-
1
-
-
0002820601
-
Poorly soluble drugs, a challenge in drug delivery
-
Müller RH, Benita S and Böhm B (eds.), Medpharm Scientific Publishers: Stuttgart
-
Speiser PP (1998) Poorly soluble drugs, a challenge in drug delivery, in Müller RH, Benita S and Böhm B (eds.), Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs, Medpharm Scientific Publishers: Stuttgart.
-
(1998)
Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs
-
-
Speiser, P.P.1
-
3
-
-
0014288096
-
Ultrastructure of membranes: Biomolecular organization
-
Bangham AD and Haydon DA (1968) Ultrastructure of membranes: Biomolecular organization. Brit Med Bull 24(2):124-6.
-
(1968)
Brit Med Bull
, vol.24
, Issue.2
, pp. 124-126
-
-
Bangham, A.D.1
Haydon, D.A.2
-
6
-
-
0028911362
-
Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)
-
Kreuter J, Kharkevich RN and Ivanov DA (1995) Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles). Brain Res 674(1):171-174.
-
(1995)
Brain Res
, vol.674
, Issue.1
, pp. 171-174
-
-
Kreuter, J.1
Kharkevich, R.N.2
Ivanov, D.A.3
-
7
-
-
0034820059
-
Estimating the relative stability of polymorphs and hydrates from heats of solution and solubility data
-
Gu Chong-Hui GDJW (2001) Estimating the relative stability of polymorphs and hydrates from heats of solution and solubility data. J Pharm Sci 90(9):1277-1287.
-
(2001)
J Pharm Sci
, vol.90
, Issue.9
, pp. 1277-1287
-
-
Gu Chong-Hui, G.D.J.W.1
-
8
-
-
1142303337
-
What is the True Solubility Advantage for Amorphous Pharmaceuticals?
-
Hancock C and Bruno P (2000) What is the True Solubility Advantage for Amorphous Pharmaceuticals? Pharm Res 17(4):397-404.
-
(2000)
Pharm Res
, vol.17
, Issue.4
, pp. 397-404
-
-
Hancock, C.1
Bruno, P.2
-
9
-
-
0028200490
-
Hydrosols - Alternatives for the Parenteral Applikation of Poorly Water Soluble Drugs
-
Gassmann P, List M, Schweitzer A and Sucker H (1994) Hydrosols - Alternatives for the Parenteral Applikation of Poorly Water Soluble Drugs. Eur J Pharm Biopharm 40:64-72.
-
(1994)
Eur J Pharm Biopharm
, vol.40
, pp. 64-72
-
-
Gassmann, P.1
List, M.2
Schweitzer, A.3
Sucker, H.4
-
10
-
-
84967543941
-
-
Pat.No. GB 2200048
-
List M and Sucker H (1988) Pat.No. GB 2200048.
-
(1988)
-
-
List, M.1
Sucker, H.2
-
12
-
-
0036006629
-
Transmission electron microscopy of Mozzarella cheeses made from microfluidized milk
-
Tunick MHVH, Diane L, Cooke PH and Malin EL (2002) Transmission electron microscopy of Mozzarella cheeses made from microfluidized milk. J Agri Food Chem 50(1):99-103.
-
(2002)
J Agri Food Chem
, vol.50
, Issue.1
, pp. 99-103
-
-
Tunick, M.H.V.H.1
Diane, L.2
Cooke, P.H.3
Malin, E.L.4
-
14
-
-
0001298289
-
General Route to Nanocrystalline Oxids by Hydrodynamic Cavitation
-
Sunstrom JEM and Marshik-Guerts B (1996) General Route to Nanocrystalline Oxids by Hydrodynamic Cavitation. Chem. Mater.
-
(1996)
Chem. Mater
-
-
Sunstrom, J.E.M.1
Marshik-Guerts, B.2
-
18
-
-
4243505839
-
-
United States Patent 5, 858, 410. USA
-
Müller RH, Becker R, Kruss B and Peters K (1999) Pharmaceutical Nanosuspensions for Medicament Administration as Systems with Increased Saturation Solubility and Rate of Solution, in United States Patent 5, 858, 410. USA.
-
(1999)
Pharmaceutical Nanosuspensions for Medicament Administration as Systems with Increased Saturation Solubility and Rate of Solution
-
-
Müller, R.H.1
Becker, R.2
Kruss, B.3
Peters, K.4
-
19
-
-
0002819692
-
Nanosuspensions for the formulation of poorly soluble drugs
-
Nielloud F and Marti-Mestres G (eds.), Marcel Dekker
-
Müller RH, Jacobs C and Kayser O (2000) Nanosuspensions for the formulation of poorly soluble drugs, in Nielloud F and Marti-Mestres G (eds.) Pharmaceutical Emulsions and Suspensions, Marcel Dekker.
-
(2000)
Pharmaceutical Emulsions and Suspensions
-
-
Müller, R.H.1
Jacobs, C.2
Kayser, O.3
-
22
-
-
6344237328
-
DissoCubes - A novel formulation for poorly soluble and poorly bioavailable drugs
-
Rathbone MJ, Hadgraft J, Roberts MS (eds.), Marcel Dekker
-
Müller RH, Jacobs C and Kayser O (2003) DissoCubes - A novel formulation for poorly soluble and poorly bioavailable drugs, in Rathbone MJ, Hadgraft J, Roberts MS (eds.), Modified-Release Drug Delivery Systems, Marcel Dekker.
-
(2003)
Modified-Release Drug Delivery Systems
-
-
Müller, R.H.1
Jacobs, C.2
Kayser, O.3
-
23
-
-
4544383493
-
Nanosuspensions in Drug Delivery
-
Rabinow BE (2004) Nanosuspensions in Drug Delivery. Nat Rev 3:785-796.
-
(2004)
Nat Rev
, vol.3
, pp. 785-796
-
-
Rabinow, B.E.1
-
24
-
-
26544475551
-
Nanopure Technology for the Production of Drug Nanocrystals and Polymeric Particles
-
Florence
-
Müller RH (2002) Nanopure Technology for the Production of Drug Nanocrystals and Polymeric Particles, in 4th World Meeting ADRITELF/APV/APGI. Florence.
-
(2002)
4th World Meeting ADRITELF/APV/APGI
-
-
Müller, R.H.1
-
25
-
-
28444441941
-
Nanocrystals of Poorly Soluble Drugs for Oral Administration
-
Bushrab NF and Müller RH (2003) Nanocrystals of Poorly Soluble Drugs for Oral Administration. New Drugs 5: 20-22.
-
(2003)
New Drugs
, vol.5
, pp. 20-22
-
-
Bushrab, N.F.1
Müller, R.H.2
-
26
-
-
0010259723
-
Nanopure™ pure drug nanoparticles for the formulation of poorly soluble Drugs
-
Radtke M (2001) Nanopure™ pure drug nanoparticles for the formulation of poorly soluble Drugs. New Drugs 3: 62-68.
-
(2001)
New Drugs
, vol.3
, pp. 62-68
-
-
Radtke, M.1
-
27
-
-
62749095284
-
Nanopure Technology - Drug Nanocrystals for the Delivery of Poorly Soluble Drugs
-
Orlando
-
Fichera MA, Keck CM and Müller RH (2004) Nanopure Technology - Drug Nanocrystals for the Delivery of Poorly Soluble Drugs, in Particles. Orlando.
-
(2004)
Particles
-
-
Fichera, M.A.1
Keck, C.M.2
Müller, R.H.3
-
28
-
-
84881671272
-
Effect of 4000 Bar Homogenisation Pressure on Particle Diminution in Drug Suspensions
-
Nürnberg
-
Fichera MA, Wissing SA and Müller RH (2004) Effect of 4000 Bar Homogenisation Pressure on Particle Diminution in Drug Suspensions, in APV. Nürnberg.
-
(2004)
APV
-
-
Fichera, M.A.1
Wissing, S.A.2
Müller, R.H.3
-
29
-
-
45449088483
-
Nanopure® Nanocrystals for Oral Delivery of Poorly Soluble Drugs
-
Orlando
-
Keck CM, Bushrab NF and Müller RH (2004) Nanopure® Nanocrystals for Oral Delivery of Poorly Soluble Drugs, in Particles. Orlando.
-
(2004)
Particles
-
-
Keck, C.M.1
Bushrab, N.F.2
Müller, R.H.3
-
31
-
-
45449112311
-
-
United States Patent 6,607,784. Baxter International Inc. (Deerfield, IL): USA
-
Kipp JE, Wong JCT, Doty MJ and Rebbeck CL (2003) Microprecipitation Method For Preparing Submicron Suspensions, in United States Patent 6,607,784. Baxter International Inc. (Deerfield, IL): USA.
-
(2003)
Microprecipitation Method For Preparing Submicron Suspensions
-
-
Kipp, J.E.1
Wong, J.C.T.2
Doty, M.J.3
Rebbeck, C.L.4
-
34
-
-
84967359339
-
Effective production of ibuprofen drug nanocrystals by high pressure homogenization using new two-step process
-
submitted. Nashville
-
Möschwitzer J and Müller RH (2005) Effective production of ibuprofen drug nanocrystals by high pressure homogenization using new two-step process, in AAPS. submitted. Nashville.
-
(2005)
AAPS
-
-
Möschwitzer, J.1
Müller, R.H.2
-
35
-
-
84967478073
-
Development of a new two-step process for the effective production drug nanocrystals by high pressure homogenization
-
submitted. Nashville
-
Möschwitzer J and Müller RH (2005) Development of a new two-step process for the effective production drug nanocrystals by high pressure homogenization. in AAPS. submitted. Nashville.
-
(2005)
AAPS
-
-
Möschwitzer, J.1
Müller, R.H.2
-
39
-
-
20844446627
-
The role of biopharmaceutics in the development of a clinical nanoparticle formulation of MK-0869: A Beagle dog model predicts improved bioavailability and diminished food effect on absorption in human
-
Wua YL, Landisb A, Hettricka E, Novaka L, Lynna L, Chenc K, Thompson A, Higgins R, Batrad U, Shelukard S, Kweia G and Storeye G (2004) The role of biopharmaceutics in the development of a clinical nanoparticle formulation of MK-0869: A Beagle dog model predicts improved bioavailability and diminished food effect on absorption in human. Int J Pharm 285(1-2):135-146.
-
(2004)
Int J Pharm
, vol.285
, Issue.1-2
, pp. 135-146
-
-
Wua, Y.L.1
Landisb, A.2
Hettricka, E.3
Novaka, L.4
Lynna, L.5
Chenc, K.6
Thompson, A.7
Higgins, R.8
Batrad, U.9
Shelukard, S.10
Kweia, G.11
Storeye, G.12
-
40
-
-
0028824401
-
Drug particle size reduction for decreasing gastric irritancy and enhancing absorption of naproxen in rats
-
Liversidge GGCP (1995) Drug particle size reduction for decreasing gastric irritancy and enhancing absorption of naproxen in rats. Int J Pharm 125:309-313.
-
(1995)
Int J Pharm
, vol.125
, pp. 309-313
-
-
Liversidge, G.G.C.P.1
-
42
-
-
84967432214
-
Production and Optimisation of Oral Cyclosporine Nanocrystals
-
Baltimore
-
Keck CM et al. (2004) Production and Optimisation of Oral Cyclosporine Nanocrystals, in AAPS. Baltimore.
-
(2004)
AAPS
-
-
Keck, C.M.1
-
43
-
-
84967541364
-
Herstellung hochfeiner Polymer- und Arzneistoffdispersionen und deren Sprühtrocknung
-
Freie Universität: Berlin
-
Krause K (2004) Herstellung hochfeiner Polymer- und Arzneistoffdispersionen und deren Sprühtrocknung, in PhD Thesis Pharmaceutical Technology, Freie Universität: Berlin.
-
(2004)
PhD Thesis Pharmaceutical Technology
-
-
Krause, K.1
-
45
-
-
0034759246
-
New antifungal agents currently under clinical development
-
Yamaguchi H and Hachioji I (2001) New antifungal agents currently under clinical development. Nippon Kagaku Ryoho Gakkai Zasshi 9(49):535-545.
-
(2001)
Nippon Kagaku Ryoho Gakkai Zasshi
, vol.9
, Issue.49
, pp. 535-545
-
-
Yamaguchi, H.1
Hachioji, I.2
-
47
-
-
0022496987
-
Evaluation of poly(lactic acid) as a biodegradable drug delivery system for parenteral administration
-
Smith A and Hunneyball LM (1986) Evaluation of poly(lactic acid) as a biodegradable drug delivery system for parenteral administration. Int J Pharm 30(2-3):215-220.
-
(1986)
Int J Pharm
, vol.30
, Issue.2-3
, pp. 215-220
-
-
Smith, A.1
Hunneyball, L.M.2
-
49
-
-
84967483106
-
Characterization of nebulized buparvaquone nanosuspensions - Effect of nebulization technology
-
submitted
-
Hernández-Trejo N, Kayser O, Müller RH and Steckel H (2004) Characterization of nebulized buparvaquone nanosuspensions - Effect of nebulization technology. Pharm Res. submitted.
-
(2004)
Pharm Res
-
-
Hernández-Trejo, N.1
Kayser, O.2
Müller, R.H.3
Steckel, H.4
-
51
-
-
0036891950
-
Ocular tolerability of Eudragit RS100 and RL100 nanosuspensions as carriers for ophthalmic controlled drug delivery
-
Pignatello R and Puglisi G (2002) Ocular tolerability of Eudragit RS100 and RL100 nanosuspensions as carriers for ophthalmic controlled drug delivery. J Pharm Sci 91(12):2636-41.
-
(2002)
J Pharm Sci
, vol.91
, Issue.12
, pp. 2636-2641
-
-
Pignatello, R.1
Puglisi, G.2
-
52
-
-
0036967917
-
Enhanced ocular anti-inflammatory activity of ibuprofen carried by an Eudragit RSIOO nanoparticle suspension
-
Bucolo CM, Puglisi G and Pignatello R (2002) Enhanced ocular anti-inflammatory activity of ibuprofen carried by an Eudragit RSIOO nanoparticle suspension. Ophthal Res 34(5):319-323.
-
(2002)
Ophthal Res
, vol.34
, Issue.5
, pp. 319-323
-
-
Bucolo, C.M.1
Puglisi, G.2
Pignatello, R.3
-
53
-
-
19944432512
-
RU 58841-myristate-prodrug development for topical treatment of acne and androgenetic alopecia
-
Münster UN, Haberland C, Jores A, Mehnert W, Rummel S, Schaller K, Korting M, Zouboulis Ch, Blume-Peytavi C and Schäfer-Korting M (2005) RU 58841-myristate-prodrug development for topical treatment of acne and androgenetic alopecia. Die Pharmazie 60(1):8-12.
-
(2005)
Die Pharmazie
, vol.60
, Issue.1
, pp. 8-12
-
-
Münster, U.N.1
Haberland, C.2
Jores, A.3
Mehnert, W.4
Rummel, S.5
Schaller, K.6
Korting, M.7
Zouboulis, C.H.8
Blume-Peytavi, C.9
Schäfer-Korting, M.10
-
54
-
-
0033976172
-
Solid lipid nanoparticles as drug carriers for topical glucocorticoids
-
Maia C, Mehnert W and Schäfer-Korting M (2000) Solid lipid nanoparticles as drug carriers for topical glucocorticoids. Int J Pharm 196:165-167.
-
(2000)
Int J Pharm
, vol.196
, pp. 165-167
-
-
Maia, C.1
Mehnert, W.2
Schäfer-Korting, M.3
-
56
-
-
0346729796
-
SolEmuls - A novel technology for the formulation of i.v. emulsions with poorly soluble drugs
-
Müller RH et al. (2004) SolEmuls - A novel technology for the formulation of i.v. emulsions with poorly soluble drugs. Int J Pharm 269:293-302.
-
(2004)
Int J Pharm
, vol.269
, pp. 293-302
-
-
Müller, R.H.1
-
57
-
-
0346729796
-
SolEmuls-novel technology for the formulation of i.v. emulsions with poorly soluble drugs
-
Muller RH et al. (2004) SolEmuls-novel technology for the formulation of i.v. emulsions with poorly soluble drugs. Int J Pharm 269(2):293-302.
-
(2004)
Int J Pharm
, vol.269
, Issue.2
, pp. 293-302
-
-
Muller, R.H.1
-
58
-
-
70449528894
-
O/W-Emulsionen fiir die intravenöse Applikation von Arzneistoffen
-
Freie Universität: Berlin
-
Buttle I (2004) O/W-Emulsionen fiir die intravenöse Applikation von Arzneistoffen, in PhD Thesis Pharmaceutical Technology, Freie Universität: Berlin.
-
(2004)
PhD Thesis Pharmaceutical Technology
-
-
Buttle, I.1
-
59
-
-
12744274624
-
Solubilisation by Emulsification
-
Akkar A and Müller RH (2004) Solubilisation by Emulsification. Pharm. Ind. 66(12): 1537-1544.
-
(2004)
Pharm. Ind
, vol.66
, Issue.12
, pp. 1537-1544
-
-
Akkar, A.1
Müller, R.H.2
-
60
-
-
0038692100
-
Intravenous itraconazole emulsions produced by SolEmuls technology
-
Akkar A and Müller RH (2003) Intravenous itraconazole emulsions produced by SolEmuls technology. Eur J Pharm Biopharm 56(1):29-36.
-
(2003)
Eur J Pharm Biopharm
, vol.56
, Issue.1
, pp. 29-36
-
-
Akkar, A.1
Müller, R.H.2
-
62
-
-
0038061596
-
Formulation of intravenous Carbamazepine emulsions by SolEmuls technology
-
Akkar A and Müller RH (2003) Formulation of intravenous Carbamazepine emulsions by SolEmuls technology. Eur J Pharm Biopharm 55(3):305-12.
-
(2003)
Eur J Pharm Biopharm
, vol.55
, Issue.3
, pp. 305-312
-
-
Akkar, A.1
Müller, R.H.2
-
63
-
-
34547923499
-
Poorly Soluble Drugs: Formulation by Nanocrystals and SolEmuls Technologies
-
Freie Universität: Berlin
-
Akkar A (2004) Poorly Soluble Drugs: Formulation by Nanocrystals and SolEmuls Technologies, in PhD Thesis Pharmaceutical Technology. Freie Universität: Berlin.
-
(2004)
PhD Thesis Pharmaceutical Technology
-
-
Akkar, A.1
-
64
-
-
0035105654
-
Lipid-based amphotericin B: A review of the last 10 years of use
-
Hann IM and Prentice HG (2001) Lipid-based amphotericin B: A review of the last 10 years of use. Int J Antimicrob Agents (17): 161-169.
-
(2001)
Int J Antimicrob Agents
, Issue.17
, pp. 161-169
-
-
Hann, I.M.1
Prentice, H.G.2
-
65
-
-
33750031850
-
-
(Patterson T. F. and McGinis M. R., ed.)
-
Lewis R (2003) Antifungal therapy cost analysis (Patterson T. F. and McGinis M. R., ed.). www.doctorfungus.org.
-
(2003)
Antifungal therapy cost analysis
-
-
Lewis, R.1
-
66
-
-
0027140491
-
Amphotericin b lipidcomplex (ABLC (TM)): A molecular rationale for the attenuation of amphotericin B related toxicities
-
Janoff A et al. (1993) Amphotericin b lipidcomplex (ABLC (TM)): A molecular rationale for the attenuation of amphotericin B related toxicities. J Liposome Res 3:451-471.
-
(1993)
J Liposome Res
, vol.3
, pp. 451-471
-
-
Janoff, A.1
|