • Holst JJ, Ørskov C, Nielsen OV, Schwartz TW. Truncated glucagon-like peptide I, an insulin-releasing hormone from the distil gut. FEBS Lett 1987; 211: 169-174.
    • (1987) FEBS Lett , vol.211 , pp. 169-174
    • Holst, J.J.1    Ørskov, C.2    Nielsen, O.V.3    Schwartz, T.W.4
  • 4
    • 0023107555 scopus 로고
    • Insunotropin: glucagon like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas
    • Mosjov S, Weir GC, Habener JF. Insunotropin: glucagon like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest 1987; 79: 616-619.
    • (1987) J Clin Invest , vol.79 , pp. 616-619
    • Mosjov, S.1    Weir, G.C.2    Habener, J.F.3
  • 5
    • 0032701468 scopus 로고    scopus 로고
    • Glucagon-like peptide-1, a gastrointestinal hormone with a pharmaceutical potential
    • Holst JJ. Glucagon-like peptide-1, a gastrointestinal hormone with a pharmaceutical potential. Curr Med Chem 1999; 6: 415-431.
    • (1999) Curr Med Chem , vol.6 , pp. 415-431
    • Holst, J.J.1
  • 6
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
    • Nauck MA, Kleine N, Ørskov C, Holst JJ, Willms B, Creutzfeldt W. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1993; 36: 741-744.
    • (1993) Diabetologia , vol.36 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Ørskov, C.3    Holst, J.J.4    Willms, B.5    Creutzfeldt, W.6
  • 7
    • 0029907680 scopus 로고    scopus 로고
    • Effects of subcutaneous glucagon-like peptide 1 (GLP-1 [7-36 amide]) in patients with NIDDM
    • Nauck MA, Wollschläger D, Werner J, Holst JJ, Orskov C, Creutzfeldt W et al. Effects of subcutaneous glucagon-like peptide 1 (GLP-1 [7-36 amide]) in patients with NIDDM. Diabetologia 1996; 39: 1546-1553.
    • (1996) Diabetologia , vol.39 , pp. 1546-1553
    • Nauck, M.A.1    Wollschläger, D.2    Werner, J.3    Holst, J.J.4    Orskov, C.5    Creutzfeldt, W.6
  • 8
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study
    • Zander M, Madsbad S, Madsen JL, Holst JJ. Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. Lancet 2002; 359: 824-830.
    • (2002) Lancet , vol.359 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3    Holst, J.J.4
  • 9
    • 0027215348 scopus 로고
    • Dipeptidyl peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1 (7-36 amide), peptide histidine methionine and is responsible for their degradation in human serum
    • Mentlein R, Gallwitz B, Schmidt WE. Dipeptidyl peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1 (7-36 amide), peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem 1993; 214: 829-835.
    • (1993) Eur J Biochem , vol.214 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 10
    • 0029118049 scopus 로고
    • Degradation of glucose-dependent insulinotropic polypeptide (GIP) and truncated glucagon-like peptide
    • Kieffer TJ, McIntosh CHS, Pederson RA. Degradation of glucose-dependent insulinotropic polypeptide (GIP) and truncated glucagon-like peptide. Endocrinology 1995; 136: 3585-3596.
    • (1995) Endocrinology , vol.136 , pp. 3585-3596
    • Kieffer, T.J.1    McIntosh, C.H.S.2    Pederson, R.A.3
  • 11
    • 0028953577 scopus 로고
    • Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide which is a major endogenous metabolite in vivo
    • Deacon CF, Johnsen AH, Holst JJ. Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide which is a major endogenous metabolite in vivo. J Clin Endocrinol Metab 1995; 80: 952-957.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 952-957
    • Deacon, C.F.1    Johnsen, A.H.2    Holst, J.J.3
  • 12
    • 0031916924 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide-1 in anesthetized pigs
    • Deacon CF, Hughes TE, Holst JJ. Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide-1 in anesthetized pigs. Diabetes 1998; 47: 764-769.
    • (1998) Diabetes , vol.47 , pp. 764-769
    • Deacon, C.F.1    Hughes, T.E.2    Holst, J.J.3
  • 13
    • 0031870418 scopus 로고    scopus 로고
    • Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV (CD26) inhibitor Ile-thiazolidide
    • Pederson RA, White HA, Schlenzig D, Pauly RP, McIntosh CH, Demuth HU. Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV (CD26) inhibitor Ile-thiazolidide. Diabetes 1998; 47: 1253-1258.
    • (1998) Diabetes , vol.47 , pp. 1253-1258
    • Pederson, R.A.1    White, H.A.2    Schlenzig, D.3    Pauly, R.P.4    McIntosh, C.H.5    Demuth, H.U.6
  • 14
    • 25844459084 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9
    • Lankas GR, Leiting B, Roy RS, Eiermann GJ, Beconi MG, Biftu T et al. Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9. Diabetes 2005; 54: 2988-2994.
    • (2005) Diabetes , vol.54 , pp. 2988-2994
    • Lankas, G.R.1    Leiting, B.2    Roy, R.S.3    Eiermann, G.J.4    Beconi, M.G.5    Biftu, T.6
  • 16
    • 0037219684 scopus 로고    scopus 로고
    • Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog
    • Rasmussen H, Branner S, Wiberg FC, Wagtmann N. Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog. Nat Struct Biol 2003; 10: 19-25.
    • (2003) Nat Struct Biol , vol.10 , pp. 19-25
    • Rasmussen, H.1    Branner, S.2    Wiberg, F.C.3    Wagtmann, N.4
  • 17
    • 33947690115 scopus 로고    scopus 로고
    • Discovery of JANUVIA (Sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
    • Thornberry NA, Weber AE. Discovery of JANUVIA (Sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Curr Top Med Chem 2007; 7: 557-568.
    • (2007) Curr Top Med Chem , vol.7 , pp. 557-568
    • Thornberry, N.A.1    Weber, A.E.2
  • 18
    • 0036583164 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes
    • Ahrén B, Simonsson E, Larsson H, Landin-Olsson M, Torgeirsson H, Jansson PA et al. Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes. Diabetes Care 2002; 25: 869-875.
    • (2002) Diabetes Care , vol.25 , pp. 869-875
    • Ahrén, B.1    Simonsson, E.2    Larsson, H.3    Landin-Olsson, M.4    Torgeirsson, H.5    Jansson, P.A.6
  • 19
    • 78649686908 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review
    • Deacon CF. Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review. Diabetes Obes Metab 2011; 13: 7-18.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 7-18
    • Deacon, C.F.1
  • 20
    • 84885384645 scopus 로고    scopus 로고
    • Safety and tolerability of sitagliptin in type 2 diabetes: pooled analysis of 25 clinical studies
    • Engel SS, Round E, Golm GT, Kaufman KD, Goldstein BJ. Safety and tolerability of sitagliptin in type 2 diabetes: pooled analysis of 25 clinical studies. Diabetes Ther 2013; 4: 119-145.
    • (2013) Diabetes Ther , vol.4 , pp. 119-145
    • Engel, S.S.1    Round, E.2    Golm, G.T.3    Kaufman, K.D.4    Goldstein, B.J.5
  • 21
    • 84906938284 scopus 로고    scopus 로고
    • Safety and tolerability of linagliptin in patients with Type 2 diabetes: a comprehensive pooled analysis of 22 placebo-controlled studies
    • Lehrke M, Marx N, Patel S, Seck T, Crowe S, Cheng K et al. Safety and tolerability of linagliptin in patients with Type 2 diabetes: a comprehensive pooled analysis of 22 placebo-controlled studies. Clin Ther 2014; 36: 1130-1146.
    • (2014) Clin Ther , vol.36 , pp. 1130-1146
    • Lehrke, M.1    Marx, N.2    Patel, S.3    Seck, T.4    Crowe, S.5    Cheng, K.6
  • 22
    • 79951607030 scopus 로고    scopus 로고
    • Assessing the general safety and tolerability of vildagliptin: value of pooled analyses from a large safety database versus evaluation of individual studies
    • Schweizer A, Dejager S, Foley JE, Kothny W. Assessing the general safety and tolerability of vildagliptin: value of pooled analyses from a large safety database versus evaluation of individual studies. Vasc Health Risk Manag 2011; 7: 49-57.
    • (2011) Vasc Health Risk Manag , vol.7 , pp. 49-57
    • Schweizer, A.1    Dejager, S.2    Foley, J.E.3    Kothny, W.4
  • 23
    • 84937053742 scopus 로고    scopus 로고
    • Effect of sitagliptin on cardiovascular outcomes in Type 2 diabetes
    • TECOS Study Group
    • Green JB, Bethel MA, Armstrong PW, Buse JB, Engel SS, Garg J et al.; TECOS Study Group. Effect of sitagliptin on cardiovascular outcomes in Type 2 diabetes. N Engl J Med 2015; 373: 232-242.
    • (2015) N Engl J Med , vol.373 , pp. 232-242
    • Green, J.B.1    Bethel, M.A.2    Armstrong, P.W.3    Buse, J.B.4    Engel, S.S.5    Garg, J.6
  • 24
    • 84883765959 scopus 로고    scopus 로고
    • Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
    • SAVOR-TIMI 53 Steering Committee and Investigators
    • Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B et al.; SAVOR-TIMI 53 Steering Committee and Investigators. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med 2013; 369: 1317-1326.
    • (2013) N Engl J Med , vol.369 , pp. 1317-1326
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3    Steg, P.G.4    Davidson, J.5    Hirshberg, B.6
  • 25
    • 84883745765 scopus 로고    scopus 로고
    • Alogliptin after acute coronary syndrome in patients with type 2 diabetes
    • EXAMINE Investigators
    • White WB, Cannon CP, Heller SR, Nissen SE, Bergenstal RM, Bakris GL et al.; EXAMINE Investigators. Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N Engl J Med 2013; 369: 1327-1335.
    • (2013) N Engl J Med , vol.369 , pp. 1327-1335
    • White, W.B.1    Cannon, C.P.2    Heller, S.R.3    Nissen, S.E.4    Bergenstal, R.M.5    Bakris, G.L.6
  • 26
    • 84920022876 scopus 로고    scopus 로고
    • Drug utilization, safety, and effectiveness of exenatide, sitagliptin, and vildagliptin for type 2 diabetes in the real world: data from the Italian AIFA Anti-diabetics Monitoring Registry
    • AIFA Anti-diabetics Monitoring Group
    • Montilla S, Marchesini G, Sammarco A, Trotta MP, Siviero PD, Tomino C et al.; AIFA Anti-diabetics Monitoring Group. Drug utilization, safety, and effectiveness of exenatide, sitagliptin, and vildagliptin for type 2 diabetes in the real world: data from the Italian AIFA Anti-diabetics Monitoring Registry. Nutr Metab Cardiovasc Dis 2014; 24: 1346-1353.
    • (2014) Nutr Metab Cardiovasc Dis , vol.24 , pp. 1346-1353
    • Montilla, S.1    Marchesini, G.2    Sammarco, A.3    Trotta, M.P.4    Siviero, P.D.5    Tomino, C.6
  • 27
    • 84937734450 scopus 로고    scopus 로고
    • Trelagliptin: first global approval
    • McKeage K. Trelagliptin: first global approval. Drugs 2015; 75: 1161-1164.
    • (2015) Drugs , vol.75 , pp. 1161-1164
    • McKeage, K.1
  • 28
    • 84962439676 scopus 로고    scopus 로고
    • Safety and efficacy of omarigliptin (MK-3102), a novel once-weekly DPP-4 inhibitor for the treatment of patients with Type 2 diabetes
    • Sheu WH, Gantz I, Chen M, Suryawanshi S, Mirza A, Goldstein BJ et al. Safety and efficacy of omarigliptin (MK-3102), a novel once-weekly DPP-4 inhibitor for the treatment of patients with Type 2 diabetes. Diabetes Care 2015; 38: 2106-2114
    • (2015) Diabetes Care , vol.38 , pp. 2106-2114
    • Sheu, W.H.1    Gantz, I.2    Chen, M.3    Suryawanshi, S.4    Mirza, A.5    Goldstein, B.J.6
  • 30
    • 0024549875 scopus 로고
    • Differentiation of angiotensin-converting enzyme (ACE) inhibitors by their selective inhibition of ACE in physiologically important target organs
    • Cushman DW, Wang FL, Fung WC, Harvey CM, DeForrest JM. Differentiation of angiotensin-converting enzyme (ACE) inhibitors by their selective inhibition of ACE in physiologically important target organs. Am J Hypertens 1989; 2: 294-306.
    • (1989) Am J Hypertens , vol.2 , pp. 294-306
    • Cushman, D.W.1    Wang, F.L.2    Fung, W.C.3    Harvey, C.M.4    DeForrest, J.M.5
  • 31
    • 0029995843 scopus 로고    scopus 로고
    • Bradykinin-evoked sensitization of airway sensory nerves: a mechanism for ACE-inhibitor cough
    • Fox AJ, Lalloo UG, Belvisi MG, Bernareggi M, Chung KF, Barnes PJ. Bradykinin-evoked sensitization of airway sensory nerves: a mechanism for ACE-inhibitor cough. Nat Med 1996; 2: 814-817.
    • (1996) Nat Med , vol.2 , pp. 814-817
    • Fox, A.J.1    Lalloo, U.G.2    Belvisi, M.G.3    Bernareggi, M.4    Chung, K.F.5    Barnes, P.J.6
  • 32
    • 84922692543 scopus 로고    scopus 로고
    • Suppression of insulin production and secretion by a decretin hormone
    • Alfa RW, Park S, Skelly KR, Poffenberger G, Jain N, Gu X et al. Suppression of insulin production and secretion by a decretin hormone. Cell Metab 2015; 21: 323-333.
    • (2015) Cell Metab , vol.21 , pp. 323-333
    • Alfa, R.W.1    Park, S.2    Skelly, K.R.3    Poffenberger, G.4    Jain, N.5    Gu, X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.